Detailed information for compound 1687690

Basic information

Technical information
  • TDR Targets ID: 1687690
  • Name: (R)-[(4S,5R,7S)-5-ethenyl-1-azabicyclo[2.2.2] octan-7-yl]-(6-methoxyquinolin-4-yl)methanol hydrobromide
  • MW: 405.329 | Formula: C20H25BrN2O2
  • H donors: 1 H acceptors: 2 LogP: 3.8 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](c1ccnc2c1cc(OC)cc2)O.Br
  • InChi: 1S/C20H24N2O2.BrH/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H/t13-,14-,19-,20+;/m0./s1
  • InChiKey: HDZGBIRSORQVNB-DSXUQNDKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (R)-(6-methoxy-4-quinolyl)-[(2S,4S,5R)-5-vinylquinuclidin-2-yl]methanol hydrobromide
  • (R)-(6-methoxy-4-quinolyl)-[(2S,4S,5R)-5-vinyl-2-quinuclidinyl]methanol hydrobromide
  • Q1750_SIGMA

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0131 1 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.5365 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0106 0.0198
Onchocerca volvulus Huntingtin homolog 0.0131 1 1
Onchocerca volvulus 0.0085 0.5365 0.5365
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.7307 0.7307
Schistosoma mansoni tar DNA-binding protein 0.0068 0.3612 0.6733
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0106 0.0198
Brugia malayi RNA binding protein 0.0068 0.3612 0.3612
Schistosoma mansoni tar DNA-binding protein 0.0068 0.3612 0.6733
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.5365 0.5365
Schistosoma mansoni tar DNA-binding protein 0.0068 0.3612 0.6733
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0106 0.0198
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.7307 0.7307
Loa Loa (eye worm) TAR-binding protein 0.0068 0.3612 0.3612
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.3974 0.3974
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0106 0.0106
Schistosoma mansoni tar DNA-binding protein 0.0068 0.3612 0.6733
Loa Loa (eye worm) hypothetical protein 0.0104 0.7307 0.7307
Schistosoma mansoni hypothetical protein 0.0071 0.3974 0.7407
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.3612 0.3612
Schistosoma mansoni hypothetical protein 0.0033 0.0106 0.0198
Echinococcus multilocularis GPCR, family 2 0.0033 0.0106 0.0198
Echinococcus granulosus GPCR family 2 0.0033 0.0106 0.0198
Loa Loa (eye worm) hypothetical protein 0.0085 0.5365 0.5365
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0106 0.0106
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.3612 0.3612
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.0106
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.7307 0.7307
Echinococcus multilocularis tar DNA binding protein 0.0068 0.3612 0.6733
Schistosoma mansoni tar DNA-binding protein 0.0068 0.3612 0.6733
Brugia malayi TAR-binding protein 0.0068 0.3612 0.3612
Onchocerca volvulus Huntingtin homolog 0.0131 1 1
Schistosoma mansoni hypothetical protein 0.0033 0.0106 0.0198
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.5365 1
Loa Loa (eye worm) hypothetical protein 0.0131 1 1
Schistosoma mansoni hypothetical protein 0.0033 0.0106 0.0198
Loa Loa (eye worm) RNA binding protein 0.0068 0.3612 0.3612
Schistosoma mansoni hypothetical protein 0.0033 0.0106 0.0198
Echinococcus granulosus tar DNA binding protein 0.0068 0.3612 0.6733
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0106 0.0106
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0106 0.0198
Loa Loa (eye worm) hypothetical protein 0.0071 0.3974 0.3974
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.5365 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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