TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 688.272 | Formula: C23H21IN2O11P2
H donors: 1 H acceptors: 4 LogP: 1.51 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: O=c1[nH]c(=O)n(cc1[125I])[C@H]1C[C@@H]([C@H](O1)COP1(=O)OCc2c(O1)cccc2)OP1(=O)OCc2c(O1)cccc2
InChi: 1S/C23H21IN2O11P2/c24-16-10-26(23(28)25-22(16)27)21-9-19(37-39(30)32-12-15-6-2-4-8-18(15)36-39)20(34-21)13-33-38(29)31-11-14-5-1-3-7-17(14)35-38/h1-8,10,19-21H,9,11-13H2,(H,25,27,28)/t19-,20+,21+,38?,39?/m0/s1/i24-2
InChiKey: FWUSREJWGLFKNE-UQRNWKOSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0018	0.0052	0.0052
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0018	0.0052	0.0438
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0016	0.0022	0.0101
Brugia malayi	Cation transporter family protein	0.0018	0.0052	0.0052
Plasmodium falciparum	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0088	0.1194	1
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0018	0.0052	0.0438
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0016	0.0022	0.0181
Mycobacterium tuberculosis	Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme)	0.0584	0.9311	1
Schistosoma mansoni	lamin	0.0026	0.0178	0.0835
Brugia malayi	PHD-finger family protein	0.0024	0.0146	0.0146
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0088	0.1194	0.1184
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0018	0.0052	0.0052
Leishmania major	trypanothione reductase	0.0046	0.0499	0.0499
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0426	0.0426
Echinococcus granulosus	synaptic glycoprotein sc2	0.0088	0.1194	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0018	0.0052	0.0052
Brugia malayi	Bromodomain containing protein	0.0037	0.0357	0.0357
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0016	0.0022	0.0181
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0088	0.1194	0.1194
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0018	0.0052	0.0052
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0018	0.0052	0.0245
Schistosoma mansoni	bromodomain containing protein	0.0061	0.0752	0.3523
Echinococcus multilocularis	lamin	0.0026	0.0178	0.1494
Schistosoma mansoni	jumonji domain containing protein	0.0057	0.0682	0.3192
Echinococcus multilocularis	musashi	0.0026	0.0178	0.1494
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0018	0.0052	0.0245
Mycobacterium tuberculosis	Probable reductase	0.0104	0.1457	0.1554
Echinococcus multilocularis	glycine receptor subunit beta	0.0018	0.0052	0.0438
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0057	0.0682	0.571
Brugia malayi	jmjC domain containing protein	0.0059	0.0712	0.0712
Plasmodium falciparum	glutathione reductase	0.0016	0.0011	0.0093
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0178	0.0178
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0018	0.0052	0.0052
Loa Loa (eye worm)	LGC-31 protein	0.0018	0.0052	0.0052
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.1194	0.1184
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Entamoeba histolytica	steroid 5-alpha reductase, putative	0.0627	1	1
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0018	0.0052	0.0438
Echinococcus granulosus	glycine receptor subunit beta	0.0018	0.0052	0.0438
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0499	0.4184
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Echinococcus multilocularis	3 oxo 5 alpha steroid 4 dehydrogenase, C terminal	0.0088	0.1194	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0011	0.0011
Plasmodium falciparum	polyprenol reductase, putative	0.0088	0.1194	1
Schistosoma mansoni	nAChR subunit	0.0018	0.0052	0.0245
Schistosoma mansoni	nAChR subunit	0.0018	0.0052	0.0245
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0627	1	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0018	0.0052	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0052	0.0052
Treponema pallidum	NADH oxidase	0.0016	0.0011	0.5
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0627	1	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0499	0.4184
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0499	0.0499
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0052	0.0052
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0499	0.0499
Brugia malayi	Synaptic glycoprotein SC2	0.0088	0.1194	0.1194
Echinococcus granulosus	nAChR subunit	0.0018	0.0052	0.0438
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0104	0.1457	0.1554
Loa Loa (eye worm)	ACC-1 protein	0.0018	0.0052	0.0052
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.1194	0.1184
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0499	0.0499
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0018	0.0052	0.0438
Brugia malayi	Bromodomain containing protein	0.0072	0.0937	0.0937
Loa Loa (eye worm)	hypothetical protein	0.0627	1	1
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0018	0.0052	0.0052
Onchocerca volvulus		0.0026	0.0178	0.1104
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0088	0.1194	0.1194
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0011	0.0011
Plasmodium vivax	polyprenol reductase, putative	0.0088	0.1194	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0018	0.0052	0.0438
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0052	0.0052
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0011	0.0011
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0499	0.4184
Loa Loa (eye worm)	hypothetical protein	0.0088	0.1194	0.1194
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0057	0.0682	0.571
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0108	0.0908
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0088	0.1194	0.1184
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0018	0.0052	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0396	0.0396
Echinococcus granulosus	lysine specific demethylase 5A	0.0059	0.0712	0.5963
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0018	0.0052	0.0438
Brugia malayi	Thioredoxin reductase	0.0046	0.0499	0.0499
Echinococcus granulosus	intermediate filament protein	0.0026	0.0178	0.1494
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0116	0.1647	0.1759
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0011	0.5
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0116	0.1647	0.1759
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0088	0.1194	0.1184
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0018	0.0052	0.0438
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0018	0.0052	0.0438
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0018	0.0052	0.0052
Brugia malayi	Cation transporter family protein	0.0018	0.0052	0.0052
Schistosoma mansoni	zinc finger protein	0.0019	0.0062	0.0288
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0178	0.0178
Brugia malayi	Cation transporter family protein	0.0018	0.0052	0.0052
Echinococcus granulosus	zinc finger protein	0.0019	0.0062	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0088	0.1194	0.1194
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0011	0.0011
Onchocerca volvulus		0.0026	0.0178	0.1104
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0011	0.0011
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0016	0.0022	0.0181
Schistosoma mansoni	nAChR subunit	0.0018	0.0052	0.0245
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0018	0.0052	0.0245
Giardia lamblia	Synaptic glycoprotein SC2	0.0088	0.1194	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0052	0.0052
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0011	0.0093
Onchocerca volvulus		0.0088	0.1194	1
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.0011	0.0011
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0018	0.0052	0.0438
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.0011	0.0011
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0011	0.0052
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0627	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Schistosoma mansoni	lamin	0.0026	0.0178	0.0835
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0011	0.0011
Plasmodium vivax	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0088	0.1194	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0016	0.0022	0.0181
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0058	0.0696	0.5828
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0018	0.0052	0.0052
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0499	0.4184
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0018	0.0052	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0018	0.0052	0.0245
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0018	0.0052	0.0052
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0016	0.0011	0.0093
Echinococcus multilocularis	lamin dm0	0.0026	0.0178	0.1494
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.0088	0.1194	0.559
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0018	0.0052	0.0052
Schistosoma mansoni	nAChR subunit	0.0018	0.0052	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0016	0.0022	0.0101
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0018	0.0052	0.0438
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0011	0.0011
Trypanosoma cruzi	trypanothione reductase, putative	0.0016	0.0011	0.0011
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0627	1	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0018	0.0052	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0088	0.1194	0.1194
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0011	0.0011
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0018	0.0052	0.0052
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0011	0.0093
Mycobacterium ulcerans	pantoate--beta-alanine ligase	0.0584	0.9311	0.931
Loa Loa (eye worm)	hypothetical protein	0.0068	0.087	0.087
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0358	0.0358
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0016	0.0011	0.0093
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0499	0.4184
Echinococcus multilocularis	synaptic glycoprotein sc2	0.0088	0.1194	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0018	0.0052	0.0438
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0018	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Echinococcus granulosus	3 oxo 5 alpha steroid 4 dehydrogenase C terminal	0.0088	0.1194	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0171	0.0171
Trypanosoma brucei	trypanothione reductase	0.0046	0.0499	0.0499
Echinococcus multilocularis	zinc finger protein	0.0019	0.0062	0.0515
Echinococcus granulosus	glycine receptor subunit beta	0.0018	0.0052	0.0438
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0016	0.0011	0.5
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0499	0.0525
Mycobacterium tuberculosis	Probable oxidoreductase	0.0116	0.1647	0.1759
Mycobacterium ulcerans	hypothetical protein	0.0627	1	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0016	0.0011	0.0011
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0016	0.0011	0.0011
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0011	0.0011
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0018	0.0052	0.0438
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0058	0.0696	0.5828
Brugia malayi	glutathione reductase	0.0046	0.0499	0.0499
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0116	0.1647	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Schistosoma mansoni	nAChR subunit	0.0018	0.0052	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0018	0.0052	0.0052
Plasmodium falciparum	glutathione reductase	0.0046	0.0499	0.4184
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0499	0.0499
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0078	0.0078
Mycobacterium tuberculosis	Probable dehydrogenase	0.0104	0.1457	0.1554
Schistosoma mansoni	nAChR subunit	0.0018	0.0052	0.0245
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.032	0.2681
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0018	0.0052	0.0438
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative	0.0627	1	1
Brugia malayi	jmjC domain containing protein	0.0057	0.0682	0.0682
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0108	0.0908
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0018	0.0052	0.0052
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0178	0.0835
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0178	0.0178
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0018	0.0052	0.0245
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0016	0.0011	0.0093
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0018	0.0052	0.0438
Plasmodium falciparum	thioredoxin reductase	0.0016	0.0011	0.0093
Echinococcus granulosus	lamin dm0	0.0026	0.0178	0.1494
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0104	0.1457	0.1554
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0016	0.0011	0.0093
Loa Loa (eye worm)	ACC-1 protein	0.0018	0.0052	0.0052
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0016	0.0022	0.0101
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0011	0.0011
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0017	0.003	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0022	0.0022
Schistosoma mansoni	nAChR subunit	0.0018	0.0052	0.0245
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.0712	0.3334
Toxoplasma gondii	NADPH-glutathione reductase	0.0016	0.0011	0.0011
Echinococcus multilocularis	nAChR subunit	0.0018	0.0052	0.0438
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0104	0.1457	0.1554
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.0088	0.1194	0.559
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0031	0.0031
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0017	0.003	0.0253
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0108	0.0508
Mycobacterium leprae	Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme)	0.0584	0.9311	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0018	0.0052	0.0438
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0088	0.1194	0.1194
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0018	0.0052	0.0438
Echinococcus multilocularis	lysine specific demethylase 5A	0.0057	0.0682	0.571
Brugia malayi	excitatory GABA receptor EXP-1A	0.0018	0.0052	0.0052
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.032	0.2681
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0016	0.0011	0.0011
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0018	0.0052	0.0438
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0018	0.0052	0.0052
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0627	1	1
Toxoplasma gondii	pantoate-beta-alanine ligase	0.0584	0.9311	0.9311
Echinococcus granulosus	lamin	0.0026	0.0178	0.1494
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0088	0.1194	0.1184
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0104	0.1457	0.1554
Schistosoma mansoni	hypothetical protein	0.002	0.0078	0.0366
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.0712	0.3334
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0011	0.0011
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0018	0.0052	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0018	0.0052	0.0052
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0011	0.0011
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0018	0.0052	0.0438
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0627	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0011	0.5
Brugia malayi	intermediate filament protein	0.0026	0.0178	0.0178
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0178	0.0178
Leishmania major	3-oxo-5-alpha-steroid 4-dehydrogenase-like protein	0.0627	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0712	0.0712
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0052
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0016	0.0022	0.0101

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2147628

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1688021