Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | acetyl-CoA carboxylase, putative | 0.0277 | 0.5211 | 0.7276 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0468 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.1514 | 0.0667 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.1514 | 0.0667 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6823 | 1 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0267 | 0.4968 | 0.407 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0172 | 0.2563 | 0.2799 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0468 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0341 | 0.6823 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0468 | 1 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0106 | 0.0907 | 0.133 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6823 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0468 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6823 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0468 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.1514 | 0.0667 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.1514 | 0.0667 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0277 | 0.5211 | 0.7276 |
Onchocerca volvulus | 0.013 | 0.1514 | 0.5 | |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0267 | 0.4968 | 0.407 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0277 | 0.5211 | 0.4733 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0468 | 1 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0277 | 0.5211 | 0.7276 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6823 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0106 | 0.0907 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1514 | 0.0667 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.1514 | 0.0667 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6823 | 1 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0277 | 0.5211 | 0.7638 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0106 | 0.0907 | 0.133 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.0277 | 0.5211 | 0.4733 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0277 | 0.5211 | 0.4733 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0468 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0468 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0468 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.73 | Inhibition of rat liver DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 6.08 | Inhibition of Toxoplasma gondii DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 0.84 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 0.84 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 0.84 uM | Inhibition of Toxoplasma gondii DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 1.88 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 1.88 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 1.88 uM | Inhibition of rat liver DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 31.5 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 31.5 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 9301665 |
Inhibition (binding) | = 4 % | Percentage inhibition against Pneumocystis carinii Dihydrofolate reductase. | ChEMBL. | 9301665 |
Inhibition (binding) | = 4 % | Percentage inhibition against Pneumocystis carinii Dihydrofolate reductase. | ChEMBL. | 9301665 |
Selectivity ratio (binding) | = 2.2 | Relative binding affinity to rat liver and Toxoplasma gondii DHFR. | ChEMBL. | 9301665 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.