Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opiate receptor-like 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | opiate receptor-like 1 | 370 aa | 349 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0069 | 0.16 | 0.1966 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 1 | 1 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0069 | 0.16 | 0.1966 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0231 | 0.8137 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0231 | 0.8137 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0231 | 0.8137 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1351 | 0.1351 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 0.5211 | 0.6404 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0069 | 0.16 | 0.16 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0231 | 0.8137 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0069 | 0.16 | 0.1966 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0231 | 0.8137 | 0.5 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0069 | 0.16 | 0.1966 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0069 | 0.16 | 0.1966 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0069 | 0.16 | 0.1966 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0231 | 0.8137 | 1 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0069 | 0.16 | 0.1966 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0231 | 0.8137 | 1 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0069 | 0.16 | 0.1966 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0062 | 0.1351 | 0.1351 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0231 | 0.8137 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 0.5211 | 0.6404 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0231 | 0.8137 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0091 | 0.2517 | 0.2517 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0231 | 0.8137 | 0.8137 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0069 | 0.16 | 0.1966 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0069 | 0.16 | 0.1966 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0231 | 0.8137 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0231 | 0.8137 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0231 | 0.8137 | 1 |
Onchocerca volvulus | 0.0277 | 1 | 0.5 | |
Brugia malayi | proteasome subunit beta type 1 | 0.0069 | 0.16 | 0.16 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0231 | 0.8137 | 0.8137 |
Echinococcus granulosus | proteasome prosome macropain | 0.0231 | 0.8137 | 1 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0231 | 0.8137 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.2517 | 0.2517 |
Echinococcus granulosus | geminin | 0.0158 | 0.5211 | 0.6404 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.1351 | 0.166 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0091 | 0.2517 | 0.2517 |
Mycobacterium ulcerans | proteasome PrcB | 0.0231 | 0.8137 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0091 | 0.2517 | 0.2517 |
Echinococcus multilocularis | geminin | 0.0158 | 0.5211 | 0.6404 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0231 | 0.8137 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kb (functional) | = 15.8 nM | Antagonist activity at human recombinant NOP receptor expressed in CHO cells assessed as inhibition of nociceptin-induced [35S]GTPgammaS binding after 2 hrs by scintillation proximity assay | ChEMBL. | 21438532 |
Ki (binding) | = 10.2 nM | Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation counting | ChEMBL. | 21438532 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.