Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.034 | 0.1996 | 0.6337 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0053 | 0.0179 | 0.0456 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0178 | 0.0686 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.034 | 0.1996 | 0.6337 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.034 | 0.1996 | 0.6337 |
Brugia malayi | nuclear receptor NHR-88 | 0.0053 | 0.0179 | 0.0456 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0178 | 0.0748 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.0182 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0128 | 0.0654 | 0.1671 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0212 | 0.0542 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0053 | 0.0179 | 0.0456 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0643 | 0.3912 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0053 | 0.0179 | 0.0456 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0166 | 0.0893 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0053 | 0.0179 | 0.0456 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.034 | 0.1996 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0128 | 0.0654 | 0.1671 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0053 | 0.0179 | 0.0456 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0103 | 0.049 | 0.2061 |
Loa Loa (eye worm) | hypothetical protein | 0.0618 | 0.3752 | 0.9592 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0103 | 0.049 | 0.0842 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0028 | 0.0019 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.049 | 0.1253 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.0654 | 0.2522 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.034 | 0.1996 | 0.6337 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0019 | 0.0049 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0019 | 0.0048 |
Loa Loa (eye worm) | RNA binding protein | 0.0128 | 0.0654 | 0.1671 |
Brugia malayi | nuclear hormone receptor | 0.0053 | 0.0179 | 0.0456 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0028 | 0.0019 | 0.0049 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0053 | 0.0179 | 0.0437 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0054 | 0.0182 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0053 | 0.0179 | 0.0689 |
Brugia malayi | hypothetical protein | 0.0127 | 0.0644 | 0.1645 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0019 | 0.0049 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0053 | 0.0179 | 0.0456 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0054 | 0.0182 | 0.0312 |
Trypanosoma brucei | protein kinase, putative | 0.0054 | 0.0182 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0644 | 0.1645 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.034 | 0.1996 | 0.6337 |
Brugia malayi | amidase | 0.0103 | 0.049 | 0.1253 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0053 | 0.0179 | 0.0689 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0053 | 0.0179 | 0.0307 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.014 | 0.0726 | 0.3054 |
Loa Loa (eye worm) | TAR-binding protein | 0.0128 | 0.0654 | 0.1671 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0166 | 0.0893 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0019 | 0.0048 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0054 | 0.0182 | 0.0464 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0178 | 0.0748 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0028 | 0.0019 | 0.0074 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0028 | 0.0019 | 0.0049 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0053 | 0.0179 | 0.0456 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0053 | 0.0179 | 0.0456 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.0182 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0053 | 0.0179 | 0.0456 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.034 | 0.1996 | 0.6337 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0054 | 0.0182 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0054 | 0.0182 | 0.0312 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0053 | 0.0179 | 0.0307 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0053 | 0.0179 | 0.0456 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0178 | 0.0686 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.034 | 0.1996 | 0.6337 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0178 | 0.0455 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0053 | 0.0179 | 0.0456 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0054 | 0.0182 | 0.5 |
Onchocerca volvulus | 0.0053 | 0.0179 | 0.0437 | |
Echinococcus granulosus | tumor protein p63 | 0.0401 | 0.2378 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0643 | 0.3912 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0434 | 0.2591 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0506 | 0.3045 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0201 | 0.1113 | 0.4296 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0053 | 0.0179 | 0.0689 |
Onchocerca volvulus | 0.0028 | 0.0019 | 0.0046 | |
Schistosoma mansoni | lipoxygenase | 0.014 | 0.0726 | 0.2803 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0054 | 0.0182 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0019 | 0.0049 |
Brugia malayi | steroid hormone receptor | 0.0053 | 0.0179 | 0.0456 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0053 | 0.0179 | 0.0456 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0053 | 0.0179 | 0.0456 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0054 | 0.0182 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0053 | 0.0179 | 0.0307 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0053 | 0.0179 | 0.0456 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0053 | 0.0179 | 0.0751 |
Echinococcus granulosus | geminin | 0.0201 | 0.1113 | 0.4681 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0053 | 0.0179 | 0.0751 |
Brugia malayi | RNA binding protein | 0.0128 | 0.0654 | 0.1671 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.034 | 0.1996 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0053 | 0.0179 | 0.0751 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0166 | 0.0893 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0054 | 0.0182 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0053 | 0.0179 | 0.0689 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0179 | 0.0456 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0028 | 0.0019 | 0.0033 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0053 | 0.0179 | 0.0307 |
Echinococcus granulosus | tar DNA binding protein | 0.0128 | 0.0654 | 0.2748 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0128 | 0.0654 | 0.1671 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0178 | 0.0306 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0179 | 0.0456 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0054 | 0.0182 | 0.0763 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0053 | 0.0179 | 0.0456 |
Onchocerca volvulus | 0.0059 | 0.0212 | 0.0518 | |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0644 | 0.1645 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0053 | 0.0179 | 0.0689 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0179 | 0.0456 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0053 | 0.0179 | 0.0307 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0671 | 0.409 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0028 | 0.0019 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0019 | 0.0049 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.0654 | 0.2522 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0053 | 0.0179 | 0.0456 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0053 | 0.0179 | 0.0751 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.014 | 0.0726 | 0.1248 |
Schistosoma mansoni | amidase | 0.0103 | 0.049 | 0.1891 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0019 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0201 | 0.1113 | 0.4296 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0053 | 0.0179 | 0.0751 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0019 | 0.0049 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0053 | 0.0179 | 0.0751 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0053 | 0.0179 | 0.0751 |
Echinococcus multilocularis | geminin | 0.0201 | 0.1113 | 0.1913 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0053 | 0.0179 | 0.0456 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.0654 | 0.2522 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0103 | 0.049 | 0.2061 |
Schistosoma mansoni | lipoxygenase | 0.0098 | 0.046 | 0.1774 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0053 | 0.0179 | 0.0689 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0059 | 0.0212 | 0.0818 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0053 | 0.0179 | 0.0456 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0053 | 0.0179 | 0.0456 |
Schistosoma mansoni | coup transcription factor | 0.0053 | 0.0179 | 0.0689 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0179 | 0.0456 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0178 | 0.0686 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.034 | 0.1996 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0128 | 0.0654 | 0.1123 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0053 | 0.0179 | 0.0456 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0178 | 0.0455 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0053 | 0.0179 | 0.0456 |
Schistosoma mansoni | thyroid hormone receptor | 0.0053 | 0.0179 | 0.0689 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0019 | 0.0048 |
Brugia malayi | ecdysteroid receptor | 0.0053 | 0.0179 | 0.0456 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0103 | 0.049 | 0.0842 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0053 | 0.0179 | 0.0456 |
Onchocerca volvulus | Huntingtin homolog | 0.0127 | 0.0644 | 0.1573 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0053 | 0.0179 | 0.0307 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0179 | 0.0456 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0053 | 0.0179 | 0.0456 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0019 | 0.0049 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.0654 | 0.2522 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0103 | 0.049 | 0.1891 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0028 | 0.0019 | 0.0074 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0053 | 0.0179 | 0.0689 |
Schistosoma mansoni | thyroid hormone receptor | 0.0053 | 0.0179 | 0.0689 |
Echinococcus multilocularis | tumor protein p63 | 0.0401 | 0.2378 | 0.4086 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0019 | 0.0048 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0053 | 0.0179 | 0.0689 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0053 | 0.0179 | 0.0307 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0053 | 0.0179 | 0.0456 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0178 | 0.0306 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0179 | 0.0456 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0179 | 0.0456 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0179 | 0.0456 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0053 | 0.0179 | 0.0751 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0053 | 0.0179 | 0.0307 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0019 | 0.0049 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0053 | 0.0179 | 0.0307 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.034 | 0.1996 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0028 | 0.0019 | 0.0049 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0019 | 0.0048 |
Brugia malayi | MAP kinase sur-1 | 0.0054 | 0.0182 | 0.0464 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.034 | 0.1996 | 0.6337 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0054 | 0.0182 | 0.0763 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.0654 | 0.2522 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0053 | 0.0179 | 0.0751 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0053 | 0.0179 | 0.0689 |
Onchocerca volvulus | Huntingtin homolog | 0.0127 | 0.0644 | 0.1573 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0944 | 0.582 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0053 | 0.0179 | 0.0437 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0054 | 0.0182 | 0.07 |
Schistosoma mansoni | nuclear hormone receptor | 0.0053 | 0.0179 | 0.0689 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 24 % | Percent inhibition value on the Sephadex-induced lung eosinophilia model at an intraperitoneal (ip) dose of 3 mg/kg | ChEMBL. | 9685237 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.