Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 3 | 305 aa | 303 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0029 | 0.3409 | 0.3409 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0052 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0029 | 0.3409 | 0.3409 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0052 | 1 | 1 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0052 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0029 | 0.3409 | 0.3409 |
Brugia malayi | nuclear receptor NHR-88 | 0.0029 | 0.3409 | 0.3409 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0052 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0029 | 0.3409 | 0.3409 |
Plasmodium falciparum | protein kinase 5 | 0.0052 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0029 | 0.3409 | 0.3409 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.3409 | 0.1178 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.8342 | 0.7485 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0052 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.8342 | 0.8342 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0029 | 0.3409 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0052 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0029 | 0.3409 | 0.3409 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.3409 | 0.1178 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0029 | 0.3409 | 0.3409 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0029 | 0.3409 | 0.3409 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0029 | 0.3409 | 0.1178 |
Echinococcus granulosus | cyclin dependent kinase | 0.0052 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0029 | 0.3409 | 0.1178 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0029 | 0.3409 | 0.1178 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.8342 | 0.7485 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0052 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0052 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 1 | 0.5 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0052 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0052 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.3409 | 0.1178 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.8342 | 0.7781 |
Onchocerca volvulus | 0.0029 | 0.3409 | 0.5 | |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0029 | 0.3409 | 0.1178 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.8342 | 0.7485 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 1 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0052 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0029 | 0.3409 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.3409 | 0.1178 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0052 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0029 | 0.3409 | 0.3409 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.3409 | 0.1178 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.8342 | 0.7485 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.3409 | 0.1178 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0052 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0029 | 0.3409 | 0.3409 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0052 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0029 | 0.3409 | 0.3409 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0029 | 0.3409 | 0.1178 |
Brugia malayi | nuclear hormone receptor | 0.0029 | 0.3409 | 0.3409 |
Plasmodium vivax | protein kinase Crk2 | 0.0052 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.8342 | 0.7485 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0052 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0029 | 0.3409 | 0.3409 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0029 | 0.3409 | 0.3409 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0029 | 0.3409 | 0.3409 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0052 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0029 | 0.3409 | 0.3409 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0052 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0052 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0029 | 0.3409 | 0.3409 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0029 | 0.3409 | 0.1178 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0029 | 0.3409 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0.2529 | 0.2529 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0029 | 0.3409 | 0.3409 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.9844 | 0.9791 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.8342 | 0.7485 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.3409 | 0.1178 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0029 | 0.3409 | 0.1178 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.8342 | 0.7485 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0029 | 0.3409 | 0.3409 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0029 | 0.3409 | 0.1178 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.3409 | 0.1178 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 24.5 nM | In vitro inhibition of Cyclin-dependent kinase 2 was determined. | ChEMBL. | 12941317 |
IC50 (binding) | = 24.5 nM | In vitro inhibition of Cyclin-dependent kinase 2 was determined. | ChEMBL. | 12941317 |
IC50 (binding) | = 398 nM | Inhibition of Cyclin-dependent kinase 1 | ChEMBL. | 12941317 |
IC50 (binding) | = 398 nM | Inhibition of Cyclin-dependent kinase 1 | ChEMBL. | 12941317 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.