Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450, putative | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0016 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0016 | 0.5 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.5 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0016 | 0.5 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0016 | 0.5 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (functional) | = 25 % | Agonist activity at S1P3 receptor at 40 uM by [35S]GTPgammaS binding assay relative to control | ChEMBL. | 23141913 |
Efficacy (functional) | = 38 % | Agonist activity at S1P1 receptor at 10 uM by [35S]GTPgammaS binding assay relative to control | ChEMBL. | 23141913 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.