Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0027 | 0.2354 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.9486 | 0.9328 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.9486 | 0.9328 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.2354 | 0.2354 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 1 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.9486 | 0.9328 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0068 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.9486 | 0.9328 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0068 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2354 | 0.2354 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.9486 | 0.9486 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.2354 | 0.2354 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.9486 | 0.9486 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.2354 | 0.2354 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0039 | 0.4644 | 0.2996 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 1 | 0.5 |
Brugia malayi | RNA binding protein | 0.0065 | 0.9486 | 0.9486 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0068 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.9486 | 0.9328 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.9486 | 0.9486 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.9486 | 0.9328 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.2354 | 0.2354 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0039 | 0.4644 | 0.2996 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.9486 | 0.9486 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2261 | 0.2261 |
Onchocerca volvulus | 0.0027 | 0.2354 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.9486 | 0.9328 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.9486 | 0.9486 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.