Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.2939 | 0.2939 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.004 | 0.5223 | 0.5 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0017 | 0.0583 | 0.0583 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.3047 | 0.3047 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.5223 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.3047 | 0.3047 |
Echinococcus multilocularis | lamin | 0.0029 | 0.3047 | 0.3047 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0064 | 1 | 1 |
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0017 | 0.0583 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0017 | 0.0583 | 0.0583 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0017 | 0.0583 | 0.0583 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.5223 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 0.5223 | 1 |
Onchocerca volvulus | 0.0029 | 0.3047 | 0.5 | |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.5223 | 0.4927 |
Echinococcus granulosus | phd:f box containing protein | 0.0017 | 0.0583 | 0.0583 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0017 | 0.0583 | 0.0583 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.287 | 0.287 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0017 | 0.0583 | 0.0583 |
Schistosoma mansoni | jumonji domain containing protein | 0.0064 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0064 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0064 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0064 | 1 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.5223 | 1 |
Echinococcus multilocularis | musashi | 0.0029 | 0.3047 | 0.3047 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0017 | 0.0583 | 0.0583 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 0.5223 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.3047 | 0.3047 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.5223 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.3047 | 0.3047 |
Echinococcus multilocularis | phd:f box containing protein | 0.0017 | 0.0583 | 0.0583 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.3047 | 0.2822 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0583 | 0.0583 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 0.5223 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.3047 | 0.2616 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0583 | 0.0583 |
Echinococcus granulosus | lamin | 0.0029 | 0.3047 | 0.3047 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0313 | 0.0313 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0017 | 0.0583 | 0.0583 |
Brugia malayi | Inositol-1 | 0.004 | 0.5223 | 0.5069 |
Brugia malayi | jmjC domain containing protein | 0.0017 | 0.0583 | 0.0279 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0036 | 0.4378 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.3047 | 0.3047 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.5223 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0017 | 0.0583 | 0.0279 |
Brugia malayi | jmjC domain containing protein | 0.0017 | 0.0583 | 0.0279 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.3047 | 0.2822 |
Brugia malayi | jmjC domain containing protein | 0.0017 | 0.0583 | 0.0279 |
Schistosoma mansoni | lamin | 0.0029 | 0.3047 | 0.2616 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.3047 | 0.3047 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.8451 | 0.8355 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0036 | 0.4378 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0064 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.5223 | 0.4927 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.5223 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.004 | 0.5223 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0017 | 0.0583 | 0.0583 |
Loa Loa (eye worm) | inositol-1 | 0.004 | 0.5223 | 0.5223 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0064 | 1 | 1 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0017 | 0.0583 | 0.0583 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0017 | 0.0583 | 0.0583 |
Schistosoma mansoni | lamin | 0.0029 | 0.3047 | 0.2616 |
Onchocerca volvulus | 0.0029 | 0.3047 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0583 | 0.0583 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0017 | 0.0583 | 0.0583 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.287 | 0.264 |
Plasmodium vivax | JmjC domain containing protein | 0.0017 | 0.0583 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0064 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.513 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.459 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (binding) | = uM | Inhibition of protein-tyrosine kinase p56lck (Not determined) | ChEMBL. | 8411019 |
IC50 (binding) | = 0 uM | Inhibition of protein-tyrosine kinase p56lck (Not determined) | ChEMBL. | 8411019 |
IC50 (functional) | = 0.2 uM | Inhibition of c-erb B-2/HER2/neu receptor | ChEMBL. | 8105084 |
IC50 (functional) | = 5 uM | Inhibition of epidermal growth factor receptor (EGFR) autophosphorylation | ChEMBL. | 8105084 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.