Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1411 | 0.2406 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0033 | 0.1215 | 0.1197 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.2256 | 0.3849 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0029 | 0.09 | 0.09 |
Brugia malayi | Bromodomain containing protein | 0.0031 | 0.1077 | 0.0937 |
Plasmodium vivax | pyruvate kinase, putative | 0.0033 | 0.1215 | 0.5383 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.3657 | 0.3657 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.7688 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.6788 | 0.8609 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0106 | 0.6788 | 0.8609 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.6788 | 0.8609 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1411 | 0.2406 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.159 | 0.3902 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.1215 | 0.2958 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.1754 | 0.2992 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.2256 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.6788 | 0.8609 |
Brugia malayi | glutathione reductase | 0.0046 | 0.2256 | 0.317 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0184 | 0.0184 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0065 | 0.3657 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.0689 | 0.1175 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.2256 | 1 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0033 | 0.1215 | 0.3724 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1268 | 0.1299 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0065 | 0.3657 | 0.5824 |
Chlamydia trachomatis | pyruvate kinase | 0.0033 | 0.1215 | 0.5 |
Brugia malayi | Cell death protein 3 precursor | 0.0061 | 0.3342 | 0.5227 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.2256 | 0.5583 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.3342 | 0.3342 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.3657 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0029 | 0.09 | 0.2165 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0037 | 0.1578 | 0.2691 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1215 | 0.2958 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.6788 | 0.8609 |
Plasmodium falciparum | pyruvate kinase | 0.0033 | 0.1215 | 0.5383 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.3185 | 0.5433 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.3262 | 0.3262 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0061 | 0.3342 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.2448 | 0.3534 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.3222 | 0.8016 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.1215 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.2256 | 0.1609 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0263 | 0.0263 |
Schistosoma mansoni | jumonji domain containing protein | 0.0074 | 0.4394 | 0.4394 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0094 | 0.5862 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0094 | 0.5862 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0033 | 0.1215 | 0.1197 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.1215 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.6788 | 0.8609 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.7688 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0184 | 0.0313 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.1502 | 0.1741 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.3453 | 0.3453 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.1502 | 0.3681 |
Echinococcus multilocularis | caspase 2 | 0.0061 | 0.3342 | 0.5701 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.2256 | 0.317 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0061 | 0.3342 | 0.5701 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2458 | 0.6091 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1767 | 0.4348 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.3657 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.1215 | 0.1215 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.2256 | 0.3849 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.3262 | 0.8379 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.1502 | 0.2562 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.2256 | 0.6918 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.2256 | 0.4265 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.3657 | 1 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0061 | 0.3342 | 0.5701 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.191 | 0.4709 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.09 | 0.276 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0184 | 0.0313 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.3262 | 0.3262 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.1407 | 0.24 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0094 | 0.5862 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.3262 | 1 |
Brugia malayi | hypothetical protein | 0.0061 | 0.3342 | 0.5227 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.09 | 0.3989 |
Giardia lamblia | Pyruvate kinase | 0.0033 | 0.1215 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.6788 | 0.8609 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.2448 | 0.3534 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.09 | 0.2165 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.1215 | 0.2958 |
Onchocerca volvulus | 0.0061 | 0.3342 | 1 | |
Giardia lamblia | PHD finger protein 15 | 0.0029 | 0.09 | 0.7411 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1411 | 0.2974 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.1215 | 0.2072 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1411 | 0.1411 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.1502 | 0.1502 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.3262 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.2448 | 0.6066 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.046 | 0.1055 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.2256 | 0.4265 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.3657 | 0.6239 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.2256 | 0.5583 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.401 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0037 | 0.1578 | 0.2691 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.09 | 0.276 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.2256 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.7688 | 1 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.09 | 0.0601 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.3262 | 0.3162 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3342 | 0.8318 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0263 | 0.0559 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.1215 | 0.2072 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0406 | 0.0692 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1411 | 0.2974 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.1215 | 0.1288 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.1215 | 0.1215 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1411 | 0.1568 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.1407 | 0.24 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1411 | 0.1411 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.1215 | 0.2072 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.1502 | 0.1502 |
Leishmania major | trypanothione reductase | 0.0046 | 0.2256 | 0.4265 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.1215 | 0.1288 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1411 | 0.2974 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.7688 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.2256 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.3262 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.1215 | 0.2072 |
Echinococcus multilocularis | peregrin | 0.0031 | 0.1077 | 0.1838 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.1584 | 0.1897 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0065 | 0.3657 | 1 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0029 | 0.09 | 0.1535 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.1754 | 0.2992 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.1215 | 0.1288 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.3262 | 0.5564 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1268 | 0.3093 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.3262 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2448 | 0.6066 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.3185 | 0.5433 |
Echinococcus granulosus | caspase 2 | 0.0061 | 0.3342 | 0.5701 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1268 | 0.1268 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1411 | 0.2974 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.3657 | 0.6239 |
Brugia malayi | Bromodomain containing protein | 0.0074 | 0.433 | 0.7097 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.1215 | 0.2958 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0029 | 0.09 | 0.1535 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.1359 | 0.2318 |
Plasmodium falciparum | phd finger protein, putative | 0.0029 | 0.09 | 0.3989 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.2373 | 0.2373 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.09 | 0.09 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.3262 | 0.5564 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0023 | 0.046 | 0.1055 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0061 | 0.3342 | 0.3342 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3342 | 0.8318 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0406 | 0.0692 |
Echinococcus granulosus | peregrin | 0.0031 | 0.1077 | 0.1838 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0406 | 0.0406 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.3657 | 0.9112 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.