Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | NADH oxidase | 0.0068 | 0.0821 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.009 | 0.0852 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0801 | 0.0801 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0274 | 0.2586 |
Onchocerca volvulus | 0.0082 | 0.1061 | 1 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0091 | 0.0857 |
Brugia malayi | glutathione reductase | 0.0196 | 0.2929 | 0.9235 |
Echinococcus granulosus | expressed protein | 0.0019 | 0.0013 | 0.0044 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0068 | 0.0821 | 0.2803 |
Giardia lamblia | GTOR | 0.0044 | 0.0421 | 0.5131 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0091 | 0.0857 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0196 | 0.2929 | 1 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0044 | 0.0421 | 0.0421 |
Echinococcus multilocularis | ferritin | 0.0019 | 0.0013 | 0.0044 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.009 | 0.0852 |
Mycobacterium ulcerans | hypothetical protein | 0.0082 | 0.1061 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0196 | 0.2929 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0068 | 0.0821 | 0.2803 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0129 | 0.1829 | 0.5765 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0068 | 0.0821 | 0.2803 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0132 | 0.1247 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0067 | 0.0801 | 0.2525 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0068 | 0.0821 | 0.2803 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0068 | 0.0821 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0082 | 0.1061 | 0.3611 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0196 | 0.2929 | 0.9235 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0447 | 0.7062 | 0.8429 |
Schistosoma mansoni | ferritin light chain | 0.0019 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0801 | 0.2525 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0035 | 0.0275 | 0.0939 |
Mycobacterium leprae | conserved hypothetical protein | 0.0082 | 0.1061 | 0.1346 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.0905 | 0.3081 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0082 | 0.1061 | 0.1266 |
Mycobacterium ulcerans | lipase LipD | 0.0082 | 0.1061 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0044 | 0.0421 | 0.397 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1061 | 0.3346 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.005 | 0.0524 | 0.1653 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0082 | 0.1061 | 0.1266 |
Echinococcus multilocularis | expressed protein | 0.0019 | 0.0013 | 0.0044 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0237 | 0.2236 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0132 | 0.1247 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0447 | 0.7062 | 0.8429 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0447 | 0.7062 | 0.8429 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0497 | 0.7883 | 0.9409 |
Mycobacterium tuberculosis | Probable reductase | 0.0447 | 0.7062 | 0.8429 |
Toxoplasma gondii | thioredoxin reductase | 0.0196 | 0.2929 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0068 | 0.0821 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0274 | 0.2586 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0068 | 0.0821 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0068 | 0.0821 | 0.2803 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0128 | 0.1207 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0905 | 0.0905 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0082 | 0.1061 | 0.1266 |
Plasmodium falciparum | glutathione reductase | 0.0068 | 0.0821 | 0.2803 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0032 | 0.0237 | 0.081 |
Trichomonas vaginalis | ferritin, putative | 0.0019 | 0.0013 | 0.0123 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0044 | 0.0421 | 0.1438 |
Brugia malayi | beta-lactamase family protein | 0.0082 | 0.1061 | 0.3346 |
Schistosoma mansoni | apoferritin-2 | 0.0019 | 0.0013 | 0.0013 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0021 | 0.0043 | 0.0146 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0801 | 0.0801 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0019 | 0.0013 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.3172 | 1 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0019 | 0.0013 | 0.0017 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0068 | 0.0821 | 0.2803 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0082 | 0.1061 | 0.1266 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0905 | 0.0905 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0044 | 0.0421 | 0.1438 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0801 | 0.0801 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0067 | 0.0801 | 0.2725 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0.1715 | 0.5836 |
Brugia malayi | MH2 domain containing protein | 0.0129 | 0.1829 | 0.5765 |
Plasmodium falciparum | glutathione reductase | 0.0196 | 0.2929 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0801 | 0.0801 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0169 | 0.1596 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0082 | 0.1061 | 1 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0044 | 0.0421 | 0.1438 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0082 | 0.1061 | 0.3346 |
Leishmania major | hypothetical protein, conserved | 0.0082 | 0.1061 | 0.3623 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0082 | 0.1061 | 0.3611 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0082 | 0.1061 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0274 | 0.2586 |
Loa Loa (eye worm) | glutathione reductase | 0.0196 | 0.2929 | 0.9235 |
Plasmodium vivax | hypothetical protein, conserved | 0.0082 | 0.1061 | 0.3623 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0082 | 0.1061 | 0.3623 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0274 | 0.2586 |
Leishmania major | trypanothione reductase | 0.0196 | 0.2929 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0068 | 0.0821 | 0.7739 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1061 | 0.3346 |
Toxoplasma gondii | ABC1 family protein | 0.0082 | 0.1061 | 0.3623 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.2074 | 0.654 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0447 | 0.7062 | 0.8429 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0082 | 0.1061 | 0.3623 |
Brugia malayi | Thioredoxin reductase | 0.0196 | 0.2929 | 0.9235 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0497 | 0.7883 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0067 | 0.0801 | 0.2525 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0447 | 0.7062 | 0.8429 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0068 | 0.0821 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0068 | 0.0821 | 0.2803 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0211 | 0.3172 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0082 | 0.1061 | 0.1266 |
Schistosoma mansoni | ferritin | 0.0019 | 0.0013 | 0.0013 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0068 | 0.0821 | 0.2803 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0067 | 0.0801 | 0.2725 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0211 | 0.3172 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.005 | 0.0524 | 0.1653 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0082 | 0.1061 | 0.1061 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0129 | 0.1829 | 0.5765 |
Schistosoma mansoni | apoferritin-2 | 0.0019 | 0.0013 | 0.0013 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0082 | 0.1061 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0082 | 0.1061 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0068 | 0.0821 | 0.2803 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0122 | 0.1715 | 0.5836 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0497 | 0.7883 | 0.9409 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0068 | 0.0821 | 0.2795 |
Onchocerca volvulus | 0.0082 | 0.1061 | 1 | |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0068 | 0.0821 | 0.7739 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0905 | 0.0905 |
Schistosoma mansoni | ferritin light chain | 0.0019 | 0.0013 | 0.0013 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0905 | 0.0905 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0044 | 0.0421 | 0.1438 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.0905 | 0.2854 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.0905 | 0.2854 |
Schistosoma mansoni | ferritin | 0.0019 | 0.0013 | 0.0013 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0068 | 0.0821 | 0.2803 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0067 | 0.0801 | 0.2725 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.0905 | 0.2854 |
Loa Loa (eye worm) | beta-lactamase | 0.0082 | 0.1061 | 0.3346 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0068 | 0.0821 | 0.2803 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0067 | 0.0801 | 0.2725 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.1876 | 0.1876 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0068 | 0.0821 | 0.2803 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0237 | 0.2236 |
Mycobacterium tuberculosis | Conserved protein | 0.0082 | 0.1061 | 0.1266 |
Brugia malayi | beta-lactamase family protein | 0.0082 | 0.1061 | 0.3346 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0527 | 0.8378 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0082 | 0.1061 | 0.1266 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0044 | 0.0421 | 0.1328 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0044 | 0.0421 | 0.397 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0197 | 0.2938 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0082 | 0.1061 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0197 | 0.2938 | 1 |
Schistosoma mansoni | ferritin | 0.0019 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1061 | 0.3346 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0068 | 0.0821 | 0.2803 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0082 | 0.1061 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0132 | 0.1247 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1061 | 0.3346 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0905 | 0.0905 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0019 | 0.0013 | 0.0016 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0068 | 0.0821 | 0.2795 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0044 | 0.0421 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0068 | 0.0821 | 0.0821 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0068 | 0.0821 | 0.2803 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0068 | 0.0821 | 0.7739 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0082 | 0.1061 | 0.1266 |
Schistosoma mansoni | hypothetical protein | 0.0144 | 0.2074 | 0.2074 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0044 | 0.0421 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0082 | 0.1061 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0447 | 0.7062 | 0.8958 |
Plasmodium falciparum | thioredoxin reductase | 0.0068 | 0.0821 | 0.2803 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0044 | 0.0421 | 0.397 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0019 | 0.0013 | 0.0159 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0068 | 0.0821 | 0.2803 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0091 | 0.0857 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0132 | 0.1876 | 0.6385 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0237 | 0.2236 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0044 | 0.0421 | 0.1438 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0067 | 0.0801 | 0.2525 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0185 | 0.1743 |
Echinococcus granulosus | ferritin | 0.0019 | 0.0013 | 0.0044 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0237 | 0.2236 |
Echinococcus multilocularis | GPCR, family 2 | 0.0067 | 0.0801 | 0.2725 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0196 | 0.2929 | 0.3496 |
Schistosoma mansoni | ferritin | 0.0019 | 0.0013 | 0.0013 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0068 | 0.0821 | 0.2803 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0044 | 0.0421 | 0.1328 |
Trypanosoma brucei | trypanothione reductase | 0.0196 | 0.2929 | 1 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0068 | 0.0821 | 0.2803 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0019 | 0.0013 | 0.0159 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0068 | 0.0821 | 0.2803 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0144 | 0.2074 | 0.654 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0237 | 0.2236 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0044 | 0.0421 | 0.1434 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0082 | 0.1061 | 0.1061 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0237 | 0.2236 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0082 | 0.1061 | 0.3346 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0068 | 0.0821 | 1 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0068 | 0.0821 | 0.2803 |
Echinococcus granulosus | GPCR family 2 | 0.0067 | 0.0801 | 0.2725 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0068 | 0.0821 | 0.098 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0068 | 0.0821 | 0.2803 |
Onchocerca volvulus | 0.0082 | 0.1061 | 1 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0211 | 0.3172 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0237 | 0.2236 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.009 | 0.0852 |
Plasmodium vivax | glutathione reductase, putative | 0.0196 | 0.2929 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.0905 | 0.3081 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0068 | 0.0821 | 0.2803 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0128 | 0.1207 |
Trichomonas vaginalis | esterase, putative | 0.0082 | 0.1061 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0082 | 0.1061 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.1876 | 0.1876 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.1715 | 0.1715 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1061 | 0.3346 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.0905 | 0.2854 |
Brugia malayi | RNA binding protein | 0.0073 | 0.0905 | 0.2854 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0068 | 0.0821 | 0.2803 |
Mycobacterium tuberculosis | Conserved protein | 0.0082 | 0.1061 | 0.1266 |
Plasmodium falciparum | thioredoxin reductase | 0.0196 | 0.2929 | 1 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0019 | 0.0013 | 0.0123 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0044 | 0.0421 | 0.1434 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0082 | 0.1061 | 0.3623 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0497 | 0.7883 | 0.9409 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0035 | 0.0275 | 0.0939 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.0905 | 0.2854 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0068 | 0.0821 | 0.2589 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0068 | 0.0821 | 0.7739 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1061 | 0.3346 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0019 | 0.0013 | 0.0123 |
Mycobacterium leprae | Probable lipase LipE | 0.0082 | 0.1061 | 0.1346 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0044 | 0.0421 | 0.1438 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0274 | 0.2586 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0316 | 0.2981 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0018 | 0.0002 | 0.0005 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0068 | 0.0821 | 0.7739 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0091 | 0.0857 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0035 | 0.0275 | 0.0939 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0082 | 0.1061 | 0.1266 |
Brugia malayi | beta-lactamase | 0.0082 | 0.1061 | 0.3346 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 4.3 mg kg-1 | Analgesic activity in albino CF1 mouse assessed as inhibition of heat-induced paw licking or jumping behaviour administered after 30 mins prior heat challenge by hot plate method | ChEMBL. | 23010454 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.