Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, beta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, eta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, theta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, delta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, alpha | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, epsilon | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 0.9356 | 0.9356 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0287 | 0.6292 | 1 |
Brugia malayi | protein kinase C II. | 0.0287 | 0.6292 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7801 | 0.7801 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0168 | 0.2397 | 0.381 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7801 | 0.7801 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0168 | 0.2388 | 0.3795 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7801 | 0.7801 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0103 | 0.0246 | 0.0246 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0168 | 0.2388 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0216 | 0.3952 | 0.5865 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0216 | 0.3952 | 0.6281 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0287 | 0.6292 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0115 | 0.0633 | 0.1006 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0234 | 0.4539 | 0.7214 |
Onchocerca volvulus | 0.0333 | 0.7801 | 0.5 | |
Echinococcus granulosus | protein kinase c epsilon type | 0.0287 | 0.6292 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0216 | 0.3952 | 0.6281 |
Echinococcus granulosus | protein kinase C gamma type | 0.0168 | 0.2397 | 0.381 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1555 | 0.1555 |
Echinococcus granulosus | protein kinase c iota type | 0.0115 | 0.0633 | 0.1006 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0216 | 0.3952 | 0.5865 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0287 | 0.6292 | 0.6292 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 81 nM | Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity assay | ChEMBL. | 22078216 |
IC50 (binding) | = 188 nM | Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity assay | ChEMBL. | 22078216 |
IC50 (binding) | = 635 nM | Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity assay | ChEMBL. | 22078216 |
IC50 (binding) | = 743 nM | Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity assay | ChEMBL. | 22078216 |
IC50 (binding) | > 1000 nM | Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity assay | ChEMBL. | 22078216 |
IC50 (binding) | > 1000 nM | Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity assay | ChEMBL. | 22078216 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.