Detailed information for compound 169087

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 512.638 | Formula: C29H40N2O6
  • H donors: 4 H acceptors: 5 LogP: 4.89 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(OC(C)(C)C)N[C@H]([C@H](C[C@H](C(=O)N[C@H](C(=O)O)C(C)C)Cc1ccccc1)O)Cc1ccccc1
  • InChi: 1S/C29H40N2O6/c1-19(2)25(27(34)35)31-26(33)22(16-20-12-8-6-9-13-20)18-24(32)23(17-21-14-10-7-11-15-21)30-28(36)37-29(3,4)5/h6-15,19,22-25,32H,16-18H2,1-5H3,(H,30,36)(H,31,33)(H,34,35)/t22-,23?,24+,25+/m1/s1
  • InChiKey: JWWUDNFHBYGDPE-MOKPPXJMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0021 0.0053
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.0087 0.0087
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0041 0.0041
Echinococcus granulosus dihydrofolate reductase 0.5588 1 1
Brugia malayi MH1 domain containing protein 0.0016 0.0005 0.0005
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0039 0.0101
Schistosoma mansoni rotamase 0.0033 0.0035 0.0032
Brugia malayi Cathepsin L-like precursor 0.0033 0.0035 0.0035
Leishmania major hypothetical protein, conserved 0.0035 0.004 0.0103
Brugia malayi MH1 domain containing protein 0.0016 0.0005 0.0005
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0044 0.0056 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0035 0.1954
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0035 0.1954
Echinococcus granulosus cysteine protease atg4b 0.0058 0.008 0.008
Brugia malayi beta-lactamase family protein 0.0035 0.004 0.0039
Brugia malayi Cathepsin L-like precursor 0.0033 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0022 0.0016 0.0015
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0011 0.0008
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0379 0.0374
Schistosoma mansoni bromodomain containing protein 0.0064 0.0092 0.0089
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.0087 0.0087
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0035 0.1954
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.008 0.448
Leishmania major eukaryotic translation initiation factor-like protein 0.0112 0.0177 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0023 0.129
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0003 0.013
Schistosoma mansoni hypothetical protein 0.0062 0.0087 0.0084
Entamoeba histolytica peptidase, C54 family 0.0022 0.0017 0.0921
Schistosoma mansoni smad1 5 8 and 0.0016 0.0005 0.0002
Echinococcus granulosus GPCR family 2 0.0062 0.0087 0.0087
Schistosoma mansoni DNA polymerase eta 0.0044 0.0056 0.0054
Giardia lamblia DINP protein human, muc B family 0.0019 0.0011 0.1921
Loa Loa (eye worm) hypothetical protein 0.0195 0.0326 0.0326
Echinococcus granulosus cathepsin L cysteine proteinase 0.0033 0.0035 0.0035
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0039 0.0101
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0039
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.0475 0.0472
Onchocerca volvulus 0.0028 0.0027 0.0364
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0028
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0011 0.0011
Echinococcus multilocularis dna polymerase eta 0.0044 0.0056 0.0056
Brugia malayi Phospholipase A2 family protein 0.009 0.0138 0.0137
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0021 0.0053
Trypanosoma brucei Eukaryotic translation initiation factor 4E-2 0.0013 0 0.0001
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0055 0.0052
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.5588 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Echinococcus granulosus expressed protein 0.0033 0.0035 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0008 0.0005
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0055 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0028
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0007 0.035
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0055 0.3071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0035 0.1954
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0112 0.0177 0.0177
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0191 0.018
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0112 0.0177 0.0464
Echinococcus multilocularis expressed protein 0.0033 0.0035 0.0035
Echinococcus multilocularis cysteine protease atg4b 0.0058 0.008 0.008
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.002 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.004 0.2208
Loa Loa (eye worm) Smad1 0.0016 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0003 0.013
Echinococcus granulosus zinc finger protein 0.0021 0.0014 0.0014
Echinococcus multilocularis lamin 0.0054 0.0074 0.0074
Brugia malayi Bromodomain containing protein 0.0076 0.0113 0.0113
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.0016 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0055 0.3071
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.2137 0.3809 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0199 0.0523
Loa Loa (eye worm) hypothetical protein 0.004 0.0049 0.0049
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0112 0.0177 0.0464
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.5588 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0011 0.0028
Entamoeba histolytica cysteine protease, putative 0.0017 0.0007 0.035
Echinococcus granulosus lamin 0.0054 0.0074 0.0074
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.0702 0.0702
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.2137 0.3809 1
Schistosoma mansoni hypothetical protein 0.002 0.0013 0.0011
Brugia malayi translation initiation factor 4E 0.0112 0.0177 0.0177
Echinococcus multilocularis musashi 0.0054 0.0074 0.0074
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0112 0.0177 0.0175
Echinococcus granulosus intermediate filament protein 0.0054 0.0074 0.0074
Brugia malayi Bromodomain containing protein 0.0038 0.0045 0.0045
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.004 0.2208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0019 0.1032
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0007 0.035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0035 0.1954
Onchocerca volvulus Phospholipase A2 homolog 0.009 0.0138 0.185
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0007 0.0016
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0035 0.0035
Plasmodium falciparum cysteine proteinase falcipain 1 0.0017 0.0007 0.0016
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.0191 0.05
Leishmania major cathepsin L-like protease 0.0033 0.0035 0.0091
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0112 0.0177 1
Echinococcus granulosus smad 0.0016 0.0005 0.0005
Loa Loa (eye worm) PHD-finger family protein 0.003 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0039
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0005 0.0005
Entamoeba histolytica peptidase, C54 family 0.0022 0.0017 0.0921
Echinococcus multilocularis cathepsin L 0.0017 0.0007 0.0007
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0086 0.0086
Trypanosoma brucei Eukaryotic translation initiation factor 4E-4 0.0013 0 0.0001
Echinococcus multilocularis cpg binding protein 0.0032 0.0034 0.0034
Echinococcus granulosus cathepsin l1 0.0033 0.0035 0.0035
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0035 0.0032
Loa Loa (eye worm) hypothetical protein 0.0025 0.0021 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0019 0.1035
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.002 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0035 0.1954
Trypanosoma cruzi major cysteine proteinase, putative 0.0098 0.0152 0.0397
Loa Loa (eye worm) beta-lactamase 0.0035 0.004 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0039 0.2165
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0112 0.0177 0.0464
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0035 0.0467
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0191 0.018
Plasmodium falciparum phd finger protein, putative 0.003 0.003 0.0077
Leishmania major cathepsin L-like protease 0.0124 0.0199 0.0522
Echinococcus multilocularis cysteine protease 0.0033 0.0035 0.0035
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0115 0.0112
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.004 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0003 0.013
Schistosoma mansoni cpg binding protein 0.0028 0.0027 0.0025
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0112 0.0177 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0007 0.0004
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0005 0.0012
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0056 0.0147
Plasmodium vivax vivapain-2 0.0033 0.0035 0.0091
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0112 0.0177 1
Schistosoma mansoni intermediate filament proteins 0.0054 0.0074 0.0071
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0005 0.0004
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0005 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.004 0.0103
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0011 0.0011
Onchocerca volvulus 0.0035 0.004 0.0527
Trypanosoma cruzi cruzipain precursor, putative 0.0124 0.0199 0.0522
Schistosoma mansoni hypothetical protein 0.0062 0.0087 0.0084
Loa Loa (eye worm) hypothetical protein 0.0033 0.0035 0.0035
Brugia malayi Cathepsin L-like precursor 0.0033 0.0035 0.0035
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0403 0.07 0.07
Onchocerca volvulus 0.0035 0.004 0.0527
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0035 0.0035
Entamoeba histolytica peptidase, C54 family 0.0022 0.0017 0.0921
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0151 0.0151
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0021 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0028
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.003 0.0077
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0058 0.008 0.0208
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0011 0.0006
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.2137 0.3809 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0103 0.0103
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.004 0.0035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0035 0.1954
Loa Loa (eye worm) hypothetical protein 0.0053 0.0072 0.0072
Onchocerca volvulus 0.0054 0.0074 0.0989
Leishmania major cathepsin L-like protease 0.0124 0.0199 0.0522
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0035 0.1954
Brugia malayi Cathepsin L-like precursor 0.0022 0.0016 0.0015
Echinococcus multilocularis dihydrofolate reductase 0.5588 1 1
Onchocerca volvulus 0.0033 0.0035 0.0467
Schistosoma mansoni cellular tumor antigen P53 0.0147 0.024 0.0237
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0034 0.1872
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0007 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0035 0.1937
Schistosoma mansoni hypothetical protein 0.0062 0.0087 0.0084
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0005
Brugia malayi CXXC zinc finger family protein 0.0028 0.0027 0.0027
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0033 0.0035 0.0091
Leishmania major cathepsin L-like protease 0.0033 0.0035 0.0091
Entamoeba histolytica cysteine protease, putative 0.0017 0.0007 0.035
Trypanosoma brucei Eukaryotic translation initiation factor 4E type 5 0.0013 0 0.0001
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0011 0.0028
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0056 0.0056
Brugia malayi latrophilin 2 splice variant baaae 0.0133 0.0216 0.0215
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0003 0.0003
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.004 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0028
Brugia malayi PHD-finger family protein 0.003 0.003 0.003
Trichomonas vaginalis esterase, putative 0.0035 0.004 0.2208
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0005 0.0005
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.0191 0.0191
Onchocerca volvulus 0.0035 0.004 0.0527
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0005
Entamoeba histolytica cysteine protease, putative 0.0017 0.0007 0.035
Echinococcus granulosus lamin dm0 0.0054 0.0074 0.0074
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.0087 0.0087
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0047 0.0047
Leishmania major DNA polymerase kappa, putative 0.0019 0.0011 0.0027
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0034 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0035 0.1954
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0112 0.0177 0.0177
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0112 0.0177 0.0465
Plasmodium vivax unspecified product 0.0017 0.0007 0.0016
Leishmania major cathepsin L-like protease 0.0033 0.0035 0.0091
Entamoeba histolytica cysteine protease, putative 0.0017 0.0007 0.035
Loa Loa (eye worm) hypothetical protein 0.0022 0.0016 0.0015
Leishmania major hypothetical protein, conserved 0.0015 0.0004 0.0009
Brugia malayi hypothetical protein 0.0071 0.0103 0.0103
Entamoeba histolytica cysteine protease, putative 0.0017 0.0007 0.035
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0191 0.0188
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.004 0.0035
Echinococcus multilocularis lamin dm0 0.0054 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0133 0.0216 0.0213
Brugia malayi hypothetical protein 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0021
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0055 0.0143
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.2717 0.2715
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0077 0.0202
Echinococcus multilocularis zinc finger protein 0.0021 0.0014 0.0014
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.004 0.0035
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.2137 0.3809 1
Echinococcus granulosus tumor protein p63 0.1002 0.1774 0.1774
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0007 0.0007
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0022 0.0017 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0035 0.1937
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0007 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0035 0.1937
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.004 0.0029
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0005 0.0011
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0035 0.0035
Echinococcus multilocularis cysteine protease 0.0033 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0035 0.1937
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.004 0.0029
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0112 0.0177 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0021 0.0053
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0035 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.004 0.0103
Leishmania major DNA polymerase eta, putative 0.0044 0.0056 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0199 0.0523
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0016 0.0861
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0035 0.1954
Entamoeba histolytica cysteine protease, putative 0.0017 0.0007 0.035
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0112 0.0177 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0017 0.0007 0.035
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0085 0.0082
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.0087 0.0087
Leishmania major eukaryotic translation initiation factor-like 0.0112 0.0177 0.0464
Loa Loa (eye worm) hypothetical protein 0.0022 0.0016 0.0015
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0035 0.1954
Entamoeba histolytica hypothetical protein 0.0071 0.0103 0.5813
Echinococcus multilocularis Smad4 0.0016 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0039 0.2165
Echinococcus multilocularis GPCR, family 2 0.0062 0.0087 0.0087
Mycobacterium tuberculosis Conserved protein 0.0035 0.004 0.0035
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0005 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0035 0.1954
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0016 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0035 0.1954
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0055 0.3071
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0013 0.0013
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0041 0.0041
Brugia malayi hypothetical protein 0.0025 0.0021 0.002
Schistosoma mansoni smad 0.0016 0.0005 0.0002
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.2137 0.3809 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0034 0.0088
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0191 0.018
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0029 0.1614
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0113 0.018 0.0472
Onchocerca volvulus 0.0033 0.0035 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0019 0.1035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0007 0.0017
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0404 0.0702 0.0699
Loa Loa (eye worm) hypothetical protein 0.0038 0.0045 0.0045
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0021 0.0053
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0007 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.004 0.0103
Leishmania major hypothetical protein, conserved 0.0025 0.0021 0.0053
Trichomonas vaginalis rotamase, putative 0.0033 0.0035 0.195
Trypanosoma cruzi ISWI complex protein 0.0015 0.0004 0.0009
Brugia malayi MH2 domain containing protein 0.0016 0.0005 0.0005
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0007 0.0004
Brugia malayi MH2 domain containing protein 0.0016 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0023 0.1264
Trichomonas vaginalis rotamase, putative 0.0032 0.0034 0.1872
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0033 0.0084
Echinococcus multilocularis tumor protein p63 0.1002 0.1774 0.1774
Loa Loa (eye worm) translation initiation factor 4E 0.0112 0.0177 0.0177
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0035 0.009
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.0191 0.0186
Onchocerca volvulus Alhambra homolog 0.003 0.003 0.0395
Trypanosoma cruzi cysteine peptidase, putative 0.0124 0.0199 0.0522
Echinococcus granulosus Smad4 0.0016 0.0005 0.0005
Schistosoma mansoni dihydrofolate reductase 0.5588 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0028
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0151 0.0151
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.004 0.004
Echinococcus granulosus cysteine protease 0.0017 0.0007 0.0007
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0023 0.0023
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0003 0.0003
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0007 0.0004
Leishmania major DNA polymerase eta, putative 0.0031 0.0033 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0028
Brugia malayi cathepsin L-like precursor 0.0022 0.0016 0.0015
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0022 0.0017 0.0043
Schistosoma mansoni hypothetical protein 0.003 0.003 0.0027
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0039 0.2165
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0805 0.1421 0.1421
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0011 0.0027
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0058 0.008 0.0077
Loa Loa (eye worm) hypothetical protein 0.007 0.0103 0.0102
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0011 0.0027
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0008 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.004 0.2208
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0035 0.1954
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0005 0.0012
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0058 0.008 0.0208
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0008 0.0008
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0426 0.0741 0.0741
Brugia malayi jmjC domain containing protein 0.0039 0.0047 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0023 0.129
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0011 0.059
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0021 0.0054
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0014 0.0035
Schistosoma mansoni zinc finger protein 0.0015 0.0004 0.0001
Plasmodium vivax vivapain-3 0.0017 0.0007 0.0016
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0007 0.0007
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.0191 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0035 0.1954
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0016 0.0861
Mycobacterium ulcerans lipase LipD 0.0035 0.004 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0035 0.1954
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0055 0.3071
Echinococcus granulosus cathepsin L 0.0017 0.0007 0.0007
Schistosoma mansoni zinc finger protein 0.0021 0.0014 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0035 0.1954
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0007 0.0016
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0055 0.0143
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0011 0.0008
Echinococcus granulosus cathepsin l1 0.0022 0.0016 0.0016
Trypanosoma brucei unspecified product 0.0019 0.0011 0.0028
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.008 0.448
Plasmodium vivax hypothetical protein, conserved 0.003 0.003 0.0077
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0055 0.0055
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.0191 0.05
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0055 0.0055
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0055 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0055 0.3071
Onchocerca volvulus 0.0033 0.0035 0.0467
Brugia malayi Latrophilin receptor protein 2 0.0062 0.0087 0.0087
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0058 0.008 0.0079
Onchocerca volvulus 0.0033 0.0035 0.0467
Loa Loa (eye worm) MH2 domain-containing protein 0.0233 0.0394 0.0393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0035 0.1937
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0039 0.0101
Loa Loa (eye worm) hypothetical protein 0.0062 0.0087 0.0087
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0195 0.0326 0.0326
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0147 0.024 0.0239
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0034 0.0087
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0035 0.1954
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0112 0.0177 0.0464
Echinococcus granulosus cathepsin l cysteine peptidase 0.0033 0.0035 0.0035
Loa Loa (eye worm) cysteine protease 0.0033 0.0035 0.0035
Brugia malayi intermediate filament protein 0.0054 0.0074 0.0073
Leishmania major cathepsin L-like protease 0.0033 0.0035 0.0091
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.0087 0.0087
Brugia malayi jmjC domain containing protein 0.0097 0.0151 0.0151
Entamoeba histolytica peptidase, C54 family 0.0022 0.0017 0.0921
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0035 0.195
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0028
Trypanosoma brucei Eukaryotic translation initiation factor 4E-3 0.0013 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0023 0.129
Onchocerca volvulus 0.0033 0.0035 0.0467
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0035 0.0091
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0003 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0043 0.2424
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.008 0.448
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.004 0.0037
Brugia malayi PHD-finger family protein 0.0026 0.0024 0.0024
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0022 0.0017 0.0043
Mycobacterium tuberculosis Conserved protein 0.0035 0.004 0.0035
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0003 0.0006
Loa Loa (eye worm) transcription factor SMAD2 0.0233 0.0394 0.0393
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0047 0.0044
Entamoeba histolytica hypothetical protein 0.0071 0.0103 0.5813
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0007 0.0016
Brugia malayi Cathepsin L-like precursor 0.0033 0.0035 0.0035
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.002 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0028
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.004 0.0035
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0022 0.0017 0.0043
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0039
Brugia malayi Peptidase family C54 containing protein 0.0058 0.008 0.0079
Loa Loa (eye worm) hypothetical protein 0.0133 0.0216 0.0215
Brugia malayi Calcitonin receptor-like protein seb-1 0.0195 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0039
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0029 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0028
Loa Loa (eye worm) hypothetical protein 0.0051 0.0068 0.0068
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0056 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0028
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0011 0.0011
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0055 0.0143
Entamoeba histolytica cysteine protease, putative 0.0017 0.0007 0.035
Entamoeba histolytica peptidase, C54 family 0.0058 0.008 0.448
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0007 0.0006
Brugia malayi MH2 domain containing protein 0.0233 0.0394 0.0393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0023 0.1264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0199 0.0523
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0011 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0035 0.1954
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.003 0.0077
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0007 0.0004
Chlamydia trachomatis dihydrofolate reductase 0.5588 1 0.5
Trypanosoma brucei ISWI complex protein 0.0015 0.0004 0.0009
Entamoeba histolytica cysteine protease, putative 0.0017 0.0007 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0019 0.1035
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0191 0.0188
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.5588 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.004 0.2208
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0008 0.0005
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0021 0.0053
Echinococcus granulosus peregrin 0.0032 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0003 0.013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0199 0.0523
Brugia malayi isocitrate dehydrogenase 0.0016 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0035 0.1937
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0055 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0007 0.0017
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0007 0.0006
Brugia malayi Bromodomain containing protein 0.0032 0.0034 0.0034
Onchocerca volvulus 0.0033 0.0035 0.0467
Loa Loa (eye worm) hypothetical protein 0.0044 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0026 0.0023 0.0023
Brugia malayi Smad1 0.0016 0.0005 0.0005
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0007 0.0016
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0007 0.035
Brugia malayi beta-lactamase family protein 0.0035 0.004 0.0039
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0054 0.0074 0.0073
Echinococcus granulosus dna polymerase eta 0.0044 0.0056 0.0056
Trypanosoma cruzi ISWI complex protein 0.0015 0.0004 0.0009
Toxoplasma gondii cathepsin CPL 0.0033 0.0035 0.0091
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.0017 0.0007 0.035
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0011 0.0028
Schistosoma mansoni smad1 5 8 and 0.0016 0.0005 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0199 0.0523
Entamoeba histolytica cysteine protease, putative 0.0017 0.0007 0.035
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0027 0.0027
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0011 0.059
Onchocerca volvulus Phospholipase A2 homolog 0.0426 0.0741 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0086 0.0086
Plasmodium vivax hypothetical protein, conserved 0.0035 0.004 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0003 0.013
Mycobacterium ulcerans beta-lactamase 0.0035 0.004 0.0029
Leishmania major cathepsin L-like protease 0.0124 0.0199 0.0522
Schistosoma mansoni hypothetical protein 0.0062 0.0087 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0019 0.1032
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0007 0.0007
Loa Loa (eye worm) fibroinase 0.0033 0.0035 0.0035
Schistosoma mansoni lamin 0.0054 0.0074 0.0071
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0003 0.0003
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0035 0.0035
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0005 0.0005
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0016 0.0861
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.008 0.448
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.008 0.448
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0039 0.2165
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0034 0.0087
Leishmania major cysteine peptidase A (CPA) 0.0033 0.0035 0.0091
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0005 0.0002
Brugia malayi Cathepsin L-like precursor 0.0033 0.0035 0.0035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0035 0.1954
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0035 0.1954
Mycobacterium ulcerans hypothetical protein 0.0035 0.004 0.0029
Schistosoma mansoni hypothetical protein 0.0071 0.0103 0.0101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0199 0.0523
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0034 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0035 0.1954
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0005 0.0002
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0035 0.0035
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0003 0.0007
Schistosoma mansoni smad1 5 8 and 0.0016 0.0005 0.0002
Loa Loa (eye worm) ctsf protein 0.0033 0.0035 0.0035
Entamoeba histolytica cysteine protease, putative 0.0017 0.0007 0.035
Echinococcus multilocularis smad 0.0016 0.0005 0.0005
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0035 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0199 0.0523
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0058 0.008 0.0209
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0008 0.0008
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0003 0.0006
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0007 0.035
Schistosoma mansoni lamin 0.0054 0.0074 0.0071
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0047 0.0047
Trypanosoma cruzi cysteine peptidase, putative 0.0124 0.0199 0.0522
Brugia malayi Dihydrofolate reductase 0.5588 1 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.004 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0027 0.1519
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0005 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0035 0.1954
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0051 0.0051
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0051 0.0051
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0195 0.0326 0.0326
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0003 0.0006
Plasmodium vivax vivapain-2 0.0033 0.0035 0.0091
Onchocerca volvulus Cathepsin F homolog 0.0033 0.0035 0.0467
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0055 0.0143
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0011 0.0027
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0074 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0199 0.0523
Entamoeba histolytica cysteine protease, putative 0.0017 0.0007 0.035
Schistosoma mansoni Smad4 0.0016 0.0005 0.0002
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.004 0.0035
Schistosoma mansoni cpg binding protein 0.0032 0.0034 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0022 0.0017 0.0043
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0403 0.07 0.07
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0047 0.0044
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0005 0.0011
Schistosoma mansoni cpg binding protein 0.0032 0.0034 0.0031
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0103 0.0101
Entamoeba histolytica cysteine proteinase 2 0.0017 0.0007 0.035
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0011 0.059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0007 0.035
Plasmodium falciparum cysteine protease ATG4, putative 0.0022 0.0017 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0199 0.0523
Onchocerca volvulus 0.0022 0.0016 0.0206
Brugia malayi Cathepsin L-like precursor 0.0022 0.0016 0.0015
Toxoplasma gondii ABC1 family protein 0.0035 0.004 0.0103
Echinococcus granulosus cpg binding protein 0.0032 0.0034 0.0034
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0003 0.0007
Giardia lamblia PHD finger protein 15 0.003 0.003 0.5387
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0071 0.0103 0.5813
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0035 0.0032
Echinococcus multilocularis Peptidase C54 0.0058 0.008 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0019 0.1035
Giardia lamblia GTOR 0.0044 0.0055 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0035 0.1954
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0058 0.008 0.0077
Brugia malayi Cathepsin L-like precursor 0.0033 0.0035 0.0035
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0074 0.0073
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0074 0.0073
Plasmodium vivax vivapain-1 0.0017 0.0007 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0035 0.1937
Loa Loa (eye worm) dihydrofolate reductase 0.5588 1 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0138 0.0137
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0011 0.0011
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0035 0.0035
Entamoeba histolytica cysteine protease, putative 0.0017 0.0007 0.035
Entamoeba histolytica cysteine protease, putative 0.0033 0.0035 0.1954
Onchocerca volvulus 0.0033 0.0035 0.0467
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0199 0.0523
Echinococcus multilocularis peregrin 0.0032 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0039 0.2165
Trypanosoma cruzi cysteine peptidase, putative 0.0124 0.0199 0.0522
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0112 0.0177 1
Entamoeba histolytica hypothetical protein 0.0071 0.0103 0.5813
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.004 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.004 0.2208
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0033 0.0035 0.0091
Onchocerca volvulus 0.0147 0.024 0.3228
Echinococcus granulosus dna polymerase kappa 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0035 0.1954
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0103 0.0103
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0035 0.1954
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0005 0.0004
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0013 0.0013
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0011 0.0006
Schistosoma mansoni autophagin-1 (C54 family) 0.0058 0.008 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0019 0.1032
Leishmania major dihydrofolate reductase-thymidylate synthase 0.2137 0.3809 1
Leishmania major cathepsin L-like protease 0.0033 0.0035 0.0091
Onchocerca volvulus 0.0054 0.0074 0.0989
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0039
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0035 0.0467
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.004 0.0037
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0029 0.0028
Plasmodium falciparum cysteine proteinase falcipain 3 0.0033 0.0035 0.0091
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0007 0.035
Echinococcus granulosus dnaJ subfamily B 0.0404 0.0702 0.0702
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.004 0.0039
Brugia malayi beta-lactamase 0.0035 0.004 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0035 0.1954
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0041 0.0041
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0009 0.0023
Echinococcus granulosus Peptidase C54 0.0058 0.008 0.008
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0055 0.0055
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0021
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.004 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0199 0.0523
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0005 0.0011
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0033 0.0084
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0011 0.0027

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 161 nM In vitro inhibition of HIV-1 protease ChEMBL. 7830273
Log IC50 (binding) = 6.79 Inhibition of human immunodeficiency virus type 1 (HIV-1) protease enzyme. ChEMBL. 11087569
Log IC50 (binding) = 6.79 Inhibitory activity against HIV-1 protease. ChEMBL. 9526559
Log IC50 (binding) = 6.793 Inhibitory activity against HIV-1 protease. ChEMBL. 10956210

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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