Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 3 | 305 aa | 303 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.009 | 0.0647 | 0.0647 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.0622 | 0.9667 | 0.9667 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.009 | 0.0647 | 0.0647 |
Mycobacterium leprae | Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0622 | 0.9667 | 0.5 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.009 | 0.0647 | 0.6021 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0647 | 0.0647 |
Plasmodium vivax | polyprenol reductase, putative | 0.009 | 0.0647 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0081 | 0.0485 | 0.4514 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0115 | 0.1074 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0641 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.009 | 0.0647 | 0.0647 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.009 | 0.0647 | 0.0647 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.009 | 0.0647 | 0.6021 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.009 | 0.0647 | 0.0647 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0622 | 0.9667 | 0.5 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.009 | 0.0647 | 0.6021 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.009 | 0.0647 | 0.0647 |
Plasmodium falciparum | polyprenol reductase, putative | 0.009 | 0.0647 | 1 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0641 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.009 | 0.0647 | 0.0647 |
Entamoeba histolytica | 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein | 0.009 | 0.0647 | 0.0647 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0641 | 1 | 1 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.009 | 0.0647 | 0.0647 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.009 | 0.0647 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.009 | 0.0647 | 0.6021 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0647 | 0.0647 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0641 | 1 | 1 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.009 | 0.0647 | 0.0647 |
Loa Loa (eye worm) | hypothetical protein | 0.0641 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0641 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.009 | 0.0647 | 0.0647 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0641 | 1 | 1 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0641 | 1 | 1 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.009 | 0.0647 | 1 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.009 | 0.0647 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0641 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0115 | 0.1074 | 1 |
Onchocerca volvulus | 0.009 | 0.0647 | 0.5 | |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.009 | 0.0647 | 0.0647 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0641 | 1 | 1 |
Entamoeba histolytica | trans-2,3-enoyl-CoA reductase, putative | 0.009 | 0.0647 | 0.0647 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.009 | 0.0647 | 0.6021 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.009 | 0.0647 | 0.6021 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0641 | 1 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.009 | 0.0647 | 0.0647 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0115 | 0.1074 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | nM | Inhibition of Cyclin-dependent kinase 1 (not determined) | ChEMBL. | 12941317 |
IC50 (binding) | 0 nM | Inhibition of Cyclin-dependent kinase 1 (not determined) | ChEMBL. | 12941317 |
IC50 (binding) | > 2000 nM | In vitro inhibition of Cyclin-dependent kinase 2 was determined. | ChEMBL. | 12941317 |
IC50 (binding) | > 2000 nM | In vitro inhibition of Cyclin-dependent kinase 2 was determined. | ChEMBL. | 12941317 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.