Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.069 | 0.0658 |
Onchocerca volvulus | 0.0341 | 0.2755 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0349 | 0.0315 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0696 | 0.604 | 0.604 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0349 | 0.0349 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Plasmodium falciparum | adenosylhomocysteinase | 0.1125 | 1 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1125 | 1 | 0.5 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.1125 | 1 | 1 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0366 | 0.299 | 0.299 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0046 | 0.0034 | 0.0034 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1125 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0696 | 0.604 | 0.604 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0696 | 0.604 | 0.604 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0117 | 0.069 | 0.069 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0046 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.2565 | 0.254 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0631 | 0.5433 | 0.5433 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.1125 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0117 | 0.069 | 0.069 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0631 | 0.5433 | 0.5433 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 0.0904 | 0.0872 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.2565 | 0.254 |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0046 | 0.0034 | 0.0034 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0046 | 0.0034 | 0.0034 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0046 | 0.0034 | 0.0034 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0046 | 0.0034 | 0.0034 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.1125 | 1 | 0.5 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0046 | 0.0034 | 0.0034 |
Echinococcus granulosus | adenosylhomocysteinase | 0.1125 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1125 | 1 | 1 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.1125 | 1 | 0.5 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.1125 | 1 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.1125 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.008 | 0.0349 | 0.0349 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0046 | 0.0034 | 0.0034 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0046 | 0.0034 | 0.0034 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0696 | 0.604 | 0.604 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0117 | 0.069 | 0.0658 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1125 | 1 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Brugia malayi | MH2 domain containing protein | 0.014 | 0.0904 | 0.0904 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0046 | 0.0034 | 0.0034 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.1125 | 1 | 0.5 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0046 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.2565 | 0.254 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.1125 | 1 | 0.5 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.1125 | 1 | 0.5 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.1125 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.28 | 0.2775 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.1125 | 1 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1125 | 1 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 0.0904 | 0.0872 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.0564 nM | The compound was tested In vitro for the ability to inhibit electrically induced contractions of the mouse vas deferens | ChEMBL. | 2536436 |
IC50 (functional) | = 0.0745 nM | The compound was tested In vitro for the ability to inhibit electrically induced contractions of the mouse vas deferens | ChEMBL. | 2536436 |
IC50 (functional) | = 13.3 nM | The compound was tested In vitro for the ability to inhibit electrically induced contractions of the guinea pig ileum | ChEMBL. | 2536436 |
IC50 (functional) | = 13.7 nM | The compound was tested In vitro for the ability to inhibit electrically induced contractions of the guinea pig ileum | ChEMBL. | 2536436 |
Ki (binding) | = 0.63 nM | The compound was tested for the ability to displace opioid receptor delta specific radioligand [3H]-DPDPE | ChEMBL. | 2536436 |
Ki (binding) | = 0.94 nM | The compound was tested for the ability to displace delta-receptor specific radioligand [3H]-DPDPE | ChEMBL. | 2536436 |
Ki (binding) | = 2.3 nM | The compound was tested for the ability to displace opioid receptor delta specific radioligand [3H]-DSLET | ChEMBL. | 2536436 |
Ki (binding) | = 3.27 nM | The compound was tested for the ability to displace delta-receptor specific radioligand [3H]-DSLET | ChEMBL. | 2536436 |
Ki (binding) | = 14.4 nM | The compound was tested for the ability to displace Opioid receptor mu 1 specific radioligand [3H]-DAGO | ChEMBL. | 2536436 |
Ki (binding) | = 20.9 nM | The compound was tested for the ability to displace mu-receptor specific radioligand [3H]-DAGO | ChEMBL. | 2536436 |
Ratio (binding) | = 178 | Ratio of inhibition of electrically induced contractions in GPI and MVD | ChEMBL. | 2536436 |
Ratio (functional) | = 242 | Ratio of inhibition of electrically induced contractions in GPI and MVD | ChEMBL. | 2536436 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.