Detailed information for compound 1691380

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 373.197 | Formula: C18H13BrO4
  • H donors: 1 H acceptors: 2 LogP: 3.83 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C=C1OC(=O)C=C1c1ccc(c(c1)Br)O
  • InChi: 1S/C18H13BrO4/c1-22-13-5-2-11(3-6-13)8-17-14(10-18(21)23-17)12-4-7-16(20)15(19)9-12/h2-10,20H,1H3
  • InChiKey: RMWGZBOMTPESNY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.1138 0.1113
Brugia malayi orphan nuclear receptor NR2E1 0.0104 0.4417 0.4359
Onchocerca volvulus 0.0104 0.4417 0.4473
Echinococcus multilocularis thyroid hormone receptor alpha 0.0221 0.9698 0.9697
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0221 0.9698 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.1017 0.0923
Brugia malayi G-protein alpha subunit 0.001 0.0144 0.0041
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.022 0.0192
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0109 0.008
Onchocerca volvulus 0.0029 0.1017 0.0914
Onchocerca volvulus 0.0035 0.1301 0.121
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.001 0.0144 0.0116
Brugia malayi Steroid receptor seven-up type 2 0.0221 0.9698 0.9695
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.001 0.0144 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0221 0.9698 0.9695
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0104 0.4417 0.4401
Echinococcus granulosus tar DNA binding protein 0.0064 0.2596 0.2575
Loa Loa (eye worm) hypothetical protein 0.0221 0.9698 0.9695
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0109 0.008
Loa Loa (eye worm) hypothetical protein 0.0221 0.9698 0.9695
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0144 0.0116
Brugia malayi nuclear receptor NHR-88 0.0221 0.9698 0.9695
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0144 0.111
Mycobacterium leprae conserved hypothetical protein 0.0035 0.1301 0.5
Brugia malayi nuclear hormone receptor 0.0221 0.9698 0.9695
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0221 0.9698 0.9695
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.1301 0.5
Brugia malayi nuclear receptor NHR-88 0.0104 0.4417 0.4359
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.001 0.0144 0.0116
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.001 0.0144 0.0041
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.001 0.0144 0.111
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0221 0.9698 0.9697
Onchocerca volvulus 0.0221 0.9698 1
Echinococcus granulosus FTZ F1 alpha 0.0221 0.9698 0.9697
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0117 0.4983 0.4968
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0221 0.9698 0.9695
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0144 0.0116
Echinococcus granulosus ecdysone induced protein 78C 0.0221 0.9698 0.9697
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.1301 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0104 0.4417 0.4401
Schistosoma mansoni nuclear receptor nhr-48 0.0104 0.4417 0.4401
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0221 0.9698 0.9697
Mycobacterium ulcerans lipase LipD 0.0035 0.1301 0.5
Loa Loa (eye worm) RNA binding protein 0.0064 0.2596 0.2514
Loa Loa (eye worm) hypothetical protein 0.0221 0.9698 0.9695
Schistosoma mansoni hypothetical protein 0.0032 0.1138 0.1113
Schistosoma mansoni cpg binding protein 0.0031 0.1092 0.1067
Loa Loa (eye worm) TAR-binding protein 0.0064 0.2596 0.2514
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0856 0.5
Loa Loa (eye worm) beta-lactamase 0.0035 0.1301 0.1205
Loa Loa (eye worm) hypothetical protein 0.0104 0.4417 0.4356
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0221 0.9698 0.9697
Schistosoma mansoni nuclear receptor 0.0104 0.4417 0.4401
Brugia malayi nuclear receptor RXR 0.0117 0.4983 0.493
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0144 0.0116
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.001 0.0144 0.0116
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0221 0.9698 0.9695
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.1301 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0221 0.9698 1
Onchocerca volvulus 0.0104 0.4417 0.4473
Entamoeba histolytica G protein alpha subunit, putative 0.001 0.0144 0.5
Echinococcus granulosus cpg binding protein 0.0031 0.1092 0.1067
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.001 0.0144 0.0116
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0228 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0104 0.4417 0.4359
Brugia malayi hypothetical protein 0.0026 0.0856 0.0761
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0036
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0221 0.9698 0.9697
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0144 0.0041
Schistosoma mansoni GTP-binding protein alpha subunit 0.001 0.0144 0.0116
Loa Loa (eye worm) DR-78 0.0104 0.4417 0.4356
Brugia malayi nuclear receptor RXR 0.0104 0.4417 0.4359
Mycobacterium leprae Probable lipase LipE 0.0035 0.1301 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1301 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.2596 0.2514
Brugia malayi hypothetical protein 0.0117 0.4983 0.493
Schistosoma mansoni cpg binding protein 0.0031 0.1092 0.1067
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.1301 0.121
Schistosoma mansoni GTP-binding protein alpha subunit 0.001 0.0144 0.0116
Echinococcus granulosus expressed protein 0.001 0.0144 0.0116
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0221 0.9698 0.9697
Onchocerca volvulus 0.0035 0.1301 0.121
Loa Loa (eye worm) hypothetical protein 0.0104 0.4417 0.4356
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0221 0.9698 0.9697
Loa Loa (eye worm) hypothetical protein 0.0104 0.4417 0.4356
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0036
Loa Loa (eye worm) hypothetical protein 0.0035 0.1301 0.1205
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.001 0.0144 0.0116
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.001 0.0144 0.0116
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0117 0.4983 0.4927
Schistosoma mansoni nuclear hormone receptor 0.0221 0.9698 0.9697
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.4242 0.4179
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0144 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0221 0.9698 0.9695
Loa Loa (eye worm) hypothetical protein 0.0117 0.4983 0.4927
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.1138 0.1113
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0104 0.4417 0.4473
Brugia malayi steroid hormone receptor 0.0221 0.9698 0.9695
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.001 0.0144 0.0041
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.1138 0.1113
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.001 0.0144 0.0041
Echinococcus granulosus nuclear receptor nhr 48 0.0104 0.4417 0.4401
Loa Loa (eye worm) hypothetical protein 0.0221 0.9698 0.9695
Schistosoma mansoni nuclear receptor 0.0104 0.4417 0.4401
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0221 0.9698 0.9695
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0221 0.9698 0.9697
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.2492 0.247
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0221 0.9698 0.9697
Loa Loa (eye worm) steroid hormone receptor 0.0221 0.9698 0.9695
Loa Loa (eye worm) hypothetical protein 0.0035 0.1301 0.1205
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.1301 0.1276
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 1 1
Loa Loa (eye worm) hypothetical protein 0.01 0.4242 0.4179
Brugia malayi photoreceptor-specific nuclear receptor 0.0221 0.9698 0.9695
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.001 0.0144 0.0116
Loa Loa (eye worm) hypothetical protein 0.0221 0.9698 0.9695
Schistosoma mansoni hypothetical protein 0.0011 0.022 0.0192
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.1138 0.1041
Brugia malayi ecdysteroid receptor 0.0221 0.9698 0.9695
Echinococcus granulosus Nuclear hormone receptor HR96 0.0104 0.4417 0.4401
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2596 0.2575
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0036
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0221 0.9698 0.9697
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0221 0.9698 0.9697
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.001 0.0144 0.0116
Loa Loa (eye worm) hypothetical protein 0.0117 0.4983 0.4927
Brugia malayi TAR-binding protein 0.0064 0.2596 0.2518
Onchocerca volvulus 0.0035 0.1301 0.121
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0144 0.0116
Schistosoma mansoni retinoic acid receptor RXR 0.0221 0.9698 0.9697
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.001 0.0144 0.111
Loa Loa (eye worm) hypothetical protein 0.0026 0.0856 0.0756
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0221 0.9698 0.9695
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0104 0.4417 0.4401
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0228 1 1
Brugia malayi hypothetical protein 0.0117 0.4983 0.493
Brugia malayi hypothetical protein 0.0016 0.0447 0.0347
Schistosoma mansoni steroid hormone receptor ad4bp 0.0221 0.9698 0.9697
Schistosoma mansoni hypothetical protein 0.0032 0.1138 0.1113
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.2806 0.273
Echinococcus multilocularis expressed protein 0.001 0.0144 0.0116
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0144 0.111
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.001 0.0144 0.111
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0036
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0144 0.111
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0104 0.4417 0.4401
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.1301 1
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.001 0.0144 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0228 1 1
Leishmania major hypothetical protein, conserved 0.0035 0.1301 1
Brugia malayi hypothetical protein 0.0104 0.4417 0.4359
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0221 0.9698 0.9697
Loa Loa (eye worm) hypothetical protein 0.0117 0.4983 0.4927
Loa Loa (eye worm) hypothetical protein 0.0104 0.4417 0.4356
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0144 0.111
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0221 0.9698 0.9697
Loa Loa (eye worm) hypothetical protein 0.0221 0.9698 0.9695
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0144 0.0041
Schistosoma mansoni cpg binding protein 0.0029 0.1017 0.0991
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0117 0.4983 0.4968
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.1017 0.0918
Loa Loa (eye worm) nuclear receptor NHR-67 0.0104 0.4417 0.4356
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2596 0.2575
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1301 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 1 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.1301 0.5
Toxoplasma gondii ABC1 family protein 0.0035 0.1301 0.3322
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0144 0.0116
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.001 0.0144 0.0041
Loa Loa (eye worm) hypothetical protein 0.0104 0.4417 0.4356
Schistosoma mansoni hypothetical protein 0.0069 0.2806 0.2785
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0221 0.9698 0.9697
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.022 0.0192
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.4242 0.4182
Loa Loa (eye worm) hypothetical protein 0.0035 0.1301 0.1205
Loa Loa (eye worm) G protein alpha subunit 3 0.001 0.0144 0.0036
Schistosoma mansoni zinc finger protein 0.0104 0.4417 0.4401
Loa Loa (eye worm) hypothetical protein 0.0104 0.4417 0.4356
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0856 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0221 0.9698 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2596 0.2575
Schistosoma mansoni trimeric G-protein alpha o subunit 0.001 0.0144 0.0116
Schistosoma mansoni nuclear hormone receptor 0.0104 0.4417 0.4401
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0221 0.9698 0.9697
Brugia malayi beta-lactamase 0.0035 0.1301 0.121
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.1301 0.1205
Schistosoma mansoni coup transcription factor 0.0221 0.9698 0.9697
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0221 0.9698 0.9697
Loa Loa (eye worm) hypothetical protein 0.0032 0.1138 0.1041
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.001 0.0144 0.0041
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.1138 0.1046
Loa Loa (eye worm) hypothetical protein 0.0035 0.1301 0.1205
Schistosoma mansoni nuclear hormone receptor 0.0104 0.4417 0.4401
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2596 0.2575
Loa Loa (eye worm) hypothetical protein 0.0104 0.4417 0.4356
Brugia malayi Nuclear hormone receptor-like 1 0.0221 0.9698 0.9695
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0221 0.9698 0.9697
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.1301 1
Trichomonas vaginalis esterase, putative 0.0035 0.1301 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.1138 0.1046
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.1301 0.1276
Loa Loa (eye worm) hypothetical protein 0.0104 0.4417 0.4356
Loa Loa (eye worm) hypothetical protein 0.0104 0.4417 0.4356
Brugia malayi Nuclear hormone receptor E75 0.0104 0.4417 0.4359
Echinococcus granulosus GPCR family 2 0.0032 0.1138 0.1113
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.1301 1
Brugia malayi beta-lactamase family protein 0.0035 0.1301 0.121
Brugia malayi nuclear receptor NHR-67 0.0104 0.4417 0.4359
Echinococcus multilocularis FTZ F1 alpha 0.0221 0.9698 0.9697
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.001 0.0144 0.111
Mycobacterium ulcerans beta-lactamase 0.0035 0.1301 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 1 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.4983 0.4927
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0104 0.4417 0.4401
Brugia malayi Nuclear hormone receptor-like 1 0.0117 0.4983 0.493
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.1301 0.1276
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0228 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0104 0.4417 0.4401
Brugia malayi nuclear hormone receptor family member nhr-6 0.0104 0.4417 0.4359
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.2194 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.4417 0.4356
Loa Loa (eye worm) nuclear hormone receptor 0.0104 0.4417 0.4356
Loa Loa (eye worm) hypothetical protein 0.0221 0.9698 0.9695
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0221 0.9698 0.9695
Brugia malayi conserved hypotetical protein 0.0104 0.4417 0.4359
Loa Loa (eye worm) hypothetical protein 0.0221 0.9698 0.9695
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.9916 1
Brugia malayi hypothetical protein 0.001 0.0144 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.0117 0.4983 0.493
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0221 0.9698 0.9695
Schistosoma mansoni thyroid hormone receptor 0.0221 0.9698 0.9697
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0104 0.4417 0.4401
Loa Loa (eye worm) hypothetical protein 0.0104 0.4417 0.4356
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0221 0.9698 0.9695
Loa Loa (eye worm) hypothetical protein 0.0117 0.4983 0.4927
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0221 0.9698 0.9695
Brugia malayi hypothetical protein 0.0104 0.4417 0.4359
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0144 0.0116
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.001 0.0144 0.0116
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.001 0.0144 0.0036
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0144 0.0116
Echinococcus multilocularis nuclear receptor nhr 48 0.0104 0.4417 0.4401
Plasmodium vivax hypothetical protein, conserved 0.0035 0.1301 1
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0144 0.0116
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.001 0.0144 0.0036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0104 0.4417 0.4401
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0221 0.9698 0.9697
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.1301 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.4242 0.4182
Echinococcus multilocularis cpg binding protein 0.0031 0.1092 0.1067
Loa Loa (eye worm) hypothetical protein 0.0035 0.1301 0.1205
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0228 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0221 0.9698 0.9697
Loa Loa (eye worm) hypothetical protein 0.0069 0.2806 0.2726
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.1301 0.1276
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.2596 0.2518
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0221 0.9698 0.9695
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0144 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0221 0.9698 0.9695
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0104 0.4417 0.4356
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0221 0.9698 0.9695
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0104 0.4417 0.4473
Echinococcus multilocularis ecdysone induced protein 78C 0.0221 0.9698 0.9697
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0104 0.4417 0.4401
Brugia malayi beta-lactamase family protein 0.0035 0.1301 0.121
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0221 0.9698 0.9697
Brugia malayi nuclear hormone receptor 0.0104 0.4417 0.4359
Brugia malayi RNA binding protein 0.0064 0.2596 0.2518
Loa Loa (eye worm) hypothetical protein 0.0104 0.4417 0.4356
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0036
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.1301 1
Brugia malayi ecdysone receptor 0.0104 0.4417 0.4359
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0221 0.9698 0.9695
Loa Loa (eye worm) hypothetical protein 0.0104 0.4417 0.4356
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0221 0.9698 0.9695
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.001 0.0144 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0221 0.9698 0.9695
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0144 0.0116
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0221 0.9698 0.9695
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0221 0.9698 0.9695
Brugia malayi Nuclear hormone receptor E75 0.0104 0.4417 0.4359
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0221 0.9698 0.9695
Brugia malayi tailless protein 0.0104 0.4417 0.4359
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2596 0.2575
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0221 0.9698 0.9697
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0117 0.4983 0.4968
Echinococcus multilocularis GPCR, family 2 0.0032 0.1138 0.1113
Schistosoma mansoni hypothetical protein 0.0032 0.1138 0.1113
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0117 0.4983 0.4968
Schistosoma mansoni hypothetical protein 0.0032 0.1138 0.1113
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.1138 0.1113
Loa Loa (eye worm) hypothetical protein 0.0035 0.1301 0.1205
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0144 0.0041
Echinococcus multilocularis tar DNA binding protein 0.0064 0.2596 0.2575
Schistosoma mansoni thyroid hormone receptor 0.0221 0.9698 0.9697
Brugia malayi nuclear hormone receptor family member odr-7 0.0104 0.4417 0.4359
Echinococcus granulosus Nuclear hormone receptor HR96 0.0104 0.4417 0.4401
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0104 0.4417 0.4401

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) Antimicrobial activity against Escherichia coli ATCC 11775 incubated for 24 hrs by microtiter broth dilution method ChEMBL. 23145884

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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