Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0015 | 0 | 0.5 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 0.4727 | 0.4727 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 0.4727 | 0.4727 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0225 | 0.8948 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0015 | 0 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0015 | 0 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.1522 | 0.1522 |
Leishmania major | pteridine reductase 1 | 0.0015 | 0 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0225 | 0.8948 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0249 | 1 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0015 | 0 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0225 | 0.8948 | 1 |
Onchocerca volvulus | 0.0051 | 0.1522 | 1 | |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.1522 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1522 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0015 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0225 | 0.8948 | 1 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | pteridine reductase 1 | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0249 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0225 | 0.8948 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0225 | 0.8948 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0225 | 0.8948 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0225 | 0.8948 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0126 | 0.4727 | 0.4727 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0225 | 0.8948 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.