Detailed information for compound 1691480

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 399.611 | Formula: C29H37N
  • H donors: 0 H acceptors: 0 LogP: 7.77 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCN(CC1)Cc1ccc(cc1)C(C12CC3CC(C2)CC(C1)C3)c1ccccc1
  • InChi: 1S/C29H37N/c1-3-7-26(8-4-1)28(29-18-23-15-24(19-29)17-25(16-23)20-29)27-11-9-22(10-12-27)21-30-13-5-2-6-14-30/h1,3-4,7-12,23-25,28H,2,5-6,13-21H2
  • InChiKey: XBXXDZJXFLUDEL-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase CtpV 0.0007 0.0008 0.0026
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0137 0.0325
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0011 0.0061 0.0224
Brugia malayi hypothetical protein 0.0078 0.1131 0.3339
Loa Loa (eye worm) hypothetical protein 0.0024 0.0268 0.0791
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0007 0.0008 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0833 0.1979
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0039 0.0039
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0137 0.0137
Mycobacterium ulcerans beta-lactamase 0.0033 0.0422 0.1515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0187 0.0685
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0039 0.0039
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0007 0.0008 0.0008
Schistosoma mansoni smad1 5 8 and 0.0007 0.0003 0.0003
Brugia malayi Cathepsin L-like precursor 0.0016 0.0137 0.0404
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0008 0.0014 0.0034
Trichomonas vaginalis cation-transporting ATPase, putative 0.0007 0.0008 0.0031
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0012 0.0082 0.0195
Mycobacterium ulcerans oxidoreductase 0.0012 0.0082 0.027
Schistosoma mansoni smad1 5 8 and 0.0007 0.0003 0.0003
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0012 0.0082 0.03
Brugia malayi Cathepsin L-like precursor 0.0016 0.0137 0.0404
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0119 0.1786 1
Brugia malayi PHD-finger family protein 0.0019 0.0196 0.0578
Loa Loa (eye worm) hypothetical protein 0.0134 0.2025 0.5982
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0033 0.0414 0.0985
Schistosoma mansoni cation-transporting atpase worm 0.0007 0.0008 0.0008
Loa Loa (eye worm) transcription factor SMAD2 0.0104 0.1552 0.4585
Loa Loa (eye worm) hypothetical protein 0.0078 0.1131 0.3339
Schistosoma mansoni smad 0.0007 0.0003 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0422 0.1541
Onchocerca volvulus 0.0033 0.0422 0.2362
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0033 0.0414 0.0985
Trypanosoma cruzi P-type H+-ATPase, putative 0.0007 0.0008 0.002
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0033 0.0414 0.3359
Brugia malayi Na,K-ATPase alpha subunit 0.0007 0.0008 0.0025
Echinococcus granulosus muscleblind protein 0.0134 0.2025 0.2025
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0039 0.0115
Schistosoma mansoni jumonji/arid domain-containing protein 0.0023 0.026 0.026
Entamoeba histolytica hypothetical protein 0.0058 0.0814 0.6603
Entamoeba histolytica hypothetical protein 0.0058 0.0814 0.6603
Echinococcus multilocularis neuropeptide s receptor 0.0406 0.6362 0.6362
Plasmodium vivax ataxin-2 like protein, putative 0.002 0.0212 0.0773
Mycobacterium tuberculosis Possible oxidoreductase 0.0012 0.0082 0.025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0039 0.0115
Trypanosoma cruzi polo-like protein kinase, putative 0.0084 0.1233 0.2931
Onchocerca volvulus 0.0012 0.0082 0.046
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0007 0.0008 0.0026
Schistosoma mansoni lamin 0.0024 0.0275 0.0275
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0012 0.0082 0.0195
Echinococcus multilocularis cation transporting atpase worm 0.0007 0.0008 0.0008
Plasmodium vivax vivapain-2 0.0016 0.0137 0.05
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0025 0.0281 0.1026
Schistosoma mansoni kinase 0.0043 0.0572 0.0572
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0059 0.0836 0.2469
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0007 0.0003 0.0003
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0137 0.0767
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0216 0.0789
Onchocerca volvulus 0.0012 0.0082 0.046
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0179 0.2736 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0414 0.1514
Echinococcus multilocularis lysine specific demethylase 5A 0.0023 0.026 0.026
Entamoeba histolytica hypothetical protein 0.0058 0.0814 0.6603
Echinococcus granulosus beta LACTamase domain containing family member 0.0033 0.0422 0.0422
Mycobacterium tuberculosis Probable lipase LipD 0.0033 0.0422 0.1282
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0003 0.0008
Trypanosoma brucei cation-transporting ATPase, putative 0.0007 0.0008 0.002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0034 0.0437 0.0437
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0069 0.0996 0.3639
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0011 0.0061 0.0224
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0026 0.0297 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0039 0.0115
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0082 0.027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0137 0.05
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0039 0.0039
Leishmania major cathepsin L-like protease 0.0016 0.0137 0.0325
Leishmania major cathepsin L-like protease 0.0059 0.0833 0.1979
Echinococcus granulosus survival motor neuron protein 1 0.0219 0.3386 0.3386
Schistosoma mansoni intermediate filament proteins 0.0024 0.0275 0.0275
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0039 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.2104 0.2104
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0043
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0082 0.027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0288 0.1052
Echinococcus granulosus cathepsin l1 0.001 0.0055 0.0055
Schistosoma mansoni ATPase 0.0007 0.0008 0.0008
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0007 0.0008 0.0008
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0196 0.0715
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0082 0.027
Schistosoma mansoni atpase class VI type 11c 0.0007 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0119 0.1786 0.5274
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.0422 0.1541
Schistosoma mansoni smad1 5 8 and 0.0007 0.0003 0.0003
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0011 0.0061 0.0496
Loa Loa (eye worm) retinol dehydrogenase 12 0.0012 0.0082 0.0243
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0034 0.0437 0.1039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0833 0.1979
Trypanosoma cruzi cysteine peptidase, putative 0.0008 0.0017 0.004
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0038 0.0497 0.118
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0011 0.0061 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0137 0.05
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0007 0.0008 0.0031
Echinococcus granulosus cation transporting atpase worm 0.0007 0.0008 0.0008
Treponema pallidum cation-transporting ATPase, P-type 0.0007 0.0008 0.0193
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0007 0.0008 0.0008
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0033 0.0414 0.3359
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0007 0.0008 0.0008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0281 0.0829
Entamoeba histolytica cysteine proteinase, putative 0.0008 0.0017 0.0137
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0008 0.0014 0.0014
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0054 0.0758 0.18
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0039 0.0115
Loa Loa (eye worm) hypothetical protein 0.0024 0.0268 0.0791
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0163
Brugia malayi Cathepsin L-like cysteine proteinase 0.001 0.0055 0.0163
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0008 0.0014 0.0117
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0033 0.0414 0.0414
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.0082 0.025
Plasmodium vivax cation transporting ATPase, putative 0.0007 0.0008 0.0031
Loa Loa (eye worm) hypothetical protein 0.0009 0.0039 0.0115
Onchocerca volvulus 0.0033 0.0422 0.2362
Loa Loa (eye worm) hypothetical protein 0.013 0.1959 0.5788
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0892 0.0892
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0137 0.0404
Echinococcus multilocularis GPCR, family 2 0.006 0.0848 0.0848
Schistosoma mansoni copper ABC transporter ATPase 0.0007 0.0008 0.0008
Giardia lamblia Copper-transporting P-type ATPase 0.0007 0.0008 0.0068
Mycobacterium tuberculosis Probable cation transporter P-type ATPase D CtpD 0.0007 0.0008 0.0026
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0007 0.0008 0.0031
Trichomonas vaginalis penicillin-binding protein, putative 0.0033 0.0422 0.1541
Onchocerca volvulus 0.0024 0.0275 0.154
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0039 0.0039
Entamoeba histolytica cysteine protease, putative 0.0008 0.0017 0.0137
Echinococcus multilocularis jumonji domain containing protein 0.0027 0.0316 0.0316
Brugia malayi beta-lactamase family protein 0.0033 0.0422 0.1246
Echinococcus granulosus phospholipid transporting ATPase VA 0.0007 0.0008 0.0008
Schistosoma mansoni eyes absent homolog 0.0078 0.1131 0.1131
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0217 0.0641
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0007 0.0008 0.002
Echinococcus multilocularis cation transporting ATPase 13A3 0.0007 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0137 0.05
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.0422 0.0422
Plasmodium falciparum phd finger protein, putative 0.0019 0.0196 0.0715
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0007 0.0008 0.0068
Brugia malayi Cathepsin L-like precursor 0.001 0.0055 0.0163
Brugia malayi intermediate filament protein 0.0024 0.0275 0.0812
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0025
Schistosoma mansoni phosphoserine phosphatase 0.0007 0.0008 0.0008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0039 0.0115
Loa Loa (eye worm) hypothetical protein 0.0009 0.0039 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0137 0.05
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0833 0.1979
Leishmania major cathepsin L-like protease 0.0059 0.0833 0.1979
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0012 0.0082 0.027
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0039 0.0115
Echinococcus multilocularis muscleblind protein 1 0.0134 0.2025 0.2025
Mycobacterium ulcerans aldehyde dehydrogenase 0.0054 0.0758 0.2746
Trichomonas vaginalis ap endonuclease, putative 0.0034 0.0437 0.1598
Echinococcus multilocularis neuropeptide receptor A26 0.0406 0.6362 0.6362
Toxoplasma gondii ABC1 family protein 0.0033 0.0422 0.1541
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0007 0.0008 0.002
Entamoeba histolytica cysteine protease, putative 0.0016 0.0137 0.111
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0011 0.0061 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0288 0.1052
Trichomonas vaginalis cation-transporting ATPase, putative 0.0007 0.0008 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0014 0.0053
Brugia malayi N-terminal motif family protein 0.0119 0.1786 0.5274
Echinococcus multilocularis beta LACTamase domain containing family member 0.0033 0.0422 0.0422
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.0833 0.1979
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0007 0.0008 0.002
Echinococcus granulosus cation transporting ATPase 13A1 0.0007 0.0008 0.0008
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0012 0.0075 0.0075
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0055 0.0447
Plasmodium falciparum cysteine proteinase falcipain 1 0.0008 0.0017 0.0062
Leishmania major phosphatidylinositol 3-kinase, putative 0.0011 0.0061 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0039 0.0115
Mycobacterium tuberculosis Probable esterase LipL 0.0033 0.0422 0.1282
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0011 0.0061 0.0061
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.0082 0.025
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0032 0.0398 0.3225
Schistosoma mansoni cathepsin F (C01 family) 0.001 0.0055 0.0055
Echinococcus granulosus peregrin 0.0019 0.0196 0.0196
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0128 0.1933 0.4594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0014 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0008 0.0017 0.004
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0007 0.0008 0.0068
Onchocerca volvulus 0.0009 0.0039 0.0217
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0025 0.0281 0.2276
Brugia malayi Cathepsin L-like precursor 0.0016 0.0137 0.0404
Trichomonas vaginalis hypothetical protein 0.0179 0.2736 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0034 0.0437 1
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0007 0.0008 0.002
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0012 0.0087 0.0206
Echinococcus granulosus PHD finger protein rhinoceros 0.0019 0.0196 0.0196
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0069 0.0996 0.3639
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0039 0.0039
Schistosoma mansoni transcription factor LCR-F1 0.0058 0.0814 0.0814
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0008 0.0014 0.0043
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0128 0.1933 0.4594
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0011 0.0061 0.0061
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.0082 0.025
Mycobacterium leprae Probable lipase LipE 0.0033 0.0422 0.1515
Echinococcus multilocularis peregrin 0.0019 0.0196 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0216 0.0789
Mycobacterium tuberculosis Probable lipase LipE 0.0033 0.0422 0.1282
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0082 0.027
Mycobacterium ulcerans aldehyde dehydrogenase 0.0054 0.0758 0.2746
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0035 0.044 0.3566
Leishmania major copper-transporting ATPase-like protein, putative 0.0007 0.0008 0.002
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0007 0.0008 0.0031
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0034 0.0437 0.1572
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0039 0.0039
Mycobacterium ulcerans hypothetical protein 0.0143 0.2164 0.7902
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0007 0.0008 0.0031
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0007 0.0008 0.0025
Brugia malayi steroid hormone receptor 0.0009 0.0039 0.0115
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0629 0.1496
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0017 0.0017
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0082 0.027
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0039 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0833 0.1979
Plasmodium vivax calcium-transporting ATPase, putative 0.0007 0.0008 0.0031
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0033 0.0422 0.1282
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0082 0.027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0039 0.0115
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0054 0.0758 0.0758
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0137 0.05
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0039 0.0115
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0633 0.1871
Entamoeba histolytica cysteine protease, putative 0.0008 0.0017 0.0137
Leishmania major cathepsin L-like protease 0.0016 0.0137 0.0325
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0012 0.0082 0.027
Brugia malayi Bromodomain containing protein 0.0019 0.0196 0.0578
Mycobacterium tuberculosis Conserved protein 0.0033 0.0422 0.1282
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0833 0.1979
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.2104 0.2104
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.2104 0.6214
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0082 0.027
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0069 0.0996 0.2366
Brugia malayi ecdysteroid receptor 0.0009 0.0039 0.0115
Loa Loa (eye worm) jmjC domain-containing protein 0.0023 0.026 0.0768
Plasmodium vivax vivapain-2 0.0016 0.0137 0.05
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0082 0.027
Mycobacterium tuberculosis Conserved protein 0.0033 0.0422 0.1282
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0007 0.0008 0.0008
Echinococcus multilocularis cysteine protease 0.0016 0.0137 0.0137
Toxoplasma gondii P-type ATPase PMA1 0.0007 0.0008 0.0031
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.0074
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0082 0.027
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0017 0.0017
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0039 0.0115
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0018 0.0172 0.1399
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0082 0.0243
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0523 0.8222 0.8222
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0179 0.2736 0.8316
Trypanosoma cruzi proton motive ATPase 1, putative 0.0007 0.0008 0.002
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0137 0.05
Schistosoma mansoni hypothetical protein 0.013 0.1959 0.1959
Trypanosoma cruzi cysteine proteinase, putative 0.0008 0.0017 0.004
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0082 0.027
Entamoeba histolytica cysteine protease, putative 0.0008 0.0017 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0313 0.1145
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0009 0.0034 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0039 0.0115
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0012 0.0082 0.0195
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0007 0.0008 0.0031
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0054 0.0751 0.1784
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0012 0.0087 0.0206
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0012 0.0082 0.0082
Toxoplasma gondii FATC domain-containing protein 0.0008 0.0014 0.0053
Loa Loa (eye worm) hypothetical protein 0.002 0.0212 0.0625
Mycobacterium tuberculosis Probable hydrolase 0.0033 0.0422 0.1282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0187 0.0684
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0039 0.0115
Echinococcus granulosus serine protein kinase ATM 0.0008 0.0014 0.0014
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0129 0.1942 0.1942
Entamoeba histolytica cysteine proteinase 2 0.0008 0.0017 0.0137
Trichomonas vaginalis cation-transporting ATPase, putative 0.0007 0.0008 0.0031
Echinococcus multilocularis cation transporting ATPase 13A1 0.0007 0.0008 0.0008
Brugia malayi cathepsin L-like precursor 0.001 0.0055 0.0163
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0212 0.0773
Onchocerca volvulus 0.0033 0.0422 0.2362
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0007 0.0008 0.002
Entamoeba histolytica cysteine protease, putative 0.0008 0.0017 0.0137
Chlamydia trachomatis oxoacy-ACP reductase 0.0012 0.0082 0.027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0137 0.05
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0137 0.0404
Loa Loa (eye worm) phosphatidylinositol 3 0.0115 0.1723 0.5088
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0271 0.4208 1
Schistosoma mansoni ATPase 0.0007 0.0008 0.0008
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0017 0.005
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0012 0.0082 0.0082
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0082 0.027
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0128 0.1933 0.4594
Loa Loa (eye worm) phosphatidylinositol 3 0.0012 0.0087 0.0256
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0011 0.0061 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0137 0.05
Mycobacterium tuberculosis Probable oxidoreductase 0.0012 0.0082 0.025
Echinococcus granulosus copper transporting ATPase 1 0.0007 0.0008 0.0008
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0082 0.027
Brugia malayi Calcitonin receptor-like protein seb-1 0.019 0.2918 0.8618
Brugia malayi jmjC domain containing protein 0.0023 0.026 0.0768
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0414 0.1514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0187 0.0684
Brugia malayi MH2 domain containing protein 0.0007 0.0003 0.0008
Schistosoma mansoni hypothetical protein 0.0058 0.0814 0.0814
Brugia malayi E1-E2 ATPase family protein 0.0007 0.0008 0.0025
Brugia malayi MH1 domain containing protein 0.0007 0.0003 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0039 0.0115
Echinococcus multilocularis phosphoserine phosphatase 0.0007 0.0008 0.0008
Echinococcus multilocularis cathepsin L 0.0008 0.0017 0.0017
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0039 0.0039
Treponema pallidum hypothetical protein 0.0007 0.0008 0.0193
Toxoplasma gondii hypothetical protein 0.0044 0.0586 0.2141
Loa Loa (eye worm) hypothetical protein 0.0009 0.0039 0.0115
Mycobacterium ulcerans aldehyde dehydrogenase 0.0054 0.0758 0.2746
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0137 0.05
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0011 0.0061 0.0181
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0012 0.0082 0.0666
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0012 0.0082 0.03
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.0833 0.1979
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0011 0.0061 0.0224
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0012 0.0082 0.027
Schistosoma mansoni fkbp-rapamycin associated protein 0.0008 0.0014 0.0014
Mycobacterium tuberculosis Possible oxidoreductase 0.0012 0.0082 0.025
Entamoeba histolytica cysteine protease, putative 0.0008 0.0017 0.0137
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0034 0.0437 0.1598
Loa Loa (eye worm) pigment dispersing factor receptor c 0.019 0.2918 0.8618
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0039 0.0039
Schistosoma mansoni coup transcription factor 0.0009 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0039 0.0115
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0082 0.027
Brugia malayi Cathepsin L-like precursor 0.0016 0.0137 0.0404
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0137 0.05
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0033 0.0422 0.1246
Entamoeba histolytica cysteine proteinase 1, putative 0.0008 0.0017 0.0137
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0007 0.0008 0.0025
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0007 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0313 0.1145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0833 0.1979
Brugia malayi hypothetical protein 0.0013 0.0097 0.0288
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0069 0.0996 0.8074
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0137 0.0137
Toxoplasma gondii P-type ATPase4, putative 0.0007 0.0008 0.0031
Toxoplasma gondii cation-transporting atpase family protein 0.0007 0.0008 0.0031
Loa Loa (eye worm) oxidoreductase 0.0012 0.0082 0.0243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0187 0.0685
Trypanosoma brucei P-type H+-ATPase, putative 0.0007 0.0008 0.002
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0033 0.0422 0.1515
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0011 0.0061 0.0145
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0007 0.0008 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0039 0.0115
Loa Loa (eye worm) hypothetical protein 0.019 0.2918 0.8618
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0017 0.005
Echinococcus multilocularis lamin dm0 0.0024 0.0275 0.0275
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0082 0.027
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0555 0.2027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0137 0.05
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0007 0.0008 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0137 0.05
Mycobacterium ulcerans hypothetical protein 0.0033 0.0422 0.1515
Plasmodium vivax P-type ATPase4, putative 0.0007 0.0008 0.0031
Entamoeba histolytica cysteine protease, putative 0.0008 0.0017 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0288 0.1052
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0048 0.0659 0.2409
Leishmania major phosphatidylinositol 3-kinase, putative 0.0012 0.0087 0.0206
Echinococcus multilocularis copper transporting ATPase 1 0.0007 0.0008 0.0008
Onchocerca volvulus 0.0016 0.0137 0.0767
Leishmania major pteridine reductase 1 0.0012 0.0082 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0017 0.0062
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0223
Echinococcus granulosus cation transporting ATPase 13A3 0.0007 0.0008 0.0008
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0008 0.0014 0.0034
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0007 0.0001 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0113 0.1692 0.1692
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0025 0.0281 0.1026
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0033 0.0422 0.1246
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0065 0.0932 0.7558
Brugia malayi Latrophilin receptor protein 2 0.006 0.0848 0.2503
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.2104 0.6214
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.2104 0.2104
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0212 0.0503
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0033 0.0414 0.0414
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.1233 0.4507
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0241 0.0882
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0422 0.1002
Schistosoma mansoni hypothetical protein 0.006 0.0848 0.0848
Loa Loa (eye worm) hypothetical protein 0.0011 0.0068 0.0202
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0039 0.0039
Trypanosoma cruzi cruzipain precursor, putative 0.0059 0.0833 0.1979
Toxoplasma gondii target of rapamycin (TOR), putative 0.0025 0.0288 0.1052
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0179 0.2736 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0007 0.0008 0.0031
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0212 0.0503
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0038 0.0497 0.118
Onchocerca volvulus 0.0045 0.0602 0.3374
Schistosoma mansoni aldehyde dehydrogenase 0.0054 0.0758 0.0758
Echinococcus multilocularis cysteine protease 0.0016 0.0137 0.0137
Entamoeba histolytica cysteine protease, putative 0.0008 0.0017 0.0137
Brugia malayi cytoplasmic intermediate filament protein 0.0013 0.0096 0.0283
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.0833 0.1979
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0187 0.0685
Entamoeba histolytica cysteine proteinase, putative 0.0008 0.0017 0.0137
Schistosoma mansoni tar DNA-binding protein 0.0113 0.1692 0.1692
Trypanosoma cruzi major cysteine proteinase, putative 0.0046 0.0631 0.1499
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0137 0.05
Entamoeba histolytica cysteine protease, putative 0.0008 0.0017 0.0137
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0137 0.0404
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0007 0.0008 0.002
Mycobacterium leprae conserved hypothetical protein 0.0033 0.0422 0.1515
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0039 0.0115
Schistosoma mansoni hypothetical protein 0.0009 0.0034 0.0034
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0179 0.2736 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0034 0.0437 0.1292
Echinococcus granulosus lamin 0.0024 0.0275 0.0275
Onchocerca volvulus 0.0016 0.0137 0.0767
Echinococcus multilocularis phosphoserine phosphatase 0.0007 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0275 0.0812
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0163
Toxoplasma gondii exonuclease III APE 0.0034 0.0437 0.1598
Leishmania major proton motive ATPase, putative 0.0007 0.0008 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0833 0.1979
Loa Loa (eye worm) calcium ATPase 0.0007 0.0008 0.0025
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0033 0.0414 0.0414
Brugia malayi Intermediate filament tail domain containing protein 0.0024 0.0275 0.0812
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0007 0.0008 0.0068
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0892 0.0892
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0084 0.1233 0.1233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0313 0.1145
Loa Loa (eye worm) fibroinase 0.0016 0.0137 0.0404
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0039 0.0039
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0015 0.0126 0.0299
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0007 0.0008 0.002
Mycobacterium ulcerans esterase/lipase LipP 0.0033 0.0422 0.1515
Brugia malayi hypothetical protein 0.0058 0.0814 0.2405
Echinococcus multilocularis phosphoserine phosphatase 0.0007 0.0008 0.0008
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0069 0.0996 0.2366
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0011 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0033 0.0422 0.1246
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0039 0.0115
Echinococcus granulosus GPCR family 2 0.006 0.0848 0.0848
Brugia malayi Smad1 0.0007 0.0003 0.0008
Leishmania major hypothetical protein, conserved 0.0033 0.0422 0.1002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0055 0.0201
Entamoeba histolytica cysteine proteinase, putative 0.0008 0.0017 0.0137
Schistosoma mansoni hypothetical protein 0.006 0.0848 0.0848
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0007 0.0008 0.0031
Entamoeba histolytica serine/threonine protein kinase, putative 0.0084 0.1233 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0137 0.05
Entamoeba histolytica cysteine protease, putative 0.0008 0.0017 0.0137
Loa Loa (eye worm) hypothetical protein 0.0033 0.0422 0.1246
Onchocerca volvulus 0.0016 0.0137 0.0767
Echinococcus granulosus jumonji domain containing protein 0.0027 0.0316 0.0316
Leishmania major oxidoreductase-like protein 0.0012 0.0082 0.0195
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.1233 0.4507
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0082 0.0243
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.006 0.0848 0.0848
Echinococcus multilocularis phosphoserine phosphatase 0.0007 0.0008 0.0008
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0046 0.0617 0.0617
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0129 0.1942 0.1942
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0196 0.0578
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0113 0.1692 0.4999
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0011 0.0061 0.0496
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0003 0.0008
Giardia lamblia Phospholipid-transporting ATPase IA, putative 0.0007 0.0008 0.0068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0137 0.05
Leishmania major P-type H -ATPase, putative 0.0007 0.0008 0.002
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0007 0.0008 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0137 0.05
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0271 0.4208 1
Schistosoma mansoni dihydropteridine reductase 0.0012 0.0082 0.0082
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0039 0.0039
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0137 0.0325
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0034 0.0437 0.0437
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0027 0.0314 0.0746
Onchocerca volvulus 0.0016 0.0137 0.0767
Entamoeba histolytica cysteine proteinase, putative 0.0008 0.0017 0.0137
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0039 0.0039
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0038 0.0497 0.118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0313 0.1145
Echinococcus granulosus cathepsin L cysteine protease 0.0008 0.0017 0.0017
Echinococcus multilocularis phosphoserine phosphatase 0.0007 0.0008 0.0008
Trypanosoma brucei oxidoreductase-like protein 0.0012 0.0082 0.0195
Leishmania major P-type H -ATPase, putative 0.0007 0.0008 0.002
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0012 0.0075 0.0075
Echinococcus granulosus smad 0.0007 0.0003 0.0003
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0011 0.0061 0.0224
Onchocerca volvulus 0.0016 0.0137 0.0767
Echinococcus multilocularis mothers against decapentaplegic 5 0.0007 0.0003 0.0003
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0007 0.0008 0.0031
Plasmodium vivax vivapain-3 0.0008 0.0017 0.0062
Trypanosoma brucei PAB1-binding protein , putative 0.002 0.0212 0.0503
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0137 0.0767
Brugia malayi nuclear receptor NHR-88 0.0009 0.0039 0.0115
Entamoeba histolytica cysteine protease, putative 0.0008 0.0017 0.0137
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0012 0.0082 0.027
Loa Loa (eye worm) hypothetical protein 0.0033 0.0422 0.1246
Schistosoma mansoni Smad4 0.0007 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0137 0.05
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0007 0.0008 0.0068
Loa Loa (eye worm) E1-E2 ATPase 0.0007 0.0008 0.0025
Schistosoma mansoni cation-transporting ATPase 0.0007 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0288 0.1052
Onchocerca volvulus 0.001 0.0055 0.0309
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0012 0.0087 0.0087
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0008 0.0014 0.0043
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.006 0.0848 0.0848
Trypanosoma cruzi cysteine proteinase, putative 0.0008 0.0017 0.004
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0179 0.2736 1
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0007 0.0008 0.0025
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0034 0.0437 0.3546
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0007 0.0008 0.002
Brugia malayi TAR-binding protein 0.0113 0.1692 0.4999
Loa Loa (eye worm) hypothetical protein 0.0016 0.0137 0.0404
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0025 0.0281 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0137 0.05
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0039 0.0039
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0012 0.0082 0.03
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0012 0.0087 0.0256
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0013 0.0096 0.0283
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0196 0.0578
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0017 0.0017
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0137 0.0137
Brugia malayi Cathepsin L-like precursor 0.0016 0.0137 0.0404
Schistosoma mansoni hypothetical protein 0.0634 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0087 0.0316
Schistosoma mansoni ap endonuclease 0.0034 0.0437 0.0437
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.1233 0.1233
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0025
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0007 0.0008 0.0031
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0019 0.0196 0.0196
Loa Loa (eye worm) TAR-binding protein 0.0113 0.1692 0.4999
Loa Loa (eye worm) hypothetical protein 0.0134 0.2025 0.5982
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0039 0.0115
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0011 0.0061 0.0061
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0196 0.0715
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0213 0.329 1
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0007 0.0008 0.0031
Brugia malayi serine/threonine-protein kinase plk-2 0.0084 0.1233 0.3642
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0039 0.0039
Toxoplasma gondii LsmAD domain-containing protein 0.002 0.0212 0.0773
Schistosoma mansoni hypothetical protein 0.0045 0.0602 0.0602
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.2104 0.2104
Brugia malayi E1-E2 ATPase family protein 0.0007 0.0008 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0053 0.0195
Loa Loa (eye worm) beta-lactamase 0.0033 0.0422 0.1246
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0007 0.0008 0.0031
Loa Loa (eye worm) intermediate filament protein 0.0024 0.0275 0.0812
Trichomonas vaginalis cation-transporting ATPase, putative 0.0007 0.0008 0.0031
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0007 0.0008 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0039 0.0115
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0082 0.027
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0082 0.027
Echinococcus granulosus mothers against decapentaplegic 5 0.0007 0.0003 0.0003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.006 0.0848 0.0848
Entamoeba histolytica cysteine protease, putative 0.0008 0.0017 0.0137
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0011 0.0061 0.0224
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0137 0.111
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0007 0.0008 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0252 0.0921
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0288 0.1052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.2104 0.2104
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0196 0.0715
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0082 0.027
Leishmania major hypothetical protein, conserved 0.002 0.0212 0.0503
Onchocerca volvulus Serine\/threonine kinase homolog 0.0084 0.1233 0.6906
Brugia malayi RNA recognition motif domain containing protein 0.0113 0.1692 0.4999
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0012 0.0087 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0216 0.0789
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0012 0.0082 0.03
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0082 0.027
Giardia lamblia PHD finger protein 15 0.0019 0.0196 0.1586
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0008 0.0017 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0288 0.1052
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0012 0.0087 0.0206
Entamoeba histolytica hypothetical protein 0.0058 0.0814 0.6603
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0007 0.0008 0.0008
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.006 0.0848 0.2503
Brugia malayi exodeoxyribonuclease III family protein 0.0034 0.0437 0.1292
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0012 0.0082 0.027
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0007 0.0008 0.002
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0017 0.0154 0.0367
Brugia malayi beta-lactamase family protein 0.0033 0.0422 0.1246
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0012 0.0082 0.025
Brugia malayi RNA binding protein 0.0113 0.1692 0.4999
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0039 0.0115
Loa Loa (eye worm) Smad1 0.0007 0.0003 0.0008
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0034 0.0437 0.1598
Loa Loa (eye worm) hypothetical protein 0.0011 0.0068 0.0202
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0034 0.0437 0.1039
Leishmania major mitochondrial DNA polymerase beta 0.0271 0.4208 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.019 0.2918 0.8618
Trypanosoma brucei pteridine reductase 1 0.0012 0.0082 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0137 0.05
Echinococcus granulosus Smad4 0.0007 0.0003 0.0003
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0212 0.0773
Echinococcus granulosus cathepsin L 0.0008 0.0017 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0833 0.1979
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.0039 0.0217
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0137 0.05
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.2104 0.2104
Echinococcus multilocularis Zinc finger, PHD finger 0.0011 0.0061 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0137 0.05
Entamoeba histolytica protein kinase rad3, putative 0.0008 0.0014 0.0117
Schistosoma mansoni jumonji domain containing protein 0.005 0.0686 0.0686
Echinococcus multilocularis survival motor neuron protein 1 0.0219 0.3386 0.3386
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0009 0.0034 0.0034
Brugia malayi Cathepsin L-like precursor 0.0016 0.0137 0.0404
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0039 0.0039
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0069 0.0996 0.2941
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0039 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0087 0.0316
Brugia malayi MH1 domain containing protein 0.0007 0.0003 0.0008
Echinococcus multilocularis tar DNA binding protein 0.0113 0.1692 0.1692
Loa Loa (eye worm) hypothetical protein 0.0009 0.0039 0.0115
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0033 0.0422 0.1282
Entamoeba histolytica hypothetical protein 0.0056 0.0776 0.6295
Trypanosoma cruzi copper-transporting ATPase, putative 0.0007 0.0008 0.002
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0008 0.0014 0.0014
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0007 0.0008 0.0025
Echinococcus granulosus lamin dm0 0.0024 0.0275 0.0275
Loa Loa (eye worm) phosphatidylinositol 3 0.0033 0.0414 0.1224
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0007 0.0008 0.0031
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0025 0.0281 0.1026
Echinococcus multilocularis Smad4 0.0007 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0017 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0213 0.0778
Schistosoma mansoni cation-transporting atpase worm 0.0007 0.0008 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0039 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.0422 0.1541
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0039 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0137 0.05
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0084 0.1233 0.3642
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0008 0.0014 0.0014
Giardia lamblia GTOR 0.0033 0.0414 0.3359
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0011 0.0061 0.0224
Trichomonas vaginalis esterase, putative 0.0033 0.0422 0.1541
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0012 0.0082 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0187 0.0685
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0011 0.0061 0.0145
Schistosoma mansoni type V p-type atpase isoform 0.0007 0.0008 0.0008
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0084 0.1233 0.2931
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0039 0.0115
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0012 0.0082 0.03
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0137 0.05
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0342 0.1251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0087 0.0316
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0007 0.0008 0.0008
Loa Loa (eye worm) RNA binding protein 0.0113 0.1692 0.4999
Echinococcus granulosus intermediate filament protein 0.0024 0.0275 0.0275
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0039 0.0039
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0007 0.0008 0.0031
Echinococcus multilocularis phosphoserine phosphatase 0.0007 0.0008 0.0008
Leishmania major cathepsin L-like protease 0.0016 0.0137 0.0325
Loa Loa (eye worm) hypothetical protein 0.0033 0.0422 0.1246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0087 0.0316
Trypanosoma brucei polo-like protein kinase 0.0084 0.1233 0.2931
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0025 0.0281 0.2276
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0012 0.0082 0.027
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0084 0.1233 0.1233
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0058 0.0814 0.0814
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0034 0.0437 0.3546
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0008 0.0014 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.1233 0.4507
Echinococcus multilocularis smad 0.0007 0.0003 0.0003
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0033 0.0414 0.0985
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0007 0.0008 0.0031
Echinococcus granulosus tar DNA binding protein 0.0113 0.1692 0.1692
Echinococcus multilocularis muscleblind protein 0.0134 0.2025 0.2025
Echinococcus multilocularis PHD finger protein rhinoceros 0.0019 0.0196 0.0196
Trypanosoma brucei P-type H+-ATPase, putative 0.0007 0.0008 0.002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0033 0.0414 0.1224
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0007 0.0008 0.0025
Echinococcus granulosus active breakpoint cluster region 0.0082 0.119 0.119
Toxoplasma gondii cathepsin CPL 0.0016 0.0137 0.05
Leishmania major cathepsin L-like protease 0.0016 0.0137 0.0325
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.1233 0.4507
Echinococcus multilocularis musashi 0.0024 0.0275 0.0275
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0039 0.0115
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.0422 0.1541
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0033 0.0414 0.0985
Onchocerca volvulus 0.0007 0.0008 0.0047
Loa Loa (eye worm) latrophilin receptor protein 2 0.006 0.0848 0.2503
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0039 0.0115
Onchocerca volvulus 0.0024 0.0275 0.154
Onchocerca volvulus Alhambra homolog 0.0019 0.0196 0.1095
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0024 0.0275 0.0812
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0137 0.05
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0055 0.0201
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0422 0.1002
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0137 0.0137
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0012 0.0082 0.0195
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0007 0.0008 0.0068
Echinococcus multilocularis serine protein kinase ATM 0.0008 0.0014 0.0014
Brugia malayi hypothetical protein 0.002 0.0212 0.0625
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0008 0.0017 0.004
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0025
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0179 0.2736 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0011 0.0061 0.0145
Loa Loa (eye worm) hypothetical protein 0.0033 0.0422 0.1246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0087 0.0316
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0034 0.0437 0.1039
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0007 0.0001 0.0002
Brugia malayi Muscleblind-like protein 0.0134 0.2025 0.5982
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.006 0.0848 0.0848
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0414 0.1514
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0021 0.0217 0.0516
Giardia lamblia Kinase, PLK 0.0084 0.1233 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0039 0.0039
Echinococcus granulosus TGF beta signal transducer SmadC 0.0007 0.0003 0.0003
Brugia malayi hypothetical protein 0.0007 0.0008 0.0025
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0056 0.0776 0.6295
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0011 0.0061 0.0145
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0034 0.0437 0.1039
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0039 0.0115
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0137 0.0137
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0007 0.0008 0.0008
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0012 0.0087 0.0206
Loa Loa (eye worm) MH2 domain-containing protein 0.0104 0.1552 0.4585
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0012 0.0082 0.025
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0555 0.2027
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0039 0.0115
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0007 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0039 0.0115
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0033 0.0422 0.1246
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0137 0.0137
Echinococcus granulosus neuropeptide s receptor 0.0406 0.6362 0.6362
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0039 0.0039
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0034 0.0437 0.1329
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0027 0.0314 0.0746
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0054 0.0758 0.0758
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0058 0.0814 0.0814
Brugia malayi latrophilin 2 splice variant baaae 0.013 0.1959 0.5788
Schistosoma mansoni hypothetical protein 0.0019 0.0196 0.0196
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0012 0.0082 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0833 0.1979
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0039 0.0039
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.0039 0.0217
Loa Loa (eye worm) hypothetical protein 0.0219 0.3386 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.1131 0.3339
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0082 0.027
Schistosoma mansoni ap endonuclease 0.0034 0.0437 0.0437
Plasmodium vivax copper-transporting ATPase, putative 0.0007 0.0008 0.0031
Mycobacterium tuberculosis Conserved protein 0.0033 0.0422 0.1282
Onchocerca volvulus 0.0016 0.0137 0.0767
Trypanosoma cruzi polo-like protein kinase, putative 0.0084 0.1233 0.2931
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0137 0.05
Leishmania major cathepsin L-like protease 0.0016 0.0137 0.0325
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0082 0.027
Brugia malayi MH2 domain containing protein 0.0007 0.0003 0.0008
Mycobacterium tuberculosis Conserved hypothetical protein 0.0143 0.2164 0.6577
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0025 0.0092
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0007 0.0008 0.0068
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0069 0.0996 0.3639
Loa Loa (eye worm) hypothetical protein 0.006 0.0848 0.2503
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0039 0.0039
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0025 0.0281 0.0667
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0007 0.0003 0.0003
Brugia malayi beta-lactamase 0.0033 0.0422 0.1246
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0213 0.0778
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0313 0.1145
Entamoeba histolytica cysteine protease, putative 0.0008 0.0017 0.0137
Trypanosoma cruzi P-type H+-ATPase, putative 0.0007 0.0008 0.002
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0522 0.1541
Schistosoma mansoni lamin 0.0024 0.0275 0.0275
Plasmodium vivax unspecified product 0.0008 0.0017 0.0062
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0033 0.0422 0.1282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0288 0.1052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0833 0.1979
Onchocerca volvulus 0.0016 0.0137 0.0767
Schistosoma mansoni hypothetical protein 0.006 0.0848 0.0848
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0034 0.0437 0.1338
Echinococcus multilocularis geminin 0.0634 1 1
Echinococcus granulosus lysine specific demethylase 5A 0.0023 0.026 0.026
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0012 0.0082 0.0195
Mycobacterium ulcerans lipase LipD 0.0033 0.0422 0.1515
Leishmania major calcium-translocating P-type ATPase 0.0007 0.0008 0.002
Echinococcus multilocularis lamin 0.0024 0.0275 0.0275
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0422 0.1002
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0163
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0033 0.0414 0.0985
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0033 0.0414 0.0985
Trichomonas vaginalis penicillin-binding protein, putative 0.0033 0.0422 0.1541
Plasmodium falciparum enoyl-acyl carrier reductase 0.0179 0.2736 1
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0137 0.0767
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0082 0.027
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0082 0.027
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0045 0.0602 0.178
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0007 0.0008 0.0031
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0012 0.0082 0.025
Brugia malayi nuclear hormone receptor 0.0009 0.0039 0.0115
Schistosoma mansoni hypothetical protein 0.006 0.0848 0.0848
Loa Loa (eye worm) hypothetical protein 0.0046 0.0617 0.1823
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.2104 0.2104
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0082 0.027
Brugia malayi Cathepsin L-like precursor 0.001 0.0055 0.0163
Brugia malayi jmjC domain containing protein 0.0063 0.0892 0.2636
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0137 0.0137
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0039 0.0039
Leishmania major cathepsin L-like protease 0.0059 0.0833 0.1979
Schistosoma mansoni tar DNA-binding protein 0.0113 0.1692 0.1692
Echinococcus granulosus cathepsin l1 0.0016 0.0137 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0187 0.0684
Loa Loa (eye worm) cysteine protease 0.0016 0.0137 0.0404
Loa Loa (eye worm) hypothetical protein 0.0033 0.0414 0.1224
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0012 0.0087 0.0206
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0009 0.0025 0.0092
Trypanosoma cruzi phospholipid-transporting ATPase-like protein, putative 0.0007 0.0008 0.002
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.1233 0.4507
Schistosoma mansoni tar DNA-binding protein 0.0113 0.1692 0.1692
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.1233 0.4507
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.0422 0.0422
Echinococcus granulosus cysteine protease 0.0008 0.0017 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0833 0.1979
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0007 0.0008 0.002
Trypanosoma cruzi cation-transporting ATPase, putative 0.0007 0.0008 0.002
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0007 0.0008 0.0025
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0137 0.111
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0012 0.0082 0.0195
Trypanosoma cruzi target of rapamycin kinase 3 0.0027 0.0314 0.0746
Schistosoma mansoni survival motor neuron protein 0.0045 0.0602 0.0602
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.1233 0.4507
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0137 0.05
Loa Loa (eye worm) hypothetical protein 0.0009 0.0039 0.0115
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0046 0.0617 0.0617
Schistosoma mansoni hypothetical protein 0.0634 1 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0012 0.0082 0.0243
Schistosoma mansoni jumonji/arid domain-containing protein 0.0023 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0012 0.0082 0.0243
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0048 0.0659 0.2409
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0012 0.0087 0.0087
Mycobacterium tuberculosis Probable metal cation transporter ATPase P-type CtpE 0.0007 0.0008 0.0026
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0082 0.027
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0179 0.2736 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0082 0.027
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0054 0.0758 0.2303
Mycobacterium tuberculosis Cation transporter P-type ATPase a CtpA 0.0007 0.0008 0.0026
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0271 0.4208 1
Trypanosoma cruzi cysteine protease, putative 0.0008 0.0017 0.004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0137 0.05
Trichomonas vaginalis cation-transporting ATPase, putative 0.0007 0.0008 0.0031
Brugia malayi MH2 domain containing protein 0.0104 0.1552 0.4585
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0014 0.0053
Toxoplasma gondii aldehyde dehydrogenase 0.0054 0.0758 0.2769
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0038 0.0497 0.118
Plasmodium vivax vivapain-1 0.0008 0.0017 0.0062
Brugia malayi hypothetical protein 0.0219 0.3386 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0129 0.1942 0.1942
Plasmodium falciparum copper-transporting ATPase 0.0007 0.0008 0.0031
Trichomonas vaginalis ap endonuclease, putative 0.0034 0.0437 0.1598
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0007 0.0008 0.0068
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0007 0.0008 0.002
Echinococcus granulosus neuropeptide receptor A26 0.0406 0.6362 0.6362
Schistosoma mansoni tar DNA-binding protein 0.0113 0.1692 0.1692
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0007 0.0008 0.0068
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0039 0.0039
Echinococcus multilocularis active breakpoint cluster region 0.0082 0.119 0.119
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0007 0.0008 0.0031
Entamoeba histolytica hypothetical protein 0.0008 0.0014 0.0117
Loa Loa (eye worm) ctsf protein 0.0016 0.0137 0.0404
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.0039 0.0217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0137 0.05
Schistosoma mansoni aldehyde dehydrogenase 0.0054 0.0758 0.0758
Entamoeba histolytica cysteine protease, putative 0.0008 0.0017 0.0137

Activities

Activity type Activity value Assay description Source Reference
GI50 (ADMET) = 23.74 nM Growth inhibition of human NHDF cells after 48 hrs by SRB assay ChEMBL. 23094992

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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