Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | endothelin converting enzyme 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | notch | 0.0193 | 0.1896 | 0.1884 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0193 | 0.1896 | 0.1502 |
Schistosoma mansoni | septate junction protein | 0.0193 | 0.1896 | 0.1884 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Brugia malayi | Cadherin domain containing protein | 0.0193 | 0.1896 | 0.1502 |
Toxoplasma gondii | peptidase family M13 protein | 0.0114 | 0.0797 | 0.2331 |
Echinococcus granulosus | neural cadherin | 0.0193 | 0.1896 | 0.1502 |
Brugia malayi | Delta serrate ligand family protein | 0.0193 | 0.1896 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.0778 | 1 | 1 |
Onchocerca volvulus | 0.0778 | 1 | 1 | |
Echinococcus granulosus | peroxidasin | 0.0778 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0778 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0385 | 0.0385 |
Brugia malayi | EGF-like domain containing protein | 0.0193 | 0.1896 | 0.1502 |
Brugia malayi | Animal haem peroxidase family protein | 0.0778 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.009 | 0.0463 | 0.5 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0193 | 0.1896 | 0.1884 |
Echinococcus granulosus | fibropellin Ia | 0.0193 | 0.1896 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.0778 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0193 | 0.1896 | 0.1502 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0114 | 0.0797 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0412 | 0.0412 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0193 | 0.1896 | 0.1502 |
Echinococcus granulosus | delta-like protein 1 | 0.0193 | 0.1896 | 0.1502 |
Giardia lamblia | High cysteine protein | 0.0193 | 0.1896 | 1 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0114 | 0.0797 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Echinococcus multilocularis | notch | 0.0193 | 0.1896 | 0.1502 |
Schistosoma mansoni | notch | 0.0193 | 0.1896 | 0.1884 |
Echinococcus multilocularis | protein jagged 1 | 0.0193 | 0.1896 | 0.1502 |
Brugia malayi | Peroxidasin | 0.0778 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0385 | 0.0385 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0193 | 0.1896 | 0.1884 |
Schistosoma mansoni | cell polarity protein | 0.0193 | 0.1896 | 0.1884 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0412 | 0.0412 |
Brugia malayi | Animal haem peroxidase family protein | 0.0778 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0193 | 0.1896 | 0.1502 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.009 | 0.0463 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.0385 | 0.0385 |
Loa Loa (eye worm) | hypothetical protein | 0.0778 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.009 | 0.0463 | 0.0449 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0385 | 0.0385 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0193 | 0.1896 | 0.1896 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1896 | 0.1884 |
Schistosoma mansoni | notch | 0.0193 | 0.1896 | 0.1884 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0412 | 0.0412 |
Schistosoma mansoni | peroxidasin | 0.0778 | 1 | 1 |
Brugia malayi | notch-like transmembrane receptor | 0.0193 | 0.1896 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Entamoeba histolytica | histone deacetylase, putative | 0.009 | 0.0463 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0385 | 0.0385 |
Trichomonas vaginalis | histone deacetylase, putative | 0.009 | 0.0463 | 0.5 |
Echinococcus multilocularis | protein jagged 2 | 0.0193 | 0.1896 | 0.1502 |
Brugia malayi | EGF-like domain containing protein | 0.0193 | 0.1896 | 0.1502 |
Echinococcus granulosus | protein jagged 1 | 0.0193 | 0.1896 | 0.1502 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0778 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Brugia malayi | Blistered cuticle protein 3 | 0.0778 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0463 | 0.0463 |
Onchocerca volvulus | 0.0778 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0778 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0778 | 1 | 1 |
Echinococcus multilocularis | neural cadherin | 0.0193 | 0.1896 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Echinococcus granulosus | notch | 0.0193 | 0.1896 | 0.1502 |
Onchocerca volvulus | Slit protein homolog | 0.0193 | 0.1896 | 0.1896 |
Brugia malayi | Muscle positioning protein 4 | 0.0193 | 0.1896 | 0.1502 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0114 | 0.0797 | 0.035 |
Brugia malayi | EGF-like domain containing protein | 0.0193 | 0.1896 | 0.1502 |
Brugia malayi | Cadherin domain containing protein | 0.0193 | 0.1896 | 0.1502 |
Onchocerca volvulus | Peroxidasin homolog | 0.0778 | 1 | 1 |
Schistosoma mansoni | notch | 0.0193 | 0.1896 | 0.1884 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1896 | 0.1884 |
Echinococcus granulosus | slit 2 protein | 0.0193 | 0.1896 | 0.1502 |
Trichomonas vaginalis | histone deacetylase, putative | 0.009 | 0.0463 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.009 | 0.0463 | 0.5 |
Schistosoma mansoni | histone deacetylase | 0.009 | 0.0463 | 0.0449 |
Brugia malayi | Animal haem peroxidase family protein | 0.0778 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0778 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.009 | 0.0463 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0778 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0778 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0778 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Trichomonas vaginalis | histone deacetylase, putative | 0.009 | 0.0463 | 0.5 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0193 | 0.1896 | 0.1502 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.009 | 0.0463 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0778 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0193 | 0.1896 | 0.1502 |
Brugia malayi | Peptidase family M13 containing protein | 0.0114 | 0.0797 | 0.035 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0193 | 0.1896 | 1 |
Echinococcus multilocularis | protein jagged 1 | 0.0193 | 0.1896 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.0778 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0797 | 0.0797 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0193 | 0.1896 | 0.1502 |
Onchocerca volvulus | 0.0778 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1896 | 0.1884 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0193 | 0.1896 | 0.1502 |
Echinococcus multilocularis | slit 2 protein | 0.0193 | 0.1896 | 0.1502 |
Trypanosoma brucei | histone deacetylase 1 | 0.009 | 0.0463 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0412 | 0.0412 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Onchocerca volvulus | 0.0193 | 0.1896 | 0.1896 | |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1896 | 0.1884 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0193 | 0.1896 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0412 | 0.0412 |
Brugia malayi | EGF-like domain containing protein | 0.0193 | 0.1896 | 0.1502 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0193 | 0.1896 | 0.1502 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0114 | 0.0797 | 0.0784 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0114 | 0.0797 | 0.035 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1896 | 0.1884 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.009 | 0.0463 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0412 | 0.0412 |
Brugia malayi | EGF-like domain containing protein | 0.0193 | 0.1896 | 0.1502 |
Loa Loa (eye worm) | Notch2 | 0.0193 | 0.1896 | 0.1896 |
Brugia malayi | Animal haem peroxidase family protein | 0.0778 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0193 | 0.1896 | 0.1502 |
Plasmodium vivax | histone deacetylase 1, putative | 0.009 | 0.0463 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.009 | 0.0463 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0778 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1896 | 0.1884 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0193 | 0.1896 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0797 | 0.0797 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0193 | 0.1896 | 0.1502 |
Onchocerca volvulus | 0.0193 | 0.1896 | 0.1896 | |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Echinococcus granulosus | protein jagged 1 | 0.0193 | 0.1896 | 0.1502 |
Onchocerca volvulus | Putative cubilin | 0.0193 | 0.1896 | 0.1896 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Echinococcus granulosus | protein jagged 2 | 0.0193 | 0.1896 | 0.1502 |
Schistosoma mansoni | slit | 0.0193 | 0.1896 | 0.1884 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0193 | 0.1896 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.0778 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0778 | 1 | 1 |
Schistosoma mansoni | notch | 0.0193 | 0.1896 | 0.1884 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Echinococcus granulosus | protein jagged 2 | 0.0193 | 0.1896 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.0778 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.009 | 0.0463 | 0.5 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0193 | 0.1896 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.0778 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Onchocerca volvulus | Peroxidasin homolog | 0.0778 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0778 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Plasmodium falciparum | histone deacetylase 1 | 0.009 | 0.0463 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0778 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0778 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.009 | 0.0463 | 0.0463 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0193 | 0.1896 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1896 | 0.1896 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0114 | 0.0797 | 0.035 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0193 | 0.1896 | 0.1896 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0114 | 0.0797 | 0.5 |
Onchocerca volvulus | 0.0193 | 0.1896 | 0.1896 | |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0797 | 0.0797 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0193 | 0.1896 | 0.1502 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0778 | 1 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.0385 | 0.0385 |
Loa Loa (eye worm) | hypothetical protein | 0.0778 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.009 | 0.0463 | 0.5 |
Loa Loa (eye worm) | notch protein | 0.0193 | 0.1896 | 0.1896 |
Schistosoma mansoni | notch | 0.0193 | 0.1896 | 0.1884 |
Onchocerca volvulus | 0.0193 | 0.1896 | 0.1896 | |
Loa Loa (eye worm) | hypothetical protein | 0.0778 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0778 | 1 | 1 |
Echinococcus multilocularis | fibropellin Ia | 0.0193 | 0.1896 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.0778 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.009 | 0.0463 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.009 | 0.0463 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1896 | 0.1884 |
Onchocerca volvulus | 0.0193 | 0.1896 | 0.1896 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.