Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.011 | 0.0399 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.011 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.003 | 0.2583 | 0.9367 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.2583 | 0.934 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.2583 | 0.934 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.003 | 0.2583 | 1 |
Leishmania major | cytochrome p450-like protein | 0.003 | 0.2583 | 0.2501 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.003 | 0.2583 | 0.2501 |
Trypanosoma cruzi | cytochrome P450, putative | 0.003 | 0.2583 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.011 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.011 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.2583 | 0.9367 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.011 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.2758 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.011 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.003 | 0.2583 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.011 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.011 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.2583 | 0.9367 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.011 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.2758 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reaction | ChEMBL. | 23067550 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.