Detailed information for compound 1692253

Basic information

Technical information
  • TDR Targets ID: 1692253
  • Name: 4-diethylaminobut-2-ynyl (2S)-2-cyclohexyl-2- hydroxy-2-phenylacetate hydrochloride
  • MW: 393.947 | Formula: C22H32ClNO3
  • H donors: 1 H acceptors: 2 LogP: 4.98 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CC#CCOC(=O)[C@@](c1ccccc1)(C1CCCCC1)O)CC.Cl
  • InChi: 1S/C22H31NO3.ClH/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20;/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3;1H/t22-;/m1./s1
  • InChiKey: SWIJYDAEGSIQPZ-VZYDHVRKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-diethylaminobut-2-ynyl (2S)-2-cyclohexyl-2-hydroxy-2-phenyl-acetate hydrochloride
  • (2S)-2-cyclohexyl-2-hydroxy-2-phenylacetic acid 4-diethylaminobut-2-ynyl ester hydrochloride
  • (2S)-2-cyclohexyl-2-hydroxy-2-phenyl-acetic acid 4-diethylaminobut-2-ynyl ester hydrochloride
  • 4-diethylaminobut-2-ynyl (2S)-2-cyclohexyl-2-hydroxy-2-phenyl-ethanoate hydrochloride
  • 230949-16-3
  • Esoxybutynin Chloride
  • Esoxybutynin Chloride [USAN]
  • 4-[(2S)-2-cyclohexyl-2-hydroxy-2-phenylacetyl]oxybut-2-ynyl-diethylazanium chloride
  • 4-[(2S)-2-cyclohexyl-2-hydroxy-2-phenyl-acetyl]oxybut-2-ynyl-diethyl-ammonium chloride
  • 4-[(2S)-2-cyclohexyl-2-hydroxy-1-oxo-2-phenylethoxy]but-2-ynyl-diethylammonium chloride
  • 4-[(2S)-2-cyclohexyl-2-hydroxy-2-phenyl-ethanoyl]oxybut-2-ynyl-diethyl-azanium chloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni DNA polymerase eta 0.0023 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0593 0.6708 0.6707
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.6315 0.6315
Mycobacterium ulcerans hypothetical protein 0.0161 0.1752 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0879 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.6315 0.6315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0002 0.0002
Toxoplasma gondii preprocathepsin c precursor, putative 0.0172 0.188 0.1766
Brugia malayi Cathepsin L-like precursor 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0459 0.5172 0.5104
Plasmodium vivax unspecified product 0.0287 0.3193 0.3098
Loa Loa (eye worm) hypothetical protein 0.0023 0.0169 0.0166
Schistosoma mansoni cpg binding protein 0.0037 0.0322 0.0322
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.012 0.012
Schistosoma mansoni cathepsin S (C01 family) 0.0172 0.188 0.188
Loa Loa (eye worm) hypothetical protein 0.0028 0.0223 0.0221
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0172 0.188 0.1766
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0172 0.188 0.188
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0172 0.188 0.1878
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0002 0.0002
Toxoplasma gondii hypothetical protein 0.0049 0.0468 0.0335
Plasmodium vivax importin-beta 2, putative 0.0028 0.0223 0.0086
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0169 0.0031
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0169 0.0169
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0172 0.188 0.1878
Brugia malayi cathepsin F-like cysteine proteinase 0.0287 0.3193 0.3192
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0459 0.5172 0.5104
Giardia lamblia Cathepsin L precursor 0.0172 0.188 0.5528
Loa Loa (eye worm) hypothetical protein 0.0019 0.012 0.0118
Giardia lamblia Cathepsin B precursor 0.0295 0.3289 1
Trypanosoma cruzi cysteine protease, putative 0.0459 0.5172 0.5104
Onchocerca volvulus 0.0879 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0879 1 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0223 0.0086
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.6315 0.6315
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0024 0.0024
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0172 0.188 0.1766
Trypanosoma brucei unspecified product 0.0023 0.0169 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Echinococcus multilocularis GPCR, family 2 0.0019 0.012 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Plasmodium falciparum serine repeat antigen 2 0.0172 0.188 0.1766
Entamoeba histolytica cysteine proteinase, putative 0.0879 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0395 0.0261
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0172 0.188 0.1766
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Onchocerca volvulus Huntingtin homolog 0.0119 0.1269 0.0999
Loa Loa (eye worm) hypothetical protein 0.0287 0.3193 0.3192
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0459 0.5172 0.5104
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0172 0.188 0.1878
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0459 0.5172 0.513
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Brugia malayi Cathepsin L-like precursor 0.0287 0.3193 0.3192
Brugia malayi Papain family cysteine protease containing protein 0.0879 1 1
Echinococcus granulosus importin subunit beta 1 0.0028 0.0223 0.0223
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0879 1 1
Echinococcus granulosus cathepsin L cysteine protease 0.0459 0.5172 0.5172
Brugia malayi Cathepsin L-like precursor 0.0593 0.6708 0.6707
Loa Loa (eye worm) ctsf protein 0.0879 1 1
Schistosoma mansoni cpg binding protein 0.0035 0.0299 0.0299
Plasmodium vivax unspecified product 0.0459 0.5172 0.5104
Giardia lamblia Cysteine protease 0.0172 0.188 0.5528
Trypanosoma cruzi cysteine proteinase, putative 0.0459 0.5172 0.5104
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0569 0.6436 0.6436
Trypanosoma cruzi cruzipain precursor, putative 0.0287 0.3193 0.3098
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0169 0.0084
Plasmodium vivax vivapain-2 0.0879 1 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0459 0.5172 0.5104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0879 1 1
Echinococcus granulosus neuropeptide s receptor 0.0558 0.6315 0.6315
Plasmodium falciparum cysteine proteinase falcipain 1 0.0459 0.5172 0.5104
Trypanosoma cruzi cysteine peptidase, putative 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0172 0.188 0.1878
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.188 0.1878
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0172 0.188 0.1766
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0169 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0172 0.188 0.1878
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0592 0.059
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0002 0.0002
Onchocerca volvulus Cathepsin F homolog 0.0879 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0223 0.0138
Echinococcus granulosus cathepsin l1 0.0593 0.6708 0.6708
Loa Loa (eye worm) hypothetical protein 0.0119 0.1269 0.1267
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Echinococcus granulosus cathepsin b 0.0569 0.6436 0.6436
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0002 0.0002
Onchocerca volvulus Cathepsin L homolog 0.0172 0.188 0.1629
Onchocerca volvulus 0.0172 0.188 0.1629
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.8954 0.8954
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0459 0.5172 0.5104
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0172 0.188 0.1766
Loa Loa (eye worm) cathepsin B 0.0295 0.3289 0.3287
Giardia lamblia DINP protein human, muc B family 0.0023 0.0169 0.0098
Entamoeba histolytica cysteine protease, putative 0.0172 0.188 0.1766
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.3415 0.3323
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0569 0.6436 0.6436
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.3337 0.3336
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0879 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0002 0.0002
Echinococcus granulosus GPCR family 2 0.0019 0.012 0.012
Brugia malayi cathepsin L precursor 0.0172 0.188 0.1878
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.012 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0172 0.188 0.1878
Brugia malayi cathepsin L-like cysteine proteinase 0.0172 0.188 0.1878
Loa Loa (eye worm) hypothetical protein 0.0172 0.188 0.1878
Loa Loa (eye worm) hypothetical protein 0.0119 0.1269 0.1267
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1564 0.1446
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0395 0.0312
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0172 0.188 0.5528
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0169 0.0031
Giardia lamblia Cathepsin B precursor 0.0172 0.188 0.5528
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0295 0.3289 0.3287
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0169 0.0169
Plasmodium vivax vivapain-1 0.0459 0.5172 0.5104
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0172 0.188 0.1766
Loa Loa (eye worm) hypothetical protein 0.0172 0.188 0.1878
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0169 0.0031
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0223 0.0223
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0172 0.188 0.1766
Schistosoma mansoni hypothetical protein 0.0205 0.2251 0.2251
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0169 0.0169
Echinococcus granulosus cathepsin L 0.0459 0.5172 0.5172
Schistosoma mansoni microtubule-associated protein tau 0.0699 0.7931 0.7931
Plasmodium vivax vivapain-2 0.0879 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0172 0.188 0.5528
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0169 0.0169
Onchocerca volvulus Huntingtin homolog 0.0119 0.1269 0.0999
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0459 0.5172 0.5172
Plasmodium falciparum serine repeat antigen 6 0.0172 0.188 0.1766
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0172 0.188 0.188
Brugia malayi Papain family cysteine protease containing protein 0.0459 0.5172 0.5171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0569 0.6436 0.6436
Loa Loa (eye worm) hypothetical protein 0.0039 0.0345 0.0343
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Onchocerca volvulus 0.0593 0.6708 0.6606
Schistosoma mansoni ran 0.0021 0.0138 0.0138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0459 0.5172 0.5171
Loa Loa (eye worm) hypothetical protein 0.0287 0.3193 0.3192
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5574 0.5574
Echinococcus multilocularis cathepsin b 0.0569 0.6436 0.6436
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0009 0.0002 0.0002
Leishmania major cathepsin L-like protease 0.0879 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.046 0.046
Leishmania major DNA polymerase kappa, putative 0.0023 0.0169 0.0031
Toxoplasma gondii cathepsin B 0.0295 0.3289 0.3195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0172 0.188 0.1878
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0162 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.188 0.1878
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0169 0.0166
Loa Loa (eye worm) hypothetical protein 0.0172 0.188 0.1878
Echinococcus multilocularis cathepsin L 0.0172 0.188 0.188
Brugia malayi CXXC zinc finger family protein 0.0035 0.0299 0.0297
Brugia malayi Papain family cysteine protease containing protein 0.0172 0.188 0.1878
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.188 0.1878
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.188 0.1878
Entamoeba histolytica cysteine protease, putative 0.0172 0.188 0.1766
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Schistosoma mansoni hypothetical protein 0.0035 0.0303 0.0303
Entamoeba histolytica cysteine proteinase, putative 0.0879 1 1
Brugia malayi Cathepsin L-like precursor 0.0879 1 1
Schistosoma mansoni hypothetical protein 0.0205 0.2251 0.2251
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0303 0.0303
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0169 0.0166
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0009 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0299 0.3337 0.3337
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0879 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0172 0.188 0.1878
Leishmania major cathepsin L-like protease 0.0879 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0593 0.6708 0.6707
Schistosoma mansoni hypothetical protein 0.0019 0.012 0.012
Echinococcus granulosus cathepsin l1 0.0879 1 1
Schistosoma mansoni hypothetical protein 0.0041 0.0374 0.0374
Trichomonas vaginalis ran, putative 0.0021 0.0138 0.0136
Brugia malayi Cathepsin L-like cysteine proteinase 0.0593 0.6708 0.6707
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0172 0.188 0.1878
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Loa Loa (eye worm) hypothetical protein 0.0172 0.188 0.1878
Entamoeba histolytica cysteine proteinase, putative 0.0459 0.5172 0.5104
Entamoeba histolytica hypothetical protein 0.0172 0.188 0.1766
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0049 0.0049
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.3415 0.3323
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0223 0.0138
Entamoeba histolytica cysteine proteinase, putative 0.0593 0.6708 0.6662
Trypanosoma cruzi cysteine peptidase, putative 0.0879 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0569 0.6436 0.6386
Echinococcus granulosus geminin 0.0205 0.2251 0.2251
Echinococcus multilocularis microtubule associated protein 2 0.0699 0.7931 0.7931
Schistosoma mansoni hypothetical protein 0.0494 0.5574 0.5574
Echinococcus multilocularis dna polymerase eta 0.0023 0.0169 0.0169
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.012 0.012
Onchocerca volvulus 0.0879 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0592 0.059
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0138 0.0138
Onchocerca volvulus 0.0879 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0656 0.0525
Giardia lamblia Cathepsin L precursor 0.0172 0.188 0.5528
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0169 0.0031
Schistosoma mansoni cathepsin F (C01 family) 0.0879 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0879 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0592 0.059
Brugia malayi Cathepsin L-like precursor 0.0593 0.6708 0.6707
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0169 0.0166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Entamoeba histolytica cysteine protease, putative 0.0172 0.188 0.1766
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0172 0.188 0.1878
Echinococcus multilocularis cysteine protease 0.0879 1 1
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0049 0.0049
Leishmania major cathepsin L-like protease 0.0879 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0172 0.188 0.188
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0299 0.0297
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0303 0.0303
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0172 0.188 0.1878
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Onchocerca volvulus 0.0879 1 1
Loa Loa (eye worm) hypothetical protein 0.0593 0.6708 0.6707
Echinococcus granulosus snurportin 1 0.0299 0.3337 0.3337
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0172 0.188 0.188
Trypanosoma brucei cysteine peptidase C (CPC) 0.0295 0.3289 0.3231
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0162 0.016
Schistosoma mansoni cathepsin F (C01 family) 0.0593 0.6708 0.6708
Giardia lamblia Hypothetical protein 0.0172 0.188 0.5528
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0172 0.188 0.1878
Entamoeba histolytica cysteine protease, putative 0.0172 0.188 0.1766
Plasmodium falciparum serine repeat antigen 3 0.0172 0.188 0.1766
Echinococcus granulosus cysteine protease 0.0459 0.5172 0.5172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Echinococcus multilocularis cathepsin b 0.0569 0.6436 0.6436
Giardia lamblia Cathepsin L precursor 0.0172 0.188 0.5528
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.012 0.012
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0002 0.0002
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0138 0.0138
Loa Loa (eye worm) cysteine protease 0.0879 1 1
Echinococcus multilocularis cpg binding protein 0.0037 0.0322 0.0322
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0002 0.0002
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Schistosoma mansoni cathepsin F (C01 family) 0.0879 1 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1564 0.1446
Entamoeba histolytica hypothetical protein 0.0035 0.0303 0.0167
Schistosoma mansoni cathepsin s 0.0287 0.3193 0.3193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.012 0.012
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0162 0.016
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0413 0.0413
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0879 1 1
Leishmania major mitochondrial DNA polymerase beta 0.0306 0.3415 0.3323
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0879 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Giardia lamblia Cathepsin B precursor 0.0295 0.3289 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0379 0.0377
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Plasmodium falciparum serine repeat antigen 7 0.0172 0.188 0.1766
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0024 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.188 0.1878
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0162 0.016
Schistosoma mansoni cathepsin C 0.0172 0.188 0.188
Brugia malayi Papain family cysteine protease containing protein 0.0459 0.5172 0.5171
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Loa Loa (eye worm) hypothetical protein 0.0593 0.6708 0.6707
Giardia lamblia Encystation-specific protease 0.0172 0.188 0.5528
Schistosoma mansoni cathepsin B (C01 family) 0.0172 0.188 0.188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Plasmodium falciparum serine repeat antigen 9 0.0172 0.188 0.1766
Entamoeba histolytica hypothetical protein 0.0035 0.0303 0.0167
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0047
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0172 0.188 0.1766
Giardia lamblia Cathepsin L precursor 0.0172 0.188 0.5528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Echinococcus multilocularis snurportin 1 0.0299 0.3337 0.3337
Brugia malayi cathepsin Z-like cysteine proteinase 0.0172 0.188 0.1878
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0374 0.0372
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0306 0.3415 0.3359
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.1564 0.1491
Brugia malayi Importin beta-1 subunit 0.0028 0.0223 0.0221
Onchocerca volvulus Cathepsin L homolog 0.0879 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0172 0.188 0.1766
Giardia lamblia Cysteine protease 0.0172 0.188 0.5528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.0049 0.0047
Leishmania major cathepsin L-like protease 0.0879 1 1
Giardia lamblia Cathepsin B precursor 0.0172 0.188 0.5528
Leishmania major cathepsin L-like protease 0.0879 1 1
Brugia malayi Cathepsin L-like precursor 0.0879 1 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0138 0.0136
Leishmania major DNA polymerase eta, putative 0.0023 0.0169 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0172 0.188 0.1878
Plasmodium vivax unspecified product 0.0172 0.188 0.1766
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0593 0.6708 0.6662
Echinococcus multilocularis cysteine protease 0.0879 1 1
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0049 0.0049
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0002 0.0002
Giardia lamblia Cathepsin B precursor 0.0172 0.188 0.5528
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0172 0.188 0.1878
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0172 0.188 0.5528
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0413 0.041
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0459 0.5172 0.5172
Brugia malayi Cathepsin L-like precursor 0.0879 1 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0395 0.0261
Trypanosoma cruzi cysteine peptidase, putative 0.0459 0.5172 0.5104
Giardia lamblia Cysteine protease 0.0172 0.188 0.5528
Giardia lamblia Cathepsin L-like protease 0.0172 0.188 0.5528
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0172 0.188 0.1766
Entamoeba histolytica cysteine protease, putative 0.0172 0.188 0.1766
Echinococcus granulosus dna polymerase eta 0.0023 0.0169 0.0169
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0162 0.0024
Plasmodium vivax serine-repeat antigen (SERA) 0.0172 0.188 0.1766
Entamoeba histolytica cysteine proteinase, putative 0.0459 0.5172 0.5104
Leishmania major cysteine peptidase A (CPA) 0.0879 1 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.188 0.1878
Plasmodium falciparum serine repeat antigen 4 0.0172 0.188 0.1766
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0569 0.6436 0.6436
Giardia lamblia Hypothetical protein 0.0172 0.188 0.5528
Plasmodium falciparum importin beta, putative 0.0028 0.0223 0.0086
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0172 0.188 0.5528
Brugia malayi Latrophilin receptor protein 2 0.0019 0.012 0.0118
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0172 0.188 0.188
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.046 0.046
Giardia lamblia Cysteine protease 0.0172 0.188 0.5528
Loa Loa (eye worm) hypothetical protein 0.0041 0.0374 0.0372
Loa Loa (eye worm) hypothetical protein 0.0569 0.6436 0.6435
Brugia malayi hypothetical protein 0.0035 0.0303 0.03
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0172 0.188 0.1878
Brugia malayi cathepsin B-like cysteine proteinase 0.0569 0.6436 0.6435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0879 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0002 0.0002
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0413 0.041
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Echinococcus multilocularis cathepsin L cysteine protease 0.0879 1 1
Entamoeba histolytica hypothetical protein 0.0035 0.0303 0.0167
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Onchocerca volvulus 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0172 0.188 0.188
Toxoplasma gondii cathepsin CPC2 0.0172 0.188 0.1766
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0169 0.0031
Giardia lamblia Cathepsin B precursor 0.0172 0.188 0.5528
Brugia malayi fibroinase precursor 0.0172 0.188 0.1878
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0172 0.188 0.188
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0169 0.0084
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0295 0.3289 0.3195
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0303 0.0303
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0138 0.0136
Trypanosoma cruzi cysteine peptidase, putative 0.0287 0.3193 0.3098
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0172 0.188 0.1766
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0049 0.0049
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Loa Loa (eye worm) hypothetical protein 0.006 0.0592 0.059
Schistosoma mansoni importin beta-1 0.0028 0.0223 0.0223
Leishmania major cathepsin L-like protease 0.0879 1 1
Giardia lamblia Cathepsin B precursor 0.0295 0.3289 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0879 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0049 0.0049
Leishmania major cathepsin L-like protease 0.0879 1 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0169 0.0166
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0379 0.0377
Echinococcus granulosus cathepsin L cysteine proteinase 0.0879 1 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0172 0.188 0.1766
Brugia malayi Cathepsin L-like precursor 0.0879 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.012 0.012
Echinococcus multilocularis cathepsin L cysteine protease 0.0879 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Echinococcus granulosus microtubule associated protein 2 0.0699 0.7931 0.7931
Schistosoma mansoni cpg binding protein 0.0037 0.0322 0.0322
Echinococcus granulosus cpg binding protein 0.0037 0.0322 0.0322
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0172 0.188 0.1766
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0009 0.0002 0.0002
Giardia lamblia Cathepsin B precursor 0.0172 0.188 0.5528
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.1752 1
Toxoplasma gondii cathepsin CPC1 0.0172 0.188 0.1766
Entamoeba histolytica hypothetical protein 0.0023 0.0162 0.0024
Brugia malayi cathepsin F-like cysteine proteinase 0.0172 0.188 0.1878
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0395 0.0261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.188 0.1878
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.188 0.1878
Onchocerca volvulus 0.0879 1 1
Echinococcus multilocularis cathepsin L 0.0459 0.5172 0.5172
Toxoplasma gondii cathepsin CPL 0.0879 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0746 0.0746
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0172 0.188 0.188
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0169 0.0084
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0295 0.3289 0.3289
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0593 0.6708 0.6707
Plasmodium falciparum serine repeat antigen 5 0.0172 0.188 0.1766
Echinococcus multilocularis geminin 0.0205 0.2251 0.2251
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0049 0.0049
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0172 0.188 0.1766
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0169 0.0084
Entamoeba histolytica cysteine proteinase 2 0.0459 0.5172 0.5104
Entamoeba histolytica cysteine protease, putative 0.0879 1 1
Loa Loa (eye worm) hypothetical protein 0.0287 0.3193 0.3192
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0169 0.0166
Onchocerca volvulus Cathepsin L homolog 0.0879 1 1
Echinococcus granulosus dna polymerase kappa 0.0023 0.0169 0.0169
Giardia lamblia Cathepsin L-like protease 0.0172 0.188 0.5528
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0295 0.3289 0.3195
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0023 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0459 0.5172 0.513
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.188 0.1878
Loa Loa (eye worm) fibroinase 0.0879 1 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0138 0.0053
Brugia malayi cathepsin L-like precursor 0.0593 0.6708 0.6707
Trypanosoma cruzi major cysteine proteinase, putative 0.0172 0.188 0.1766
Leishmania major cathepsin L-like protease 0.0879 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0172 0.188 0.1878
Giardia lamblia Cathepsin L precursor 0.0172 0.188 0.5528
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.012 0.0118
Echinococcus granulosus cathepsin L 0.0172 0.188 0.188
Giardia lamblia Cathepsin L precursor 0.0172 0.188 0.5528
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.012 0.0118
Echinococcus granulosus cathepsin b 0.0569 0.6436 0.6436
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0503 0.037
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0172 0.188 0.188
Loa Loa (eye worm) hypothetical protein 0.0172 0.188 0.1878
Schistosoma mansoni ran 0.0021 0.0138 0.0138
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0002 0.0002
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0172 0.188 0.1766
Brugia malayi RNA, U transporter 1 0.008 0.0816 0.0814
Plasmodium vivax vivapain-3 0.0459 0.5172 0.5104
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0172 0.188 0.1878
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0287 0.3193 0.3192
Entamoeba histolytica hypothetical protein 0.0035 0.0303 0.0167
Onchocerca volvulus 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0459 0.5172 0.5171
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0009 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0879 1 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0009 0.0002 0.0002
Brugia malayi Papain family cysteine protease containing protein 0.0172 0.188 0.1878
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0172 0.188 0.1766
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0024 0.0024
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0413 0.0413
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0169 0.0169
Brugia malayi hypothetical protein 0.0119 0.1269 0.1267
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0169 0.0031
Echinococcus granulosus cathepsin l cysteine peptidase 0.0879 1 1
Entamoeba histolytica cysteine protease, putative 0.0172 0.188 0.1766
Plasmodium falciparum serine repeat antigen 1 0.0172 0.188 0.1766
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0287 0.3193 0.3192
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5574 0.5574
Plasmodium vivax serine-repeat antigen (SERA) 0.0172 0.188 0.1766
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0459 0.5172 0.5172
Plasmodium falciparum serine repeat antigen 8 0.0172 0.188 0.1766
Schistosoma mansoni hypothetical protein 0.0019 0.012 0.012

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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