Detailed information for compound 1692374

Basic information

Technical information
  • TDR Targets ID: 1692374
  • Name: N-[4-(1-adamantylcarbamoylamino)phenyl]acetam ide
  • MW: 327.421 | Formula: C19H25N3O2
  • H donors: 3 H acceptors: 2 LogP: 2.78 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)NC(=O)C)NC12CC3CC(C2)CC(C1)C3
  • InChi: 1S/C19H25N3O2/c1-12(23)20-16-2-4-17(5-3-16)21-18(24)22-19-9-13-6-14(10-19)8-15(7-13)11-19/h2-5,13-15H,6-11H2,1H3,(H,20,23)(H2,21,22,24)
  • InChiKey: WMMHANRRDBYZRY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[[(1-adamantylamino)-oxomethyl]amino]phenyl]acetamide
  • N-[4-(1-adamantylcarbamoylamino)phenyl]ethanamide
  • IVK/9143981
  • ZINC05519139
  • AK-968/15605980

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.02 0.02
Brugia malayi N-terminal motif family protein 0.0006 0.0074 0.0074
Onchocerca volvulus 0.0009 0.0176 0.0202
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0525 0.4022
Echinococcus granulosus lamin 0.0027 0.0897 0.1234
Mycobacterium tuberculosis Conserved protein 0.0036 0.1257 0.0865
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.1257 0.0865
Echinococcus multilocularis Smad4 0.0009 0.0179 0.0247
Schistosoma mansoni hypothetical protein 0.0187 0.7268 1
Schistosoma mansoni tar DNA-binding protein 0.0123 0.4693 0.6457
Toxoplasma gondii exonuclease III APE 0.0018 0.0525 0.2644
Loa Loa (eye worm) hypothetical protein 0.001 0.02 0.02
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0176 0.0176
Entamoeba histolytica hypothetical protein 0.0034 0.1167 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.02 0.0275
Loa Loa (eye worm) hypothetical protein 0.0005 0.0032 0.0032
Echinococcus granulosus lamin dm0 0.0027 0.0897 0.1234
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0021 0.0021
Echinococcus multilocularis lamin dm0 0.0027 0.0897 0.1234
Onchocerca volvulus 0.001 0.02 0.0229
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.5068 0.5068
Loa Loa (eye worm) hepatopoietin HPO2 0.0033 0.1143 0.1143
Brugia malayi nuclear receptor RXR 0.0005 0.0021 0.0021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.1257 0.173
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.02 0.02
Echinococcus multilocularis FTZ F1 alpha 0.001 0.02 0.0275
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.1257 0.0865
Schistosoma mansoni cpg binding protein 0.0029 0.0956 0.1316
Brugia malayi hypothetical protein 0.0009 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0005 0.0032 0.0032
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0525 0.5
Echinococcus multilocularis son of sevenless 1 0.0006 0.0074 0.0102
Loa Loa (eye worm) quiescin Q6 0.0005 0.0032 0.0032
Loa Loa (eye worm) RNA binding protein 0.0123 0.4693 0.4693
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0176 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.02 0.02
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.1257 0.0865
Schistosoma mansoni hypothetical protein 0.0187 0.7268 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.1257 0.1257
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.02 0.02
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0176 0.0242
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0006 0.0074 0.0102
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.1257 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0525 0.5
Onchocerca volvulus 0.0006 0.0074 0.0085
Schistosoma mansoni hypothetical protein 0.0034 0.1167 0.1605
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.02 0.0275
Onchocerca volvulus 0.0223 0.8699 1
Brugia malayi nuclear receptor NHR-88 0.001 0.02 0.02
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1257 0.1381
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0176 0.0242
Mycobacterium tuberculosis Conserved protein 0.0036 0.1257 0.0865
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.1257 0.173
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0021 0.0021
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0176 0.0242
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0034 0.1167 0.1605
Brugia malayi MH2 domain containing protein 0.0009 0.0179 0.0179
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0058 0.214 0.2944
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0961 0.1322
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0006 0.0074 0.0102
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0021 0.0029
Schistosoma mansoni ras GTP exchange factor 0.0006 0.0074 0.0102
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.1257 0.0865
Schistosoma mansoni dishevelled 0.0009 0.0176 0.0242
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0176 0.0242
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0176 0.0242
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0525 0.0525
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0341 0.0469
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1257 0.1381
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0074 0.0074
Loa Loa (eye worm) steroid hormone receptor 0.001 0.02 0.02
Brugia malayi beta-lactamase 0.0036 0.1257 0.1257
Onchocerca volvulus 0.0027 0.0897 0.1031
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0033 0.1143 0.1572
Loa Loa (eye worm) beta-lactamase 0.0036 0.1257 0.1257
Echinococcus granulosus Protein son of sevenless 0.0006 0.0074 0.0102
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0525 0.0525
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0176 0.0176
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.02 0.0275
Loa Loa (eye worm) hypothetical protein 0.0005 0.0021 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1583 0.2178
Brugia malayi CXXC zinc finger family protein 0.0027 0.0895 0.0895
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0176 0.0242
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.02 0.0275
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1583 0.2178
Loa Loa (eye worm) Smad1 0.0009 0.0179 0.0179
Schistosoma mansoni transcription factor LCR-F1 0.0034 0.1167 0.1605
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0074 0.0102
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.02 0.0229
Trypanosoma cruzi hypothetical protein 0.0006 0.0074 0.0347
Brugia malayi MH2 domain containing protein 0.0132 0.5068 0.5068
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.02 0.0275
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.1257 0.1257
Brugia malayi intermediate filament protein 0.0027 0.0897 0.0897
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.02 0.0275
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.02 0.0275
Mycobacterium ulcerans beta-lactamase 0.0036 0.1257 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0196 0.7624 0.7624
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.02 0.0275
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0525 0.4022
Schistosoma mansoni tar DNA-binding protein 0.0123 0.4693 0.6457
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.702 0.807
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0123 0.4693 0.4693
Brugia malayi beta-lactamase family protein 0.0036 0.1257 0.1257
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.02 0.02
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0525 0.4438
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0176 0.0242
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0525 0.0532
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0525 0.0722
Trichomonas vaginalis ras GTP exchange factor, putative 0.0006 0.0074 0.0011
Entamoeba histolytica hypothetical protein 0.0034 0.1167 1
Schistosoma mansoni cpg binding protein 0.0029 0.0956 0.1316
Entamoeba histolytica hypothetical protein 0.0034 0.1167 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0195 0.0195
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.1257 0.1381
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.1257 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.1257 0.0865
Echinococcus multilocularis smad 0.0009 0.0179 0.0247
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0176 0.0176
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0895 0.0895
Echinococcus granulosus cpg binding protein 0.0029 0.0956 0.1316
Loa Loa (eye worm) hypothetical protein 0.0027 0.0877 0.0877
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0176 0.0242
Echinococcus multilocularis tar DNA binding protein 0.0123 0.4693 0.6457
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0074 0.0074
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.02 0.0275
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0033 0.1143 0.9064
Schistosoma mansoni coup transcription factor 0.001 0.02 0.0275
Brugia malayi Pre-SET motif family protein 0.0029 0.0961 0.0961
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.1583 0.1583
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1583 0.2178
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0005 0.0032 0.0037
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0176 0.0242
Loa Loa (eye worm) hypothetical protein 0.0036 0.1257 0.1257
Brugia malayi RasGEF domain containing protein 0.0006 0.0074 0.0074
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0034 0.1167 0.1605
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0341 0.0469
Trichomonas vaginalis set domain proteins, putative 0.0223 0.8699 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0897 0.0897
Echinococcus granulosus son of sevenless 1 0.0006 0.0074 0.0102
Brugia malayi hypothetical protein 0.0005 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0013 0.0341 0.0341
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0036 0.1257 0.1257
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.02 0.0275
Onchocerca volvulus Bile acid receptor homolog 0.001 0.02 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.02 0.02
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0191 0.0191
Schistosoma mansoni ap endonuclease 0.0018 0.0525 0.0722
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0961 0.1322
Loa Loa (eye worm) hypothetical protein 0.001 0.02 0.02
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1583 0.2178
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0179 0.0247
Brugia malayi Steroid receptor seven-up type 2 0.001 0.02 0.02
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0074 0.0102
Brugia malayi RNA recognition motif domain containing protein 0.0123 0.4693 0.4693
Loa Loa (eye worm) hypothetical protein 0.001 0.02 0.02
Schistosoma mansoni dep domain containing protein 0.0009 0.0176 0.0242
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0027 0.0897 0.0897
Mycobacterium ulcerans hypothetical protein 0.0036 0.1257 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1257 0.1381
Brugia malayi quiescin Q6 0.0005 0.0032 0.0032
Schistosoma mansoni dishevelled 0.0009 0.0176 0.0242
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0176 0.0176
Brugia malayi Augmenter of liver regeneration 0.0033 0.1143 0.1143
Loa Loa (eye worm) hypothetical protein 0.0009 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0013 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.001 0.02 0.02
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.02 0.0275
Loa Loa (eye worm) hypothetical protein 0.0006 0.0074 0.0074
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0176 0.0242
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0897 0.1233
Toxoplasma gondii histone lysine methyltransferase SET1 0.0052 0.1897 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0033 0.1143 0.9064
Echinococcus multilocularis cpg binding protein 0.0029 0.0956 0.1316
Loa Loa (eye worm) TAR-binding protein 0.0123 0.4693 0.4693
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.02 0.02
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0179 0.0179
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0021 0.0029
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.02 0.02
Brugia malayi MH1 domain containing protein 0.0009 0.0179 0.0179
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0961 0.1322
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.02 0.0275
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0006 0.0074 0.0011
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.02 0.0275
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0006 0.0074 0.0102
Brugia malayi RNA binding protein 0.0123 0.4693 0.4693
Schistosoma mansoni lamin 0.0027 0.0897 0.1234
Schistosoma mansoni Smad4 0.0009 0.0179 0.0247
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.02 0.0229
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0033 0.1143 0.9064
Brugia malayi RasGEF domain containing protein 0.0006 0.0074 0.0074
Brugia malayi DIX domain containing protein 0.0009 0.0176 0.0176
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0176 0.0242
Schistosoma mansoni intermediate filament proteins 0.0027 0.0897 0.1234
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.8994 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.02 0.02
Mycobacterium leprae Probable lipase LipE 0.0036 0.1257 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.02 0.02
Brugia malayi hypothetical protein 0.0034 0.1167 0.1167
Loa Loa (eye worm) nuclear factor I 0.0005 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0005 0.0021 0.0021
Brugia malayi hypothetical protein 0.0005 0.0021 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0123 0.4693 0.6457
Schistosoma mansoni nuclear hormone receptor 0.001 0.02 0.0275
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.1257 1
Loa Loa (eye worm) Erv1/Alr family protein 0.0005 0.0032 0.0032
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.013 0.0178
Onchocerca volvulus 0.0027 0.0897 0.1031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.02 0.02
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.02 0.02
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.1257 0.0865
Brugia malayi MH1 domain containing protein 0.0005 0.0019 0.0019
Trichomonas vaginalis esterase, putative 0.0036 0.1257 0.1381
Echinococcus granulosus ras GTP exchange factor 0.0006 0.0074 0.0102
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.02 0.0275
Schistosoma mansoni smad1 5 8 and 0.0009 0.0179 0.0247
Loa Loa (eye worm) hypothetical protein 0.0009 0.0176 0.0176
Schistosoma mansoni ap endonuclease 0.0018 0.0525 0.0722
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.013 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.02 0.02
Echinococcus multilocularis ras GTP exchange factor 0.0006 0.0074 0.0102
Schistosoma mansoni tar DNA-binding protein 0.0123 0.4693 0.6457
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.02 0.02
Schistosoma mansoni quiescin q6-related sulfhydryl oxidase 0.0005 0.0032 0.0044
Brugia malayi N-terminal motif family protein 0.0006 0.0074 0.0074
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.1257 0.173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1583 0.2178
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0179 0.0247
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0176 0.0242
Toxoplasma gondii Erv1 / Alr family protein 0.0033 0.1143 0.5957
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0961 0.4983
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0179 0.0247
Brugia malayi TAR-binding protein 0.0123 0.4693 0.4693
Echinococcus multilocularis musashi 0.0027 0.0897 0.1234
Brugia malayi N-terminal motif family protein 0.0181 0.702 0.702
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.02 0.0275
Brugia malayi MH1 domain containing protein 0.0009 0.0179 0.0179
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0179 0.0247
Leishmania major hypothetical protein, conserved 0.0036 0.1257 1
Echinococcus granulosus geminin 0.0187 0.7268 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0021 0.0029
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0036 0.1257 0.1257
Plasmodium vivax hypothetical protein, conserved 0.0036 0.1257 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.02 0.0275
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.1257 1
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0033 0.1143 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.02 0.02
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.02 0.0275
Brugia malayi MH2 domain containing protein 0.0009 0.0179 0.0179
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0006 0.0074 0.0347
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.02 0.0275
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0195 0.0268
Loa Loa (eye worm) hypothetical protein 0.001 0.02 0.02
Echinococcus granulosus intermediate filament protein 0.0027 0.0897 0.1234
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0006 0.0074 0.0011
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0525 0.0722
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0525 0.4124
Echinococcus granulosus sulfhydryl oxidase 1 0.0005 0.0032 0.0044
Echinococcus multilocularis geminin 0.0187 0.7268 1
Entamoeba histolytica hypothetical protein 0.0034 0.1167 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0006 0.0074 0.0085
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.02 0.0275
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0176 0.0202
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0961 0.1322
Loa Loa (eye worm) hypothetical protein 0.0005 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0036 0.1257 0.1257
Echinococcus granulosus smad 0.0009 0.0179 0.0247
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0033 0.1143 0.9064
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.02 0.0275
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0961 0.1322
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.02 0.0275
Toxoplasma gondii Erv1 / Alr family protein 0.0033 0.1143 0.5957
Loa Loa (eye worm) hypothetical protein 0.0006 0.0074 0.0074
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0897 0.0897
Loa Loa (eye worm) hypothetical protein 0.0013 0.0321 0.0321
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.1257 0.173
Onchocerca volvulus 0.0036 0.1257 0.1445
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0176 0.0176
Mycobacterium ulcerans lipase LipD 0.0036 0.1257 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0961 0.7582
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.013 0.0178
Brugia malayi Erv1 / Alr family protein 0.0005 0.0032 0.0032
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0525 0.4022
Toxoplasma gondii ABC1 family protein 0.0036 0.1257 0.6573
Brugia malayi nuclear hormone receptor 0.001 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0036 0.1257 0.1257
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0195 0.0268
Loa Loa (eye worm) hypothetical protein 0.0005 0.0021 0.0021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.02 0.0275
Echinococcus granulosus tar DNA binding protein 0.0123 0.4693 0.6457
Brugia malayi MH1 domain containing protein 0.0005 0.0019 0.0019
Brugia malayi RasGEF domain containing protein 0.0006 0.0074 0.0074
Leishmania major hypothetical protein, conserved 0.0033 0.1143 0.8433
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.001 0.02 0.02
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0021 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.02 0.02
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1583 0.2178
Toxoplasma gondii hypothetical protein 0.0009 0.0176 0.0774
Echinococcus multilocularis Protein son of sevenless 0.0006 0.0074 0.0102
Brugia malayi Smad1 0.0009 0.0179 0.0179
Schistosoma mansoni smad 0.0009 0.0179 0.0247
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0398 0.0398
Mycobacterium leprae conserved hypothetical protein 0.0036 0.1257 0.5
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0179 0.0247
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0897 0.0897
Schistosoma mansoni lamin 0.0027 0.0897 0.1234
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0181 0.702 0.702
Onchocerca volvulus 0.0036 0.1257 0.1445
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0525 0.4022
Brugia malayi ecdysteroid receptor 0.001 0.02 0.02
Brugia malayi Pre-SET motif family protein 0.0196 0.7624 0.7624
Schistosoma mansoni tar DNA-binding protein 0.0123 0.4693 0.6457
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.02 0.0275
Loa Loa (eye worm) hypothetical protein 0.0005 0.0021 0.0021
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.013 0.0178
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0021 0.0021
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.1257 0.0865
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0033 0.1143 0.9064
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.1257 0.0865
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.02 0.0275
Echinococcus granulosus Smad4 0.0009 0.0179 0.0247
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0525 0.0532
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.1257 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0398 0.0398
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0179 0.0179
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.5068 0.5068
Schistosoma mansoni smad1 5 8 and 0.0009 0.0179 0.0247
Echinococcus multilocularis sulfhydryl oxidase 1 0.0005 0.0032 0.0044
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.0074 0.0102
Schistosoma mansoni smad1 5 8 and 0.0009 0.0179 0.0247
Loa Loa (eye worm) hypothetical protein 0.0036 0.1257 0.1257
Onchocerca volvulus 0.0036 0.1257 0.1445
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0006 0.0074 0.0102
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0009 0.0176 0.0176
Brugia malayi steroid hormone receptor 0.001 0.02 0.02
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0033 0.1143 0.1572
Onchocerca volvulus 0.0027 0.0895 0.1029
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.02 0.02
Echinococcus multilocularis lamin 0.0027 0.0897 0.1234
Brugia malayi beta-lactamase family protein 0.0036 0.1257 0.1257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.02 0.02
Schistosoma mansoni thyroid hormone receptor 0.001 0.02 0.0275
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0005 0.0032 0.0037
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0062 0.0085
Schistosoma mansoni cpg binding protein 0.0027 0.0895 0.1232
Loa Loa (eye worm) hypothetical protein 0.0029 0.0961 0.0961
Loa Loa (eye worm) hypothetical protein 0.001 0.02 0.02
Brugia malayi hypothetical protein 0.0009 0.0176 0.0176
Trypanosoma cruzi hypothetical protein 0.0006 0.0074 0.0347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.02 0.02
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1583 0.2178
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0525 0.5
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0074 0.0102
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.02 0.0275
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.013 0.0178
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0961 0.1322
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.1583 0.1583
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0005 0.0032 0.0037
Loa Loa (eye worm) hypothetical protein 0.0005 0.0019 0.0019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.02 0.0275
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0961 0.1322
Echinococcus granulosus FTZ F1 alpha 0.001 0.02 0.0275
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.1257 0.1381
Onchocerca volvulus 0.0029 0.0961 0.1105
Trichomonas vaginalis ras GTP exchange factor, putative 0.0006 0.0074 0.0011

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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