Detailed information for compound 1692378

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 296.364 | Formula: C18H20N2O2
  • H donors: 0 H acceptors: 2 LogP: 3.15 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(ccn(c1=O)CCC(C)C)c1ccccc1OC
  • InChi: 1S/C18H20N2O2/c1-13(2)8-10-20-11-9-14(16(12-19)18(20)21)15-6-4-5-7-17(15)22-3/h4-7,9,11,13H,8,10H2,1-3H3
  • InChiKey: HEJMVUTXIWZLLU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutamate receptor, metabotropic 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum ko:K04606 glutamate receptor, metabotropic 3, putative Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum Metabotropic glutamate receptor precursor, putative Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi Metabotropic glutamate receptor precursor. Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0092 0.4515 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0043 0.1851 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0087 0.0087
Onchocerca volvulus 0.0011 0.0087 0.0156
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.004 0.1673 0.8831
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0092 0.4515 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0141 0.7224 0.8468
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0323 0.0265
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.1792 0.9624
Brugia malayi RNA binding protein 0.0074 0.3553 0.3553
Echinococcus multilocularis cpg binding protein 0.007 0.3325 0.3325
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0092 0.4515 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.1792 0.9624
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.006 0.277 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.1792 0.1792
Brugia malayi Probable ClpP-like protease 0.0092 0.4515 0.4515
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.1851 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0087 0.0087
Schistosoma mansoni cpg binding protein 0.007 0.3325 0.3897
Brugia malayi Receptor family ligand binding region containing protein 0.0016 0.0318 0.0318
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0043 0.1851 0.1851
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0087 0.0087
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0087 0.0087
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0323 0.0323
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0092 0.4515 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0087 0.0156
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.004 0.1673 0.1673
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0107 0.5375 0.5375
Schistosoma mansoni tar DNA-binding protein 0.0074 0.3553 0.4165
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.004 0.1673 0.1436
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0362 0.0362
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.1792 0.9624
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.004 0.1673 0.1436
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0323 0.0265
Brugia malayi TAR-binding protein 0.0074 0.3553 0.3553
Echinococcus multilocularis tar DNA binding protein 0.0074 0.3553 0.3553
Loa Loa (eye worm) hepatopoietin HPO2 0.004 0.1673 0.1673
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0087 0.0156
Loa Loa (eye worm) hypothetical protein 0.0011 0.0087 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0087 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0087 0.0087
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.1792 0.9614
Schistosoma mansoni alpha-glucosidase 0.0164 0.8531 1
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0016 0.0318 0.0318
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0087 0.0087
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0043 0.1851 0.1851
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0087 0.0087
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0323 0.0582
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.3553 0.3553
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.004 0.1673 0.8831
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0087 0.0087
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0323 0.0265
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0087 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0107 0.5375 0.63
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0362 0.0362
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.1851 0.1974
Schistosoma mansoni metabotropic glutamate receptor 0.003 0.1098 0.1288
Loa Loa (eye worm) TAR-binding protein 0.0074 0.3553 0.3553
Schistosoma mansoni tar DNA-binding protein 0.0074 0.3553 0.4165
Echinococcus multilocularis peptidase Clp (S14 family) 0.006 0.277 0.277
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0043 0.1851 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0087 0.0087
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0092 0.4515 0.4515
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.1792 0.9614
Brugia malayi metabotropic glutamate receptor type 2 0.003 0.1098 0.1098
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.1792 0.1792
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0092 0.4515 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0087 0.0087
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.1792 0.9624
Echinococcus granulosus peptidase Clp S14 family 0.006 0.277 0.277
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.1792 0.1147
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0087 0.0102
Echinococcus granulosus cpg binding protein 0.007 0.3325 0.3325
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0107 0.5375 0.5375
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0087 0.0087
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0323 0.0265
Echinococcus granulosus metabotropic glutamate receptor 5 0.0075 0.3611 0.3611
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0087 0.0156
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.1792 0.9614
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0362 0.0424
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.006 0.277 0.4744
Onchocerca volvulus 0.0066 0.3116 0.5612
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0323 0.0265
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.3553 0.3553
Echinococcus granulosus tar DNA binding protein 0.0074 0.3553 0.3553
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0087 0.0102
Schistosoma mansoni metabotropic glutamate receptor 0.0051 0.2282 0.2675
Brugia malayi nuclear hormone receptor 0.0011 0.0087 0.0087
Brugia malayi steroid hormone receptor 0.0011 0.0087 0.0087
Schistosoma mansoni ap endonuclease 0.0043 0.1851 0.217
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0043 0.1851 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0191 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0087 0.0087
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0087 0.0087
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0087 0.0102
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0087 0.0102
Toxoplasma gondii histone lysine methyltransferase SET1 0.0126 0.6394 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0087 0.0087
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0043 0.1851 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0075 0.3611 0.3611
Loa Loa (eye worm) glutamate receptor 0.0024 0.0781 0.0781
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0092 0.4515 0.4515
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0087 0.0087
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0092 0.4515 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0043 0.1851 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0087 0.0087
Schistosoma mansoni alpha glucosidase 0.0042 0.1792 0.2101
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.1792 0.1792
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0191 1 1
Loa Loa (eye worm) glutamate receptor 0.0061 0.283 0.283
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0323 0.0265
Brugia malayi exodeoxyribonuclease III family protein 0.0043 0.1851 0.1851
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0087 0.0102
Schistosoma mansoni peptidase Clp (S14 family) 0.0092 0.4515 0.5292
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0362 0.0362
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0087 0.0087
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0092 0.4515 0.6385
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0087 0.0087
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0323 0.0265
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.1792 0.9614
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0087 0.0087
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.1792 0.9624
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0016 0.0323 0.0323
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.3116 0.3116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0087 0.0087
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0087 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0087 0.0087
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0087 0.0087
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0087 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0087 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0074 0.3553 0.4165
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0087 0.0087
Trypanosoma brucei glucosidase, putative 0.0042 0.1792 0.9614
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0107 0.5375 0.63
Loa Loa (eye worm) hypothetical protein 0.0011 0.0087 0.0087
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0087 0.0087
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0092 0.4515 0.6385
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0092 0.4515 0.5
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.1851 0.1974
Schistosoma mansoni tar DNA-binding protein 0.0074 0.3553 0.4165
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0107 0.5375 0.5375
Onchocerca volvulus 0.011 0.5553 1
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0571 0.0571
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0087 0.0087
Schistosoma mansoni ap endonuclease 0.0043 0.1851 0.217
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0087 0.0087
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.006 0.277 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0087 0.0102
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0585 0.0585
Brugia malayi nuclear receptor NHR-88 0.0011 0.0087 0.0087
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0362 0.0362
Schistosoma mansoni cpg binding protein 0.0066 0.3116 0.3653
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.1792 0.1792
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0092 0.4515 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.1792 0.9624
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.004 0.1673 0.1673
Echinococcus granulosus lysosomal alpha glucosidase 0.0191 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0087 0.0087
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0585 0.0585
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0323 0.0265
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0069 0.3294 0.3861
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.004 0.1673 0.8831
Echinococcus multilocularis lysosomal alpha glucosidase 0.0191 1 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.1792 0.9624
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0087 0.0087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0087 0.0087
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0087 0.0102
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0087 0.0087
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0043 0.1851 0.5
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0016 0.0318 0.0318
Brugia malayi Metabotropic glutamate receptor precursor. 0.0061 0.283 0.283
Loa Loa (eye worm) hypothetical protein 0.0075 0.3611 0.3611
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0087 0.0087
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0092 0.4515 1
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0087 0.0102
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.1792 0.9624
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0087 0.0087
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0087 0.0087
Schistosoma mansoni alpha-glucosidase 0.0164 0.8531 1
Schistosoma mansoni coup transcription factor 0.0011 0.0087 0.0102
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0087 0.0102
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.004 0.1673 0.8831
Schistosoma mansoni cpg binding protein 0.007 0.3325 0.3897
Toxoplasma gondii exonuclease III APE 0.0043 0.1851 0.1261
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0107 0.5375 0.63
Leishmania major hypothetical protein, conserved 0.004 0.1673 0.8831
Toxoplasma gondii Erv1 / Alr family protein 0.004 0.1673 0.0917
Schistosoma mansoni tar DNA-binding protein 0.0074 0.3553 0.4165
Toxoplasma gondii Erv1 / Alr family protein 0.004 0.1673 0.0917
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0051 0.2282 0.2282
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.1792 0.9624
Loa Loa (eye worm) hypothetical protein 0.0092 0.4515 0.4515
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0087 0.0102
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0087 0.0087
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0585 0.0585
Loa Loa (eye worm) RNA binding protein 0.0074 0.3553 0.3553
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0055 0.2513 0.2513
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0087 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0087 0.0087
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0107 0.5375 0.5375
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0107 0.5375 0.5375
Brugia malayi ecdysteroid receptor 0.0011 0.0087 0.0087
Echinococcus granulosus metabotropic glutamate receptor 2 0.0051 0.2282 0.2282
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0087 0.0087
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0016 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0011 0.0087 0.0087
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0087 0.0102
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0107 0.5375 0.5375
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0087 0.0087
Treponema pallidum exodeoxyribonuclease (exoA) 0.0043 0.1851 0.1974
Brugia malayi CXXC zinc finger family protein 0.0066 0.3116 0.3116
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0087 0.0087
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.1792 0.9614
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0043 0.1851 0.1851
Brugia malayi Augmenter of liver regeneration 0.004 0.1673 0.1673
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.1851 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 10000 nM Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by liquid scintillation counting ChEMBL. 22364337
Emax (functional) = 120 % Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by liquid scintillation counting relative to glutamate ChEMBL. 22364337

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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