Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) subunit, beta type, 5 | Starlite/ChEMBL | References |
Homo sapiens | proteasome (prosome, macropain) subunit, beta type, 8 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | proteasome subunit beta type 1, putative | proteasome (prosome, macropain) subunit, beta type, 8 | 272 aa | 251 aa | 23.1 % |
Plasmodium falciparum | proteasome subunit alpha type-5, putative | proteasome (prosome, macropain) subunit, beta type, 5 | 160 aa | 148 aa | 23.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0172 | 0.5 | 0.5 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0172 | 0.5 | 0.5 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0172 | 0.5 | 0.5 |
Echinococcus granulosus | proteasome prosome macropain | 0.0172 | 0.5 | 0.5 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0172 | 0.5 | 0.5 |
Mycobacterium ulcerans | proteasome PrcB | 0.0172 | 0.5 | 0.5 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0172 | 0.5 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0172 | 0.5 | 0.5 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0172 | 0.5 | 0.5 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0172 | 0.5 | 0.5 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0172 | 0.5 | 0.5 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0172 | 0.5 | 0.5 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0172 | 0.5 | 0.5 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0172 | 0.5 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0172 | 0.5 | 0.5 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0172 | 0.5 | 0.5 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0172 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 nM | Irreversible inhibition of inducible 20S proteasome subunit beta5i chymotrypsin-like activity in human WM cells using suc-LLVY-amc as substrate after 2 hrs by fluorescence assay | ChEMBL. | 22978849 |
IC50 (binding) | = 10 nM | Irreversible inhibition of constitutive 20S proteasome subunit beta5 chymotrypsin-like activity in human WM cells using suc-LLVY-amc as substrate after 2 hrs by fluorescence assay | ChEMBL. | 22978849 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.