Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.1388 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.1388 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.4963 | 1 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.4963 | 0.4963 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.4963 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.4963 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0.0689 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0689 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.4963 | 0.4963 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.4963 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.4963 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.0689 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.4963 | 0.4963 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.1388 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.5 |
Brugia malayi | RNA binding protein | 0.0071 | 0.4963 | 0.4963 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0689 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0689 | 0.1388 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.1388 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.4963 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0.0689 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.0689 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0.0689 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.0689 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0689 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.1388 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.4963 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0.0689 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.4963 | 0.4963 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0689 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.4963 | 0.4963 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.1388 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 100 % | Antimalarial activity against Plasmodium berghei infected in CD1 mouse assessed as decrease in parasitemia at 20 mg/kg, po administered using Na2CO3 vehicle measured on day 4 relative to control | ChEMBL. | 22364416 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.