Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitochondrial DNA topoisomerase II | 0.1155 | 0.2466 | 1 |
Mycobacterium tuberculosis | Probable two component sensor kinase | 0.0085 | 0.0098 | 0.0046 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0207 | 0.0367 | 0.0867 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0063 | 0.0048 | 0.0196 |
Trichomonas vaginalis | endoplasmin, putative | 0.014 | 0.0218 | 0.1388 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0106 | 0.0143 | 0.0046 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0115 | 0.0163 | 0.0735 |
Brugia malayi | glutaminase DH11.1 | 0.0271 | 0.0508 | 0.3515 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0463 | 0.0933 | 0.6636 |
Mycobacterium leprae | Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) | 0.4557 | 1 | 1 |
Mycobacterium ulcerans | two component sensory transduction histidine kinase MtrB | 0.0085 | 0.0098 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.0721 | 0.5074 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0098 | 0.0126 | 0.0088 |
Trypanosoma brucei | heat shock protein, putative | 0.0191 | 0.0332 | 0.1346 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0409 | 0.2791 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.058 | 0.1193 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0048 | 0.0196 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0048 | 0.0196 |
Loa Loa (eye worm) | endoplasmin | 0.0191 | 0.0332 | 0.2222 |
Echinococcus multilocularis | heat shock protein | 0.0191 | 0.0332 | 0.0778 |
Schistosoma mansoni | ap endonuclease | 0.0065 | 0.0051 | 0.0165 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0967 | 0.2049 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0191 | 0.0332 | 0.1243 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.1557 | 0.3357 | 1 |
Echinococcus multilocularis | endoplasmin | 0.0106 | 0.0143 | 0.0292 |
Mycobacterium tuberculosis | Conserved protein | 0.0085 | 0.0098 | 0.0046 |
Entamoeba histolytica | DNA topoisomerase III, putative | 0.0115 | 0.0163 | 0.0984 |
Treponema pallidum | chemotaxis histidine kinase (cheA) | 0.0085 | 0.0098 | 0.0139 |
Plasmodium vivax | SET domain protein, putative | 0.0066 | 0.0055 | 0.0079 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0063 | 0.0048 | 0.0196 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DosT | 0.0085 | 0.0098 | 0.0046 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.067 | 0.1392 | 0.4095 |
Mycobacterium ulcerans | sensor kinase from two component regulatory system | 0.0085 | 0.0098 | 0.0046 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0065 | 0.0051 | 0.0165 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0115 | 0.0163 | 0.0984 |
Leishmania major | cathepsin L-like protease | 0.0063 | 0.0048 | 0.0079 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0065 | 0.0051 | 0.0209 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0106 | 0.0143 | 0.0092 |
Trichomonas vaginalis | heat shock protein, putative | 0.014 | 0.0218 | 0.1388 |
Trypanosoma brucei | DNA topoisomerase III, putative | 0.0115 | 0.0163 | 0.0662 |
Treponema pallidum | DNA topoisomerase I (topA) | 0.0115 | 0.0163 | 0.0338 |
Mycobacterium ulcerans | integral membrane indolylacetylinositol arabinosyltransferase EmbC | 0.4557 | 1 | 1 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0191 | 0.0332 | 0.2435 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0048 | 0.0196 |
Echinococcus granulosus | heat shock protein 90 | 0.0106 | 0.0143 | 0.0835 |
Onchocerca volvulus | 0.0066 | 0.0055 | 0.0227 | |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0065 | 0.0261 |
Trichomonas vaginalis | set domain proteins, putative | 0.0527 | 0.1075 | 0.7675 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.1557 | 0.3357 | 1 |
Onchocerca volvulus | 0.0527 | 0.1075 | 0.8985 | |
Mycobacterium tuberculosis | Possible two component sensor kinase | 0.0085 | 0.0098 | 0.0046 |
Trichomonas vaginalis | glutaminase, putative | 0.0271 | 0.0508 | 0.3515 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0207 | 0.0367 | 0.2477 |
Plasmodium vivax | heat shock protein 86, putative | 0.0191 | 0.0332 | 0.091 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0085 | 0.0098 | 0.0176 |
Wolbachia endosymbiont of Brugia malayi | signal transduction histidine kinase and receiver | 0.0085 | 0.0098 | 0.0139 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0115 | 0.0163 | 0.0984 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.0721 | 0.5074 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0434 | 0.0869 | 0.0822 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0065 | 0.0051 | 0.0068 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0207 | 0.0367 | 0.2477 |
Leishmania major | heat shock protein 83-1 | 0.0191 | 0.0332 | 0.1243 |
Giardia lamblia | Pms1-like protein | 0.0085 | 0.0098 | 0.04 |
Leishmania major | heat shock protein 83-1 | 0.0191 | 0.0332 | 0.1243 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0191 | 0.0332 | 0.2222 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0066 | 0.0055 | 0.0194 |
Schistosoma mansoni | heat shock protein | 0.0191 | 0.0332 | 0.2222 |
Mycobacterium ulcerans | two component regulator - sensor kinase | 0.0085 | 0.0098 | 0.0046 |
Leishmania major | heat shock protein 83-1 | 0.0191 | 0.0332 | 0.1243 |
Mycobacterium ulcerans | two component sensor histidine kinase PrrB | 0.0085 | 0.0098 | 0.0046 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0191 | 0.0332 | 0.2222 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.002 | 0.0081 |
Plasmodium falciparum | heat shock protein 90 | 0.0191 | 0.0332 | 0.091 |
Trichomonas vaginalis | heat shock protein, putative | 0.0106 | 0.0143 | 0.0835 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0106 | 0.0143 | 0.0579 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.067 | 0.1392 | 1 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.0085 | 0.0098 | 0.0281 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.0065 | 0.0261 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0065 | 0.0261 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0115 | 0.0163 | 0.0662 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0048 | 0.0196 |
Entamoeba histolytica | DNA topoisomerase III, putative | 0.0115 | 0.0163 | 0.0984 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0434 | 0.0869 | 0.2366 |
Mycobacterium ulcerans | two component sensor kinase MprB | 0.0085 | 0.0098 | 0.0046 |
Trichomonas vaginalis | receptor histidine kinase, putative | 0.0085 | 0.0098 | 0.0503 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0191 | 0.0332 | 0.2222 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0106 | 0.0143 | 0.0793 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.067 | 0.1392 | 0.3499 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0191 | 0.0332 | 0.1564 |
Brugia malayi | kinase, mitochondrial precursor | 0.0085 | 0.0098 | 0.0503 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0434 | 0.0869 | 0.2523 |
Trypanosoma brucei | heat shock protein, putative | 0.0191 | 0.0332 | 0.1346 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0257 | 0.0478 | 0.0429 |
Plasmodium vivax | hypothetical protein, conserved | 0.0085 | 0.0098 | 0.0206 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0064 | 0.005 | 0.0154 |
Leishmania major | DNA topoisomerase 1A | 0.0115 | 0.0163 | 0.055 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0555 | 0.1137 | 0.4612 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0115 | 0.0163 | 0.0662 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0066 | 0.0055 | 0.0068 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.1557 | 0.3357 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0066 | 0.0055 | 0.0194 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0065 | 0.0261 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0294 | 0.056 | 0.227 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.0217 | 0.077 |
Leishmania major | heat shock protein 83-1 | 0.0191 | 0.0332 | 0.1243 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0106 | 0.0143 | 0.0835 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0106 | 0.0143 | 0.0092 |
Echinococcus granulosus | DNA topoisomerase 3 alpha | 0.0115 | 0.0163 | 0.0984 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0555 | 0.1137 | 0.4612 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.1557 | 0.3357 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1155 | 0.2466 | 1 |
Mycobacterium ulcerans | integral membrane indolylacetylinositol arabinosyltransferase EmbB | 0.4557 | 1 | 1 |
Mycobacterium ulcerans | two component system membrane associated sensor kinase | 0.0085 | 0.0098 | 0.0046 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0048 | 0.0196 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0191 | 0.0332 | 0.1346 |
Mycobacterium tuberculosis | Two component sensor histidine kinase PrrB | 0.0085 | 0.0098 | 0.0046 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0191 | 0.0332 | 0.1346 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0294 | 0.056 | 0.227 |
Trichomonas vaginalis | mismatch repair protein Mlh1C (mutL homolog) | 0.0085 | 0.0098 | 0.0503 |
Trichomonas vaginalis | sensor histidine kinase, putative | 0.0085 | 0.0098 | 0.0503 |
Toxoplasma gondii | heat shock protein 75, putative | 0.0054 | 0.0029 | 0.0076 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.0217 | 0.0879 |
Leishmania major | heat shock protein 83-1 | 0.0191 | 0.0332 | 0.1243 |
Trichomonas vaginalis | heat shock protein, putative | 0.0106 | 0.0143 | 0.0835 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0048 | 0.0196 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0191 | 0.0332 | 0.1346 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0409 | 0.2791 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0048 | 0.0196 |
Schistosoma mansoni | ap endonuclease | 0.0065 | 0.0051 | 0.0165 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0085 | 0.0098 | 0.0503 |
Plasmodium vivax | endoplasmin, putative | 0.0191 | 0.0332 | 0.091 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0063 | 0.0048 | 0.0196 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0191 | 0.0332 | 0.1346 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.058 | 0.1193 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0098 | 0.0503 |
Leishmania major | heat shock protein 83-1 | 0.0191 | 0.0332 | 0.1243 |
Mycobacterium ulcerans | putative regultory protein | 0.0085 | 0.0098 | 0.0046 |
Brugia malayi | Pre-SET motif family protein | 0.0463 | 0.0933 | 0.6636 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0191 | 0.0332 | 0.1346 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0058 | 0.0036 | 0.0147 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0066 | 0.0055 | 0.0194 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0555 | 0.1137 | 0.4612 |
Brugia malayi | DNA topoisomerase III | 0.0115 | 0.0163 | 0.0984 |
Loa Loa (eye worm) | DNA topoisomerase III beta-1 | 0.0115 | 0.0163 | 0.0984 |
Toxoplasma gondii | Hsp90 domain-containing protein | 0.0054 | 0.0029 | 0.0076 |
Trichomonas vaginalis | two component sensor and regulator histidine kinase bacteria, putative | 0.0085 | 0.0098 | 0.0503 |
Trichomonas vaginalis | receptor histidine kinase, putative | 0.0085 | 0.0098 | 0.0503 |
Trypanosoma cruzi | DNA topoisomerase IA, putative | 0.0115 | 0.0163 | 0.0662 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0055 | 0.0194 |
Trypanosoma brucei | heat shock protein, putative | 0.0191 | 0.0332 | 0.1346 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0085 | 0.0098 | 0.0413 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0139 | 0.0217 | 0.0879 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0191 | 0.0332 | 0.1346 |
Leishmania major | DNA topoisomerase III, putative | 0.0115 | 0.0163 | 0.055 |
Plasmodium falciparum | DNA gyrase subunit B | 0.1557 | 0.3357 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0191 | 0.0332 | 0.1346 |
Mycobacterium tuberculosis | Possible two component sensor kinase TcrY | 0.0085 | 0.0098 | 0.0046 |
Toxoplasma gondii | exonuclease III APE | 0.0065 | 0.0051 | 0.0187 |
Leishmania major | DNA topoisomerase III, putative | 0.0115 | 0.0163 | 0.055 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0137 | 0.0211 | 0.0857 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0434 | 0.0869 | 0.2472 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0434 | 0.0869 | 0.0822 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0066 | 0.0055 | 0.0068 |
Mycobacterium ulcerans | integral membrane indolylacetylinositol arabinosyltransferase EmbA | 0.4557 | 1 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.1072 | 0.2284 | 0.6706 |
Mycobacterium tuberculosis | Probable sensor protein KdpD | 0.0085 | 0.0098 | 0.0046 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0294 | 0.056 | 0.2178 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.1813 | 0.3924 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0207 | 0.0367 | 0.2477 |
Trypanosoma cruzi | DNA topoisomerase IA, putative | 0.0115 | 0.0163 | 0.0662 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.0085 | 0.0098 | 0.0396 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.0348 | 0.2337 |
Echinococcus multilocularis | rho GTPase activating protein 20 | 0.0115 | 0.0163 | 0.0344 |
Plasmodium falciparum | DNA topoisomerase VI, b subunit, putative | 0.0085 | 0.0098 | 0.0206 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0434 | 0.0869 | 0.4202 |
Trichomonas vaginalis | sensory transduction histidine kinase bacterial, putative | 0.0085 | 0.0098 | 0.0503 |
Leishmania major | heat shock protein 83-1 | 0.0191 | 0.0332 | 0.1243 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0523 | 0.1066 | 0.0978 |
Brugia malayi | hypothetical protein | 0.0071 | 0.0065 | 0.0261 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0115 | 0.0163 | 0.0984 |
Brugia malayi | Pre-SET motif family protein | 0.0066 | 0.0055 | 0.0194 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.067 | 0.1392 | 1 |
Trypanosoma brucei | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative | 0.0085 | 0.0098 | 0.0396 |
Schistosoma mansoni | DNA topoisomerase II | 0.067 | 0.1392 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0191 | 0.0332 | 0.1243 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0434 | 0.0869 | 0.2523 |
Trypanosoma cruzi | heat shock protein, putative | 0.0054 | 0.0029 | 0.0118 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0065 | 0.0051 | 0.0209 |
Leishmania major | cathepsin L-like protease | 0.0063 | 0.0048 | 0.0079 |
Trypanosoma brucei | heat shock protein, putative | 0.0191 | 0.0332 | 0.1346 |
Mycobacterium tuberculosis | Possible two component system response sensor kinase membrane associated PhoR | 0.0085 | 0.0098 | 0.0046 |
Mycobacterium tuberculosis | Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) | 0.4557 | 1 | 1 |
Mycobacterium ulcerans | two component system response phosphate sensor kinase, PhoR | 0.0085 | 0.0098 | 0.0046 |
Echinococcus granulosus | geminin | 0.0198 | 0.0348 | 0.2337 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.0065 | 0.0091 |
Loa Loa (eye worm) | glutaminase | 0.0271 | 0.0508 | 0.3515 |
Leishmania major | DNA topoisomerase ii | 0.0555 | 0.1137 | 0.4548 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0065 | 0.0261 |
Trypanosoma brucei | heat shock protein, putative | 0.0191 | 0.0332 | 0.1346 |
Trypanosoma brucei | heat shock protein, putative | 0.0191 | 0.0332 | 0.1346 |
Schistosoma mansoni | heat shock protein | 0.0191 | 0.0332 | 0.2222 |
Loa Loa (eye worm) | DNA topoisomerase III | 0.0115 | 0.0163 | 0.0984 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.0085 | 0.0098 | 0.0396 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0106 | 0.0143 | 0.0467 |
Mycobacterium ulcerans | hypothetical protein | 0.0155 | 0.0252 | 0.0201 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0555 | 0.1137 | 0.4612 |
Trichomonas vaginalis | sensory transduction histidine kinase bacterial, putative | 0.0085 | 0.0098 | 0.0503 |
Mycobacterium ulcerans | two component sensor histidine kinase DevS | 0.0085 | 0.0098 | 0.0046 |
Giardia lamblia | DNA topoisomerase II | 0.0584 | 0.1203 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0065 | 0.0051 | 0.0165 |
Trichomonas vaginalis | heat shock protein, putative | 0.0191 | 0.0332 | 0.2222 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DevS | 0.0085 | 0.0098 | 0.0046 |
Trypanosoma brucei | DNA topoisomerase III, putative | 0.0115 | 0.0163 | 0.0662 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0065 | 0.0051 | 0.0092 |
Mycobacterium ulcerans | DNA topoisomerase I | 0.0115 | 0.0163 | 0.0112 |
Mycobacterium ulcerans | glutaminase | 0.0271 | 0.0508 | 0.0459 |
Brugia malayi | GRF zinc finger family protein | 0.0115 | 0.0163 | 0.0984 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0207 | 0.0367 | 0.2477 |
Plasmodium falciparum | endoplasmin, putative | 0.014 | 0.0218 | 0.0568 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.0065 | 0.0261 |
Trypanosoma brucei | DNA topoisomerase IA, putative | 0.0115 | 0.0163 | 0.0662 |
Echinococcus granulosus | DNA topoisomerase 3 beta 1 | 0.0115 | 0.0163 | 0.0984 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.005 | 0.0018 | 0.0075 |
Trypanosoma brucei | heat shock protein, putative | 0.0191 | 0.0332 | 0.1346 |
Echinococcus granulosus | heat shock protein | 0.0191 | 0.0332 | 0.2222 |
Brugia malayi | Endoplasmin precursor | 0.0191 | 0.0332 | 0.2222 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0065 | 0.0051 | 0.0165 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0048 | 0.0196 |
Treponema pallidum | heat shock protein 90 | 0.0106 | 0.0143 | 0.0276 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.1557 | 0.3357 | 0.3323 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0063 | 0.0048 | 0.0196 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0106 | 0.0143 | 0.0579 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0434 | 0.0869 | 0.2472 |
Echinococcus granulosus | endoplasmin | 0.0106 | 0.0143 | 0.0835 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0155 | 0.0252 | 0.0201 |
Mycobacterium tuberculosis | Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) | 0.4557 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0207 | 0.0367 | 0.2477 |
Trichomonas vaginalis | sensory transduction histidine kinase, putative | 0.0085 | 0.0098 | 0.0503 |
Onchocerca volvulus | 0.0115 | 0.0163 | 0.1152 | |
Mycobacterium tuberculosis | Two component sensor kinase [second part] | 0.0085 | 0.0098 | 0.0046 |
Brugia malayi | Probable DNA topoisomerase II | 0.067 | 0.1392 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.1557 | 0.3357 | 0.3323 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.067 | 0.1392 | 0.4095 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0207 | 0.0367 | 0.2477 |
Echinococcus multilocularis | heat shock protein 90 | 0.0106 | 0.0143 | 0.0292 |
Echinococcus multilocularis | DNA topoisomerase 3 beta 1 | 0.0115 | 0.0163 | 0.0344 |
Brugia malayi | heat shock protein 90 | 0.0191 | 0.0332 | 0.2222 |
Mycobacterium leprae | Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( | 0.0115 | 0.0163 | 0.0066 |
Leishmania major | heat shock protein 83-1 | 0.0191 | 0.0332 | 0.1243 |
Mycobacterium leprae | Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) | 0.4557 | 1 | 1 |
Plasmodium falciparum | DNA topoisomerase 3, putative | 0.0115 | 0.0163 | 0.0403 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0115 | 0.0163 | 0.0984 |
Schistosoma mansoni | glutaminase | 0.0271 | 0.0508 | 0.3515 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0106 | 0.0143 | 0.0276 |
Brugia malayi | DNA topoisomerase III beta-1 | 0.0115 | 0.0163 | 0.0984 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0065 | 0.0051 | 0.0165 |
Giardia lamblia | DNA topoisomerase III | 0.0115 | 0.0163 | 0.097 |
Giardia lamblia | DNA topoisomerase III | 0.0115 | 0.0163 | 0.097 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.0348 | 0.2337 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0066 | 0.0055 | 0.0194 |
Echinococcus multilocularis | geminin | 0.0198 | 0.0348 | 0.0818 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0294 | 0.056 | 0.227 |
Leishmania major | heat shock protein 83-1 | 0.0191 | 0.0332 | 0.1243 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0066 | 0.0055 | 0.0206 |
Leishmania major | heat shock protein 83-1 | 0.0191 | 0.0332 | 0.1243 |
Echinococcus multilocularis | heat shock protein 90 | 0.0191 | 0.0332 | 0.0778 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0048 | 0.0196 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.067 | 0.1392 | 1 |
Trypanosoma cruzi | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative | 0.0085 | 0.0098 | 0.0396 |
Mycobacterium ulcerans | two component sensor histidine kinase TrcS | 0.0085 | 0.0098 | 0.0046 |
Schistosoma mansoni | endoplasmin | 0.0191 | 0.0332 | 0.2222 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.067 | 0.1392 | 0.6772 |
Leishmania major | heat shock protein 83-1 | 0.0191 | 0.0332 | 0.1243 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.058 | 0.1193 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0066 | 0.0055 | 0.0194 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0207 | 0.0367 | 0.2477 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0191 | 0.0332 | 0.1346 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0207 | 0.0367 | 0.0867 |
Loa Loa (eye worm) | glutaminase 2 | 0.0271 | 0.0508 | 0.3515 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0065 | 0.0051 | 0.0209 |
Mycobacterium tuberculosis | Two component sensory transduction histidine kinase MtrB | 0.0085 | 0.0098 | 0.0046 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0191 | 0.0332 | 0.1564 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0048 | 0.0196 |
Toxoplasma gondii | DNA topoisomerase family protein | 0.0115 | 0.0163 | 0.0735 |
Leishmania major | heat shock protein 83-1 | 0.0191 | 0.0332 | 0.1243 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0115 | 0.0163 | 0.0662 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.067 | 0.1392 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0065 | 0.0261 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0085 | 0.0098 | 0.0176 |
Leishmania major | cathepsin L-like protease | 0.0063 | 0.0048 | 0.0079 |
Plasmodium vivax | DNA topoisomerase 3, putative | 0.0115 | 0.0163 | 0.0403 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.067 | 0.1392 | 1 |
Mycobacterium tuberculosis | Two component sensor kinase MprB | 0.0085 | 0.0098 | 0.0046 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0115 | 0.0163 | 0.0201 |
Giardia lamblia | Grp94/Hsp90 | 0.0106 | 0.0143 | 0.0793 |
Mycobacterium tuberculosis | Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) | 0.4557 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0085 | 0.0098 | 0.0281 |
Leishmania major | heat shock protein 83-1 | 0.0191 | 0.0332 | 0.1243 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0085 | 0.0098 | 0.0413 |
Mycobacterium tuberculosis | Two component sensor histidine kinase TrcS | 0.0085 | 0.0098 | 0.0046 |
Trypanosoma brucei | heat shock protein 84, putative | 0.0054 | 0.0029 | 0.0118 |
Trypanosoma brucei | DNA topoisomerase ii | 0.1155 | 0.2466 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0191 | 0.0332 | 0.1243 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0065 | 0.0051 | 0.0068 |
Wolbachia endosymbiont of Brugia malayi | topoisomerase IA, TopA | 0.0115 | 0.0163 | 0.0338 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0048 | 0.0196 |
Echinococcus granulosus | heat shock protein 90 | 0.0191 | 0.0332 | 0.2222 |
Wolbachia endosymbiont of Brugia malayi | membrane associated signal transduction histidine kinase | 0.0085 | 0.0098 | 0.0139 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0065 | 0.0051 | 0.0165 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0178 | 0.0303 | 0.0208 |
Mycobacterium ulcerans | two component sensor histidine kinase SenX3 | 0.0085 | 0.0098 | 0.0046 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0085 | 0.0098 | 0.0503 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0065 | 0.0051 | 0.0058 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0191 | 0.0332 | 0.1346 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.067 | 0.1392 | 1 |
Schistosoma mansoni | endoplasmin | 0.0191 | 0.0332 | 0.2222 |
Leishmania major | heat shock protein 83-1 | 0.0191 | 0.0332 | 0.1243 |
Trichomonas vaginalis | heat shock protein, putative | 0.0106 | 0.0143 | 0.0835 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1155 | 0.2466 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0065 | 0.0051 | 0.0165 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.