Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.1895 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1895 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1895 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1895 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1895 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1895 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1895 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1895 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1895 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1895 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1895 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1895 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = -15 % | Antihypertensive activity expressed as change in mean arterial blood pressure (MABP) in spontaneously hypertensive rats (SHR),at 0.5-2h after 30 mg/kg oral administration | ChEMBL. | 1920352 |
Change (functional) | = -10 % | Antihypertensive activity expressed as change in mean arterial blood pressure (MABP) in spontaneously hypertensive rats (SHR), at 3-6h after 30 mg/kg oral administration | ChEMBL. | 1920352 |
pA2 (functional) | = 9 | Calcium channel-blocking activity by determined by ability to antagonize calcium-induced contractions of isolated rabbit aortic strips | ChEMBL. | 1920352 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.