Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.1869 | 0.1869 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.1869 | 0.1869 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2422 | 0.2422 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1221 | 0.1221 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3117 | 1 |
Brugia malayi | RNA binding protein | 0.0063 | 0.3117 | 0.3117 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.3117 | 0.3117 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.2422 | 0.2422 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1869 | 0.3417 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.3117 | 0.1535 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.3117 | 0.3117 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.0731 | 0.0731 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3117 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3117 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.2422 | 0.2422 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.0731 | 0.0731 |
Leishmania major | cytochrome p450-like protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.3117 | 0.3117 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.3117 | 0.1535 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.2422 | 0.2422 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3117 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1869 | 0.3417 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3117 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.3117 | 0.3117 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.1221 | 0.1221 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.7311 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.016 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1869 | 0.3417 |
Trypanosoma brucei | cytochrome P450, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.3117 | 0.3117 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.016 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.016 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0122 | 0.7311 | 0.7311 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.7311 | 0.7311 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.7311 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.7311 | 0.7311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.