Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1535 | 0.7457 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.1435 | 0.6935 | 0.9272 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0735 | 0.3277 | 0.4171 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2022 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0683 | 0.3005 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1535 | 0.7457 | 0.5 |
Brugia malayi | thymidylate synthase | 0.1435 | 0.6935 | 0.925 |
Brugia malayi | hypothetical protein | 0.0683 | 0.3005 | 0.3605 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0683 | 0.3005 | 0.4031 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1535 | 0.7457 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.1435 | 0.6935 | 0.925 |
Onchocerca volvulus | 0.023 | 0.0642 | 0.0773 | |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0735 | 0.3277 | 0.4171 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2022 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1535 | 0.7457 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2022 | 1 | 1 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0162 | 0.0287 | 0.0385 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1535 | 0.7457 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1535 | 0.7457 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1535 | 0.7457 | 1 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0735 | 0.3277 | 1 |
Onchocerca volvulus | 0.0162 | 0.0287 | 0.0253 | |
Brugia malayi | Dihydrofolate reductase | 0.1535 | 0.7457 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.1535 | 0.7457 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1435 | 0.6935 | 0.9272 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2022 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1435 | 0.6935 | 0.93 |
Onchocerca volvulus | 0.1435 | 0.6935 | 1 | |
Schistosoma mansoni | dihydrofolate reductase | 0.1535 | 0.7457 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2022 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.