Detailed information for compound 1695786

Basic information

Technical information
  • TDR Targets ID: 1695786
  • Name: ethyl 2-[hydroxy-(2-methoxyphenyl)methyl]prop -2-enoate
  • MW: 236.264 | Formula: C13H16O4
  • H donors: 1 H acceptors: 2 LogP: 1.86 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C(=C)C(c1ccccc1OC)O
  • InChi: 1S/C13H16O4/c1-4-17-13(15)9(2)12(14)10-7-5-6-8-11(10)16-3/h5-8,12,14H,2,4H2,1,3H3
  • InChiKey: QOZCPFVDPFSTDT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[hydroxy-(2-methoxyphenyl)methyl]prop-2-enoic acid ethyl ester
  • 2-[hydroxy-(2-methoxyphenyl)methyl]acrylic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0027 0.0013 0.0091
Brugia malayi CHE-14 protein 0.0087 0.0074 0.0074
Echinococcus granulosus nibrin 0.002 0.0007 0.0012
Trypanosoma brucei metacaspase MCA2 0.0029 0.0016 0.0048
Onchocerca volvulus Protein ultraspiracle homolog 0.0016 0.0002 0.0015
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.0061 0.1088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0031 0.0018 0.0034
Onchocerca volvulus Bile acid receptor homolog 0.0016 0.0002 0.0015
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.002 0.0006 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0009 0.006
Mycobacterium tuberculosis Conserved protein 0.0082 0.0069 0.1255
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0008 0.0044
Echinococcus granulosus neuropeptide receptor A26 0.0641 0.0637 0.1215
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0082 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0013 0.0719
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0008 0.0014
Echinococcus granulosus Protein patched homolog 1 0.0087 0.0074 0.014
Loa Loa (eye worm) hypothetical protein 0.0123 0.011 0.011
Trypanosoma brucei importin beta-1 subunit, putative 0.0019 0.0005 0.0016
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0 0.0003
Echinococcus multilocularis caspase 8 0.0029 0.0016 0.0029
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0007 0.0351
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0007 0.0044
Mycobacterium ulcerans hypothetical protein 0.0073 0.0061 0.1713
Trichomonas vaginalis ap endonuclease, putative 0.0031 0.0018 0.1002
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.5179 0.5241 1
Loa Loa (eye worm) choline O-acetyltransferase 0.1388 0.1394 0.1394
Echinococcus granulosus sentrin specific protease 7 0.0162 0.015 0.0286
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0013 0.0719
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0016 0.0002 0.0004
Trypanosoma cruzi major cysteine proteinase, putative 0.008 0.0067 0.0127
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0031 0.0018 0.0034
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0022 0.0008 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0016 0.0862
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0008 0.0044
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0 0.0003
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0008 0.0857
Brugia malayi TAR-binding protein 0.0149 0.0137 0.0137
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0149 0.0137 0.098
Plasmodium falciparum cysteine proteinase falcipain 3 0.0027 0.0013 0.2454
Onchocerca volvulus 0.0073 0.0061 0.0431
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0008 0.0059
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0016 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0202 0.0191 0.0191
Onchocerca volvulus 0.0022 0.0008 0.0054
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0002
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.5179 0.5241 1
Brugia malayi glutaminase DH11.1 0.0188 0.0177 0.0177
Brugia malayi hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0008 0.0008
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0057 0.0044 0.0083
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0024 0.0011 0.0555
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0008 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0022 0.0157
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.3133 0.3166 0.604
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0029 0.0016 0.0016
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0016 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0089 0.0279
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0057 0.0044 0.0083
Schistosoma mansoni coup transcription factor 0.0016 0.0002 0.0015
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0014 0 0.0007
Echinococcus granulosus expressed protein 0.0047 0.0034 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0013 0.0719
Trypanosoma brucei metacaspase 0.0029 0.0016 0.0048
Plasmodium falciparum metacaspase 1 0.0029 0.0016 0.2942
Loa Loa (eye worm) hypothetical protein 0.0055 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0006
Plasmodium falciparum sentrin-specific protease 1 0.0014 0 0.0012
Loa Loa (eye worm) oxidoreductase 0.0022 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0007 0.0351
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0013 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0016 0.0002 0.0002
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0024 0.001 0.0019
Leishmania major hypothetical protein, conserved 0.0022 0.0008 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.1388 0.1394 0.266
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0002 0.0015
Leishmania major cathepsin L-like protease 0.0101 0.0089 0.0169
Loa Loa (eye worm) cysteine protease 0.0027 0.0013 0.0013
Schistosoma mansoni inositol monophosphatase 0.0024 0.0011 0.0076
Trypanosoma cruzi hypothetical protein, conserved 0.1388 0.1394 0.266
Schistosoma mansoni hypothetical protein 0.0057 0.0044 0.031
Echinococcus multilocularis inositol monophosphatase 1 0.0024 0.0011 0.002
Schistosoma mansoni survival motor neuron protein 0.0053 0.004 0.0282
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0059 0.0046 0.0087
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0022 0.0009 0.0016
Toxoplasma gondii pyruvate kinase PyKII 0.0033 0.002 0.2214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0214
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0016 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0054 0.0041 0.0041
Onchocerca volvulus 0.0022 0.0009 0.0059
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0024 0.0011 0.002
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0007 0.0351
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0013 0.0719
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0 0.0003
Onchocerca volvulus 0.0027 0.0013 0.0091
Echinococcus multilocularis pyruvate kinase 0.0051 0.0038 0.0072
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0014 0.0001 0.0037
Brugia malayi Muscleblind-like protein 0.0252 0.0241 0.0241
Echinococcus multilocularis protein dispatched 1 0.0099 0.0086 0.0164
Loa Loa (eye worm) hypothetical protein 0.006 0.0047 0.0047
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0007 0.0326
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0039 0.066
Loa Loa (eye worm) hypothetical protein 0.0082 0.0069 0.0069
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0024 0.0011 0.0139
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0013 0.0013
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0087 0.0074 0.0074
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0052 0.037
Echinococcus multilocularis muscleblind protein 1 0.0252 0.0241 0.046
Brugia malayi Niemann-Pick C1 protein precursor 0.0202 0.0191 0.0191
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0015 0.0002 0.0082
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0007 0.0351
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0032 0.0018 0.0034
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0008 0.0044
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0002 0.0015
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.1388 0.1394 0.266
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.0022
Trichomonas vaginalis rotamase, putative 0.0047 0.0034 0.1912
Onchocerca volvulus 0.0027 0.0013 0.0091
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0022 0.0008 0.0282
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0027 0.0013 0.0013
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0027 0.0013 0.2454
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0002 0.0002
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0007 0.0007
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0013 0.0091
Schistosoma mansoni ap endonuclease 0.0031 0.0018 0.0127
Loa Loa (eye worm) RNA binding protein 0.0149 0.0137 0.0137
Echinococcus granulosus cathepsin l1 0.0018 0.0004 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0002 0.0002
Trichomonas vaginalis inositol monophosphatase, putative 0.0024 0.0011 0.0599
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0007 0.0351
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.0042 0.072
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0013 0.0719
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0008 0.0857
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0008 0.0059
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0007 0.07
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0013 0.0719
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0004
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0082 0.0069 0.1255
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0013 0.0719
Echinococcus granulosus caspase 2 0.0029 0.0016 0.0029
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0061 0.0115
Echinococcus multilocularis thyroid hormone receptor alpha 0.0016 0.0002 0.0004
Plasmodium falciparum importin beta, putative 0.0019 0.0005 0.099
Trypanosoma cruzi ISWI complex protein 0.0022 0.0008 0.0014
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0016 0.0002 0.0004
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0008 0.0059
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0083 0.0071 0.0505
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0004 0.0198
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0 0.0003
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0029 0.0016 0.1719
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0074 0.417
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0061 0.1713
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0033 0.0234
Echinococcus granulosus caspase 8 0.0029 0.0016 0.0029
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.0061 0.1713
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0013 0.0719
Echinococcus granulosus lamin 0.002 0.0006 0.0011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0031 0.0018 0.0018
Leishmania major pyruvate kinase 0.0065 0.0052 0.0099
Schistosoma mansoni zinc finger protein 0.0028 0.0014 0.0098
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0008 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.1388 0.1394 0.266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0013 0.0719
Loa Loa (eye worm) ctsf protein 0.0027 0.0013 0.0013
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0085 0.0073 0.0519
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0039 0.066
Schistosoma mansoni hypothetical protein 0.0526 0.052 0.3724
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0008 0.0008
Loa Loa (eye worm) fibroinase 0.0027 0.0013 0.0013
Schistosoma mansoni myelin transcription factor 1 myt1 0.0097 0.0085 0.0606
Onchocerca volvulus 0.0085 0.0073 0.0519
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0089 0.0279
Schistosoma mansoni tar DNA-binding protein 0.0149 0.0137 0.098
Trypanosoma cruzi metacaspase, putative 0.0029 0.0016 0.0029
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0031 0.0018 0.2573
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0016 0.0002 0.0002
Echinococcus multilocularis choline O acetyltransferase 0.1388 0.1394 0.266
Trichomonas vaginalis set domain proteins, putative 0.0177 0.0165 0.9347
Trypanosoma cruzi hypothetical protein, conserved 0.1388 0.1394 0.266
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0029 0.0016 0.1719
Plasmodium falciparum pyruvate kinase 2 0.0033 0.002 0.3789
Schistosoma mansoni pyruvate kinase 0.0033 0.002 0.0141
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.3133 0.3166 0.3166
Brugia malayi topoisomerase 0.002 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0089 0.0279
Onchocerca volvulus 0.0018 0.0004 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0002 0.0002
Onchocerca volvulus 0.0082 0.0069 0.0492
Echinococcus multilocularis cysteine protease 0.0027 0.0013 0.0024
Echinococcus granulosus lamin dm0 0.002 0.0006 0.0011
Leishmania major cathepsin L-like protease 0.0027 0.0013 0.0024
Brugia malayi Bromodomain containing protein 0.0106 0.0093 0.0093
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0033 0.0234
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0014 0 0.0007
Loa Loa (eye worm) steroid hormone receptor 0.0016 0.0002 0.0002
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.5179 0.5241 1
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0052 0.037
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0061 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0061 0.1713
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0031 0.0018 0.0034
Trypanosoma brucei metacaspase MCA3 0.0029 0.0016 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0007 0.0351
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0149 0.0137 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0013 0.0719
Loa Loa (eye worm) hypothetical protein 0.0087 0.0074 0.0074
Echinococcus multilocularis ecdysone induced protein 78C 0.0016 0.0002 0.0004
Echinococcus granulosus fetal alzheimer antigen falz 0.0032 0.0018 0.0034
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0061 0.0115
Brugia malayi beta-lactamase family protein 0.0082 0.0069 0.0069
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.3133 0.3166 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0214
Trypanosoma cruzi metacaspase, putative 0.0029 0.0016 0.0029
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0008 0.0044
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0069 1
Trypanosoma cruzi hypothetical protein, conserved 0.1388 0.1394 0.266
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0088 0.0076 0.0238
Mycobacterium ulcerans esterase/lipase LipP 0.0082 0.0069 0.1984
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0036 0.0022 0.0042
Mycobacterium ulcerans pyruvate kinase 0.0065 0.0052 0.1444
Echinococcus multilocularis cysteine protease 0.0027 0.0013 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0069 0.3894
Onchocerca volvulus 0.002 0.0007 0.0044
Schistosoma mansoni inositol monophosphatase 0.0024 0.0011 0.0076
Plasmodium vivax vivapain-2 0.0027 0.0013 0.1847
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0084 0.0071 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0089 0.0279
Loa Loa (eye worm) hypothetical protein 0.0055 0.0042 0.0042
Schistosoma mansoni sex comb on midleg homolog 0.0085 0.0073 0.0519
Loa Loa (eye worm) hypothetical protein 0.0065 0.0052 0.0052
Mycobacterium leprae Probable pyruvate kinase PykA 0.0065 0.0052 0.728
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0016 0.0002 0.0002
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.1388 0.1394 0.266
Echinococcus multilocularis tumor protein p63 0.0239 0.0228 0.0435
Echinococcus granulosus caspase 3 0.008 0.0067 0.0127
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0 0.0003
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0084 0.0071 0.0136
Onchocerca volvulus 0.0027 0.0013 0.0091
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0097 0.0085 0.0161
Trichomonas vaginalis esterase, putative 0.0082 0.0069 0.3894
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0628 0.0623 0.1188
Plasmodium falciparum pyruvate kinase 0.0065 0.0052 1
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0022 0.0008 0.0222
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0008 0.0044
Onchocerca volvulus 0.1388 0.1394 1
Schistosoma mansoni choline o-acyltransferase 0.1388 0.1394 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0016 0.0862
Echinococcus granulosus caspase 0.0109 0.0096 0.0183
Schistosoma mansoni hypothetical protein 0.0029 0.0016 0.0109
Brugia malayi hypothetical protein 0.002 0.0007 0.0007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0069 0.0493
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0016 0.0862
Onchocerca volvulus 0.0082 0.0069 0.0492
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0024 0.0011 0.1194
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0016 0.0002 0.0015
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0016 0.0862
Brugia malayi Cathepsin L-like precursor 0.0027 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0002
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0297 0.0288 0.0907
Echinococcus granulosus cathepsin l cysteine peptidase 0.0027 0.0013 0.0024
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0 0.0003
Leishmania major hypothetical protein, conserved 0.0082 0.0069 0.0131
Schistosoma mansoni hypothetical protein 0.0022 0.0008 0.0054
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0108 0.0095 0.0181
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0013 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0039 0.066
Schistosoma mansoni pyruvate kinase 0.0065 0.0052 0.0371
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0002 0.0002
Trypanosoma cruzi metacaspase 5, putative 0.0029 0.0016 0.0029
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0016 0.0862
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.1388 0.1394 0.1394
Schistosoma mansoni importin beta-1 0.0019 0.0005 0.0037
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0097 0.0085 0.0161
Trypanosoma brucei Metacaspase-4 0.0029 0.0016 0.0048
Schistosoma mansoni hypothetical protein 0.0123 0.011 0.0789
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0031 0.0018 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Brugia malayi Choline O-acetyltransferase 0.1388 0.1394 0.1394
Brugia malayi mbt repeat family protein 0.0085 0.0073 0.0073
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0008 0.0014
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0031 0.0018 0.0257
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0033 0.0062
Brugia malayi Latrophilin receptor protein 2 0.0057 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0013 0.0719
Trypanosoma brucei metacaspase 5, putative 0.0029 0.0016 0.0048
Echinococcus multilocularis tar DNA binding protein 0.0149 0.0137 0.0261
Echinococcus granulosus expressed protein 0.0257 0.0247 0.047
Loa Loa (eye worm) hypothetical protein 0.0259 0.0249 0.0249
Echinococcus granulosus replication factor c subunit 1 0.002 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0082 0.0069 0.0069
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0047 0.0034 0.0034
Mycobacterium tuberculosis Conserved protein 0.0082 0.0069 0.1255
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0029 0.0016 0.0109
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0016 0.0862
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.1388 0.1394 0.4404
Mycobacterium tuberculosis Probable esterase LipL 0.0082 0.0069 0.1255
Loa Loa (eye worm) hypothetical protein 0.0073 0.0061 0.0061
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0008 0.0044
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0008 0.0054
Trypanosoma cruzi ISWI complex protein 0.0022 0.0008 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0008 0.0044
Loa Loa (eye worm) hypothetical protein 0.9868 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0002 0.0015
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0 0.0003
Leishmania major cysteine peptidase A (CPA) 0.0027 0.0013 0.0024
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0031 0.0018 0.0034
Onchocerca volvulus 0.0022 0.0008 0.0054
Onchocerca volvulus 0.1388 0.1394 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0019 0.0005 0.0016
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0089 0.0279
Schistosoma mansoni bromodomain containing protein 0.0089 0.0077 0.0546
Echinococcus granulosus pyruvate kinase 0.0033 0.002 0.0037
Echinococcus multilocularis importin subunit beta 1 0.0019 0.0005 0.001
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0008 0.0008
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0016 0.0862
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0008
Echinococcus multilocularis neuropeptide receptor A26 0.0641 0.0637 0.1215
Leishmania major importin beta-1 subunit, putative 0.0015 0.0002 0.0003
Loa Loa (eye worm) pyruvate kinase-PB 0.0045 0.0032 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0022 0.0157
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0036 0.0022 0.0042
Echinococcus granulosus tumor protein p63 0.0239 0.0228 0.0435
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0021 0.0008 0.0014
Mycobacterium tuberculosis Probable lipase LipE 0.0082 0.0069 0.1255
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0014 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0267 0.0258 0.1845
Loa Loa (eye worm) hypothetical protein 0.0057 0.0044 0.0044
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0024 0.0011 0.002
Mycobacterium ulcerans lipase LipD 0.0082 0.0069 0.1984
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0008 0.1468
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0007 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0022 0.0009 0.006
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0202 0.0191 1
Onchocerca volvulus 0.1388 0.1394 1
Echinococcus granulosus pyruvate kinase 0.0033 0.002 0.0037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0069 0.0131
Echinococcus multilocularis expressed protein 0.0047 0.0034 0.0064
Trichomonas vaginalis Sentrin-specific protease, putative 0.0014 0 0.0003
Echinococcus multilocularis snurportin 1 0.0204 0.0193 0.0368
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0082 0.0069 0.0069
Entamoeba histolytica hypothetical protein 0.0015 0.0002 0.0076
Mycobacterium leprae conserved hypothetical protein 0.0082 0.0069 1
Echinococcus multilocularis survival motor neuron protein 1 0.0259 0.0249 0.0474
Schistosoma mansoni topbp1 0.002 0.0007 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0016 0.0002 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0061 0.1088
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0088 0.0076 0.0144
Giardia lamblia Pyruvate kinase 0.0033 0.002 0.3789
Mycobacterium tuberculosis Probable lipase LipD 0.0082 0.0069 0.1255
Entamoeba histolytica hypothetical protein 0.002 0.0007 0.0325
Loa Loa (eye worm) bromodomain containing protein 0.0025 0.0011 0.0011
Schistosoma mansoni cellular tumor antigen P53 0.0035 0.0022 0.0152
Entamoeba histolytica hypothetical protein 0.0059 0.0046 0.2397
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0036 0.0022 0.0042
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0069 0.3894
Echinococcus multilocularis muscleblind protein 0.0252 0.0241 0.046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0055 0.0042 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0016 0.0862
Echinococcus multilocularis Niemann Pick C1 protein 0.0202 0.0191 0.0363
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.0061 0.1713
Brugia malayi Cathepsin L-like cysteine proteinase 0.0018 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0013 0.0719
Schistosoma mansoni lamin 0.002 0.0006 0.0041
Leishmania major metacaspase, putative 0.0029 0.0016 0.0029
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0061 0.316
Trypanosoma cruzi pyruvate kinase 2, putative 0.0065 0.0052 0.0099
Brugia malayi Pre-SET motif family protein 0.0022 0.0009 0.0009
Brugia malayi Pre-SET motif family protein 0.0155 0.0144 0.0144
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0522 0.0516 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0204 0.0193 0.0193
Brugia malayi exodeoxyribonuclease III family protein 0.0031 0.0018 0.0018
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0065 0.0052 0.0922
Echinococcus multilocularis sterol regulatory element binding protein 0.0087 0.0074 0.014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0008 0.0059
Brugia malayi beta-lactamase 0.0082 0.0069 0.0069
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0007 0.0902
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0069 0.3894
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0089 0.0279
Brugia malayi Bromodomain containing protein 0.0054 0.0041 0.0041
Onchocerca volvulus 0.0027 0.0013 0.0091
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0002
Onchocerca volvulus 0.0027 0.0013 0.0091
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0045 0.0032 0.0032
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.1388 0.1394 0.4404
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0013 0.0719
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0057 0.0044 0.0083
Echinococcus granulosus survival motor neuron protein 1 0.0259 0.0249 0.0474
Schistosoma mansoni rotamase 0.0047 0.0034 0.0242
Echinococcus granulosus pyruvate kinase 0.0033 0.002 0.0037
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0016 0.2214
Plasmodium vivax sentrin-specific protease 1, putative 0.0014 0 0.0009
Echinococcus multilocularis caspase 3 0.008 0.0067 0.0127
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0052 0.0052
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0008 0.0014
Echinococcus granulosus GPCR family 2 0.0057 0.0044 0.0083
Mycobacterium tuberculosis Conserved hypothetical protein 0.0331 0.0322 0.6195
Loa Loa (eye worm) hypothetical protein 0.0073 0.0061 0.0061
Trypanosoma brucei pyruvate kinase 1, putative 0.0065 0.0052 0.0163
Leishmania major carnitine/choline acetyltransferase, putative 0.1388 0.1394 0.266
Trichomonas vaginalis pyruvate kinase, putative 0.0065 0.0052 0.293
Mycobacterium tuberculosis Conserved protein 0.0082 0.0069 0.1255
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Echinococcus granulosus inositol monophosphatase 1 0.0024 0.0011 0.002
Echinococcus multilocularis protein patched 0.0087 0.0074 0.014
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0031 0.0018 0.0928
Trichomonas vaginalis glutaminase, putative 0.0188 0.0177 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0628 0.0623 0.1188
Trypanosoma cruzi cysteine peptidase, putative 0.0101 0.0089 0.0169
Trypanosoma cruzi importin beta-1 subunit, putative 0.0015 0.0002 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0007 0.0012
Plasmodium vivax acyl-CoA synthetase, putative 0.0055 0.0042 0.6019
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0082 0.0069 0.1255
Trypanosoma brucei hypothetical protein, conserved 0.1388 0.1394 0.4404
Echinococcus multilocularis neuropeptide s receptor 0.0641 0.0637 0.1215
Trypanosoma brucei pyruvate kinase 1 0.0065 0.0052 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0016 0.0862
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0002 0.0015
Echinococcus granulosus importin subunit beta 1 0.0019 0.0005 0.001
Echinococcus multilocularis expressed conserved protein 0.0189 0.0178 0.034
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0007 0.0351
Plasmodium vivax vivapain-2 0.0027 0.0013 0.1847
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0057 0.0044 0.0083
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0031 0.0018 0.0364
Echinococcus granulosus ecdysone induced protein 78C 0.0016 0.0002 0.0004
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0297 0.0288 0.0548
Leishmania major cathepsin L-like protease 0.0101 0.0089 0.0169
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.1388 0.1394 0.266
Giardia lamblia Sentrin specific protease, putative 0.0014 0 0.0012
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0162 0.015 0.7867
Onchocerca volvulus Cathepsin F homolog 0.0027 0.0013 0.0091
Trypanosoma cruzi metacaspase, putative 0.0029 0.0016 0.0029
Leishmania major cathepsin L-like protease 0.0027 0.0013 0.0024
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0055 0.0042 0.7996
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0008 0.0059
Brugia malayi ecdysteroid receptor 0.0016 0.0002 0.0002
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0008 0.0014
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0008 0.0059
Brugia malayi DKFZp564C0469 protein 0.002 0.0007 0.0007
Brugia malayi hypothetical protein 0.0109 0.0097 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0089 0.0279
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0002 0.0015
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0007 0.0701
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0008 0.0008
Echinococcus multilocularis musashi 0.002 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0034 0.1912
Echinococcus granulosus SAM and MBT domain containing protein 0.0085 0.0073 0.0138
Entamoeba histolytica hypothetical protein 0.0059 0.0046 0.2397
Echinococcus granulosus geminin 0.0267 0.0258 0.0491
Loa Loa (eye worm) hypothetical protein 0.0252 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0002
Echinococcus granulosus neuropeptide s receptor 0.0641 0.0637 0.1215
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0069 0.0131
Echinococcus multilocularis pyruvate kinase 0.0033 0.002 0.0037
Onchocerca volvulus 0.0082 0.0069 0.0492
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0179 0.0168 0.0168
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0205 0.0194 0.1389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0013 0.0719
Brugia malayi Cathepsin L-like precursor 0.0027 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0179 0.0168 0.0168
Schistosoma mansoni glutaminase 0.0188 0.0177 0.1266
Trichomonas vaginalis pyruvate kinase, putative 0.0065 0.0052 0.293
Echinococcus granulosus beta LACTamase domain containing family member 0.0082 0.0069 0.0131
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0051 0.0037 0.0071
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0002
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0343 0.0334 0.0637
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0008 0.0044
Leishmania major cathepsin L-like protease 0.0027 0.0013 0.0024
Leishmania major pyruvate kinase 0.0065 0.0052 0.0099
Echinococcus multilocularis expressed protein 0.0257 0.0247 0.047
Toxoplasma gondii ABC1 family protein 0.0082 0.0069 0.7764
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.3133 0.3166 0.3166
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.1388 0.1394 0.266
Schistosoma mansoni caspase-7 (C14 family) 0.0109 0.0096 0.0689
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0085 0.0073 0.0519
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0162 0.015 0.1075
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0002 0.0015
Echinococcus multilocularis geminin 0.0267 0.0258 0.0491
Onchocerca volvulus 0.0016 0.0002 0.0015
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.1388 0.1394 0.266
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0032 0.0018 0.0129
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0013 0.0719
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0013 0.0091
Onchocerca volvulus 0.0053 0.004 0.0282
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0024 0.0011 0.0599
Loa Loa (eye worm) beta-lactamase 0.0082 0.0069 0.0069
Trichomonas vaginalis rotamase, putative 0.0046 0.0033 0.1848
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0002 0.0002
Echinococcus granulosus methyl CpG binding domain protein 2 0.0024 0.001 0.0019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0069 0.0493
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0008
Plasmodium vivax pyruvate kinase, putative 0.0065 0.0052 0.7525
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0008 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0016 0.0862
Brugia malayi steroid hormone receptor 0.0016 0.0002 0.0002
Brugia malayi Choline O-acetyltransferase 0.1388 0.1394 0.1394
Loa Loa (eye worm) glutaminase 2 0.0188 0.0177 0.0177
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0082 0.0069 0.1255
Echinococcus multilocularis lamin dm0 0.002 0.0006 0.0011
Schistosoma mansoni hypothetical protein 0.0057 0.0044 0.031
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0155 0.0144 0.0144
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0059 0.0046 0.2397
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0031 0.0018 0.0056
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0033 0.0062
Loa Loa (eye worm) hypothetical protein 0.0073 0.0061 0.0061
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.004 0.004
Trypanosoma cruzi cruzipain precursor, putative 0.0101 0.0089 0.0169
Schistosoma mansoni tar DNA-binding protein 0.0149 0.0137 0.098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0013 0.0719
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0013 0.0719
Echinococcus multilocularis microtubule associated protein 2 0.1221 0.1225 0.2338
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0008 0.0857
Brugia malayi RNA binding protein 0.0149 0.0137 0.0137
Trichomonas vaginalis penicillin-binding protein, putative 0.0082 0.0069 0.3894
Echinococcus multilocularis expressed conserved protein 0.0148 0.0136 0.0258
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0031 0.0018 0.0034
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0024 0.0011 0.0599
Toxoplasma gondii HEAT repeat-containing protein 0.0019 0.0005 0.0578
Schistosoma mansoni hypothetical protein 0.0057 0.0044 0.031
Chlamydia trachomatis pyruvate kinase 0.0065 0.0052 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0082 0.0069 0.0069
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0097 0.0085 0.0085
Trichomonas vaginalis importin beta-1, putative 0.0015 0.0002 0.0082
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0016
Echinococcus multilocularis pyruvate kinase 0.0065 0.0052 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0013 0.0719
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0007 0.0351
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0013 0.0719
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0016 0.0002 0.0002
Brugia malayi Cathepsin L-like precursor 0.0018 0.0004 0.0004
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0047 0.0034 0.0034
Plasmodium falciparum metacaspase-like protein 0.0029 0.0016 0.2942
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0008 0.0024
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0008 0.1104
Brugia malayi cathepsin L-like precursor 0.0018 0.0004 0.0004
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0052 0.0052
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0052 0.037
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.1388 0.1394 0.4404
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0013 0.0091
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0002 0.0015
Trypanosoma brucei ISWI complex protein 0.0022 0.0008 0.0024
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.0007 0.0012
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0014 0 0.0007
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.002 0.0006 0.0006
Schistosoma mansoni caspase-7 (C14 family) 0.0029 0.0016 0.0109
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0008 0.0059
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0061 0.0115
Loa Loa (eye worm) mbt repeat family protein 0.0085 0.0073 0.0073
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0013 0.0719
Echinococcus granulosus histone acetyltransferase MYST2 0.0097 0.0085 0.0161
Echinococcus granulosus sterol regulatory element binding protein 0.0087 0.0074 0.014
Trypanosoma cruzi metacaspase 5, putative 0.0029 0.0016 0.0029
Echinococcus granulosus zinc finger protein 0.0028 0.0014 0.0026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0039 0.066
Echinococcus granulosus polycomb protein SCMH1 0.0085 0.0073 0.0138
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0002 0.0004
Brugia malayi mbt repeat family protein 0.0085 0.0073 0.0073
Mycobacterium ulcerans hypothetical protein 0.0331 0.0322 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0109 0.0096 0.0183
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0036 0.0022 0.0022
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0343 0.0334 0.0637
Loa Loa (eye worm) hypothetical protein 0.0055 0.0042 0.0042
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0002 0.0015
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0082 0.0069 0.0069
Onchocerca volvulus 0.0022 0.0008 0.0054
Plasmodium vivax importin-beta 2, putative 0.0019 0.0005 0.0745
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0006
Echinococcus multilocularis caspase 0.0109 0.0096 0.0183
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0016 0.0002 0.0004
Echinococcus multilocularis lamin 0.002 0.0006 0.0011
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0109 0.0096 0.0183
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0008 0.0008
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0007 0.0012
Leishmania major mitochondrial DNA polymerase beta 0.0628 0.0623 0.1188
Toxoplasma gondii cathepsin CPL 0.0027 0.0013 0.1434
Leishmania major cathepsin L-like protease 0.0101 0.0089 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0016 0.0862
Entamoeba histolytica pyruvate kinase, putative 0.0045 0.0032 0.1667
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0016 0.0862
Loa Loa (eye worm) hypothetical protein 0.1388 0.1394 0.1394
Plasmodium vivax sentrin-specific protease 2, putative 0.0014 0 0.0009
Brugia malayi nuclear receptor NHR-88 0.0016 0.0002 0.0002
Trypanosoma cruzi pyruvate kinase 2, putative 0.0065 0.0052 0.0099
Brugia malayi Cathepsin L-like precursor 0.0018 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0013 0.0719
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0001 0.0001
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0149 0.0137 0.098
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0085 0.0073 0.0073
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0022 0.0008 0.0222
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0036 0.0022 0.0042
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0008 0.0044
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0013 0.0024
Toxoplasma gondii peptidylprolyl isomerase 0.0046 0.0033 0.3685
Brugia malayi Intermediate filament tail domain containing protein 0.002 0.0006 0.0006
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0042 0.1116
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0014 0 0.0003
Echinococcus multilocularis pyruvate kinase 0.0065 0.0052 0.0099
Loa Loa (eye worm) hypothetical protein 0.0109 0.0097 0.0097
Schistosoma mansoni caspase-3 (C14 family) 0.0109 0.0096 0.0689
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0013 0.0719
Onchocerca volvulus Cell death protein 3 homolog 0.0029 0.0016 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0089 0.0279
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0297 0.0288 0.0548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0089 0.0279
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0013 0.0024
Loa Loa (eye worm) MBCTL1 0.0097 0.0085 0.0085
Schistosoma mansoni intermediate filament proteins 0.002 0.0006 0.0041
Onchocerca volvulus 0.1388 0.1394 1
Leishmania major carnitine palmitoyltransferase-like protein 0.3133 0.3166 0.604
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0088 0.0076 0.0144
Loa Loa (eye worm) inositol-1 0.0024 0.0011 0.0011
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0061 0.8635
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0002 0.0015
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0002 0.0015
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0001 0.0001
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0008 0.043
Schistosoma mansoni methyl-cpg binding protein mbd 0.0024 0.001 0.0072
Schistosoma mansoni topbp1 0.002 0.0007 0.0044
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0013 0.0013
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0008 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0002 0.0002
Brugia malayi Cell death protein 3 precursor 0.0029 0.0016 0.0016
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0008 0.0014
Echinococcus multilocularis nibrin 0.002 0.0007 0.0012
Onchocerca volvulus 0.0022 0.0008 0.0054
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0024 0.0011 0.0033
Brugia malayi RNA recognition motif domain containing protein 0.0149 0.0137 0.0137
Schistosoma mansoni ap endonuclease 0.0031 0.0018 0.0127
Echinococcus multilocularis caspase 2 0.0029 0.0016 0.0029
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0024 0.0011 0.002
Entamoeba histolytica acyl-coA synthetase, putative 0.0073 0.0061 0.316
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0013 0.0719
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0007 0.002
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0008 0.0398
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0008 0.043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0089 0.0279
Loa Loa (eye worm) glutaminase 0.0188 0.0177 0.0177
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0 0.0003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0008 0.0008
Echinococcus multilocularis pyruvate kinase 0.0033 0.002 0.0037
Schistosoma mansoni hypothetical protein 0.0204 0.0193 0.1382
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.0007 0.1199
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.002 0.0007 0.3384
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0016 0.0862
Loa Loa (eye worm) hypothetical protein 0.01 0.0087 0.0087
Echinococcus granulosus expressed conserved protein 0.0148 0.0136 0.0258
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0016 0.0862
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.1388 0.1394 0.1394
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.0042 0.7999
Schistosoma mansoni hypothetical protein 0.0083 0.0071 0.0505
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0092 0.008 0.0152
Toxoplasma gondii pyruvate kinase PyK1 0.0065 0.0052 0.5843
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0088 0.0076 0.0144
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0061 0.316
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.3133 0.3166 0.604
Echinococcus granulosus snurportin 1 0.0204 0.0193 0.0368
Brugia malayi latrophilin 2 splice variant baaae 0.0123 0.011 0.011
Echinococcus granulosus cathepsin L cysteine proteinase 0.0027 0.0013 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0014 0 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0007 0.0012
Schistosoma mansoni hypothetical protein 0.0267 0.0258 0.1845
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0 0.0003
Schistosoma mansoni transcription factor LCR-F1 0.0059 0.0046 0.0327
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0013 0.0024
Toxoplasma gondii exonuclease III APE 0.0031 0.0018 0.1998
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0008 0.0044
Loa Loa (eye worm) hypothetical protein 0.0057 0.0044 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0008 0.0008
Brugia malayi Inositol-1 0.0024 0.0011 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0083 0.0071 0.0505
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0059 0.0046 0.0087
Echinococcus multilocularis beta LACTamase domain containing family member 0.0082 0.0069 0.0131
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.0061 0.1713
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0016 0.0002 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0002 0.0002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0061 0.1713
Giardia lamblia Pyruvate kinase 0.0065 0.0052 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0015 0.0002 0.0082
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0008 0.0044
Schistosoma mansoni sex comb on midleg homolog 0.0085 0.0073 0.0519
Schistosoma mansoni lamin 0.002 0.0006 0.0041
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0061 0.8635
Trypanosoma cruzi metacaspase, putative 0.0029 0.0016 0.0029
Brugia malayi beta-lactamase family protein 0.0082 0.0069 0.0069
Schistosoma mansoni microtubule-associated protein tau 0.1221 0.1225 0.8788
Schistosoma mansoni hypothetical protein 0.0057 0.0044 0.031
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0002 0.0004
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0027 0.0013 0.2454
Plasmodium vivax pyruvate kinase 2, putative 0.0033 0.002 0.2852
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0022 0.0009 0.0939
Onchocerca volvulus 0.0027 0.0013 0.0091
Brugia malayi PHD-finger family protein 0.0035 0.0022 0.0022
Trichomonas vaginalis penicillin-binding protein, putative 0.0082 0.0069 0.3894
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0046 0.0033 0.0062
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0008 0.0014
Giardia lamblia Replication factor C, subunit 1 0.002 0.0007 0.1199
Echinococcus multilocularis zinc finger protein 0.0028 0.0014 0.0026
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0007 0.0351
Treponema pallidum exodeoxyribonuclease (exoA) 0.0031 0.0018 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0046 0.0033 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0061 0.1713
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0002 0.0002
Brugia malayi Cathepsin L-like precursor 0.0027 0.0013 0.0013
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0007 0.0351
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0002 0.0015
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0008 0.0014
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0082 0.0069 0.1984
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0008 0.0059
Echinococcus granulosus intermediate filament protein 0.002 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0106 0.0094 0.0094
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0008 0.0044
Schistosoma mansoni pyruvate kinase 0.0065 0.0052 0.0371
Toxoplasma gondii hypothetical protein 0.0101 0.0089 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0016 0.0862
Echinococcus granulosus pyruvate kinase 0.0065 0.0052 0.0099
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0008 0.0059
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0013 0.0666
Schistosoma mansoni tar DNA-binding protein 0.0149 0.0137 0.098
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0002 0.0015
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0628 0.0623 0.1968
Leishmania major cathepsin L-like protease 0.0027 0.0013 0.0024
Echinococcus granulosus cathepsin l1 0.0027 0.0013 0.0024
Loa Loa (eye worm) intermediate filament protein 0.002 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0083 0.0071 0.0505
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0 0.0003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0016 0.0002 0.0004
Brugia malayi nuclear hormone receptor 0.0016 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0016 0.0002 0.0002
Onchocerca volvulus 0.0177 0.0165 0.1183
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0013 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0013 0.0719
Echinococcus granulosus choline O acetyltransferase 0.1388 0.1394 0.266
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0022 0.0008 0.0067
Schistosoma mansoni methyl-cpg binding protein mbd 0.0024 0.001 0.0072
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0004 0.0027
Trypanosoma cruzi cysteine peptidase, putative 0.0101 0.0089 0.0169
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0016 0.0002 0.0004
Schistosoma mansoni choline o-acyltransferase 0.1388 0.1394 1
Trypanosoma brucei hypothetical protein, conserved 0.0082 0.0069 0.0217
Entamoeba histolytica hypothetical protein 0.0059 0.0046 0.2397
Plasmodium vivax SET domain protein, putative 0.0022 0.0009 0.121
Echinococcus granulosus Niemann Pick C1 protein 0.0288 0.0279 0.0531
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0008 0.0044
Echinococcus multilocularis polycomb protein SCMH1 0.0085 0.0073 0.0138
Loa Loa (eye worm) hypothetical protein 0.0055 0.0042 0.0042
Schistosoma mansoni DNA ligase IV 0.002 0.0007 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0089 0.0279
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0057 0.0044 0.0044
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0008 0.0044
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0046 0.0033 0.0062
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0052 0.0052
Brugia malayi Pyruvate kinase, M2 isozyme 0.0065 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0097 0.0085 0.0085
Brugia malayi Cathepsin L-like precursor 0.0027 0.0013 0.0013
Echinococcus granulosus FTZ F1 alpha 0.0016 0.0002 0.0004
Schistosoma mansoni patched 1 0.0087 0.0074 0.0528
Echinococcus granulosus Niemann Pick C1 protein 0.0202 0.0191 0.0363
Schistosoma mansoni hypothetical protein 0.0053 0.004 0.0282
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Brugia malayi intermediate filament protein 0.002 0.0006 0.0006
Echinococcus granulosus microtubule associated protein 2 0.1221 0.1225 0.2338
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0008 0.0059
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0179 0.0168 0.0168
Echinococcus multilocularis histone acetyltransferase MYST2 0.0097 0.0085 0.0161
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0031 0.0018 0.3419
Brugia malayi Cathepsin L-like precursor 0.0027 0.0013 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0022 0.0157
Entamoeba histolytica cysteine protease, putative 0.0027 0.0013 0.0666
Echinococcus multilocularis SAM and MBT domain containing protein 0.0085 0.0073 0.0138
Trypanosoma cruzi cysteine peptidase, putative 0.0101 0.0089 0.0169
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0008 0.0014
Plasmodium vivax metacaspase 1, putative 0.0029 0.0016 0.2214
Brugia malayi RNA, U transporter 1 0.0054 0.0041 0.0041
Echinococcus multilocularis FTZ F1 alpha 0.0016 0.0002 0.0004
Brugia malayi Importin beta-1 subunit 0.0019 0.0005 0.0005
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.5179 0.5241 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0 0.0003
Echinococcus granulosus pyruvate kinase 0.0065 0.0052 0.0099
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0008 0.0044
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0031 0.0018 0.3419
Loa Loa (eye worm) hypothetical protein 0.0252 0.0241 0.0241
Mycobacterium ulcerans glutaminase 0.0188 0.0177 0.5402
Brugia malayi Pyruvate kinase, muscle isozyme 0.0065 0.0052 0.0052
Brugia malayi Calcitonin receptor-like protein seb-1 0.0179 0.0168 0.0168
Echinococcus multilocularis sentrin specific protease 7 0.0162 0.015 0.0286
Echinococcus multilocularis Niemann Pick C1 protein 0.0288 0.0279 0.0531
Schistosoma mansoni hypothetical protein 0.0059 0.0046 0.0327
Loa Loa (eye worm) hypothetical protein 0.0082 0.0069 0.0069
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.3133 0.3166 0.604
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0029 0.0016 0.1719
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0013 0.0719
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0046 0.0033 0.0103
Echinococcus multilocularis GPCR, family 2 0.0057 0.0044 0.0083
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0051 0.0037 0.0071
Mycobacterium ulcerans beta-lactamase 0.0082 0.0069 0.1984
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0036 0.0022 0.0022
Echinococcus granulosus muscleblind protein 0.0252 0.0241 0.046
Schistosoma mansoni zinc finger protein 0.0022 0.0008 0.0054
Brugia malayi hypothetical protein 0.0259 0.0249 0.0249
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0046 0.0033 0.0062
Onchocerca volvulus 0.002 0.0006 0.004
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0016
Loa Loa (eye worm) latrophilin receptor protein 2 0.0057 0.0044 0.0044
Chlamydia trachomatis DNA ligase 0.002 0.0007 0.1189
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0002 0.0004
Onchocerca volvulus 0.0035 0.0022 0.0152
Loa Loa (eye worm) hypothetical protein 0.0082 0.0069 0.0069
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0013 0.0666
Echinococcus granulosus expressed conserved protein 0.0189 0.0178 0.034
Mycobacterium tuberculosis Probable hydrolase 0.0082 0.0069 0.1255
Onchocerca volvulus 0.002 0.0006 0.004
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0002 0.0002
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.5179 0.5241 1
Mycobacterium leprae Probable lipase LipE 0.0082 0.0069 1
Onchocerca volvulus 0.0109 0.0097 0.0694
Leishmania major cathepsin L-like protease 0.0027 0.0013 0.0024
Mycobacterium ulcerans hypothetical protein 0.0082 0.0069 0.1984
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0002
Loa Loa (eye worm) TAR-binding protein 0.0149 0.0137 0.0137
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0016 0.0002 0.0004
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0002 0.0002
Brugia malayi hypothetical protein 0.0059 0.0046 0.0046
Trichomonas vaginalis ap endonuclease, putative 0.0031 0.0018 0.1002
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0 0.0003
Echinococcus granulosus tar DNA binding protein 0.0149 0.0137 0.0261
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0024 0.0011 0.5902
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0046 0.0033 0.1712
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3678 0.3719 0.7095
Echinococcus multilocularis pyruvate kinase 0.0033 0.002 0.0037
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0008 0.0014

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 12 ug ml-1 Antimicrobial activity against Candida albicans ChEMBL. 22632793
MIC (functional) = 21 ug ml-1 Antimicrobial activity against Escherichia coli ChEMBL. 22632793

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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