Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0476 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0468 | 0.9706 | 0.9706 |
Onchocerca volvulus | 0.0476 | 1 | 0.5 | |
Giardia lamblia | Hypothetical protein | 0.0281 | 0.2852 | 0.5 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0476 | 1 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0476 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0468 | 0.9706 | 0.9706 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0281 | 0.2852 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0476 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.9706 | 0.9604 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0468 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0476 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0281 | 0.2852 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0281 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0468 | 0.9706 | 0.9706 |
Mycobacterium ulcerans | hypothetical protein | 0.0281 | 0.2852 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0476 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 2.6 mg kg-1 | 50% inhibition of solid tumour growth (Sarcoma 180 cells) in mice | ChEMBL. | 7636865 |
ED50 (functional) | = 2.6 mg kg-1 | 50% inhibition of solid tumour growth (Sarcoma 180 cells) in mice | ChEMBL. | 7636865 |
IC50 ratio (functional) | = 3.2 | Inhibition of HeLa S3 cell growth relative to mitomycin C action (ratio of IC50 values) | ChEMBL. | 7636865 |
OD (functional) | = 5 mg kg-1 | Optimal dose was measured against sarcoma 180 cell in mice | ChEMBL. | 7636865 |
T/C (functional) | = 0.25 min | T/C value was measured as tumour volume in the treated versus control mice. | ChEMBL. | 7636865 |
T/C (functional) | = 0.25 min | T/C value was measured as tumour volume in the treated versus control mice. | ChEMBL. | 7636865 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.