Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3494 | 0.3494 |
Plasmodium vivax | thioredoxin reductase, putative | 0.005 | 0.2299 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.2332 | 0.2332 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.2332 | 0.2332 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3494 | 0.3494 |
Plasmodium falciparum | thioredoxin reductase | 0.005 | 0.2299 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0114 | 0.6806 | 0.8837 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.3494 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.2332 | 0.6674 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.3494 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0017 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.005 | 0.2299 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.2332 | 0.6674 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0114 | 0.6806 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0127 | 0.7701 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0114 | 0.6806 | 0.8837 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0114 | 0.6806 | 0.8837 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.3494 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0127 | 0.7701 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0017 | 0 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0127 | 0.7701 | 1 |
Brugia malayi | RNA binding protein | 0.0067 | 0.3494 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.005 | 0.2299 | 0.2985 |
Brugia malayi | glutathione reductase | 0.005 | 0.2299 | 0.658 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.2332 | 0.6674 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0114 | 0.6806 | 0.8837 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.005 | 0.2299 | 0.658 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.3494 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.2332 | 0.0275 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0127 | 0.7701 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.2332 | 0.6674 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.3494 | 1 |
Leishmania major | trypanothione reductase | 0.005 | 0.2299 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3494 | 0.3494 |
Trypanosoma brucei | trypanothione reductase | 0.005 | 0.2299 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.2332 | 0.6674 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0017 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0114 | 0.6806 | 0.8837 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.3494 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.2332 | 0.2332 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0017 | 0 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.005 | 0.2299 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.005 | 0.2299 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.005 | 0.2299 | 0.658 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0017 | 0 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.3494 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0017 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.005 | 0.2299 | 1 |
Brugia malayi | Thioredoxin reductase | 0.005 | 0.2299 | 0.658 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3494 | 0.3494 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3494 | 0.3494 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.