Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.2628 | 0.3259 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0.2628 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0474 | 0.1806 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0022 | 0.2628 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.2097 | 0.2097 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.2097 | 0.2601 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.2628 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0063 | 0.8861 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0474 | 0.1806 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0022 | 0.2628 | 0.5651 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0474 | 0.1806 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0474 | 0.1806 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0.2628 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 0.2628 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0474 | 0.1806 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0891 | 0.1916 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0584 | 0.1257 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.2097 | 0.2601 |
Echinococcus multilocularis | cpg binding protein | 0.0035 | 0.465 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0474 | 0.1806 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0474 | 0.1806 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.2628 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0584 | 0.1257 |
Echinococcus granulosus | cpg binding protein | 0.0035 | 0.465 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.5301 | 0.6575 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.5301 | 0.5301 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.5301 | 0.6575 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.8063 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0022 | 0.2628 | 0.5651 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.2628 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0474 | 0.1806 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.2097 | 0.2601 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.2628 | 1 |
Onchocerca volvulus | 0.0033 | 0.4363 | 1 | |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.2628 | 0.3259 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.2628 | 0.2628 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.2097 | 0.4509 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.2097 | 0.2601 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0474 | 0.1806 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0474 | 0.1806 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.2097 | 0.4509 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.2628 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.4363 | 0.4363 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0474 | 0.1806 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0474 | 0.1806 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.2628 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.2097 | 0.4509 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0474 | 0.1806 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0584 | 0.1257 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.2097 | 0.4509 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.2628 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.2628 | 0.2628 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0584 | 0.1257 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.2628 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0474 | 0.1806 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.2097 | 0.2097 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0474 | 0.1806 |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 0.2628 | 0.2966 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.2097 | 0.2097 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.2628 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.8063 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.465 | 0.465 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0474 | 0.1806 |
Brugia malayi | CXXC zinc finger family protein | 0.0033 | 0.4363 | 0.5411 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.2628 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.465 | 0.465 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0033 | 0.4363 | 0.5411 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0474 | 0.1806 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0056 | 0.0056 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0891 | 0.1105 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.2097 | 0.2097 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0584 | 0.0584 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.8063 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0891 | 0.1916 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.2097 | 0.4509 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.2097 | 0.4509 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0871 | 0.108 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0474 | 0.1806 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.8063 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.