Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0388 | 1 | 1 |
Trypanosoma brucei | aldo/keto reductase, putative | 0.0113 | 0.2449 | 0.2336 |
Giardia lamblia | Aldose reductase | 0.0388 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0388 | 1 | 1 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0113 | 0.2449 | 1 |
Onchocerca volvulus | 0.0388 | 1 | 1 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0603 | 0.0462 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0603 | 0.0462 |
Plasmodium vivax | aldehyde reductase, putative | 0.0113 | 0.2449 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0276 | 0.6921 | 0.6875 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0388 | 1 | 1 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0113 | 0.2449 | 0.2336 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0113 | 0.2449 | 0.2336 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0388 | 1 | 1 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0113 | 0.2449 | 0.2336 |
Leishmania major | aldo-keto reductase-like protein | 0.0388 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0603 | 0.0462 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0388 | 1 | 1 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0113 | 0.2449 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0388 | 1 | 1 |
Onchocerca volvulus | 0.0388 | 1 | 1 | |
Leishmania major | prostaglandin f synthase, putative | 0.0388 | 1 | 1 |
Onchocerca volvulus | 0.0388 | 1 | 1 | |
Giardia lamblia | Aldose reductase | 0.0388 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0303 | 0.7665 | 0.763 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0113 | 0.2449 | 0.2449 |
Echinococcus granulosus | aldo keto reductase | 0.0388 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0603 | 0.0462 |
Brugia malayi | RNA, U transporter 1 | 0.0081 | 0.158 | 0.1454 |
Loa Loa (eye worm) | oxidoreductase | 0.0388 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0388 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0388 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0113 | 0.2449 | 0.2449 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0113 | 0.2449 | 0.2449 |
Onchocerca volvulus | 0.0388 | 1 | 1 | |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0388 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0388 | 1 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0276 | 0.6921 | 0.6875 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0113 | 0.2449 | 0.2449 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0388 | 1 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0303 | 0.7665 | 0.763 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0388 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.2587 | 0.2477 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0388 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0388 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0388 | 1 | 1 |
Toxoplasma gondii | aldo-keto reductase | 0.0113 | 0.2449 | 0.2336 |
Toxoplasma gondii | aldo/keto reductase family oxidoreductase | 0.0113 | 0.2449 | 0.2336 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0388 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0603 | 0.0462 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0388 | 1 | 1 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0113 | 0.2449 | 1 |
Toxoplasma gondii | oxidoreductase, aldo/keto reductase family protein | 0.0113 | 0.2449 | 0.2336 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0388 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0388 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0388 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0388 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0388 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0388 | 1 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0388 | 1 | 1 |
Brugia malayi | NADH-dependent xylose reductase | 0.0113 | 0.2449 | 0.2336 |
Entamoeba histolytica | aldose reductase, putative | 0.0388 | 1 | 1 |
Onchocerca volvulus | 0.0388 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0388 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0388 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0388 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0388 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0603 | 0.0462 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0603 | 0.0462 |
Mycobacterium ulcerans | oxidoreductase | 0.0388 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0603 | 0.0462 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0388 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0388 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0388 | 1 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0303 | 0.7665 | 0.763 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0388 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0388 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0388 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0388 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0388 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0113 | 0.2449 | 0.2449 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0388 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0603 | 0.0462 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0303 | 0.7665 | 0.763 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0388 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0388 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0388 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0388 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0388 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0388 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0113 | 0.2449 | 0.2336 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0113 | 0.2449 | 0.2336 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0388 | 1 | 1 |
Onchocerca volvulus | 0.0388 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase | 0.0388 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0388 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0388 | 1 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0113 | 0.2449 | 0.2449 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0388 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0388 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0388 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0388 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0388 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0388 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0388 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0388 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0388 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0388 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0388 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.2587 | 0.2477 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0276 | 0.6921 | 0.5922 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0388 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0388 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0388 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0388 | 1 | 1 |
Leishmania major | aldo/keto reductase, putative,aldo/keto reductase family-like protein | 0.0113 | 0.2449 | 0.2449 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0113 | 0.2449 | 0.2449 |
Echinococcus multilocularis | aldo keto reductase | 0.0388 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0388 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0113 | 0.2449 | 0.2449 |
Schistosoma mansoni | potassium channel beta | 0.0113 | 0.2449 | 0.2336 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0388 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0388 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.2587 | 0.2477 |
Entamoeba histolytica | aldose reductase, putative | 0.0388 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | mM | In vitro inhibitory activity against sialyl Lewisx expressing HL60 cell binding to recombinant human E-selectin; ND indicates not determined | ChEMBL. | 8544173 |
IC50 (binding) | mM | In vitro inhibitory activity against sialyl Lewisx expressing HL60 cell binding Selectin P; ND indicates not determined | ChEMBL. | 8544173 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.