Detailed information for compound 1698136

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 667.776 | Formula: C32H41N7O7S
  • H donors: 6 H acceptors: 8 LogP: 1.8 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 3
  • SMILES: N#Cc1[nH]c2c(c1C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H]3N(C(=O)[C@H](NC1=O)CC(=O)O)CCC3)C(SC)(C)C)C(C)C)cccc2
  • InChi: 1S/C32H41N7O7S/c1-16(2)25-29(44)35-20(13-18-17-9-6-7-10-19(17)34-22(18)15-33)27(42)36-21(14-24(40)41)31(46)39-12-8-11-23(39)28(43)38-26(30(45)37-25)32(3,4)47-5/h6-7,9-10,16,20-21,23,25-26,34H,8,11-14H2,1-5H3,(H,35,44)(H,36,42)(H,37,45)(H,38,43)(H,40,41)/t20-,21+,23-,25+,26+/m0/s1
  • InChiKey: ZAKOLOWBBBGFHG-YHWCJKPGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Endothelin receptor ET-B Starlite/ChEMBL References
Homo sapiens endothelin receptor type B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Endothelin receptor ET-B   443 aa 392 aa 23.5 %
Onchocerca volvulus Endothelin receptor ET-B   443 aa 371 aa 20.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0011 0.0044
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0118 0.0244 0.024
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0104 0.0208 0.0425
Echinococcus multilocularis fmrfamide receptor 0.0512 0.1238 0.1731
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0059 0.0096 0.019
Loa Loa (eye worm) hypothetical protein 0.0046 0.0063 0.0058
Schistosoma mansoni microtubule-associated protein tau 0.2854 0.7152 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0009 0.0013
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0127 0.0266 0.0373
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0195 0.044 0.0615
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0024 0.0008 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0512 0.1238 0.1731
Schistosoma mansoni caspase-7 (C14 family) 0.0107 0.0217 0.0304
Brugia malayi cytochrome P450 0.0059 0.0096 0.0091
Echinococcus granulosus pyruvate kinase 0.0035 0.0036 0.0051
Toxoplasma gondii ion channel protein 0.0071 0.0126 0.307
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0065 0.011 0.0106
Onchocerca volvulus 0.0071 0.0126 0.0628
Brugia malayi glucose-6-phosphate dehydrogenase 0.0101 0.0201 0.0196
Toxoplasma gondii transporter, cation channel family protein 0.0074 0.0133 0.3262
Echinococcus granulosus BC026374 protein S09 family 0.0046 0.0063 0.0088
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Entamoeba histolytica hypothetical protein 0.0048 0.0068 0.0429
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0067 0.0094
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0053 0.0081 0.0113
Echinococcus granulosus cpg binding protein 0.0095 0.0185 0.0259
Onchocerca volvulus Huntingtin homolog 0.0126 0.0264 0.1356
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0024 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0011 0.0006
Onchocerca volvulus Cell death protein 3 homolog 0.0107 0.0217 0.111
Echinococcus granulosus fmrfamide receptor 0.0512 0.1238 0.1731
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0101 0.0201 0.8289
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.0147 0.0206
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0244 0.0563 0.0787
Echinococcus multilocularis caspase 2 0.0107 0.0217 0.0304
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.009 0.0086
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0512 0.1238 0.1731
Schistosoma mansoni hypothetical protein 0.1518 0.3779 0.5283
Plasmodium vivax pyruvate kinase, putative 0.0069 0.0121 0.5268
Schistosoma mansoni inositol monophosphatase 0.0039 0.0045 0.0062
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0512 0.1238 0.1234
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0059 0.0096 0.019
Brugia malayi ORL1-like opioid receptor 0.0512 0.1238 0.1234
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Brugia malayi Carboxylesterase family protein 0.0273 0.0635 0.063
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.0642 0.2932
Echinococcus multilocularis G protein coupled receptor 139 0.0512 0.1238 0.1731
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0045 0.004
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0127 0.0266 0.0373
Entamoeba histolytica hypothetical protein 0.0079 0.0147 0.0968
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0512 0.1238 0.6487
Echinococcus granulosus flap endonuclease 1 0.0059 0.0096 0.0134
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0512 0.1238 0.1731
Echinococcus multilocularis rhodopsin orphan GPCR 0.0512 0.1238 0.1731
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0244 0.0563 0.0787
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0057 0.2292
Echinococcus granulosus G protein coupled receptor 139 0.0512 0.1238 0.1731
Brugia malayi mothers against decapentaplegic homolog 3 0.0024 0.0007 0.0002
Schistosoma mansoni twik family of potassium channels-related 0.0071 0.0126 0.0176
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0066 0.2734
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0057 0.1283
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0026 0.0036
Schistosoma mansoni smad1 5 8 and 0.0053 0.0081 0.0113
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Onchocerca volvulus 0.0039 0.0045 0.0201
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0086 0.0121
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0086 0.205
Echinococcus granulosus neuropeptide receptor 0.0512 0.1238 0.1731
Schistosoma mansoni calcium-activated potassium channel 0.0071 0.0126 0.0176
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0067 0.1544
Brugia malayi putative neuropeptide receptor NPR1 0.0512 0.1238 0.1234
Echinococcus multilocularis dro:myosuppressin receptor 0.0512 0.1238 0.1731
Mycobacterium tuberculosis Conserved protein 0.008 0.0147 0.0298
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0071 0.0126 0.0121
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0067 0.0286
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0011 0.0006
Brugia malayi hypothetical protein 0.0512 0.1238 0.1234
Echinococcus granulosus tachykinin peptides receptor 99D 0.0512 0.1238 0.1731
Schistosoma mansoni neuropeptide F-like receptor 0.0512 0.1238 0.1731
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.009 0.0394
Brugia malayi beta-lactamase family protein 0.008 0.0147 0.0143
Onchocerca volvulus 0.0512 0.1238 0.6487
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0086 0.0121
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0071 0.0126 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0099 0.0198 0.0277
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0099 0.0198 0.0277
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.011 0.0224 0.022
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0107 0.0216 0.0974
Plasmodium falciparum potassium channel 0.0071 0.0126 0.5485
Schistosoma mansoni ran 0.0044 0.0057 0.0079
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0071 0.0126 0.0121
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0024 0.0008 0.0011
Brugia malayi Cell death protein 3 precursor 0.0107 0.0217 0.0213
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0512 0.1238 0.1731
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.008 0.0147 0.0143
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0082 0.0153 0.0681
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0101 0.0201 0.0902
Plasmodium vivax flap endonuclease 1, putative 0.0059 0.0096 0.4113
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0045 0.0184
Echinococcus multilocularis g-protein coupled receptor 0.0512 0.1238 0.1731
Leishmania major hypothetical protein, conserved 0.008 0.0147 0.0143
Echinococcus multilocularis sex peptide receptor 0.0512 0.1238 0.1731
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Brugia malayi jmjC domain containing protein 0.0036 0.0037 0.0032
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0066 0.0062
Echinococcus granulosus voltage dependent calcium channel 0.0127 0.0266 0.0373
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0126 0.0121
Echinococcus multilocularis mothers against decapentaplegic 2 0.0024 0.0007 0.0009
Echinococcus multilocularis geminin 0.1487 0.37 0.5173
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0512 0.1238 0.1731
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0068 0.0291
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0195 0.044 0.0615
Echinococcus granulosus potassium channel subfamily K 0.0071 0.0126 0.0176
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Entamoeba histolytica Ran family GTPase 0.0044 0.0057 0.0353
Echinococcus multilocularis lamin dm0 0.0124 0.0259 0.0362
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0045 0.0063
Brugia malayi MH2 domain containing protein 0.0024 0.0007 0.0002
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.002 0.0088
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0193 0.0435 0.0608
Echinococcus granulosus g protein coupled receptor 0.0512 0.1238 0.1731
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.0233 0.0326
Schistosoma mansoni gliotactin 0.0046 0.0063 0.0088
Schistosoma mansoni DNA polymerase eta 0.0023 0.0005 0.0007
Echinococcus granulosus serotonin transporter 0.0279 0.0652 0.0911
Onchocerca volvulus 0.0071 0.0126 0.0628
Schistosoma mansoni hypothetical protein 0.0035 0.0035 0.0049
Schistosoma mansoni hypothetical protein 0.0041 0.0049 0.0068
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.016 0.3949
Loa Loa (eye worm) G-protein coupled receptor 0.0512 0.1238 0.1234
Trypanosoma brucei pyruvate kinase 1 0.0069 0.0121 0.0116
Loa Loa (eye worm) mbt repeat family protein 0.0057 0.0091 0.0086
Chlamydia trachomatis recombinase RecA 0.0117 0.0241 1
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Brugia malayi Carboxylesterase family protein 0.0046 0.0063 0.0058
Onchocerca volvulus Pyruvate kinase homolog 0.0069 0.0121 0.0603
Brugia malayi MH2 domain containing protein 0.0053 0.0081 0.0076
Brugia malayi hypothetical protein 0.0041 0.0049 0.0044
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0086 0.3664
Trypanosoma brucei trypanothione reductase 0.0041 0.005 0.0045
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0057 0.0354
Schistosoma mansoni biogenic amine receptor 0.0512 0.1238 0.1731
Schistosoma mansoni sodium/chloride dependent transporter 0.0279 0.0652 0.0911
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Brugia malayi Probable ClpP-like protease 0.0084 0.016 0.0155
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0134 0.0284 0.0398
Mycobacterium ulcerans hypothetical protein 0.008 0.0147 0.0656
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0127 0.0266 0.0373
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0059 0.0096 0.019
Schistosoma mansoni opsin-like receptor 0.0512 0.1238 0.1731
Onchocerca volvulus Huntingtin homolog 0.0126 0.0264 0.1356
Echinococcus granulosus rhodopsin orphan GPCR 0.0512 0.1238 0.1731
Echinococcus granulosus hyperpolarization activated cyclic 0.0024 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.1518 0.3779 0.3776
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0007 0.0002
Loa Loa (eye worm) carboxylesterase 0.0273 0.0635 0.063
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.011 0.0223 0.1006
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0403 0.1832
Toxoplasma gondii hypothetical protein 0.0047 0.0066 0.153
Onchocerca volvulus 0.0512 0.1238 0.6487
Onchocerca volvulus 0.0512 0.1238 0.6487
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0066 0.0093
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Schistosoma mansoni lipoxygenase 0.0041 0.0049 0.0068
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.005 0.0094
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0011 0.0024
Echinococcus granulosus cytoplasmic intermediate filament protein 0.006 0.0097 0.0136
Brugia malayi Cyclic-nucleotide gated cation channel 0.0024 0.0008 0.0003
Brugia malayi CXXC zinc finger family protein 0.0089 0.0173 0.0168
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.016 0.0223
Loa Loa (eye worm) pyruvate kinase-PB 0.0048 0.0068 0.0064
Schistosoma mansoni cytochrome P450 0.0059 0.0096 0.0134
Loa Loa (eye worm) nuclear factor I 0.0029 0.0021 0.0016
Schistosoma mansoni P2X receptor subunit 0.007 0.0123 0.0173
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0512 0.1238 0.1234
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0089 0.0171 0.0166
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0059 0.0096 0.0418
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0059 0.0096 0.019
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0097 0.0191 0.8488
Mycobacterium tuberculosis Probable esterase LipL 0.008 0.0147 0.0298
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0104 0.0208 0.1207
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0071 0.0126 0.0121
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0046 0.0063 0.0088
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0512 0.1238 0.1731
Onchocerca volvulus 0.0279 0.0652 0.3399
Echinococcus granulosus acetylcholinesterase 0.0273 0.0635 0.0888
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0066 0.0093
Echinococcus granulosus p2X purinoceptor 4 0.007 0.0123 0.0173
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0093 0.0182 0.1049
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0096 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0403 0.1832
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0026 0.0011 0.0108
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0059 0.0096 0.0091
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0287 0.0671 0.3065
Loa Loa (eye worm) glutaminase 0.0884 0.2177 0.2174
Schistosoma mansoni hypothetical protein 0.1274 0.3164 0.4424
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.0226 0.0221
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.0226 0.0221
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0512 0.1238 0.1731
Entamoeba histolytica pyruvate kinase, putative 0.0048 0.0068 0.0432
Schistosoma mansoni neuropeptide F-like receptor 0.0512 0.1238 0.1731
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0071 0.0126 0.0121
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0101 0.0201 0.0196
Schistosoma mansoni hypothetical protein 0.0059 0.0096 0.0134
Onchocerca volvulus 0.0071 0.0126 0.0628
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0071 0.0126 0.0176
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0045 0.0968
Leishmania major ion transport protein-like protein 0.0071 0.0126 0.0121
Toxoplasma gondii thioredoxin reductase 0.0041 0.005 0.1101
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0195 0.044 0.0436
Onchocerca volvulus Glucosylceramidase homolog 0.0181 0.0403 0.2086
Brugia malayi MAP kinase sur-1 0.0057 0.009 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.044 0.0615
Onchocerca volvulus 0.0776 0.1905 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0134 0.0284 0.0398
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.0013 0.0018
Brugia malayi G-protein coupled receptor 0.0512 0.1238 0.1234
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0045 0.1602
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0512 0.1238 0.1731
Onchocerca volvulus 0.0041 0.0049 0.0223
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Echinococcus granulosus neuropeptide Y receptor 0.0512 0.1238 0.1731
Echinococcus granulosus carboxylesterase 5A 0.0273 0.0635 0.0888
Onchocerca volvulus 0.0512 0.1238 0.6487
Entamoeba histolytica hypothetical protein 0.0079 0.0147 0.0968
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0134 0.0284 0.028
Mycobacterium ulcerans beta-lactamase 0.008 0.0147 0.0656
Mycobacterium tuberculosis Probable hydrolase 0.008 0.0147 0.0298
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0012 0.0017
Schistosoma mansoni P2X receptor subunit 0.007 0.0123 0.0173
Brugia malayi MH2 domain containing protein 0.0781 0.1918 0.1914
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0071 0.0126 0.0121
Echinococcus multilocularis serotonin receptor 0.2345 0.5867 0.8203
Echinococcus multilocularis neuropeptide receptor 0.0512 0.1238 0.1731
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0512 0.1238 0.1731
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.1918 0.4788 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0063 0.0058
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0195 0.044 0.0436
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0275 0.0642 0.0637
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0047 0.0066 0.0093
Echinococcus multilocularis neuropeptide FF receptor 2 0.0512 0.1238 0.1731
Echinococcus multilocularis pyruvate kinase 0.0035 0.0036 0.0051
Brugia malayi Melatonin receptor type 1A 0.0512 0.1238 0.1234
Leishmania major sterol C-24 reductase, putative 0.0046 0.0063 0.0058
Treponema pallidum exodeoxyribonuclease (exoA) 0.0097 0.0191 0.125
Echinococcus multilocularis RUN 0.0041 0.0049 0.0068
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0101 0.0201 0.0281
Echinococcus granulosus dro:myosuppressin receptor 0.0512 0.1238 0.1731
Loa Loa (eye worm) carboxylesterase 0.0046 0.0063 0.0058
Brugia malayi jmjC domain containing protein 0.0036 0.0037 0.0032
Leishmania major protein kinase, putative 0.0025 0.0009 0.0004
Echinococcus granulosus pyruvate kinase 0.0035 0.0036 0.0051
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0512 0.1238 0.1731
Echinococcus multilocularis musashi 0.0124 0.0259 0.0362
Onchocerca volvulus 0.0512 0.1238 0.6487
Schistosoma mansoni histamine h1 receptor 0.0512 0.1238 0.1731
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0024 0.0008 0.0011
Loa Loa (eye worm) voltage-dependent calcium channel 0.0074 0.0133 0.0128
Loa Loa (eye worm) hypothetical protein 0.0057 0.0091 0.0086
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0045 0.0062
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0057 0.0052
Echinococcus multilocularis twik family of potassium channels 0.0071 0.0126 0.0176
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0089 0.0171 0.0166
Loa Loa (eye worm) hypothetical protein 0.0065 0.011 0.0106
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0066 0.0093
Schistosoma mansoni lamin 0.0124 0.0259 0.0362
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0066 0.0093
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0066 0.0113 0.2728
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0047 0.0066 0.0062
Brugia malayi Dopamine receptor protein 1 0.2709 0.6785 0.6783
Brugia malayi follicle stimulating hormone receptor 0.0512 0.1238 0.1234
Brugia malayi larval opioid receptor 0.0512 0.1238 0.1234
Loa Loa (eye worm) hypothetical protein 0.0041 0.0049 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0403 0.1832
Schistosoma mansoni amine GPCR 0.0512 0.1238 0.1731
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0922 0.2275 0.3181
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0074 0.0133 0.0128
Schistosoma mansoni voltage-gated potassium channel 0.0096 0.019 0.0265
Schistosoma mansoni alpha-1 adrenergic receptor 0.0512 0.1238 0.1731
Echinococcus multilocularis orexin receptor type 2 0.0512 0.1238 0.1731
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0066 0.0093
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Echinococcus multilocularis neuropeptide receptor 0.0512 0.1238 0.1731
Echinococcus multilocularis pyruvate kinase 0.0069 0.0121 0.0169
Loa Loa (eye worm) MH2 domain-containing protein 0.0781 0.1918 0.1914
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0059 0.0096 0.2302
Echinococcus granulosus lysine specific demethylase 6a 0.0036 0.0037 0.0051
Schistosoma mansoni ap endonuclease 0.0097 0.0191 0.0267
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0097 0.0191 0.0186
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0086 0.0082
Echinococcus granulosus neuropeptides capa receptor 0.0512 0.1238 0.1731
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0036 0.0037 0.0762
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0005 0.0007
Brugia malayi G-protein coupled receptor 0.0512 0.1238 0.1234
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0427 0.1945
Echinococcus granulosus voltage gated potassium channel 0.0032 0.0027 0.0037
Schistosoma mansoni twik family of potassium channels-related 0.0071 0.0126 0.0176
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0403 0.1832
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0086 0.3664
Schistosoma mansoni amine GPCR 0.0512 0.1238 0.1731
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Echinococcus multilocularis potassium channel subfamily K 8 0.0071 0.0126 0.0176
Echinococcus multilocularis rhodopsin orphan GPCR 0.0512 0.1238 0.1731
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0059 0.0096 0.019
Onchocerca volvulus 0.0046 0.0063 0.0296
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.0091 0.0127
Echinococcus multilocularis fmrfamide receptor 0.0512 0.1238 0.1731
Trypanosoma cruzi DNA repair protein, putative 0.0036 0.0037 0.0032
Echinococcus granulosus small conductance calcium activated potassium 0.1518 0.3779 0.5283
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0059 0.0096 0.0418
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0036 0.0037 0.0032
Schistosoma mansoni hypothetical protein 0.0025 0.0009 0.0013
Brugia malayi hypothetical protein 0.0071 0.0126 0.0121
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0067 0.2759
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0059 0.0096 0.0418
Loa Loa (eye worm) hypothetical protein 0.006 0.0099 0.0094
Plasmodium falciparum pyruvate kinase 0.0069 0.0121 0.5268
Loa Loa (eye worm) hypothetical protein 0.0036 0.0037 0.0032
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Loa Loa (eye worm) hypothetical protein 0.045 0.1082 0.1078
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0147 0.0656
Toxoplasma gondii pyruvate kinase PyKII 0.0035 0.0036 0.075
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0071 0.0126 0.0253
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Brugia malayi Smad1 0.0053 0.0081 0.0076
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.276 0.6914 0.9667
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0071 0.0126 0.0121
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0057 0.0079
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0066 0.0093
Echinococcus granulosus neuropeptide Y receptor 0.0512 0.1238 0.1731
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0512 0.1238 0.1731
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.0356 0.0497
Loa Loa (eye worm) hypothetical protein 0.0279 0.0652 0.0647
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0089 0.0171 0.0239
Mycobacterium tuberculosis Probable dehydrogenase 0.0093 0.0182 0.037
Mycobacterium leprae putative cytochrome p450 0.0059 0.0096 0.0531
Schistosoma mansoni calcium-activated potassium channel 0.1385 0.3443 0.4814
Echinococcus granulosus neuropeptide receptor 0.0512 0.1238 0.1731
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0071 0.0126 0.0121
Echinococcus granulosus potassium channel subfamily K 8 0.0071 0.0126 0.0176
Echinococcus granulosus 7TM GPCR rhodopsin 0.0512 0.1238 0.1731
Echinococcus multilocularis JmjC domain containing protein 4 0.0036 0.0037 0.0051
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0118 0.0244 0.0342
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0066 0.0093
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0059 0.0096 0.0418
Loa Loa (eye worm) melatonin receptor type 1A 0.0512 0.1238 0.1234
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0059 0.0096 0.0418
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0024 0.0008 0.0011
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0059 0.0096 0.0418
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0059 0.0096 0.0091
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0071 0.0126 0.0121
Brugia malayi GnHR receptor homolog 0.0512 0.1238 0.1234
Loa Loa (eye worm) hypothetical protein 0.0047 0.0066 0.0062
Mycobacterium leprae conserved hypothetical protein 0.008 0.0147 0.0842
Loa Loa (eye worm) hypothetical protein 0.0177 0.0393 0.0388
Loa Loa (eye worm) acetylcholinesterase 1 0.0273 0.0635 0.063
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.005 0.0045
Brugia malayi Muscleblind-like protein 0.0177 0.0393 0.0388
Echinococcus granulosus muscleblind protein 0.0177 0.0393 0.0549
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0512 0.1238 0.1731
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0127 0.0266 0.0373
Plasmodium falciparum thioredoxin reductase 0.0041 0.005 0.1967
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.016 0.0223
Trypanosoma brucei calcium-activated potassium channel, putative 0.0071 0.0126 0.0121
Loa Loa (eye worm) hypothetical protein 0.0059 0.0096 0.0092
Echinococcus multilocularis twik family of potassium channels 0.0071 0.0126 0.0176
Mycobacterium ulcerans pyruvate kinase 0.0069 0.0121 0.0535
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0066 0.0093
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0059 0.0096 0.0091
Schistosoma mansoni hypothetical protein 0.0071 0.0126 0.0176
Loa Loa (eye worm) hypothetical protein 0.0279 0.0652 0.0647
Schistosoma mansoni biogenic amine receptor 0.0512 0.1238 0.1731
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0512 0.1238 0.1731
Echinococcus granulosus biogenic amine 5HT receptor 0.0922 0.2275 0.3181
Loa Loa (eye worm) hypothetical protein 0.0074 0.0133 0.0128
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0035 0.003
Trichomonas vaginalis spcc417.12 protein, putative 0.0046 0.0063 0.0267
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0007 0.0011
Schistosoma mansoni hypothetical protein 0.0079 0.0147 0.0206
Brugia malayi Pre-SET motif family protein 0.0682 0.1668 0.1664
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0024 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0176 0.0392 0.0387
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0147 0.0656
Echinococcus multilocularis neuropeptide s receptor 0.0512 0.1238 0.1731
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0068 0.0291
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0097 0.0191 0.0856
Leishmania major hypothetical protein, conserved 0.0036 0.0037 0.0032
Loa Loa (eye worm) hypothetical protein 0.006 0.0097 0.0093
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0026 0.0036
Mycobacterium leprae Conserved hypothetical protein 0.0684 0.1672 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0057 0.0079
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0066 0.0093
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0066 0.0093
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.0013 0.0018
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.0356 0.0351
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0071 0.0126 0.0121
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Toxoplasma gondii pyruvate kinase PyK1 0.0069 0.0121 0.2948
Echinococcus multilocularis neuropeptide receptor A26 0.0512 0.1238 0.1731
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0117 0.0241 0.1403
Onchocerca volvulus 0.0512 0.1238 0.6487
Schistosoma mansoni hypothetical protein 0.0035 0.0035 0.0049
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0093 0.0182 0.037
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0011 0.0013
Plasmodium vivax amine transporter, putative 0.0047 0.0066 0.2734
Onchocerca volvulus 0.0047 0.0066 0.0314
Onchocerca volvulus 0.0512 0.1238 0.6487
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0011 0.0006
Brugia malayi Cytochrome P450 family protein 0.0107 0.0216 0.0212
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.0126 0.0557
Loa Loa (eye worm) hypothetical protein 0.0035 0.0035 0.003
Loa Loa (eye worm) flap endonuclease-1 0.0059 0.0096 0.0091
Echinococcus granulosus rhodopsin orphan GPCR 0.0512 0.1238 0.1731
Loa Loa (eye worm) intermediate filament protein 0.0124 0.0259 0.0254
Echinococcus granulosus neuropeptide s receptor 0.0512 0.1238 0.1731
Loa Loa (eye worm) hypoxia-induced factor 1 0.0163 0.0357 0.0352
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.0642 0.2932
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0127 0.0266 0.0373
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0059 0.0096 0.019
Brugia malayi jmjC domain containing protein 0.0134 0.0284 0.028
Echinococcus granulosus smad 0.0053 0.0081 0.0113
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0147 0.0656
Onchocerca volvulus Pyruvate kinase homolog 0.0069 0.0121 0.0603
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0012 0.0017
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0512 0.1238 0.1234
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0066 0.0113 0.0496
Brugia malayi MH1 domain containing protein 0.0053 0.0081 0.0076
Echinococcus granulosus lamin b receptor 0.0046 0.0063 0.0089
Echinococcus granulosus mothers against decapentaplegic 6 0.0024 0.0007 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0512 0.1238 0.1731
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.009 0.0086
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0011 0.0024
Loa Loa (eye worm) MBCTL1 0.0065 0.011 0.0106
Schistosoma mansoni hypothetical protein 0.0035 0.0035 0.0049
Schistosoma mansoni lamin 0.0124 0.0259 0.0362
Echinococcus multilocularis voltage gated potassium channel 0.0032 0.0027 0.0037
Mycobacterium ulcerans glutaminase 0.0884 0.2177 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0011 0.003
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0059 0.0096 0.019
Schistosoma mansoni opsin-like receptor 0.0512 0.1238 0.1731
Echinococcus multilocularis flap endonuclease 1 0.0059 0.0096 0.0134
Schistosoma mansoni P2X receptor subunit 0.007 0.0123 0.0173
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0162 0.0227
Echinococcus multilocularis g protein coupled receptor 0.0512 0.1238 0.1731
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Loa Loa (eye worm) hypothetical protein 0.008 0.0147 0.0143
Brugia malayi hypothetical protein 0.0071 0.0126 0.0121
Echinococcus multilocularis neuropeptide Y receptor 0.0512 0.1238 0.1731
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0059 0.0096 0.0418
Loa Loa (eye worm) hypothetical protein 0.0046 0.0063 0.0058
Onchocerca volvulus 0.0512 0.1238 0.6487
Leishmania major hypothetical protein, conserved 0.0071 0.0126 0.0121
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0066 0.0062
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0024 0.0008 0.0003
Loa Loa (eye worm) CYP4Cod1 0.0107 0.0216 0.0212
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0127 0.0266 0.0373
Brugia malayi hypothetical protein 0.0041 0.0049 0.0044
Echinococcus granulosus histone acetyltransferase KAT2B 0.0157 0.0344 0.0481
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0071 0.0126 0.0121
Echinococcus granulosus Smad4 0.0053 0.0081 0.0113
Schistosoma mansoni neuropeptide receptor 0.0512 0.1238 0.1731
Loa Loa (eye worm) serotonin transporter b 0.0279 0.0652 0.0647
Echinococcus multilocularis voltage dependent calcium channel 0.0127 0.0266 0.0373
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0041 0.005 0.0069
Brugia malayi Intermediate filament tail domain containing protein 0.0124 0.0259 0.0254
Plasmodium falciparum flap endonuclease 1 0.0059 0.0096 0.4113
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0049 0.0068
Toxoplasma gondii ion channel protein 0.0071 0.0126 0.307
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0512 0.1238 0.1731
Loa Loa (eye worm) uncoordinated protein 58 0.0071 0.0126 0.0121
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0059 0.0096 0.0418
Brugia malayi Thioredoxin reductase 0.0041 0.005 0.0045
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0059 0.0096 0.019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0512 0.1238 0.1731
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.016 0.6533
Mycobacterium leprae Probable pyruvate kinase PykA 0.0069 0.0121 0.0684
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0008 0.0011
Schistosoma mansoni ran 0.0044 0.0057 0.0079
Loa Loa (eye worm) pyruvate kinase 0.0069 0.0121 0.0116
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.016 0.0916
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Echinococcus granulosus jumonji domain containing 1A 0.0036 0.0037 0.0051
Schistosoma mansoni smad1 5 8 and 0.0053 0.0081 0.0113
Echinococcus granulosus neuroligin 0.0046 0.0063 0.0088
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0059 0.0096 0.0091
Schistosoma mansoni Lamin B receptor (ERG24) 0.0046 0.0063 0.0089
Echinococcus multilocularis apoptotic protease activating factor 1 0.0086 0.0164 0.0229
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0057 0.0091 0.0127
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.1801 0.4494 0.9385
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0071 0.0126 0.0176
Loa Loa (eye worm) hypothetical protein 0.0055 0.0086 0.0082
Schistosoma mansoni amine GPCR 0.0903 0.2227 0.3113
Echinococcus multilocularis potassium channel subfamily K 8 0.0071 0.0126 0.0176
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.016 0.7056
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0071 0.0126 0.0121
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0097 0.0191 0.7859
Onchocerca volvulus 0.0512 0.1238 0.6487
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0512 0.1238 0.1731
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.0642 0.2932
Onchocerca volvulus 0.0512 0.1238 0.6487
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0066 0.153
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0512 0.1238 0.1234
Toxoplasma gondii hypothetical protein 0.006 0.0099 0.2374
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0024 0.0008 0.0011
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0005 0.0007
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0097 0.0191 0.1264
Leishmania major hypothetical protein, conserved 0.0055 0.0086 0.0082
Trypanosoma cruzi cytochrome P450, putative 0.0107 0.0216 0.0212
Toxoplasma gondii exonuclease III APE 0.0097 0.0191 0.475
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0118 0.0244 0.0342
Brugia malayi Dopamine receptor protein 2 0.0512 0.1238 0.1234
Echinococcus granulosus potassium channel subfamily K 8 0.0071 0.0126 0.0176
Echinococcus multilocularis g protein coupled receptor 0.0512 0.1238 0.1731
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.008 0.0147 0.0298
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0066 0.0093
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0045 0.0062
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0059 0.0096 0.019
Schistosoma mansoni biogenic amine (5HT) receptor 0.0922 0.2275 0.3181
Echinococcus multilocularis rhodopsin orphan GPCR 0.0512 0.1238 0.1731
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0279 0.0652 0.0911
Echinococcus multilocularis calcium activated potassium channel variant 0.0071 0.0126 0.0176
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0057 0.2296
Schistosoma mansoni sodium-dependent amino acid transporter 0.0047 0.0066 0.0093
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0071 0.0126 0.0176
Echinococcus granulosus caspase 2 0.0107 0.0217 0.0304
Loa Loa (eye worm) hypothetical protein 0.0036 0.0037 0.0032
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0512 0.1238 0.1731
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.011 0.0223 0.5596
Treponema pallidum sodium- and chloride- dependent transporter 0.0279 0.0652 0.439
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0051 0.0071
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0124 0.0259 0.0254
Schistosoma mansoni phd/f-box containing protein 0.0036 0.0037 0.0051
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0057 0.0052
Loa Loa (eye worm) hypothetical protein 0.0024 0.0008 0.0003
Leishmania major potassium channel subunit-like protein 0.0071 0.0126 0.0121
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Onchocerca volvulus 0.0046 0.0063 0.0296
Brugia malayi hypothetical protein 0.0512 0.1238 0.1234
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0059 0.0096 0.019
Echinococcus multilocularis histone acetyltransferase MYST2 0.0065 0.011 0.0154
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0074 0.0133 0.0128
Schistosoma mansoni smad 0.0053 0.0081 0.0113
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.0147 0.0206
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0082 0.0153 0.0681
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.0049 0.0068
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0045 0.004
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Echinococcus granulosus hypothetical protein 0.0512 0.1238 0.1731
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0606 0.1476 0.677
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0067 0.1544
Loa Loa (eye worm) hypothetical protein 0.0084 0.016 0.0155
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0512 0.1238 0.1731
Echinococcus granulosus serotonin receptor 0.0512 0.1238 0.1731
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0099 0.0198 0.0277
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0134 0.0284 0.028
Brugia malayi hypothetical protein 0.0512 0.1238 0.1234
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.009 0.2152
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0275 0.0642 0.0637
Entamoeba histolytica hypothetical protein 0.0079 0.0147 0.0968
Plasmodium vivax JmjC domain containing protein 0.0036 0.0037 0.1363
Schistosoma mansoni smad1 5 8 and 0.0053 0.0081 0.0113
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0071 0.0126 0.0121
Plasmodium falciparum pyruvate kinase 2 0.0035 0.0036 0.134
Mycobacterium tuberculosis Conserved protein 0.008 0.0147 0.0298
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0512 0.1238 0.1731
Plasmodium falciparum importin beta, putative 0.0059 0.0096 0.4119
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0045 0.004
Schistosoma mansoni hypothetical protein 0.0076 0.0138 0.0193
Echinococcus granulosus snurportin 1 0.0633 0.1545 0.2159
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0066 0.0093
Schistosoma mansoni neuropeptide receptor 0.0512 0.1238 0.1731
Echinococcus multilocularis transcription factor Dp 1 0.0077 0.0142 0.0199
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0138 0.0133
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0101 0.0201 0.1319
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0036 0.0037 0.0032
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0127 0.0266 0.0373
Leishmania major calcium/potassium channel (CAKC), putative 0.0071 0.0126 0.0121
Schistosoma mansoni neuropeptide receptor 0.0512 0.1238 0.1731
Echinococcus multilocularis SAM and MBT domain containing protein 0.0057 0.0091 0.0127
Plasmodium vivax potassium channel, putative 0.0071 0.0126 0.5485
Plasmodium falciparum transporter, putative 0.0047 0.0066 0.2734
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0059 0.0096 0.0418
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0066 0.0062
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0114 0.0235 0.1567
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0117 0.0241 1
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0096 0.2305
Loa Loa (eye worm) hypothetical protein 0.006 0.0099 0.0094
Loa Loa (eye worm) TWK-7 protein 0.0071 0.0126 0.0121
Brugia malayi jmjC domain containing protein 0.0139 0.0297 0.0293
Loa Loa (eye worm) hypothetical protein 0.0026 0.0011 0.0006
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0097 0.0191 0.8488
Onchocerca volvulus 0.0071 0.0126 0.0628
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0063 0.0121
Loa Loa (eye worm) hypothetical protein 0.0078 0.0144 0.014
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.016 0.1039
Echinococcus granulosus g protein coupled receptor 0.0512 0.1238 0.1731
Loa Loa (eye worm) hypothetical protein 0.0127 0.0266 0.0262
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1542 0.384 0.5368
Loa Loa (eye worm) G-protein coupled receptor 0.0512 0.1238 0.1234
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0024 0.0008 0.0011
Trypanosoma brucei C-14 sterol reductase, putative 0.0046 0.0063 0.0058
Echinococcus granulosus voltage dependent calcium channel 0.0074 0.0133 0.0186
Loa Loa (eye worm) hypothetical protein 0.0178 0.0397 0.0392
Loa Loa (eye worm) hypothetical protein 0.008 0.0147 0.0143
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0066 0.0093
Plasmodium falciparum amino acid transporter, putative 0.0047 0.0066 0.2734
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Mycobacterium ulcerans esterase/lipase LipP 0.008 0.0147 0.0656
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0195 0.044 0.0615
Echinococcus granulosus tm gpcr rhodopsin 0.1542 0.384 0.5368
Loa Loa (eye worm) jmjC domain-containing protein 0.0139 0.0297 0.0293
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0011 0.003
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0512 0.1238 0.1731
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0036 0.0037 0.0032
Echinococcus multilocularis pyruvate kinase 0.0035 0.0036 0.0051
Echinococcus granulosus rhodopsin orphan GPCR 0.0512 0.1238 0.1731
Schistosoma mansoni myelin transcription factor 1 myt1 0.0065 0.011 0.0154
Echinococcus granulosus polycomb protein SCMH1 0.0057 0.0091 0.0127
Loa Loa (eye worm) hypothetical protein 0.0086 0.0164 0.0159
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0059 0.0096 0.019
Echinococcus multilocularis hyperpolarization activated cyclic 0.0024 0.0008 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.008 0.0147 0.0143
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0162 0.0157
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0097 0.0191 0.1264
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Plasmodium falciparum JmjC domain-containing protein, putative 0.0036 0.0037 0.1363
Brugia malayi Carboxylesterase family protein 0.0046 0.0063 0.0058
Echinococcus granulosus importin subunit beta 1 0.0059 0.0096 0.0135
Brugia malayi hypothetical protein 0.0176 0.0392 0.0387
Echinococcus granulosus neuropeptide receptor A26 0.0512 0.1238 0.1731
Echinococcus granulosus histone lysine methyltransferase setb 0.0099 0.0198 0.0277
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0512 0.1238 0.1731
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0059 0.0096 0.0418
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0071 0.0126 0.0121
Loa Loa (eye worm) hypothetical protein 0.008 0.0147 0.0143
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.016 0.7056
Loa Loa (eye worm) Smad1 0.0053 0.0081 0.0076
Loa Loa (eye worm) hypothetical protein 0.0107 0.0217 0.0213
Brugia malayi hypothetical protein 0.0512 0.1238 0.1234
Echinococcus granulosus alpha 1A adrenergic receptor 0.0512 0.1238 0.1731
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0147 0.0206
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0059 0.0096 0.019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0512 0.1238 0.1731
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0059 0.0096 0.019
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Trypanosoma brucei pyruvate kinase 1, putative 0.0069 0.0121 0.0116
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0066 0.153
Loa Loa (eye worm) cytochrome P450 family protein 0.0107 0.0216 0.0212
Onchocerca volvulus 0.0046 0.0063 0.0296
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.016 0.6533
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0057 0.0353
Echinococcus multilocularis smad 0.0053 0.0081 0.0113
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.0642 0.2932
Loa Loa (eye worm) hypothetical protein 0.0047 0.0066 0.0062
Onchocerca volvulus 0.0512 0.1238 0.6487
Schistosoma mansoni single-minded 0.0053 0.0079 0.0111
Echinococcus multilocularis 0.0059 0.0096 0.0134
Loa Loa (eye worm) hypothetical protein 0.008 0.0147 0.0143
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0099 0.0198 0.0277
Echinococcus multilocularis p2X purinoceptor 4 0.007 0.0123 0.0173
Echinococcus multilocularis rhodopsin orphan GPCR 0.0512 0.1238 0.1731
Echinococcus granulosus SAM and MBT domain containing protein 0.0057 0.0091 0.0127
Leishmania major hypothetical protein, conserved 0.0071 0.0126 0.0121
Brugia malayi hypothetical protein 0.0512 0.1238 0.1234
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0127 0.0266 0.0373
Brugia malayi hypothetical protein 0.0086 0.0164 0.0159
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0057 0.2292
Chlamydia trachomatis pyruvate kinase 0.0069 0.0121 0.4877
Brugia malayi hypoxia-induced factor 1 0.0163 0.0357 0.0352
Schistosoma mansoni calcium-activated potassium channel 0.0071 0.0126 0.0176
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.008 0.0147 0.0143
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0035 0.003
Loa Loa (eye worm) hypothetical protein 0.2345 0.5867 0.5865
Loa Loa (eye worm) hypothetical protein 0.0047 0.0066 0.0062
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0059 0.0096 0.0091
Loa Loa (eye worm) hypothetical protein 0.008 0.0147 0.0143
Echinococcus multilocularis potassium channel subfamily K 0.0071 0.0126 0.0176
Echinococcus multilocularis phd:f box containing protein 0.0036 0.0037 0.0051
Schistosoma mansoni flap endonuclease-1 0.0054 0.0082 0.0114
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0035 0.0049
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0097 0.0191 0.0186
Mycobacterium tuberculosis Carboxylesterase LipT 0.0046 0.0063 0.0121
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0045 0.0271
Brugia malayi hypothetical protein 0.0055 0.0086 0.0082
Schistosoma mansoni hypothetical protein 0.0633 0.1545 0.2159
Schistosoma mansoni opsin-like receptor 0.0512 0.1238 0.1731
Loa Loa (eye worm) hypothetical protein 0.0047 0.0066 0.0062
Loa Loa (eye worm) pyruvate kinase 0.0069 0.0121 0.0116
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0606 0.1476 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0099 0.0198 0.4931
Echinococcus granulosus rhodopsin orphan GPCR 0.0512 0.1238 0.1731
Brugia malayi Inositol-1 0.0039 0.0045 0.004
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0067 0.0286
Leishmania major cytochrome p450-like protein 0.0059 0.0096 0.0091
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0403 0.1832
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0096 0.0092
Schistosoma mansoni jumonji/arid domain-containing protein 0.0139 0.0297 0.0416
Leishmania major pyruvate kinase 0.0069 0.0121 0.0116
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0032 0.0027 0.0037
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0007 0.0011
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0402 0.0961 0.6504
Giardia lamblia Pyruvate kinase 0.0069 0.0121 0.0791
Onchocerca volvulus 0.0046 0.0063 0.0296
Brugia malayi neuropeptide F receptor 0.0512 0.1238 0.1234
Plasmodium vivax glutathione reductase, putative 0.0041 0.005 0.1967
Onchocerca volvulus 0.0512 0.1238 0.6487
Loa Loa (eye worm) hypothetical protein 0.0069 0.0121 0.0116
Echinococcus granulosus biogenic amine 5HT receptor 0.2345 0.5867 0.8203
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0512 0.1238 0.1731
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0036 0.0037 0.0762
Schistosoma mansoni adenoreceptor 0.0512 0.1238 0.1731
Brugia malayi hypothetical protein 0.0512 0.1238 0.1234
Brugia malayi Doublecortin family protein 0.0041 0.0049 0.0044
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Trichomonas vaginalis ran, putative 0.0044 0.0057 0.0239
Loa Loa (eye worm) hypothetical protein 0.0361 0.0858 0.0854
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0026 0.0012 0.0017
Schistosoma mansoni amine GPCR 0.0512 0.1238 0.1731
Schistosoma mansoni twik family of potassium channels-related 0.0071 0.0126 0.0176
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0047 0.0066 0.0093
Brugia malayi putative neuropeptide receptor 0.0512 0.1238 0.1234
Loa Loa (eye worm) glutaminase 2 0.0884 0.2177 0.2174
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.005 0.0045
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0059 0.0096 0.0418
Toxoplasma gondii hypothetical protein 0.0047 0.0066 0.153
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0147 0.0656
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0086 0.0082
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0037 0.0032
Trichomonas vaginalis flap endonuclease-1, putative 0.0059 0.0096 0.042
Onchocerca volvulus 0.0512 0.1238 0.6487
Leishmania major importin beta-1 subunit, putative 0.0048 0.0068 0.0063
Echinococcus granulosus mixed lineage leukemia protein mll 0.0026 0.0012 0.0017
Echinococcus granulosus somatostatin receptor 0.0512 0.1238 0.1731
Schistosoma mansoni ap endonuclease 0.0097 0.0191 0.0267
Echinococcus granulosus sex peptide receptor 0.0512 0.1238 0.1731
Onchocerca volvulus 0.0089 0.0173 0.0874
Echinococcus granulosus calcium activated potassium channel variant 0.0071 0.0126 0.0176
Mycobacterium ulcerans ion transport protein 0.0071 0.0126 0.0557
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Trypanosoma cruzi ion transport protein, putative 0.0071 0.0126 0.0121
Brugia malayi hypothetical protein 0.0361 0.0858 0.0854
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0512 0.1238 0.1731
Echinococcus multilocularis pyruvate kinase 0.0035 0.0036 0.0051
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0011 0.0044
Echinococcus multilocularis lamin b receptor 0.0046 0.0063 0.0089
Echinococcus granulosus pyruvate kinase 0.0035 0.0036 0.0051
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0059 0.0096 0.0091
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0024 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0024 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Echinococcus multilocularis serotonin receptor 0.2345 0.5867 0.8203
Schistosoma mansoni Smad4 0.0024 0.0007 0.0009
Mycobacterium ulcerans lipase LipD 0.008 0.0147 0.0656
Brugia malayi jmjC domain containing protein 0.0036 0.0037 0.0032
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0066 0.0114 0.0109
Echinococcus multilocularis pyruvate kinase 0.0069 0.0121 0.0169
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.0356 0.0497
Schistosoma mansoni hypothetical protein 0.1487 0.37 0.5173
Schistosoma mansoni phosphatidylserine receptor 0.0036 0.0037 0.0051
Schistosoma mansoni pyruvate kinase 0.0069 0.0121 0.0169
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0606 0.1476 0.677
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0071 0.0126 0.0121
Brugia malayi Carboxylesterase family protein 0.0046 0.0063 0.0058
Brugia malayi hypothetical protein 0.0046 0.0063 0.0058
Loa Loa (eye worm) histone methyltransferase 0.0031 0.0026 0.0021
Brugia malayi beta-lactamase family protein 0.008 0.0147 0.0143
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0011 0.0044
Schistosoma mansoni cpg binding protein 0.0095 0.0185 0.0259
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0036 0.0037 0.0032
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0118 0.0244 0.024
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0057 0.0052
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0059 0.0096 0.0418
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0093 0.0182 0.037
Loa Loa (eye worm) TWK-28 protein 0.0071 0.0126 0.0121
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0032 0.0027 0.0022
Loa Loa (eye worm) hypothetical protein 0.073 0.1789 0.1786
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0007 0.0002
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0032 0.0027 0.0037
Giardia lamblia Pyruvate kinase 0.0035 0.0036 0.0213
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0512 0.1238 0.1234
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0066 0.0093
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.0284 0.028
Echinococcus multilocularis hyperpolarization activated cyclic 0.0024 0.0008 0.0011
Brugia malayi mbt repeat family protein 0.0057 0.0091 0.0086
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0079 0.0111
Echinococcus granulosus para nitrobenzyl esterase 0.0046 0.0063 0.0088
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0035 0.003
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0512 0.1238 0.1731
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0071 0.0126 0.0121
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0041 0.005 0.0069
Echinococcus multilocularis cpg binding protein 0.0095 0.0185 0.0259
Echinococcus granulosus microtubule associated protein 2 0.2854 0.7152 1
Echinococcus granulosus single minded 2 0.0046 0.0063 0.0089
Trypanosoma cruzi pyruvate kinase 2, putative 0.0069 0.0121 0.0116
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0068 0.0291
Loa Loa (eye worm) hypothetical protein 0.3982 1 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.0264 0.0259
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0071 0.0126 0.0121
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0512 0.1238 0.1731
Loa Loa (eye worm) hypothetical protein 0.0273 0.0635 0.063
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0633 0.1545 0.154
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0147 0.0143
Echinococcus multilocularis neuroligin 0.0046 0.0063 0.0088
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0071 0.0126 0.0121
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.011 0.0223 0.1006
Echinococcus multilocularis dnaJ subfamily B 0.1274 0.3164 0.4424
Onchocerca volvulus 0.008 0.0147 0.0742
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.0284 0.028
Onchocerca volvulus Pyruvate kinase homolog 0.0069 0.0121 0.0603
Echinococcus multilocularis rhodopsin orphan GPCR 0.0512 0.1238 0.1731
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0096 0.0135
Schistosoma mansoni calcium-activated potassium channel 0.1518 0.3779 0.5283
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0606 0.1476 0.677
Entamoeba histolytica hypothetical protein 0.0079 0.0147 0.0968
Schistosoma mansoni cpg binding protein 0.0089 0.0173 0.0241
Schistosoma mansoni hypothetical protein 0.0035 0.0035 0.0049
Echinococcus multilocularis snurportin 1 0.0633 0.1545 0.2159
Brugia malayi G protein-coupled receptor 0.0512 0.1238 0.1234
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0011 0.0006
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0101 0.0201 0.0281
Loa Loa (eye worm) calcium channel 0.0127 0.0266 0.0262
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0059 0.0096 0.0418
Loa Loa (eye worm) hypothetical protein 0.0273 0.0635 0.063
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0012 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.0642 0.2932
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0035 0.0035 0.0063
Echinococcus granulosus JmjC domain containing protein 4 0.0036 0.0037 0.0051
Echinococcus granulosus GPCR family 2 0.0035 0.0035 0.0049
Schistosoma mansoni jumonji domain containing protein 0.0036 0.0037 0.0051
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0057 0.0091 0.0442
Brugia malayi cytoplasmic intermediate filament protein 0.0066 0.0114 0.0109
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0512 0.1238 0.1731
Brugia malayi Pre-SET motif family protein 0.0099 0.0198 0.0193
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0101 0.0201 0.0196
Echinococcus granulosus histone acetyltransferase MYST2 0.0065 0.011 0.0154
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0005 0.0007
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.0049 0.1931
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0097 0.0191 0.0186
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0101 0.0201 0.0281
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.002 0.0077
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0036 0.0037 0.0051
Entamoeba histolytica Flap nuclease, putative 0.0059 0.0096 0.0621
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0097 0.0191 0.0267
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0053 0.0081 0.0113
Schistosoma mansoni twik family of potassium channels-related 0.0071 0.0126 0.0176
Schistosoma mansoni twik family of potassium channels-related 0.0071 0.0126 0.0176
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0403 0.1832
Echinococcus multilocularis G-protein coupled receptor, putative 0.0512 0.1238 0.1731
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0047 0.0066 0.0093
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Mycobacterium tuberculosis Conserved protein 0.008 0.0147 0.0298
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0178 0.0397 0.2664
Trichomonas vaginalis ap endonuclease, putative 0.0097 0.0191 0.0856
Brugia malayi Importin beta-1 subunit 0.0059 0.0096 0.0092
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0134 0.0284 0.0398
Mycobacterium tuberculosis Probable conserved lipoprotein 0.008 0.0147 0.0298
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0059 0.0096 0.0091
Onchocerca volvulus 0.0046 0.0063 0.0296
Echinococcus granulosus dna polymerase kappa 0.0023 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0011 0.0006
Brugia malayi hypothetical protein 0.0512 0.1238 0.1234
Brugia malayi sulfakinin receptor protein 0.0512 0.1238 0.1234
Loa Loa (eye worm) hypothetical protein 0.0177 0.0393 0.0388
Loa Loa (eye worm) hypothetical protein 0.0046 0.0063 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0606 0.1476 0.677
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0162 0.0227
Giardia lamblia Flap structure-specific endonuclease 0.0059 0.0096 0.0621
Loa Loa (eye worm) hypothetical protein 0.0085 0.0162 0.0157
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0059 0.0096 0.019
Leishmania major trypanothione reductase 0.0041 0.005 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0147 0.0143
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0063 0.0121
Leishmania major C-8 sterol isomerase-like protein 0.3982 1 1
Loa Loa (eye worm) beta-lactamase 0.008 0.0147 0.0143
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0045 0.0183
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0034 0.0062
Schistosoma mansoni lipoxygenase 0.0114 0.0233 0.0326
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.008 0.0147 0.0298
Plasmodium vivax importin-beta 2, putative 0.0059 0.0096 0.4119
Trypanosoma cruzi C-14 sterol reductase, putative 0.0046 0.0063 0.0058
Echinococcus multilocularis allatostatin A receptor 0.0512 0.1238 0.1731
Loa Loa (eye worm) hypothetical protein 0.2345 0.5867 0.5865
Loa Loa (eye worm) neuropeptide F receptor 0.0512 0.1238 0.1234
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0101 0.0201 0.0196
Schistosoma mansoni pyruvate kinase 0.0035 0.0036 0.0051
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.009 0.0394
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.0284 0.028
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.009 0.0394
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0011 0.003
Brugia malayi PAS domain containing protein 0.0053 0.0079 0.0074
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Loa Loa (eye worm) hypothetical protein 0.0048 0.0067 0.0063
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0011 0.0006
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.002 0.0594
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0512 0.1238 0.1731
Schistosoma mansoni intermediate filament proteins 0.0124 0.0259 0.0362
Mycobacterium tuberculosis Probable oxidoreductase 0.0104 0.0208 0.0425
Giardia lamblia Hypothetical protein 0.0071 0.0126 0.0823
Mycobacterium ulcerans recombinase A 0.0117 0.0241 0.1086
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0059 0.0096 0.0418
Onchocerca volvulus 0.0071 0.0126 0.0628
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0071 0.0126 0.0121
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0296 0.0694 0.144
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.016 0.6533
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0035 0.0049
Loa Loa (eye worm) hypothetical protein 0.0046 0.0063 0.0058
Trichomonas vaginalis pyruvate kinase, putative 0.0069 0.0121 0.0535
Trypanosoma brucei protein kinase, putative 0.0057 0.009 0.0086
Loa Loa (eye worm) hypothetical protein 0.0047 0.0066 0.0062
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.009 0.0086
Leishmania major cytochrome p450-like protein 0.0059 0.0096 0.0091
Schistosoma mansoni hypothetical protein 0.0512 0.1238 0.1731
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.009 0.0582
Echinococcus granulosus cytochrome P450 2K1 0.0059 0.0096 0.0134
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0512 0.1238 0.1731
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0035 0.0049
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Loa Loa (eye worm) hypothetical protein 0.0062 0.0103 0.0098
Brugia malayi Cytochrome P450 family protein 0.0059 0.0096 0.0091
Echinococcus multilocularis acetylcholinesterase 0.0273 0.0635 0.0888
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0512 0.1238 0.1234
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Giardia lamblia Fructose-bisphosphate aldolase 0.0606 0.1476 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Schistosoma mansoni glutaminase 0.0884 0.2177 0.3044
Entamoeba histolytica hypothetical protein 0.0024 0.0007 0.0016
Brugia malayi hypothetical protein 0.0512 0.1238 0.1234
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0063 0.0088
Brugia malayi hypothetical protein 0.0512 0.1238 0.1234
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0512 0.1238 0.1731
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0032 0.0028 0.0024
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.006 0.0097 0.0136
Loa Loa (eye worm) hypothetical protein 0.2035 0.5085 0.5083
Loa Loa (eye worm) hypothetical protein 0.008 0.0147 0.0143
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.009 0.0126
Schistosoma mansoni biogenic amine receptor 0.0512 0.1238 0.1731
Loa Loa (eye worm) hypothetical protein 0.0279 0.0652 0.0647
Echinococcus multilocularis pyruvate kinase 0.0055 0.0084 0.0118
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0086 0.017
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0045 0.0183
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.011 0.0223 0.1487
Echinococcus granulosus neuropeptide FF receptor 2 0.0512 0.1238 0.1731
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Brugia malayi glutaminase DH11.1 0.0884 0.2177 0.2174
Echinococcus multilocularis acetylcholinesterase 0.0273 0.0635 0.0888
Mycobacterium tuberculosis Probable lipase LipE 0.008 0.0147 0.0298
Brugia malayi MH1 domain containing protein 0.0029 0.0021 0.0016
Loa Loa (eye worm) MH2 domain-containing protein 0.0053 0.0081 0.0076
Trypanosoma brucei C-8 sterol isomerase, putative 0.3982 1 1
Echinococcus granulosus twik family of potassium channels 0.0071 0.0126 0.0176
Brugia malayi hypothetical protein 0.0036 0.0037 0.0032
Echinococcus multilocularis muscleblind protein 1 0.0177 0.0393 0.0549
Mycobacterium tuberculosis Probable lipase LipD 0.008 0.0147 0.0298
Schistosoma mansoni jumonji/arid domain-containing protein 0.0139 0.0297 0.0416
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Treponema pallidum recombinase A 0.0117 0.0241 0.1591
Mycobacterium ulcerans carboxylesterase, LipT 0.0046 0.0063 0.0267
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0057 0.0052
Schistosoma mansoni sodium/chloride dependent transporter 0.0048 0.0068 0.0095
Onchocerca volvulus 0.0057 0.0091 0.0442
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Echinococcus multilocularis dna polymerase eta 0.0023 0.0005 0.0007
Onchocerca volvulus Neuropeptide F receptor homolog 0.0512 0.1238 0.6487
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0059 0.0096 0.0418
Schistosoma mansoni growth hormone secretagogue receptor 0.0512 0.1238 0.1731
Entamoeba histolytica hypothetical protein 0.0114 0.0235 0.1567
Echinococcus multilocularis mothers against decapentaplegic 5 0.0053 0.0081 0.0113
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0089 0.0171 0.0239
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0512 0.1238 0.1731
Echinococcus granulosus rhodopsin orphan GPCR 0.0512 0.1238 0.1731
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0046 0.0063 0.0088
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.011 0.0223 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0046 0.0063 0.0088
Echinococcus granulosus transcription factor Dp 1 0.0077 0.0142 0.0199
Schistosoma mansoni hypothetical protein 0.0512 0.1238 0.1731
Echinococcus granulosus lamin 0.0124 0.0259 0.0362
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0086 0.017
Schistosoma mansoni acetylcholinesterase 0.0046 0.0063 0.0088
Schistosoma mansoni voltage-gated potassium channel 0.0096 0.019 0.0265
Mycobacterium ulcerans transmembrane cation transporter 0.0071 0.0126 0.0557
Onchocerca volvulus 0.0041 0.0049 0.0223
Schistosoma mansoni hypothetical protein 0.1487 0.37 0.5173
Toxoplasma gondii ABC1 family protein 0.008 0.0147 0.3629
Loa Loa (eye worm) cytochrome P450 family protein 0.0107 0.0216 0.0212
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0066 0.153
Loa Loa (eye worm) hypothetical protein 0.0046 0.0063 0.0058
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0071 0.0126 0.0121
Loa Loa (eye worm) hypothetical protein 0.0057 0.0092 0.0087
Echinococcus granulosus RUN 0.0041 0.0049 0.0068
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0097 0.0191 0.0389
Echinococcus multilocularis g protein coupled receptor 0.0512 0.1238 0.1731
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0005 0.0007
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0034 0.0163
Echinococcus multilocularis neuropeptides capa receptor 0.0512 0.1238 0.1731
Echinococcus multilocularis serotonin transporter 0.0279 0.0652 0.0911
Echinococcus granulosus orexin receptor type 2 0.0512 0.1238 0.1731
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0097 0.0191 0.0267
Schistosoma mansoni Smad4 0.0053 0.0081 0.0113
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0134 0.0284 0.0398
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0071 0.0126 0.0121
Plasmodium vivax pyruvate kinase 2, putative 0.0035 0.0036 0.134
Onchocerca volvulus 0.0512 0.1238 0.6487
Loa Loa (eye worm) CXXC zinc finger family protein 0.0089 0.0173 0.0168
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0047 0.0066 0.0093
Trichomonas vaginalis esterase, putative 0.008 0.0147 0.0656
Echinococcus multilocularis mothers against decapentaplegic 6 0.0024 0.0007 0.0009
Schistosoma mansoni jumonji domain containing protein 0.0134 0.0284 0.0398
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0279 0.0652 0.0647
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0134 0.0284 0.1901
Brugia malayi beta-lactamase 0.008 0.0147 0.0143
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0059 0.0096 0.019
Plasmodium falciparum glutathione reductase 0.0041 0.005 0.1967
Loa Loa (eye worm) hypothetical protein 0.0047 0.0066 0.0062
Trypanosoma cruzi C-14 sterol reductase, putative 0.0046 0.0063 0.0058
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Echinococcus granulosus p2X purinoceptor 4 0.007 0.0123 0.0173
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0147 0.0206
Echinococcus granulosus dna polymerase eta 0.0023 0.0005 0.0007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.0147 0.0206
Schistosoma mansoni twik family of potassium channels-related 0.0071 0.0126 0.0176
Giardia lamblia DNA repair protein RAD52 0.0402 0.0961 0.6504
Brugia malayi exodeoxyribonuclease III family protein 0.0097 0.0191 0.0186
Echinococcus multilocularis neuropeptide Y receptor 0.0512 0.1238 0.1731
Onchocerca volvulus 0.0086 0.0164 0.0829
Echinococcus granulosus g protein coupled receptor 0.0512 0.1238 0.1731
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0086 0.0475
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0045 0.0183
Echinococcus granulosus geminin 0.1487 0.37 0.5173
Leishmania major GTP-binding protein, putative 0.0044 0.0057 0.0052
Loa Loa (eye worm) hypothetical protein 0.0046 0.0063 0.0058
Schistosoma mansoni P2X receptor subunit 0.007 0.0123 0.0173
Echinococcus granulosus mothers against decapentaplegic 2 0.0024 0.0007 0.0009
Brugia malayi Tachykinin-like peptides receptor 99D 0.0512 0.1238 0.1234
Echinococcus granulosus rhodopsin orphan GPCR 0.0512 0.1238 0.1731
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0134 0.0284 0.0398
Echinococcus multilocularis beta LACTamase domain containing family member 0.008 0.0147 0.0206
Plasmodium falciparum potassium channel 0.0071 0.0126 0.5485
Onchocerca volvulus 0.0071 0.0126 0.0628
Echinococcus multilocularis GPCR, family 2 0.0035 0.0035 0.0049
Echinococcus multilocularis polycomb protein SCMH1 0.0057 0.0091 0.0127
Echinococcus granulosus lysine specific demethylase 5A 0.0139 0.0297 0.0416
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Trypanosoma cruzi sterol C-24 reductase, putative 0.0046 0.0063 0.0058
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.009 0.0126
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0512 0.1238 0.1731
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0093 0.0182 0.037
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0024 0.0008 0.0011
Brugia malayi hypothetical protein 0.0512 0.1238 0.1234
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0051 0.0071
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0512 0.1238 0.1234
Brugia malayi Serotonin receptor 0.0971 0.2398 0.2394
Schistosoma mansoni myosin xvIII 0.0512 0.1238 0.1731
Onchocerca volvulus 0.0047 0.0066 0.0314
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0118 0.0244 0.1103
Loa Loa (eye worm) hypothetical protein 0.0057 0.0092 0.0087
Schistosoma mansoni rab6-interacting 0.0041 0.0049 0.0068
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0024 0.0008 0.0011
Echinococcus multilocularis lamin 0.0124 0.0259 0.0362
Onchocerca volvulus 0.0361 0.0858 0.4485
Toxoplasma gondii histone lysine methyltransferase SET1 0.0177 0.0394 1
Onchocerca volvulus 0.0512 0.1238 0.6487
Brugia malayi RE15519p 0.0512 0.1238 0.1234
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.009 0.0086
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0059 0.0096 0.019
Loa Loa (eye worm) hypothetical protein 0.0076 0.0138 0.0133
Loa Loa (eye worm) pyruvate kinase 0.0069 0.0121 0.0116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.044 0.0615
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0059 0.0096 0.0418
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0059 0.0096 0.0418
Echinococcus granulosus phd:f box containing protein 0.0036 0.0037 0.0051
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0027 0.0037
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0069 0.0121 0.0243
Trypanosoma cruzi pyruvate kinase 2, putative 0.0069 0.0121 0.0116
Toxoplasma gondii hypothetical protein 0.0029 0.002 0.0333
Schistosoma mansoni voltage-gated cation channel 0.0127 0.0266 0.0373
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0287 0.0671 0.3065
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0512 0.1238 0.1234
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0118 0.0244 0.1103
Echinococcus granulosus apoptotic protease activating factor 1 0.0086 0.0164 0.0229
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0127 0.0266 0.0262
Loa Loa (eye worm) carboxylesterase 0.0046 0.0063 0.0058
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0045 0.004
Echinococcus multilocularis somatostatin receptor 0.0512 0.1238 0.1731
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0049 0.0068
Loa Loa (eye worm) neuropeptide F receptor 0.0512 0.1238 0.1234
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.011 0.0223 0.1006
Echinococcus granulosus g-protein coupled receptor 0.0512 0.1238 0.1731
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0071 0.0126 0.0121
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0059 0.0096 0.0418
Echinococcus multilocularis Smad4 0.0053 0.0081 0.0113
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0059 0.0096 0.0091
Brugia malayi intermediate filament protein 0.0124 0.0259 0.0254
Echinococcus granulosus hyperpolarization activated cyclic 0.0024 0.0008 0.0011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0606 0.1476 0.677
Brugia malayi hypothetical protein 0.0126 0.0264 0.0259
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0024 0.0008 0.0011
Schistosoma mansoni cpg binding protein 0.0095 0.0185 0.0259
Schistosoma mansoni amine GPCR 0.0512 0.1238 0.1731
Brugia malayi hypothetical protein 0.0047 0.0066 0.0062
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Echinococcus granulosus pyruvate kinase 0.0069 0.0121 0.0169
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0071 0.0126 0.0121
Schistosoma mansoni inositol monophosphatase 0.0039 0.0045 0.0062
Onchocerca volvulus 0.0047 0.0066 0.0314
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Echinococcus multilocularis small conductance calcium activated potassium 0.1518 0.3779 0.5283
Brugia malayi RNA, U transporter 1 0.0169 0.0372 0.0368
Schistosoma mansoni protein phosphatase 2C 0.0036 0.0037 0.0051
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.009 0.0086
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.008 0.0147 0.0656
Echinococcus granulosus lamin dm0 0.0124 0.0259 0.0362
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0011 0.0013
Plasmodium vivax SET domain protein, putative 0.0099 0.0198 0.8811
Loa Loa (eye worm) cytochrome P450 0.0059 0.0096 0.0091
Schistosoma mansoni neuropeptide receptor 0.0512 0.1238 0.1731
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0508 0.123 0.2561
Loa Loa (eye worm) hypothetical protein 0.0655 0.16 0.1596
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0512 0.1238 0.1731
Schistosoma mansoni loxhd1 0.0041 0.0049 0.0068
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0512 0.1238 0.1731
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0127 0.0266 0.0373
Leishmania major pyruvate kinase 0.0069 0.0121 0.0116
Echinococcus multilocularis jumonji domain containing 1A 0.0036 0.0037 0.0051
Mycobacterium leprae Probable lipase LipE 0.008 0.0147 0.0842
Schistosoma mansoni importin beta-1 0.0059 0.0096 0.0135
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0027 0.0037
Mycobacterium leprae Conserved hypothetical protein 0.0059 0.0096 0.0531
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0024 0.0008 0.0011
Echinococcus multilocularis carboxylesterase 5A 0.0273 0.0635 0.0888
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0606 0.1476 0.677
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.0091 0.0127
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0427 0.1945
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0273 0.0635 0.0888
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0512 0.1238 0.1234
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0059 0.0096 0.0418
Loa Loa (eye worm) inositol-1 0.0039 0.0045 0.004
Mycobacterium tuberculosis Probable reductase 0.0093 0.0182 0.037
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0037 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0011 0.003
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.002 0.0594
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0005 0.0007
Schistosoma mansoni Smad4 0.0024 0.0007 0.0009
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0065 0.011 0.0154
Loa Loa (eye worm) hypothetical protein 0.0099 0.0198 0.0193
Loa Loa (eye worm) hypothetical protein 0.0036 0.0037 0.0032
Loa Loa (eye worm) hypothetical protein 0.2709 0.6785 0.6783
Onchocerca volvulus 0.0085 0.0162 0.0819
Brugia malayi Carboxylesterase family protein 0.0273 0.0635 0.063
Echinococcus multilocularis p2X purinoceptor 4 0.007 0.0123 0.0173
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0024 0.0008 0.0014
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0047 0.0066 0.2531
Echinococcus multilocularis BC026374 protein (S09 family) 0.0046 0.0063 0.0088
Schistosoma mansoni hypothetical protein 0.0512 0.1238 0.1731
Echinococcus granulosus beta LACTamase domain containing family member 0.008 0.0147 0.0206
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.009 0.0086
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0046 0.0063 0.0267
Trichomonas vaginalis ap endonuclease, putative 0.0097 0.0191 0.0856
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0059 0.0096 0.0418
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0104 0.0208 0.0425
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0094 0.0184 0.0257
Trichomonas vaginalis pyruvate kinase, putative 0.0069 0.0121 0.0535
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0512 0.1238 0.1731
Loa Loa (eye worm) hypothetical protein 0.0124 0.0259 0.0254
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0033 0.0031 0.0026
Brugia malayi hypothetical protein 0.0079 0.0147 0.0142
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.0049 0.1931
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.009 0.0126
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0049 0.0068
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.005 0.1967
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0025 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.0642 0.2932
Echinococcus granulosus neuropeptides capa receptor 0.0512 0.1238 0.1731
Echinococcus granulosus twik family of potassium channels 0.0071 0.0126 0.0176
Echinococcus granulosus allatostatin A receptor 0.0512 0.1238 0.1731
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0049 0.0068
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0178 0.0397 0.2664
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0147 0.0656
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0146 0.0316 0.1433
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.016 0.0223
Onchocerca volvulus 0.0362 0.0861 0.4501
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Echinococcus granulosus acetylcholinesterase 0.0273 0.0635 0.0888
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0057 0.0354
Mycobacterium ulcerans hypothetical protein 0.0026 0.0011 0.003
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0045 0.0183
Onchocerca volvulus 0.0071 0.0126 0.0628
Brugia malayi Cytochrome P450 family protein 0.0123 0.0258 0.0253
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0099 0.0198 0.0277
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0059 0.0096 0.019
Echinococcus multilocularis lysine specific demethylase 5A 0.0134 0.0284 0.0398
Schistosoma mansoni pyruvate kinase 0.0069 0.0121 0.0169
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0086 0.3664
Treponema pallidum fructose-bisphosphate aldolase 0.0606 0.1476 1
Echinococcus granulosus dnaJ subfamily B 0.1274 0.3164 0.4424
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Trypanosoma cruzi C-8 sterol isomerase, putative 0.3982 1 1
Onchocerca volvulus 0.0512 0.1238 0.6487
Echinococcus granulosus mothers against decapentaplegic 5 0.0053 0.0081 0.0113
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0063 0.0088
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Trichomonas vaginalis set domain proteins, putative 0.0776 0.1905 0.8747
Echinococcus multilocularis neuropeptides capa receptor 0.0512 0.1238 0.1731
Schistosoma mansoni smad 0.0024 0.0007 0.0009
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0134 0.0284 0.028
Loa Loa (eye worm) doublecortin family protein 0.0041 0.0049 0.0044
Schistosoma mansoni biogenic amine (5HT) receptor 0.2345 0.5867 0.8203
Loa Loa (eye worm) hypothetical protein 0.0041 0.0049 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0606 0.1476 0.677
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0002
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.016 0.3949
Schistosoma mansoni twik family of potassium channels-related 0.0071 0.0126 0.0176
Onchocerca volvulus 0.0124 0.0259 0.1328
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0146 0.0316 0.1433
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0071 0.0126 0.0121
Onchocerca volvulus 0.0124 0.0259 0.1328
Brugia malayi MH1 domain containing protein 0.0029 0.0021 0.0016
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0063 0.0088
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0066 0.0093
Brugia malayi MH2 domain containing protein 0.0053 0.0081 0.0076
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0047 0.0066 0.0093
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0403 0.1832
Loa Loa (eye worm) cytochrome P450 family protein 0.0123 0.0258 0.0253
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.009 0.0086
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.009 0.0126
Onchocerca volvulus 0.0026 0.0011 0.0024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0512 0.1238 0.1731
Leishmania major cytochrome p450-like protein 0.0107 0.0216 0.0212
Echinococcus granulosus p2X purinoceptor 4 0.007 0.0123 0.0173
Brugia malayi glutathione reductase 0.0041 0.005 0.0045
Brugia malayi jmjC domain containing protein 0.0036 0.0037 0.0032
Leishmania major C-14 sterol reductase, putative 0.0046 0.0063 0.0058
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0071 0.0126 0.0121
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.016 0.0713
Brugia malayi MH1 domain containing protein 0.0053 0.0081 0.0076
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0011 0.003
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0099 0.0198 0.0277
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0065 0.011 0.0154
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0097 0.0191 0.0186
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Loa Loa (eye worm) glutathione reductase 0.0041 0.005 0.0045
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0296 0.0694 0.4122
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0097 0.0191 0.0186
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.009 0.0394
Echinococcus multilocularis microtubule associated protein 2 0.2854 0.7152 1
Brugia malayi AKH receptor 0.0512 0.1238 0.1234
Loa Loa (eye worm) hypothetical protein 0.0111 0.0226 0.0221
Onchocerca volvulus 0.0512 0.1238 0.6487
Onchocerca volvulus 0.0071 0.0126 0.0628
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0512 0.1238 0.1731
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0682 0.1668 0.1664
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0007 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.044 0.0615
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0066 0.0062
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Toxoplasma gondii cytochrome p450 superfamily protein 0.0059 0.0096 0.2287
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0126 0.0121
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.016 0.0713
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0086 0.0082
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.011 0.0223 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0093 0.0182 0.037
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0011 0.003
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0606 0.1476 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0069 0.0121 0.0116
Echinococcus granulosus rhodopsin orphan GPCR 0.0512 0.1238 0.1731
Trypanosoma cruzi ion transport protein, putative 0.0071 0.0126 0.0121
Loa Loa (eye worm) hypothetical protein 0.0047 0.0066 0.0062
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0066 0.0062
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Loa Loa (eye worm) hypothetical protein 0.0121 0.0253 0.0248
Trypanosoma cruzi sterol C-24 reductase, putative 0.0046 0.0063 0.0058
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0059 0.0096 0.019
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0071 0.0126 0.0823
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0162 0.0227
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0035 0.0049
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0101 0.0201 0.0196
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0059 0.0096 0.019
Echinococcus granulosus peptide allatostatin:somatostatin 0.0512 0.1238 0.1731
Brugia malayi neuropeptide F receptor 0.0512 0.1238 0.1234
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0071 0.0126 0.0176
Loa Loa (eye worm) norepinephrine transporter 0.0279 0.0652 0.0647
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0512 0.1238 0.1234
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Trypanosoma cruzi DNA repair protein, putative 0.0036 0.0037 0.0032
Echinococcus granulosus TGF beta signal transducer SmadC 0.0053 0.0081 0.0113
Echinococcus multilocularis p2X purinoceptor 4 0.007 0.0123 0.0173
Echinococcus granulosus tm gpcr rhodopsin 0.0512 0.1238 0.1731
Loa Loa (eye worm) MH1 domain-containing protein 0.0053 0.0081 0.0076
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0118 0.0244 0.0342
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0267 0.062 0.1286
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0606 0.1476 0.677
Schistosoma mansoni hypothetical protein 0.0512 0.1238 0.1731
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0118 0.0244 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0021 0.0016
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.009 0.0086
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0068 0.0063
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0037 0.0032
Schistosoma mansoni neuroligin 3 (S09 family) 0.0046 0.0063 0.0088
Echinococcus multilocularis muscleblind protein 0.0177 0.0393 0.0549
Onchocerca volvulus 0.0099 0.0198 0.1007
Trypanosoma brucei cytochrome P450, putative 0.0107 0.0216 0.0212
Echinococcus multilocularis voltage dependent calcium channel 0.0127 0.0266 0.0373
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Brugia malayi Dopamine receptor 0.0512 0.1238 0.1234
Echinococcus granulosus tm gpcr rhodopsin 0.0512 0.1238 0.1731
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0195 0.044 0.0615
Brugia malayi Cytochrome P450 family protein 0.0107 0.0216 0.0212
Echinococcus granulosus intermediate filament protein 0.0124 0.0259 0.0362
Brugia malayi Pyruvate kinase, muscle isozyme 0.0069 0.0121 0.0116
Onchocerca volvulus 0.008 0.0147 0.0742
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0296 0.0694 0.317
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0011 0.003
Schistosoma mansoni polycystin 1-related 0.0041 0.0049 0.0068
Brugia malayi mbt repeat family protein 0.0057 0.0091 0.0086
Loa Loa (eye worm) acetyltransferase 0.0162 0.0356 0.0351
Schistosoma mansoni BC026374 protein (S09 family) 0.0046 0.0063 0.0088
Schistosoma mansoni twik family of potassium channels-related 0.0071 0.0126 0.0176
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.0049 0.0068
Loa Loa (eye worm) hypothetical protein 0.0512 0.1238 0.1234
Echinococcus granulosus 7tm_1 domain containing protein 0.0512 0.1238 0.1731
Schistosoma mansoni hypothetical protein 0.0086 0.0164 0.0229
Loa Loa (eye worm) transcription factor SMAD2 0.0781 0.1918 0.1914
Schistosoma mansoni neuropeptide f receptor 76f 0.0512 0.1238 0.1731
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0059 0.0096 0.019
Schistosoma mansoni rab6-interacting 0.0041 0.0049 0.0068
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0011 0.0006
Echinococcus multilocularis lysine specific demethylase 6a 0.0036 0.0037 0.0051
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.0226 0.0221
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0512 0.1238 0.1731
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0512 0.1238 0.1731
Loa Loa (eye worm) TYRA-2 protein 0.0512 0.1238 0.1234
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0121
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0512 0.1238 0.1731
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0512 0.1238 0.1731
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0057 0.0052
Plasmodium vivax hypothetical protein, conserved 0.008 0.0147 0.6485
Schistosoma mansoni hypothetical protein 0.0366 0.0871 0.1217
Loa Loa (eye worm) hypothetical protein 0.0048 0.0068 0.0064
Brugia malayi Serotonin receptor 0.0512 0.1238 0.1234
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0011 0.0006
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.0233 0.0326
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0007 0.0005
Brugia malayi Flap endonuclease-1 0.0059 0.0096 0.0091
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0512 0.1238 0.1731
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0045 0.004
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.009 0.0126
Trypanosoma cruzi cytochrome P450, putative 0.0107 0.0216 0.0212
Loa Loa (eye worm) solute carrier family 6 member 4 0.0279 0.0652 0.0647
Loa Loa (eye worm) hypothetical protein 0.0032 0.0027 0.0022
Brugia malayi G protein-coupled receptor F59B2.13 0.0512 0.1238 0.1234
Trichomonas vaginalis glutaminase, putative 0.0884 0.2177 1
Plasmodium vivax potassium channel, putative 0.0071 0.0126 0.5485
Onchocerca volvulus 0.008 0.0147 0.0742
Echinococcus granulosus pyruvate kinase 0.0069 0.0121 0.0169
Brugia malayi Carboxylesterase family protein 0.0046 0.0063 0.0058
Loa Loa (eye worm) hypothetical protein 0.0126 0.0264 0.0259

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 29 nM Binding affinity towards Endothelin B receptor in human girardi heart cell membranes ChEMBL. 8691426
IC50 (binding) = 6200 nM Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes ChEMBL. 8691426
IC50 (binding) = 0.022 uM Binding affinity towards endothelin B receptor in porcine cerebellum membranes ChEMBL. 8691426
IC50 (binding) = 23 uM Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes. ChEMBL. 8691426

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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