Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | aldo keto reductase | 0.0591 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0591 | 1 | 0.5 |
Onchocerca volvulus | 0.0591 | 1 | 1 | |
Loa Loa (eye worm) | oxidoreductase | 0.0591 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0591 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0546 | 0.7404 | 0.7404 |
Onchocerca volvulus | 0.0591 | 1 | 1 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0591 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0591 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0591 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0591 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0591 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0591 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0591 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0591 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0591 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0591 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0591 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0591 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0591 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0591 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0591 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0591 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0591 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0591 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0591 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0591 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0591 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0591 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0591 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0591 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0591 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0591 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0591 | 1 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0591 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0591 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0591 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0591 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0591 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0591 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0591 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0591 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0591 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0591 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0591 | 1 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0591 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0591 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0591 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0591 | 1 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0546 | 0.7404 | 0.7404 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0591 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0591 | 1 | 0.5 |
Onchocerca volvulus | 0.0591 | 1 | 1 | |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0591 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0591 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0591 | 1 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.0591 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0591 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0591 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0591 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0591 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0591 | 1 | 1 |
Onchocerca volvulus | 0.0591 | 1 | 1 | |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0591 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0591 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0591 | 1 | 1 |
Onchocerca volvulus | 0.0591 | 1 | 1 | |
Entamoeba histolytica | aldose reductase, putative | 0.0591 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0591 | 1 | 1 |
Onchocerca volvulus | 0.0591 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0591 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0591 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0591 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0591 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0591 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0591 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0591 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0591 | 1 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0591 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0591 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0591 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0591 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0591 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 14.6 mM | In vitro inhibition of HL60 (human leukaemia) cell binding to human recombinant e-selectin. | ChEMBL. | 8544173 |
Inhibition (binding) | = 0 % | In vitro inhibitory activity against sialyl Lewisx expressing HL60 cell binding Selectin P at 20 mM concentration | ChEMBL. | 8544173 |
Inhibition (binding) | = 0 % | In vitro inhibitory activity against sialyl Lewisx expressing HL60 cell binding to Selectin L at 7 mM concentration | ChEMBL. | 8544173 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.