Detailed information for compound 169861

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 487.872 | Formula: C26H27Cl3N3-
  • H donors: 1 H acceptors: 1 LogP: 7.93 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCCN(c1ccc(cc1)CCCNc1c2ccccc2nc2c1cccc2)CCCl.[Cl-]
  • InChi: 1S/C26H27Cl2N3.ClH/c27-15-18-31(19-16-28)21-13-11-20(12-14-21)6-5-17-29-26-22-7-1-3-9-24(22)30-25-10-4-2-8-23(25)26;/h1-4,7-14H,5-6,15-19H2,(H,29,30);1H/p-1
  • InChiKey: FRHCNUWVUVGTRP-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Calcitonin receptor-like protein seb-1 0.025 0.2214 0.4904
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.2788 0.6097
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0121 0.0012
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0454 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0121 0.0024
Brugia malayi RNA recognition motif domain containing protein 0.0313 0.2812 0.623
Onchocerca volvulus 0.0152 0.1278 0.5844
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.018 0.024
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0134 0.0298
Echinococcus granulosus importin subunit beta 1 0.0029 0.0111 0.0002
Echinococcus multilocularis peregrin 0.0029 0.0113 0.0002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0121 0.0012
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0051
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0103 0.0817 0.0883
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0172 0.0076
Brugia malayi hypothetical protein 0.0027 0.0091 0.0201
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.018 0.024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.018 0.0255
Brugia malayi Carboxylesterase family protein 0.0066 0.0459 0.1017
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0134 0.1909
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0113 0.0007
Trichomonas vaginalis esterase, putative 0.0036 0.018 0.0591
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0454 0.1268
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0113 0.0312
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0113 0.253
Brugia malayi beta-lactamase 0.0036 0.018 0.0399
Echinococcus granulosus tar DNA binding protein 0.0313 0.2812 0.6135
Echinococcus granulosus snurportin 1 0.031 0.2788 0.6079
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0134 0.6223
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.049 0.1402
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.018 0.0591
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0869 0.8102 1
Onchocerca volvulus 0.01 0.0789 0.339
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0454 0.0779
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0459 0.0435
Plasmodium vivax SET domain protein, putative 0.003 0.0121 0.3404
Echinococcus granulosus acetylcholinesterase 0.0066 0.0459 0.0791
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0121 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0274 0.037
Loa Loa (eye worm) hypothetical protein 0.0492 0.4514 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0817 0.2614
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.018 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.018 0.0399
Leishmania major hypothetical protein, conserved 0.0027 0.0091 0.0801
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0134 0.4889
Giardia lamblia DNA repair protein RAD52 0.1069 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0274 0.0601
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0459 0.0791
Schistosoma mansoni tar DNA-binding protein 0.0313 0.2812 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0454 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0817 0.2614
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.018 0.0591
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.018 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0121 0.0036
Plasmodium vivax importin-beta 2, putative 0.0029 0.0111 0.2314
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.018 0.0591
Schistosoma mansoni survival motor neuron protein 0.01 0.0789 0.251
Loa Loa (eye worm) hypothetical protein 0.0069 0.049 0.0903
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0091 0.261
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.018 1
Brugia malayi Pre-SET motif family protein 0.003 0.0121 0.0268
Brugia malayi TAR-binding protein 0.0313 0.2812 0.623
Brugia malayi RNA binding protein 0.0313 0.2812 0.623
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0459 0.0833
Loa Loa (eye worm) hypothetical protein 0.0171 0.1461 0.3098
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0274 0.0413
Brugia malayi Muscleblind-like protein 0.015 0.1262 0.2796
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0113 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0274 0.0203
Schistosoma mansoni tar DNA-binding protein 0.0313 0.2812 1
Toxoplasma gondii melibiase subfamily protein 0.0103 0.0817 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.049 0.1402
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0274 0.037
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0172 0.0224
Brugia malayi Bromodomain containing protein 0.0029 0.0113 0.0251
Echinococcus multilocularis survival motor neuron protein 1 0.0492 0.4514 0.551
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0134 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0121 0.0036
Loa Loa (eye worm) carboxylesterase 0.0066 0.0459 0.0833
Onchocerca volvulus 0.0036 0.018 0.0335
Loa Loa (eye worm) pigment dispersing factor receptor c 0.025 0.2214 0.48
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0134 0.0029
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.1831 0.3935
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0789 0.1748
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0202
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0172 0.0139
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0588 0.0596
Onchocerca volvulus 0.0036 0.018 0.0335
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0134 0.0029
Echinococcus multilocularis GPCR, family 2 0.0079 0.0588 0.0596
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0274 0.0203
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0588 0.0596
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0454 0.4998
Onchocerca volvulus 0.003 0.0121 0.0039
Loa Loa (eye worm) hypothetical protein 0.0079 0.0588 0.1123
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0817 0.2614
Schistosoma mansoni tar DNA-binding protein 0.0313 0.2812 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0134 0.0029
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.018 0.0591
Mycobacterium tuberculosis Conserved protein 0.0036 0.018 0.024
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0202
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0134 0.0602
Schistosoma mansoni hypothetical protein 0.0079 0.0588 0.1763
Echinococcus granulosus peregrin 0.0029 0.0113 0.0006
Loa Loa (eye worm) TAR-binding protein 0.0313 0.2812 0.6153
Schistosoma mansoni tar DNA-binding protein 0.0313 0.2812 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0111 0.0247
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0111 0.2314
Brugia malayi RNA, U transporter 1 0.0083 0.0621 0.1377
Echinococcus multilocularis muscleblind protein 0.015 0.1262 0.144
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0134 0.0085
Mycobacterium leprae Probable lipase LipE 0.0036 0.018 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.018 0.0591
Onchocerca volvulus 0.0239 0.2107 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0459 0.0833
Schistosoma mansoni hypothetical protein 0.0079 0.0588 0.1763
Loa Loa (eye worm) hypothetical protein 0.005 0.0312 0.0501
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0313 0.2812 0.6153
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0274 0.0601
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.018 0.024
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.2041 1
Plasmodium vivax hypothetical protein, conserved 0.0036 0.018 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0134 0.0099
Schistosoma mansoni jumonji domain containing protein 0.0076 0.056 0.1659
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0202
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0172 0.0224
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0134 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0817 0.2614
Echinococcus granulosus GPCR family 2 0.0079 0.0588 0.1083
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0454 0.1675
Echinococcus multilocularis tar DNA binding protein 0.0313 0.2812 0.338
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0747 0.0795
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0454 1
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0304 0.2727 0.2684
Brugia malayi MH2 domain containing protein 0.0118 0.0955 0.2116
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0379 0.3442 0.4168
Brugia malayi hypothetical protein 0.0152 0.1278 0.2832
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.018 0.0202
Echinococcus granulosus acetylcholinesterase 0.0066 0.0459 0.0791
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.025 0.2214 0.4904
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0113 0.0051
Brugia malayi jmjC domain containing protein 0.0035 0.0172 0.0381
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0588 0.1083
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0222 0.0254
Entamoeba histolytica hypothetical protein 0.0304 0.2727 0.2684
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.018 0.024
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0069 0.049 0.2104
Plasmodium falciparum phd finger protein, putative 0.0029 0.0113 0.5174
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0202
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0111 0.0285
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0111 0.2314
Echinococcus granulosus survival motor neuron protein 1 0.0492 0.4514 1
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0459 0.0435
Schistosoma mansoni hypothetical protein 0.0029 0.0113 0.0007
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0113 0.0002
Brugia malayi PHD-finger family protein 0.0029 0.0113 0.0251
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0134 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0274 0.0601
Toxoplasma gondii ABC1 family protein 0.0036 0.018 0.1231
Brugia malayi latrophilin 2 splice variant baaae 0.0171 0.1461 0.3237
Echinococcus multilocularis muscleblind protein 1 0.015 0.1262 0.144
Brugia malayi beta-lactamase family protein 0.0036 0.018 0.0399
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0454 0.0429
Leishmania major hypothetical protein, conserved 0.0036 0.018 0.3067
Loa Loa (eye worm) hypothetical protein 0.0066 0.0459 0.0833
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.041 0.0722
Echinococcus granulosus muscleblind protein 0.015 0.1262 0.2615
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0134 0.4889
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0103 0.0817 0.0883
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0459 0.1288
Schistosoma mansoni hypothetical protein 0.01 0.0789 0.251
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0454 0.1268
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0134 0.0602
Schistosoma mansoni hypothetical protein 0.031 0.2788 0.9909
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0459 0.0435
Brugia malayi beta-lactamase family protein 0.0036 0.018 0.0399
Loa Loa (eye worm) hypothetical protein 0.025 0.2214 0.48
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0454 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0588 0.1083
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.018 0.0158
Brugia malayi jmjC domain containing protein 0.0096 0.0747 0.1655
Brugia malayi Melibiase family protein 0.0069 0.049 0.1085
Loa Loa (eye worm) hypothetical protein 0.015 0.1262 0.2648
Loa Loa (eye worm) hypothetical protein 0.0152 0.1278 0.2685
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0113 0.0312
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0222 0.0139
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0202
Schistosoma mansoni tar DNA-binding protein 0.0313 0.2812 1
Plasmodium falciparum importin beta, putative 0.0029 0.0111 0.4733
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.0069
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0202
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0274 0.0606
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0955 0.1954
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.018 0.0086
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0588 0.1123
Trichomonas vaginalis set domain proteins, putative 0.0239 0.2107 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0172 0.0184
Echinococcus multilocularis snurportin 1 0.031 0.2788 0.3349
Loa Loa (eye worm) beta-lactamase 0.0036 0.018 0.0202
Schistosoma mansoni hypothetical protein 0.0171 0.1461 0.4997
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0588 0.1302
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0134 0.4889
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0134 0.0029
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0379 0.3442 0.7565
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0134 0.6223
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.018 0.024
Brugia malayi isocitrate dehydrogenase 0.0032 0.0134 0.0298
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0091 0.261
Mycobacterium leprae conserved hypothetical protein 0.0036 0.018 0.5
Brugia malayi hypothetical protein 0.0492 0.4514 1
Schistosoma mansoni hypothetical protein 0.0079 0.0588 0.1763
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0588 0.1302
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.018 0.024
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0121 0.0036
Schistosoma mansoni hypothetical protein 0.0079 0.0588 0.1763
Mycobacterium tuberculosis Conserved protein 0.0036 0.018 0.024
Loa Loa (eye worm) hypothetical protein 0.015 0.1262 0.2648
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0955 0.1954
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.018 0.024
Loa Loa (eye worm) hypothetical protein 0.0029 0.0111 0.0047
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0747 0.1445
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0103 0.0817 0.1605
Onchocerca volvulus 0.0036 0.018 0.0335
Brugia malayi Carboxylesterase family protein 0.0066 0.0459 0.1017
Mycobacterium tuberculosis Conserved protein 0.0036 0.018 0.024
Brugia malayi Pre-SET motif family protein 0.021 0.1831 0.4057
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0121 0.0419
Loa Loa (eye worm) RNA binding protein 0.0313 0.2812 0.6153
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.018 0.0255

Activities

Activity type Activity value Assay description Source Reference
DNA crosslinking (functional) 0 DNA crosslinking ability of the compound at a concentration of 0.2 uM determined after Agarose gel electrophoresis run for 24 hr; + indicates Significant crosslinking ChEMBL. 2231599
DNA crosslinking (functional) 0 pBR322/DHFR26 DNA crosslinking ability at a concentration of 0.2 uM determined after Agarose gel electrophoresis run for 4 hr; + indicates Significant crosslinking ChEMBL. 2231599
DNA crosslinking (functional) +/- 0 pBR322/DHFR26 DNA crosslinking ability at a concentration of 0.02 uM determined after Agarose gel electrophoresis run for 4 hr; +/- indicates Slight crosslinking ChEMBL. 2231599
DNA crosslinking (functional) NT 0 pBR322/DHFR26 DNA crosslinking ability at a concentration of 0.002 uM determined after Agarose gel electrophoresis run for 4 hr; - indicates no crosslinking ChEMBL. 2231599
HF (functional) = 43 Relative cytotoxic potency given as Hypersensitivity ratio of (IC50 for AA8 cell line) to (IC50 for P388 leukemia cell line) ChEMBL. 2231599
IC50 (functional) = 0.061 uM Cytotoxicity against P388 leukemia cell line ChEMBL. 2231599
IC50 (functional) = 0.31 uM Cytotoxicity against AA8 cell line ChEMBL. 2231599
ILS (functional) = 25 % Increase in life span of the drug treated animals against P388 leukemia when treated at a optimal dose of 45 mg/kg ChEMBL. 2231599
KH (ADMET) = 14500 s-1 Rate constant for hydrolysis of the compound in aqueous acetone. ChEMBL. 2231599
KNBP (ADMET) = 146000 s-1 Rate constant for alkylation of 4-(4-nitrobenzyl)pyridine ChEMBL. 2231599
OD (functional) = 45 mg kg-1 Optimal dose (i.p.) given after inoculation with wild type 10 E 6 P388/W leukemia cell lines, measured on day 1 ChEMBL. 2231599
Relative lipophilicity = 0.67 Relative lipophilicity ChEMBL. 2231599

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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