Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.3848 | 0.3848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.1983 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.7163 | 0.7163 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1983 | 0.1983 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.3848 | 0.3848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1983 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0019 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3848 | 0.3848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.7163 | 0.7163 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0.0005 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1983 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.1983 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.7163 | 0.7163 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.1983 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.1983 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Brugia malayi | hypothetical protein | 0.002 | 0.0105 | 0.0105 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.1983 | 0.1983 |
Brugia malayi | isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.7163 | 0.7163 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1983 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1983 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3981 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.2387 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.581 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.