Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0624 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0115 | 0.1458 | 0.1443 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0144 | 0.0127 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0362 | 0.0345 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0105 | 0.1302 | 0.1287 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0109 | 0.1364 | 0.1349 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1323 | 0.1307 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0043 | 0.025 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0144 | 0.0127 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0105 | 0.1302 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1302 | 0.1287 |
Echinococcus multilocularis | acetylcholinesterase | 0.0624 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0624 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0624 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0624 | 1 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0144 | 0.0879 |
Echinococcus granulosus | expressed conserved protein | 0.0093 | 0.1102 | 0.1102 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.0352 | 0.0335 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0309 | 0.4717 | 0.4708 |
Brugia malayi | Carboxylesterase family protein | 0.0105 | 0.1302 | 0.1287 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0105 | 0.1302 | 0.1287 |
Brugia malayi | Carboxylesterase family protein | 0.0105 | 0.1302 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1356 | 0.134 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0105 | 0.1302 | 0.1287 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0043 | 0.025 | 0.025 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0144 | 0.0127 |
Onchocerca volvulus | 0.0105 | 0.1302 | 0.3826 | |
Onchocerca volvulus | 0.0229 | 0.3375 | 1 | |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0309 | 0.4717 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0224 | 0.0207 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.0362 | 0.0345 |
Onchocerca volvulus | 0.0036 | 0.0144 | 0.0377 | |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.1458 | 0.1443 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0099 | 0.1204 | 0.1188 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0099 | 0.1204 | 0.1188 |
Echinococcus granulosus | carbonic anhydrase II | 0.0309 | 0.4717 | 0.4717 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.2067 | 0.2053 |
Echinococcus multilocularis | GPCR, family 2 | 0.0049 | 0.0362 | 0.0345 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0352 | 0.0335 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.1458 | 0.1443 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0105 | 0.1302 | 0.3518 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0309 | 0.4717 | 1 |
Onchocerca volvulus | 0.0105 | 0.1302 | 0.3826 | |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0201 | 0.2909 | 0.2896 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0115 | 0.1458 | 0.1443 |
Echinococcus granulosus | carboxylesterase 5A | 0.0624 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0624 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0362 | 0.0345 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0105 | 0.1302 | 0.3584 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0239 | 0.3545 | 0.3533 |
Echinococcus granulosus | acetylcholinesterase | 0.0624 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0309 | 0.4717 | 0.4708 |
Echinococcus granulosus | neuroligin | 0.0105 | 0.1302 | 0.1302 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0099 | 0.1204 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0099 | 0.1204 | 0.1204 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0115 | 0.1458 | 0.1443 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0309 | 0.4717 | 0.4708 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.0362 | 0.0362 |
Schistosoma mansoni | carbonic anhydrase | 0.0115 | 0.1458 | 0.1443 |
Schistosoma mansoni | patched 1 | 0.0043 | 0.025 | 0.0233 |
Echinococcus multilocularis | muscleblind protein | 0.0151 | 0.2067 | 0.2053 |
Echinococcus granulosus | carbonic anhydrase | 0.0115 | 0.1458 | 0.1458 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0101 | 0.1229 | 0.1214 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0115 | 0.1458 | 0.1443 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0151 | 0.2067 | 0.2053 |
Loa Loa (eye worm) | carboxylesterase | 0.0624 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0144 | 0.0127 |
Echinococcus granulosus | carbonic anhydrase | 0.0115 | 0.1458 | 0.1458 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.025 | 0.0328 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0309 | 0.4717 | 0.4708 |
Echinococcus granulosus | transcription factor eb | 0.0109 | 0.1364 | 0.1364 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0078 | 0.0843 | 0.0826 |
Echinococcus granulosus | muscleblind protein | 0.0151 | 0.2067 | 0.2067 |
Echinococcus granulosus | GPCR family 2 | 0.0049 | 0.0362 | 0.0362 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0043 | 0.025 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1302 | 0.1287 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0224 | 0.0207 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0239 | 0.3545 | 0.3545 |
Brugia malayi | Muscleblind-like protein | 0.0151 | 0.2067 | 0.2053 |
Echinococcus multilocularis | carbonic anhydrase | 0.0115 | 0.1458 | 0.1443 |
Echinococcus multilocularis | protein patched | 0.0043 | 0.025 | 0.0233 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0144 | 0.0144 |
Echinococcus multilocularis | transcription factor eb | 0.0109 | 0.1364 | 0.1349 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.1559 | 0.1544 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0144 | 0.5 |
Onchocerca volvulus | 0.0105 | 0.1302 | 0.3826 | |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.1458 | 0.1443 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0232 | 0.3435 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0115 | 0.1458 | 0.1443 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0144 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0107 | 0.1323 | 0.1307 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0105 | 0.1302 | 0.1302 |
Leishmania major | carbonic anhydrase-like protein | 0.0309 | 0.4717 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.1559 | 0.1544 |
Plasmodium falciparum | carbonic anhydrase | 0.0115 | 0.1458 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.0362 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1302 | 0.1287 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0105 | 0.1302 | 0.1287 |
Onchocerca volvulus | 0.0049 | 0.0352 | 0.0995 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0105 | 0.1302 | 0.1287 |
Onchocerca volvulus | 0.0036 | 0.0144 | 0.0377 | |
Brugia malayi | Pre-SET motif family protein | 0.0201 | 0.2909 | 0.2896 |
Echinococcus multilocularis | protein dispatched 1 | 0.0049 | 0.0352 | 0.0334 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0105 | 0.1302 | 0.1302 |
Loa Loa (eye worm) | carboxylesterase | 0.0105 | 0.1302 | 0.1287 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0144 | 0.0127 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0115 | 0.1458 | 0.1443 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0078 | 0.0843 | 0.0826 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0105 | 0.1302 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0624 | 1 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0144 | 0.0127 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0156 | 0.2151 | 0.2137 |
Onchocerca volvulus | 0.0036 | 0.0144 | 0.0377 | |
Brugia malayi | CHE-14 protein | 0.0043 | 0.025 | 0.0233 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0144 | 0.0127 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0018 | 0.0018 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0105 | 0.1302 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1302 | 0.1287 |
Onchocerca volvulus | 0.0105 | 0.1302 | 0.3826 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0105 | 0.1302 | 0.3518 |
Onchocerca volvulus | 0.0105 | 0.1302 | 0.3826 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0105 | 0.1302 | 0.3518 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0144 | 0.0127 |
Schistosoma mansoni | acetylcholinesterase | 0.0105 | 0.1302 | 0.1287 |
Brugia malayi | Carboxylesterase family protein | 0.0105 | 0.1302 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.025 | 0.0233 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0362 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0412 | 0.0394 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.1559 | 0.1544 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.2151 | 0.2137 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1302 | 0.1287 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.0109 | 0.1356 | 0.134 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0843 | 0.0826 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0624 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0224 | 0.0207 |
Toxoplasma gondii | hypothetical protein | 0.0115 | 0.1458 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0144 | 0.0127 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0309 | 0.4717 | 0.4708 |
Echinococcus multilocularis | carbonic anhydrase | 0.0115 | 0.1458 | 0.1443 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0309 | 0.4717 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.2067 | 0.2053 |
Brugia malayi | hypothetical protein | 0.0105 | 0.1302 | 0.1287 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0142 | 0.192 | 0.192 |
Loa Loa (eye worm) | carboxylesterase | 0.0105 | 0.1302 | 0.1287 |
Brugia malayi | hypothetical protein | 0.0239 | 0.3545 | 0.3533 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0362 | 0.0345 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0107 | 0.1323 | 0.1307 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0105 | 0.1302 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0144 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1302 | 0.1287 |
Echinococcus multilocularis | acetylcholinesterase | 0.0624 | 1 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0144 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0142 | 0.192 | 0.1906 |
Echinococcus granulosus | carbonic anhydrase | 0.0115 | 0.1458 | 0.1458 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0105 | 0.1302 | 0.1302 |
Brugia malayi | hypothetical protein | 0.0078 | 0.0843 | 0.0826 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0144 | 0.0127 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0144 | 0.0127 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0144 | 0.0127 |
Schistosoma mansoni | gliotactin | 0.0105 | 0.1302 | 0.1287 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0115 | 0.1458 | 0.1443 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0105 | 0.1302 | 0.3584 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0144 | 0.0127 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.0352 | 0.0335 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0309 | 0.4717 | 0.4708 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0224 | 0.0207 |
Echinococcus multilocularis | expressed conserved protein | 0.0093 | 0.1102 | 0.1086 |
Trichomonas vaginalis | set domain proteins, putative | 0.0229 | 0.3375 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0049 | 0.0362 | 0.0345 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0156 | 0.2151 | 0.2137 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0049 | 0.0362 | 0.0345 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0144 | 0.0127 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0115 | 0.1458 | 0.1443 |
Brugia malayi | Carboxylesterase family protein | 0.0105 | 0.1302 | 0.1287 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0043 | 0.025 | 0.025 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0362 | 0.0345 |
Echinococcus multilocularis | neuroligin | 0.0105 | 0.1302 | 0.1287 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0078 | 0.0843 | 0.0843 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0115 | 0.1458 | 0.1443 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0049 | 0.0362 | 0.0345 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0309 | 0.4717 | 0.4708 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1204 | 0.1188 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1302 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.3545 | 0.3533 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0115 | 0.1458 | 0.1443 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0156 | 0.2151 | 0.2137 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.1458 | 0.1443 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.