Detailed information for compound 169892

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 563.552 | Formula: C30H29NO10
  • H donors: 1 H acceptors: 2 LogP: 4.36 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CNC(=O)OC1(OC(=O)C(=C1Cc1cc(OC)c(c(c1)OC)OC)c1ccc2c(c1)OCO2)c1ccc(cc1)OC
  • InChi: 1S/C30H29NO10/c1-31-29(33)41-30(19-7-9-20(34-2)10-8-19)21(12-17-13-24(35-3)27(37-5)25(14-17)36-4)26(28(32)40-30)18-6-11-22-23(15-18)39-16-38-22/h6-11,13-15H,12,16H2,1-5H3,(H,31,33)
  • InChiKey: OFDMTNIWJSEJHX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens endothelin receptor type B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0022 0.0091
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1924 0.9292 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0245 0.0234
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1161 0.8595
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0186 0.2656
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0058 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0144 0.516
Echinococcus granulosus transcription factor Dp 1 0.0038 0.013 0.0124
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0743 0.5481
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.014 0.0357
Onchocerca volvulus 0.0133 0.0594 0.7885
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0026 0.001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0015 0.0007
Schistosoma mansoni coup transcription factor 0.004 0.014 0.0128
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0022 0.0008
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.014 0.0128
Schistosoma mansoni hypothetical protein 0.0164 0.0743 0.0742
Echinococcus multilocularis lamin 0.0026 0.0073 0.0067
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.014 0.0128
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1349 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0186 0.1322
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0038 0.0024
Onchocerca volvulus 0.0026 0.0073 0.0501
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0015 0.0007
Mycobacterium ulcerans carboxylesterase, LipT 0.0133 0.0594 0.0566
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0264 0.3873
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0144 0.516
Brugia malayi isocitrate dehydrogenase 0.0015 0.0021 0.0017
Echinococcus granulosus dna polymerase eta 0.0014 0.0016 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0743 0.5481
Brugia malayi intermediate filament protein 0.0026 0.0073 0.0156
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0112 0.3879
Echinococcus multilocularis FTZ F1 alpha 0.004 0.014 0.0135
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0086
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0238 0.0234
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0186 0.2768
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0186 0.1322
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1349 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0245 0.0634
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0124 0.0118
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.014 0.0135
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0021 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0786 0.5801
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.014 0.0333
Echinococcus multilocularis para nitrobenzyl esterase 0.0133 0.0594 0.0597
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0115
Loa Loa (eye worm) hypothetical protein 0.0133 0.0594 0.156
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.014 0.0333
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0124 0.0112
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.014 0.0128
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0632 0.0664
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.014 0.0135
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0124 0.0861
Loa Loa (eye worm) hypothetical protein 0.0026 0.0071 0.0174
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.014 0.0135
Onchocerca volvulus 0.0023 0.0058 0.0288
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0124 0.0118
Brugia malayi hypothetical protein 0.0133 0.0594 0.154
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0038 0.0031
Loa Loa (eye worm) hypothetical protein 0.0133 0.0594 0.156
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0124 0.5
Mycobacterium ulcerans hypothetical protein 0.0023 0.0058 0.0028
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.1349 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0022 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.014 0.0333
Loa Loa (eye worm) hypothetical protein 0.004 0.014 0.0357
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.014 0.1447
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0264 0.0684
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0124 0.1688
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0144 0.516
Echinococcus granulosus para nitrobenzyl esterase 0.0133 0.0594 0.0597
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0031 0.0024
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0038 0.0031
Echinococcus granulosus FTZ F1 alpha 0.004 0.014 0.0135
Echinococcus multilocularis carboxylesterase 5A 0.0789 0.3778 0.3838
Onchocerca volvulus 0.0133 0.0594 0.7885
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0049 0.0115
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0124 0.0118
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1161 0.8595
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0086
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.014 0.0135
Brugia malayi Cytochrome P450 family protein 0.0024 0.0064 0.013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0086
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0144 0.1998
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.0743 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0016 0.0002
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0186 0.0181
Trichomonas vaginalis spcc417.12 protein, putative 0.0133 0.0594 0.4368
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0186 0.2656
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0026 0.001
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0049 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.014 0.0333
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0124 0.0587
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0058 0.0028
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0124 0.0112
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0632 0.0604
Loa Loa (eye worm) hypothetical protein 0.0133 0.0594 0.156
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.014 0.0333
Brugia malayi nuclear receptor NHR-67 0.0019 0.0038 0.0062
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0073 0.018
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0038 0.0024
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0044
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.0022 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0743 0.5481
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0038 0.0024
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.1056 0.1067
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0144 0.516
Schistosoma mansoni lamin 0.0026 0.0073 0.006
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0146 0.0655 0.0627
Loa Loa (eye worm) hypothetical protein 0.0146 0.0655 0.1721
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0144 0.0114
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.014 0.0333
Loa Loa (eye worm) hypothetical protein 0.004 0.014 0.0357
Brugia malayi ecdysteroid receptor 0.004 0.014 0.0333
Brugia malayi hypothetical protein 0.0228 0.1056 0.2768
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0264 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0264 0.026
Schistosoma mansoni inositol monophosphatase 0.0036 0.0124 0.0111
Mycobacterium tuberculosis Possible oxidoreductase 0.0146 0.0655 0.0688
Schistosoma mansoni hypothetical protein 0.08 0.3832 0.3889
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0021 0.0017
Loa Loa (eye worm) hypothetical protein 0.0031 0.0096 0.024
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0124 0.0863
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0038 0.0062
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0044
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0124 0.0118
Onchocerca volvulus 0.0056 0.022 0.2575
Schistosoma mansoni nuclear receptor 0.0019 0.0038 0.0024
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0119 0.0525 0.052
Schistosoma mansoni neuroligin 3 (S09 family) 0.0133 0.0594 0.059
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.014 0.0333
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1161 0.8595
Loa Loa (eye worm) carboxylesterase 0.0133 0.0594 0.156
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1349 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.014 0.0333
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0096 0.3223
Brugia malayi Inositol-1 0.0036 0.0124 0.0291
Schistosoma mansoni amine oxidase 0.0146 0.0655 0.0652
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.014 0.0333
Mycobacterium tuberculosis Carboxylesterase LipT 0.0133 0.0594 0.0623
Loa Loa (eye worm) hypothetical protein 0.0133 0.0594 0.156
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0105 0.0096
Schistosoma mansoni thyroid hormone receptor 0.004 0.014 0.0128
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1349 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0186 0.2656
Brugia malayi jmjC domain containing protein 0.0058 0.0229 0.057
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0238 0.3547
Brugia malayi hypothetical protein 0.0019 0.0038 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0086
Onchocerca volvulus 0.0133 0.0594 0.7885
Brugia malayi hypothetical protein 0.0146 0.0655 0.1701
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0229 0.0218
Brugia malayi Cytochrome P450 family protein 0.0024 0.0064 0.013
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0058 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0144 0.516
Schistosoma mansoni nuclear receptor 0.0019 0.0038 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1349 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0186 0.2656
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0058 0.0658
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0124 0.0863
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0124 0.1691
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0186 0.0181
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0144 0.0114
Echinococcus multilocularis neuroligin 0.0133 0.0594 0.0597
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0124 0.0291
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0133 0.0594 0.059
Plasmodium vivax hypothetical protein, conserved 0.0146 0.0655 1
Brugia malayi nuclear receptor RXR 0.0019 0.0038 0.0062
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.014 0.0135
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0038 0.0031
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0264 0.0254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.014 0.0357
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0016 0.0004
Loa Loa (eye worm) hypothetical protein 0.0133 0.0594 0.156
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0022 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0026 0.0408
Echinococcus multilocularis acetylcholinesterase 0.0789 0.3778 0.3838
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0186 0.2656
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0038 0.0031
Loa Loa (eye worm) DR-78 0.0019 0.0038 0.0086
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0049 0.0091
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0058 0.0315
Echinococcus granulosus dna polymerase kappa 0.0041 0.0144 0.0138
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.014 0.0128
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0038 0.0086
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0133 0.0594 0.0623
Echinococcus granulosus BC026374 protein S09 family 0.0133 0.0594 0.0597
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0038 0.0031
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0065
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0064 0.074
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0016 0.0002
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.014 0.0135
Echinococcus granulosus acetylcholinesterase 0.0789 0.3778 0.3838
Echinococcus granulosus phd:f box containing protein 0.0015 0.0022 0.0014
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0124 0.4367
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0186 0.0181
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0038 0.0031
Brugia malayi nuclear hormone receptor 0.0019 0.0038 0.0062
Loa Loa (eye worm) hypothetical protein 0.004 0.014 0.0357
Echinococcus multilocularis cpg binding protein 0.0059 0.0235 0.0231
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0022 0.0044
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.013 0.0124
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0038 0.0062
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0021 0.0013
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0022 0.0328
Schistosoma mansoni thyroid hormone receptor 0.004 0.014 0.0128
Brugia malayi SWIRM domain containing protein 0.0146 0.0655 0.1701
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0021 0.0041
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0022 0.0014
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0238 0.0209
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.014 0.0357
Echinococcus granulosus lamin 0.0026 0.0073 0.0067
Echinococcus granulosus intermediate filament protein 0.0026 0.0073 0.0067
Schistosoma mansoni hypothetical protein 0.0164 0.0743 0.0742
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0105 0.0791
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.014 0.0333
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0026 0.0408
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0115
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0743 0.5481
Loa Loa (eye worm) carboxylesterase 0.0789 0.3778 1
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.003 0.0041
Echinococcus granulosus geminin 0.0164 0.0743 0.0749
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0016 0.0009
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0038 0.0062
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0021 0.0013
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0058 0.0028
Brugia malayi jmjC domain containing protein 0.0015 0.0022 0.002
Echinococcus granulosus carboxylesterase 5A 0.0789 0.3778 0.3838
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0031 0.0024
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0124 0.1847
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0064 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.014 0.0357
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0264 0.1855
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.022 0.0567
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0058 0.0315
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0238 0.0209
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0022 0.0014
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0021 0.0005
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0229 0.0225
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0021 0.0075
Toxoplasma gondii histone lysine methyltransferase SET1 0.0106 0.0464 0.6905
Onchocerca volvulus 0.004 0.014 0.1447
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0238 0.0228
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0038 0.0086
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.014
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0038 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0086
Schistosoma mansoni cpg binding protein 0.0059 0.0235 0.0225
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0064 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.014 0.0333
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.025 0.1161 0.3046
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0133 0.0594 0.0623
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1161 0.8595
Schistosoma mansoni inositol monophosphatase 0.0036 0.0124 0.0111
Brugia malayi jmjC domain containing protein 0.0015 0.0022 0.002
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0632 0.9615
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0115
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0031 0.0068
Brugia malayi ecdysone receptor 0.0019 0.0038 0.0062
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.014 0.0135
Leishmania major hypothetical protein, conserved 0.0015 0.0022 0.0091
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0021 0.0314
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0058 0.0028
Schistosoma mansoni microtubule-associated protein tau 0.2036 0.9831 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0058 0.0116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1349 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0086
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0743 0.5481
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.014 0.0128
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0022 0.0014
Schistosoma mansoni hypothetical protein 0.0047 0.0173 0.0161
Brugia malayi Carboxylesterase family protein 0.0789 0.3778 1
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0022 0.0008
Loa Loa (eye worm) hypothetical protein 0.0789 0.3778 1
Brugia malayi hypothetical protein 0.0019 0.0038 0.0062
Brugia malayi polk-prov protein 0.0031 0.0096 0.0216
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0264 0.026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0086
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.025 0.1161 0.3062
Leishmania major DNA polymerase kappa, putative 0.0021 0.0048 0.0496
Loa Loa (eye worm) hypothetical protein 0.0789 0.3778 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0238 0.0239
Schistosoma mansoni BC026374 protein (S09 family) 0.0133 0.0594 0.059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0086
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0021 0.0013
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0146 0.0655 1
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0245 0.0241
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.014 0.0135
Brugia malayi nuclear receptor NHR-88 0.004 0.014 0.0333
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0124 0.1688
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0124 0.0863
Schistosoma mansoni lamin 0.0026 0.0073 0.006
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0049 0.0042
Onchocerca volvulus 0.0146 0.0655 0.8745
Brugia malayi steroid hormone receptor 0.004 0.014 0.0333
Onchocerca volvulus Bile acid receptor homolog 0.004 0.014 0.1447
Loa Loa (eye worm) hypothetical protein 0.004 0.014 0.0357
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0015 0.0007
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0022 0.0014
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0073 0.018
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1161 0.8595
Schistosoma mansoni cpg binding protein 0.0056 0.022 0.0209
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0144 0.516
Loa Loa (eye worm) hypothetical protein 0.0037 0.0124 0.0315
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.003 0.0142
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0022 0.0091
Echinococcus multilocularis BC026374 protein (S09 family) 0.0133 0.0594 0.0597
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0016 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0058 0.0028
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0124 0.0118
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0124 0.081
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1161 0.8595
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0021 0.0075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0073 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0096 0.3223
Schistosoma mansoni amine oxidase 0.0146 0.0655 0.0652
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0044
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0146 0.0655 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0124 0.0861
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0021 0.0013
Echinococcus granulosus lamin dm0 0.0026 0.0073 0.0067
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0086
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.014 0.0135
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0022 0.0235
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0133 0.0594 0.059
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0264 0.3873
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0186 0.0174
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0086
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.014
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.014 0.0333
Plasmodium vivax JmjC domain containing protein 0.0015 0.0022 0.0016
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0149 0.0671 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0144 0.1009
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0016 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0058 0.0045
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0006
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0021 0.0013
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0073 0.0156
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0021 0.0013
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0048 0.0496
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0049 0.0042
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0144 0.516
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0124 0.1691
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0022 0.0328
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0785 0.3759 0.3818
Brugia malayi Carboxylesterase family protein 0.0133 0.0594 0.154
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0186 0.2656
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0146 0.0655 0.0652
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.014 0.0128
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0115
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0058 0.0658
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0021 0.0314
Onchocerca volvulus 0.0026 0.0073 0.0501
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0038 0.0086
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0022 0.0008
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0038 0.003
Schistosoma mansoni zinc finger protein 0.0019 0.0038 0.0024
Echinococcus granulosus microtubule associated protein 2 0.2036 0.9831 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0146 0.0655 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0173 0.0421
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.003 0.0142
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0786 0.5801
Loa Loa (eye worm) hypothetical protein 0.0146 0.0655 0.1721
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0064 0.0154
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0064 0.0154
Echinococcus multilocularis acetylcholinesterase 0.0789 0.3778 0.3838
Echinococcus multilocularis lamin dm0 0.0026 0.0073 0.0067
Mycobacterium ulcerans dehydrogenase 0.0146 0.0655 0.0627
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0144 0.516
Echinococcus granulosus neuroligin 0.0133 0.0594 0.0597
Brugia malayi Carboxylesterase family protein 0.0133 0.0594 0.154
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0144 0.516
Loa Loa (eye worm) hypothetical protein 0.0133 0.0594 0.156
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0146 0.0655 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.014 0.0128
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0086
Loa Loa (eye worm) hypothetical protein 0.0146 0.0655 0.1721
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.014 0.0135
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0022 0.0044
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0038 0.0031
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0021 0.0075
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0133 0.0594 0.4368
Echinococcus granulosus cpg binding protein 0.0059 0.0235 0.0231
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0743 0.5481
Brugia malayi amine oxidase, flavin-containing family protein 0.0146 0.0655 0.1701
Schistosoma mansoni intermediate filament proteins 0.0026 0.0073 0.006
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0058 0.0028
Brugia malayi nuclear receptor RXR 0.0021 0.0049 0.0091
Echinococcus multilocularis dna polymerase eta 0.0014 0.0016 0.0009
Brugia malayi Carboxylesterase family protein 0.0789 0.3778 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0038 0.0031
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0186 0.1322
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.014 0.0135
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0038 0.0031
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.014 0.0128
Brugia malayi MAP kinase sur-1 0.0049 0.0186 0.0455
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0144 0.1998
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0048 0.0034
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0016 0.0028
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0146 0.0655 1
Brugia malayi nuclear hormone receptor 0.004 0.014 0.0333
Loa Loa (eye worm) hypothetical protein 0.0146 0.0655 0.1721
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0146 0.0655 1
Loa Loa (eye worm) carboxylesterase 0.0133 0.0594 0.156
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0058 0.0658
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0229 0.0225
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.014 0.0135
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0021 0.0195
Echinococcus multilocularis 0.0146 0.0655 0.0659
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0058 0.0315
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0026 0.001
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0124 0.4358
Schistosoma mansoni cpg binding protein 0.0059 0.0235 0.0225
Echinococcus multilocularis microtubule associated protein 2 0.2036 0.9831 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0065
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0238 0.0209
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0026 0.001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.003 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1349 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0245 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0026 0.0408
Loa Loa (eye worm) acetylcholinesterase 1 0.0789 0.3778 1
Brugia malayi nuclear receptor NHR-88 0.0019 0.0038 0.0062
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0238 0.3475
Loa Loa (eye worm) hypothetical protein 0.0146 0.0655 0.1721
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0186 0.6859
Echinococcus granulosus acetylcholinesterase 0.0789 0.3778 0.3838
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0743 0.5481
Toxoplasma gondii histone lysine-specific demethylase 0.0146 0.0655 0.9752
Echinococcus granulosus dnaJ subfamily B 0.08 0.3832 0.3893
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0186 0.106
Leishmania major UDP-galactopyranose mutase 0.0146 0.0655 1
Brugia malayi tailless protein 0.0019 0.0038 0.0062
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0038 0.0024
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0238 0.0228
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.1349 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0038 0.0031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0038 0.0031
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0133 0.0594 0.0597
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0133 0.0594 0.059
Brugia malayi Steroid receptor seven-up type 2 0.004 0.014 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.014 0.0333
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0124 0.0861
Schistosoma mansoni nuclear hormone receptor 0.004 0.014 0.0128
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0124 0.1691
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0186 0.0478
Loa Loa (eye worm) hypothetical protein 0.004 0.014 0.0357
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.014 0.0135
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0133 0.0594 0.0597
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0049 0.0091
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0124 0.1688
Loa Loa (eye worm) hypothetical protein 0.004 0.014 0.0357
Schistosoma mansoni DNA polymerase eta 0.0014 0.0016 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0186 0.1322
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.207 1 1
Brugia malayi Carboxylesterase family protein 0.0133 0.0594 0.154
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.014 0.0135
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0124 0.0118
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0144 0.1998
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.014 0.0333
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0065
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0065
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1349 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0058 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.014 0.0357
Brugia malayi CXXC zinc finger family protein 0.0056 0.022 0.0545
Brugia malayi Carboxylesterase family protein 0.0133 0.0594 0.154
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0022 0.0014
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0038 0.0031
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.1349 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0229 0.0225
Schistosoma mansoni gliotactin 0.0133 0.0594 0.059
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0038 0.0062
Loa Loa (eye worm) hypothetical protein 0.0133 0.0594 0.156
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0058 0.0045
Echinococcus multilocularis protoporphyrinogen oxidase 0.0146 0.0655 0.0659
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0064 0.074
Trypanosoma brucei unspecified product 0.0034 0.0112 0.3879
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.1349 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0144 0.516
Onchocerca volvulus 0.0047 0.0173 0.1916
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0086
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.014 0.1447
Schistosoma mansoni acetylcholinesterase 0.0133 0.0594 0.059
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.1056 0.1067
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0124 0.0809
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0146 0.0655 0.0652
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0015 0.0007
Brugia malayi jmjC domain containing protein 0.0061 0.0245 0.0611
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0144 0.1009
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0058 0.0116
Brugia malayi jmjC domain containing protein 0.0015 0.0022 0.002
Mycobacterium ulcerans oxidoreductase 0.0146 0.0655 0.0627
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0186 0.0181
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0015 0.0024
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.014 0.0135
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0038 0.0024
Echinococcus multilocularis dnaJ subfamily B 0.08 0.3832 0.3893
Schistosoma mansoni survival motor neuron protein 0.0047 0.0173 0.0161
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0238 0.0234
Loa Loa (eye worm) hypothetical protein 0.004 0.014 0.0357
Echinococcus multilocularis geminin 0.0164 0.0743 0.0749
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0264 0.0661
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0065
Leishmania major cytochrome p450-like protein 0.0024 0.0064 0.074
Onchocerca volvulus 0.0133 0.0594 0.7885
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0086
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0789 0.3778 0.3834
Echinococcus granulosus lysine specific histone demethylase 1A 0.0146 0.0655 0.0659
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0144 0.516
Brugia malayi hypothetical protein 0.0021 0.0049 0.0091
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0146 0.0655 0.0659
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.014 0.0357
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0038 0.0062
Mycobacterium ulcerans monoamine oxidase 0.0146 0.0655 0.0627
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.014
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0022 0.0008
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.014 0.0128
Brugia malayi jmjC domain containing protein 0.0015 0.0022 0.002
Loa Loa (eye worm) inositol-1 0.0036 0.0124 0.0314
Echinococcus granulosus lysine specific histone demethylase 1A 0.0146 0.0655 0.0659
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0022 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0144 0.1998
Brugia malayi hypothetical protein 0.0021 0.0049 0.0091
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.014 0.0135
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0022 0.0014
Loa Loa (eye worm) hypothetical protein 0.0146 0.0655 0.1721
Chlamydia trachomatis protoporphyrinogen oxidase 0.0146 0.0655 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0264 0.3873
Trypanosoma brucei protein kinase, putative 0.0049 0.0186 0.6859
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.014 0.0357
Plasmodium falciparum protoporphyrinogen oxidase 0.0146 0.0655 1
Loa Loa (eye worm) hypothetical protein 0.0228 0.1056 0.2785
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0064 0.1912
Plasmodium vivax hypothetical protein, conserved 0.0146 0.0655 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0146 0.0655 0.0688
Loa Loa (eye worm) hypothetical protein 0.004 0.014 0.0357
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0048 0.128
Brugia malayi conserved hypotetical protein 0.0019 0.0038 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.014 0.0333
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0124 0.0118
Trypanosoma cruzi UDP-galactopyranose mutase 0.0146 0.0655 1
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0144 0.0138
Onchocerca volvulus 0.0133 0.0594 0.7885
Echinococcus multilocularis musashi 0.0026 0.0073 0.0067
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0124 0.0094
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0124 0.0118
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0049 0.0035
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0038 0.0062
Loa Loa (eye worm) steroid hormone receptor 0.004 0.014 0.0357
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0021 0.0195

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 9 nM Binding affinity for human Endothelin A receptor expressed in LtK- cells ChEMBL. No reference
IC50 (binding) = 9 nM Binding affinity for human Endothelin A receptor expressed in LtK- cells ChEMBL. No reference
IC50 (binding) > 2500 nM Binding affinity for human endothelin B receptor expressed in CHO-K1 cells. ChEMBL. No reference
IC50 (binding) > 2500 nM Binding affinity for human endothelin B receptor expressed in CHO-K1 cells. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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