Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.2658 | 0.5004 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2658 | 0.2577 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2658 | 0.2577 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0525 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.0754 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.4678 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.8867 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.2658 | 0.5004 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.2658 | 0.1977 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.4393 | 0.395 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0634 | 0.0531 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.4393 | 0.3936 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.2658 | 0.5004 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.4678 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.9714 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.2658 | 0.1959 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.9714 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.4678 | 0.4619 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.2658 | 0.5004 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.2658 | 0.5004 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.6448 | 0.6409 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.2658 | 0.1959 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2658 | 0.2577 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2658 | 0.2577 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.9714 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.4678 | 0.4619 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.6448 | 0.6286 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.9714 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.4393 | 0.4331 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Onchocerca volvulus | 0.0029 | 0.4393 | 0.5 | |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.2658 | 0.1977 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.6448 | 0.6278 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.0754 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.2658 | 0.5004 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.