Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thymidylate synthase | 0.1718 | 0.2004 | 0.2004 |
Echinococcus multilocularis | thymidylate synthase | 0.1718 | 0.2004 | 0.2004 |
Onchocerca volvulus | 0.1718 | 0.2004 | 0.5 | |
Chlamydia trachomatis | dihydrofolate reductase | 0.8173 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1718 | 0.2004 | 0.1225 |
Brugia malayi | thymidylate synthase | 0.1718 | 0.2004 | 0.2004 |
Schistosoma mansoni | dihydrofolate reductase | 0.8173 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.8173 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.6096 | 0.7427 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.8173 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.8173 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.8173 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.8173 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.8173 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.1718 | 0.2004 | 0.2004 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1718 | 0.2004 | 0.2004 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.6096 | 0.7427 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.6096 | 0.7427 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0817 | 0.0888 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.6096 | 0.7427 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.8173 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.6096 | 0.7427 | 0.5 |
Brugia malayi | hypothetical protein | 0.0817 | 0.0888 | 0.0888 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.6096 | 0.7427 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
2x APTT (functional) | = 1.29 uM | Ability to double the activated partial thromboplastin time (2x APTT) in human plasma | ChEMBL. | 15163182 |
Ki (binding) | = 6.3 nM | Inhibitory potency against human thrombin | ChEMBL. | 15163182 |
Ki (binding) | = 6.3 nM | Inhibitory potency against human thrombin | ChEMBL. | 15163182 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.