Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.3501 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.3501 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0503 | 0.5237 | 0.5196 |
Onchocerca volvulus | 0.013 | 0.1225 | 1 | |
Echinococcus multilocularis | insulin receptor | 0.0302 | 0.308 | 0.2972 |
Schistosoma mansoni | dihydrofolate reductase | 0.0468 | 0.4862 | 0.4818 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0788 | 0.83 | 0.8274 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0302 | 0.308 | 0.3015 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.3501 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0866 | 0.078 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0351 | 0.0351 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.075 | 0.0663 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0351 | 0.026 |
Echinococcus granulosus | dihydrofolate reductase | 0.0468 | 0.4862 | 0.4783 |
Schistosoma mansoni | tyrosine kinase | 0.0503 | 0.5237 | 0.5196 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.1225 | 0.1089 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0468 | 0.4862 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0946 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0508 | 0.5294 | 0.5221 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0153 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0186 | 0.0094 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0186 | 0.0186 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0062 | 0.0494 | 0.1175 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0186 | 0.0102 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0351 | 0.026 |
Echinococcus multilocularis | 0.0293 | 0.2978 | 0.2869 | |
Schistosoma mansoni | tyrosine kinase | 0.0503 | 0.5237 | 0.5196 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.3501 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.003 | 0.0153 | 0.0153 |
Schistosoma mansoni | tyrosine kinase | 0.0508 | 0.5294 | 0.5254 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0468 | 0.4862 | 0.4783 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0341 | 0.3501 | 1 |
Schistosoma mansoni | eyes absent homolog | 0.0086 | 0.075 | 0.0671 |
Brugia malayi | Dihydrofolate reductase | 0.0468 | 0.4862 | 0.4862 |
Brugia malayi | hypothetical protein | 0.0086 | 0.075 | 0.075 |
Entamoeba histolytica | heat shock transcription factor, putative | 0.0096 | 0.0866 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.0153 | 0.0153 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0508 | 0.5294 | 0.5221 |
Entamoeba histolytica | heat shock transcription factor, putative | 0.0096 | 0.0866 | 1 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0494 | 0.0494 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0946 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0468 | 0.4862 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0468 | 0.4862 | 0.4862 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0206 | 0.0206 |
Onchocerca volvulus | Heat shock factor protein 2 homolog | 0.0096 | 0.0866 | 0.6648 |
Schistosoma mansoni | tyrosine kinase | 0.0302 | 0.308 | 0.302 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0468 | 0.4862 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0468 | 0.4862 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.1225 | 0.1142 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0302 | 0.308 | 0.2972 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0206 | 0.0054 |
Schistosoma mansoni | tyrosine kinase | 0.0302 | 0.308 | 0.302 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.1225 | 0.1089 |
Brugia malayi | HSF-type DNA-binding domain containing protein | 0.0096 | 0.0866 | 0.0866 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0302 | 0.308 | 0.2972 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.0494 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0468 | 0.4862 | 0.4814 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.075 | 0.0663 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0946 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0206 | 0.0054 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.3501 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.1225 | 0.1674 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0206 | 0.0122 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1225 | 0.115 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.003 | 0.0153 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0153 | 0.006 |
Brugia malayi | Protein kinase domain containing protein | 0.0302 | 0.308 | 0.308 |
Schistosoma mansoni | tyrosine kinase | 0.0946 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.013 | 0.1225 | 0.1225 |
Schistosoma mansoni | tyrosine kinase | 0.0508 | 0.5294 | 0.5254 |
Entamoeba histolytica | heat shock transcription factor, putative | 0.0096 | 0.0866 | 1 |
Echinococcus granulosus | insulin receptor | 0.0302 | 0.308 | 0.2972 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0508 | 0.5294 | 0.5221 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0153 | 0.0068 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0351 | 0.0351 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0206 | 0.0122 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0067 uM | Inhibitory activity against Dihydrofolate reductase from rat liver was evaluated using 90 microM dihydrofolic acid as substrate | ChEMBL. | 9301666 |
IC50 (binding) | = 0.0067 uM | Inhibitory activity against Dihydrofolate reductase from rat liver was evaluated using 90 microM dihydrofolic acid as substrate | ChEMBL. | 9301666 |
IC50 (binding) | = 0.0071 uM | Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii was evaluated using 90 microM dihydrofolic acid as substrate | ChEMBL. | 9301666 |
IC50 (binding) | = 0.0071 uM | Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii was evaluated using 90 microM dihydrofolic acid as substrate | ChEMBL. | 9301666 |
IC50 (binding) | = 0.45 uM | Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii was evaluated using 90 microM dihydrofolic acid as substrate | ChEMBL. | 9301666 |
IC50 (binding) | = 0.45 uM | Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii was evaluated using 90 microM dihydrofolic acid as substrate | ChEMBL. | 9301666 |
Selectivity ratio (binding) | = 0.01 | Selectivity ratio is IC50 of rat liver DHFR to that of Pneumocystis carinii DHFR | ChEMBL. | 9301666 |
Selectivity ratio (binding) | = 0.94 | Selectivity ratio is IC50 of rat liver DHFR to that of Toxoplasma gondii DHFR | ChEMBL. | 9301666 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.