Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2X, ligand-gated ion channel, 7 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0379 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.5829 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.1544 | 0.1477 |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0.0379 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0082 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0379 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.1544 | 0.1138 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3846 | 0.615 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0458 | 0.0382 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.1544 | 0.1681 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.1544 | 0.1138 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.6402 | 0.5 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.3378 | 0.306 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0082 | 1 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0379 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.3172 | 0.4856 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0379 | 1 |
Onchocerca volvulus | 0.0028 | 0.3172 | 0.5 | |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.1544 | 0.1704 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0379 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0379 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0379 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0082 | 1 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.006 | 0.722 | 0.7198 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0379 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.5829 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0379 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0082 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.1544 | 0.1138 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.3846 | 0.3797 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5829 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0678 | 0.0231 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0379 | 1 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.3378 | 0.306 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.1544 | 0.1477 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.1544 | 0.1138 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0379 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0082 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0082 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.3378 | 0.3325 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0379 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0379 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.1544 | 0.1138 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0082 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0379 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.3172 | 0.4842 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.3378 | 0.3325 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.3172 | 0.3118 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.1544 | 0.1681 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.1544 | 0.1138 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.1544 | 0.1704 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.3846 | 0.616 |
Schistosoma mansoni | P2X receptor subunit | 0.0082 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.5829 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.1544 | 0.1477 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0678 | 0.0231 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0379 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.1544 | 0.1477 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0379 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0379 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.4 | SUPPLEMENTARY: Inhibition of human P2X7 receptor assessed as inhibition of ethidium bromide accumulation. Same assay as CHEMBL1103860 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.