Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3094 | 0.3094 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3094 | 0.3559 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1949 | 0.1949 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3094 | 0.3094 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.8694 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1313 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1949 | 0.1949 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3094 | 0.3559 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1949 | 0.1949 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1313 | 0.1511 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3094 | 0.3094 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1949 | 0.1949 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1313 | 0.1313 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1313 | 0.1313 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.8694 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1949 | 0.1949 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3094 | 0.3559 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.119 | 0.1368 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1313 | 0.1313 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.8694 | 0.8694 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.119 | 0.119 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1949 | 0.1949 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.119 | 0.1368 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2216 | 0.2549 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1949 | 0.1949 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2216 | 0.2549 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3094 | 0.3094 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3094 | 0.3094 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3094 | 0.3559 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1313 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.8694 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1949 | 0.2242 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1313 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2216 | 0.2549 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.8694 | 0.8694 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3094 | 0.3094 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.8694 | 0.8694 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1313 | 0.1313 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1313 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3094 | 0.3094 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2216 | 0.2549 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3094 | 0.3559 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3094 | 0.3559 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1949 | 0.2242 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.