TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 399.92 | Formula: C20H26ClN7
H donors: 3 H acceptors: 3 LogP: 3.97 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: NC1CCC(CC1)Nc1nc(Nc2cccc(c2)Cl)c2c(n1)n(cn2)C(C)C
InChi: 1S/C20H26ClN7/c1-12(2)28-11-23-17-18(24-16-5-3-4-13(21)10-16)26-20(27-19(17)28)25-15-8-6-14(22)7-9-15/h3-5,10-12,14-15H,6-9,22H2,1-2H3,(H2,24,25,26,27)
InChiKey: AUZUZIZPNYPPHU-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cyclin-dependent kinase 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	cyclin dependent kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium berghei	cdc2-related kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	cell division protein kinase 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	ko:K02087 cyclin-dependent kinase 1, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania donovani	cell division protein kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	ko:K02090 cyclin-dependent kinase 5, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Giardia lamblia	Kinase, CMGC CDK	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma congolense	cdc2-related kinase 1, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	cell division control protein 2 homolog	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium knowlesi	Cell division control protein 2 homolog	Get druggable targets OG5_126712	All targets in OG5_126712
Babesia bovis	cell division control protein 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium vivax	protein kinase Crk2	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania braziliensis	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania infantum	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Giardia lamblia	Kinase, CMGC CDK	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium falciparum	protein kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium yoelii	cdc2-related kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei gambiense	cell division related protein kinase 2, putative,CDC2-related protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	cell division protein kinase 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium parvum	Cdc2-like CDK2/CDC28 like protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania braziliensis	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania major	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania donovani	cdc2-related kinase 3, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Theileria parva	cell division control protein 2 related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania infantum	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium hominis	cdc2-like protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma congolense	cdc2-related kinase 3, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei gambiense	cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Neospora caninum	CMGC kinase, CDK family TgPK2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	cyclin-dependent kinase 3	305 aa	303 aa	32.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0021	0.0019
Echinococcus granulosus	g-protein coupled receptor	0.0055	0.0639	0.0638
Schistosoma mansoni	neuropeptide receptor	0.0055	0.0639	0.0626
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.122	0.1207
Loa Loa (eye worm)	melatonin receptor type 1A	0.0055	0.0639	0.0741
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.001	0.0015	0.0013
Onchocerca volvulus		0.0055	0.0639	0.0727
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0052	0.0605	0.0603
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0021	0.0006
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0639	0.0626
Entamoeba histolytica	cell division protein kinase 2, putative	0.0052	0.0605	0.0687
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Schistosoma mansoni	rab6-interacting	0.0021	0.0161	0.0146
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0214	0.0233
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.011	0.0128
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0218	0.2944	0.2943
Echinococcus granulosus	cyclin dependent kinase	0.0052	0.0605	0.0603
Echinococcus granulosus	tumor protein p63	0.0364	0.4996	0.4995
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0639	0.0638
Brugia malayi	Serotonin receptor	0.0055	0.0639	0.0742
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0096	0.122	0.1415
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0218	0.2944	1
Echinococcus multilocularis	serotonin receptor	0.0055	0.0639	0.0638
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0055	0.0639	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.001	0.0015	0.0013
Echinococcus multilocularis	tumor protein p63	0.0364	0.4996	0.4995
Onchocerca volvulus		0.0055	0.0639	0.0727
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0055	0.0639	0.0638
Brugia malayi	hypothetical protein	0.0055	0.0639	0.0742
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.001	0.0015	0.0013
Schistosoma mansoni	hypothetical protein	0.0178	0.2379	0.2368
Schistosoma mansoni	hypothetical protein	0.0017	0.011	0.0096
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0621	0.8611	0.8611
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0639	0.0626
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0639	0.0626
Brugia malayi	intermediate filament protein	0.0029	0.028	0.0325
Schistosoma mansoni	loxhd1	0.0021	0.0161	0.0146
Echinococcus granulosus	g protein coupled receptor	0.0055	0.0639	0.0638
Brugia malayi	sulfakinin receptor protein	0.0055	0.0639	0.0742
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0052	0.0605	0.0701
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0055	0.0639	0.0727
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0639	0.0626
Schistosoma mansoni	neuropeptide receptor	0.0055	0.0639	0.0626
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0621	0.8611	0.8609
Brugia malayi	Doublecortin family protein	0.0021	0.0161	0.0187
Echinococcus multilocularis	g protein coupled receptor	0.0055	0.0639	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0055	0.0639	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Schistosoma mansoni	growth hormone secretagogue receptor	0.0055	0.0639	0.0626
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0055	0.0639	0.0741
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0084	0.1057	0.3254
Toxoplasma gondii	hypothetical protein	0.0029	0.028	0.0474
Schistosoma mansoni	ran	0.0022	0.0183	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0021	0.0007
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0021	0.0024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0621	0.8611	0.8611
Trypanosoma brucei	cdc2-related kinase 1	0.0052	0.0605	0.0687
Echinococcus granulosus	neuropeptide receptor A26	0.0055	0.0639	0.0638
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0055	0.0639	0.0742
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.028	0.0325
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0403	0.5538	0.6426
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.001	0.0015	0.0015
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.001	0.0015	0.0013
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0021	0.0019
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0639	0.0626
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0055	0.0639	0.0626
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.028	0.0324
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0218	0.2944	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0055	0.0639	0.0638
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0021	0.0019
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0639	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0061	0.0069
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0055	0.0639	0.0741
Trichomonas vaginalis	ran, putative	0.0022	0.0183	0.0196
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0055	0.0639	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0597	0.0691
Echinococcus multilocularis	sex peptide receptor	0.0055	0.0639	0.0638
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0055	0.0639	0.0626
Echinococcus granulosus	tm gpcr rhodopsin	0.0055	0.0639	0.0638
Brugia malayi	ecdysteroid receptor	0.0011	0.0021	0.0024
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.001	0.0015	0.0013
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0055	0.0639	0.0626
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0021	0.0024
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.001	0.0015	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0022
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.011	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0021	0.0022
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0321	0.4389	0.5097
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0055	0.0639	0.0638
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1057	0.1075
Echinococcus granulosus	cyclin dependent kinase 1	0.0052	0.0605	0.0603
Schistosoma mansoni	lipoxygenase	0.0058	0.0682	0.0668
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0055	0.0639	0.0638
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0055	0.0639	0.0626
Echinococcus multilocularis	neuropeptide receptor A26	0.0055	0.0639	0.0638
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.001	0.0015	0.0013
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.001	0.0015	0.0013
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.122	0.1218
Echinococcus multilocularis	g-protein coupled receptor	0.0055	0.0639	0.0638
Brugia malayi	Dopamine receptor protein 1	0.0055	0.0639	0.0742
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0055	0.0639	0.0626
Schistosoma mansoni	opsin-like receptor	0.0055	0.0639	0.0626
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0055	0.0639	0.0638
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0055	0.0639	0.0626
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0021	0.0019
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.001	0.0015	0.0013
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0021	0.0006
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0639	0.0638
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0639	0.0638
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0294	0.0526
Schistosoma mansoni	polycystin 1-related	0.0021	0.0161	0.0146
Mycobacterium ulcerans	aminopeptidase N PepN	0.0621	0.8611	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0639	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Loa Loa (eye worm)	hypothetical protein	0.0403	0.5538	0.6431
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0022
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0055	0.0639	0.0626
Echinococcus multilocularis	orexin receptor type 2	0.0055	0.0639	0.0638
Brugia malayi	G protein-coupled receptor F59B2.13	0.0055	0.0639	0.0742
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0061	0.0069
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.001	0.0015	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0218	0.2944	0.2943
Echinococcus granulosus	G protein coupled receptor 139	0.0055	0.0639	0.0638
Brugia malayi	nuclear hormone receptor	0.0011	0.0021	0.0024
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0183	0.0196
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0021	0.0024
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0069	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0021	0.0022
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0021	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Echinococcus multilocularis	GPCR, family 2	0.0017	0.011	0.0109
Schistosoma mansoni	neuropeptide receptor	0.0055	0.0639	0.0626
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0218	0.2944	0.3418
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.001	0.0015	0.0013
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Schistosoma mansoni	hypothetical protein	0.0055	0.0639	0.0626
Echinococcus multilocularis	aminopeptidase N	0.0621	0.8611	0.8611
Echinococcus granulosus	hypothetical protein	0.0055	0.0639	0.0638
Echinococcus multilocularis	cpg binding protein	0.0032	0.0317	0.0315
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0055	0.0639	0.0626
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.009	0.0105
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0084	0.1057	0.3254
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.001	0.0015	0.0013
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0055	0.0639	0.0638
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0055	0.0649	0.0647
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0021	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0017	0.011	0.0126
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0218	0.2944	0.2934
Brugia malayi	Dopamine receptor protein 2	0.0055	0.0639	0.0742
Schistosoma mansoni	amine GPCR	0.0055	0.0639	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Echinococcus multilocularis	lamin dm0	0.0029	0.028	0.0279
Echinococcus granulosus	neuropeptide s receptor	0.0055	0.0639	0.0638
Echinococcus granulosus	biogenic amine 5HT receptor	0.0055	0.0639	0.0638
Echinococcus granulosus	neuropeptide Y receptor	0.0055	0.0639	0.0638
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.001	0.0015	0.0013
Onchocerca volvulus		0.0621	0.8611	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0021	0.0019
Echinococcus granulosus	somatostatin receptor	0.0055	0.0639	0.0638
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.001	0.0015	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0161	0.0185
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Loa Loa (eye worm)	G-protein coupled receptor	0.0055	0.0639	0.0741
Echinococcus granulosus	g protein coupled receptor	0.0055	0.0639	0.0638
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0055	0.0639	0.0626
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0214	0.0233
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.001	0.0015	0.0015
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.001	0.0015	0.0015
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.028	0.0324
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Onchocerca volvulus		0.0029	0.028	0.0309
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0055	0.0639	0.0638
Brugia malayi	G-protein coupled receptor	0.0055	0.0639	0.0742
Onchocerca volvulus		0.0055	0.0639	0.0727
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0403	0.5538	0.5537
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Echinococcus multilocularis	dnaJ subfamily B	0.0426	0.5875	0.5874
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0055	0.0639	0.0742
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Brugia malayi	hypothetical protein	0.0021	0.0161	0.0187
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.122	0.1207
Trypanosoma brucei	cdc2-related kinase 3	0.0052	0.0605	0.0687
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.0183	0.2849
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0388	0.0449
Onchocerca volvulus		0.0055	0.0639	0.0727
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0021	0.0019
Schistosoma mansoni	hypothetical protein	0.0021	0.0161	0.0146
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0021	0.0024
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.001	0.0015	0.0015
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0147	0.0169
Schistosoma mansoni	opsin-like receptor	0.0055	0.0639	0.0626
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0621	0.8611	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.001	0.0015	0.0015
Onchocerca volvulus		0.0053	0.0621	0.0706
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0621	0.8611	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.028	0.0324
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0302	0.4128	0.4793
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0021	0.0022
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0147	0.0154
Schistosoma mansoni	ap endonuclease	0.002	0.0147	0.0133
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0147	0.0146
Echinococcus granulosus	g protein coupled receptor	0.0055	0.0639	0.0638
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Loa Loa (eye worm)	TYRA-2 protein	0.0055	0.0639	0.0741
Schistosoma mansoni	hypothetical protein	0.0055	0.0639	0.0626
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0055	0.0639	0.0626
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.001	0.0015	0.0013
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0021	0.0019
Loa Loa (eye worm)	TATA binding protein associated factor	0.0218	0.2944	0.3418
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0021	0.0007
Brugia malayi	putative neuropeptide receptor NPR1	0.0055	0.0639	0.0742
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Loa Loa (eye worm)	protein tyrosine phosphatase	0.001	0.0015	0.0015
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0183	0.0196
Echinococcus multilocularis	cyclin dependent kinase 5	0.0052	0.0605	0.0603
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0052	0.0605	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0218	0.2944	0.3418
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0621	0.8611	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.001	0.0015	0.0015
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0021	0.0006
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0218	0.2944	0.2934
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0183	0.0181
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0214	0.0233
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0161	0.0159
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0627	0.0727
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.011	0.0109
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0621	0.8611	0.8611
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0183	0.0127
Schistosoma mansoni	opsin-like receptor	0.0055	0.0639	0.0626
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0055	0.0639	0.0626
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0055	0.0639	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Brugia malayi	hypothetical protein	0.001	0.0015	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0021	0.0024
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.001	0.0015	0.0015
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0021	0.0024
Echinococcus granulosus	peptidase Clp S14 family	0.0055	0.0649	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0621	0.072
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0055	0.0639	0.0727
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0021	0.0006
Echinococcus granulosus	GPCR family 2	0.0017	0.011	0.0109
Echinococcus granulosus	Polycystic kidney disease protein	0.0021	0.0161	0.0159
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0021	0.0007
Loa Loa (eye worm)	neuropeptide F receptor	0.0055	0.0639	0.0741
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.011	0.0128
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0183	0.0196
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0021	0.0006
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0621	0.8611	0.8611
Echinococcus granulosus	biogenic amine 5HT receptor	0.0055	0.0639	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0273	0.0315
Schistosoma mansoni	cellular tumor antigen P53	0.0053	0.0621	0.0608
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0021	0.0006
Echinococcus granulosus	importin subunit beta 1	0.003	0.0294	0.0293
Plasmodium falciparum	protein kinase 5	0.0052	0.0605	0.1636
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.001	0.0015	0.0015
Echinococcus multilocularis	neuropeptide Y receptor	0.0055	0.0639	0.0638
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0055	0.0639	0.0638
Echinococcus granulosus	intermediate filament protein	0.0029	0.028	0.0279
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0055	0.0639	0.0638
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1057	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0029	0.028	0.1457
Entamoeba histolytica	Ran family GTPase	0.0022	0.0183	0.0196
Schistosoma mansoni	hypothetical protein	0.0055	0.0639	0.0626
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0055	0.0639	0.0741
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0021	0.0022
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0021	0.0024
Brugia malayi	hypothetical protein	0.0621	0.8611	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.001	0.0015	0.0015
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0161	0.0159
Brugia malayi	putative neuropeptide receptor	0.0055	0.0639	0.0742
Echinococcus granulosus	dro:myosuppressin receptor	0.0055	0.0639	0.0638
Echinococcus granulosus	lamin dm0	0.0029	0.028	0.0279
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0055	0.0649	1
Schistosoma mansoni	importin beta-1	0.003	0.0294	0.028
Echinococcus multilocularis	hypothetical protein	0.001	0.0015	0.0013
Schistosoma mansoni	lipoxygenase	0.0021	0.0161	0.0146
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0639	0.0638
Brugia malayi	hypothetical protein	0.0055	0.0639	0.0742
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0294	0.0326
Plasmodium falciparum	LCCL domain-containing protein	0.0021	0.0161	0.0048
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0147	0.0154
Brugia malayi	Protein-tyrosine phosphatase	0.001	0.0015	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0218	0.2944	0.3408
Brugia malayi	Probable ClpP-like protease	0.0084	0.1057	0.1228
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0055	0.0639	0.0638
Schistosoma mansoni	hypothetical protein	0.0426	0.5875	0.5869
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0621	0.8611	0.8609
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.067	0.1869
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0055	0.0639	0.0626
Trypanosoma cruzi	aminopeptidase, putative	0.0218	0.2944	0.3408
Brugia malayi	Dopamine receptor	0.0055	0.0639	0.0742
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Onchocerca volvulus		0.0055	0.0639	0.0727
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.001	0.0015	0.0013
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0021	0.0024
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0064	0.0765	0.0752
Brugia malayi	hypothetical protein	0.0055	0.0639	0.0742
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0621	0.8611	0.8611
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.001	0.0015	0.0015
Brugia malayi	RE15519p	0.0055	0.0639	0.0742
Onchocerca volvulus		0.0055	0.0639	0.0727
Echinococcus granulosus	neuropeptide receptor	0.0055	0.0639	0.0638
Echinococcus granulosus	7tm_1 domain containing protein	0.0055	0.0639	0.0638
Plasmodium falciparum	importin beta, putative	0.003	0.0294	0.0526
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.001	0.0015	0.0015
Schistosoma mansoni	intermediate filament proteins	0.0029	0.028	0.0266
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0055	0.0639	0.0741
Toxoplasma gondii	aminopeptidase N protein	0.0218	0.2944	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0055	0.0639	0.0638
Brugia malayi	hypothetical protein	0.001	0.0015	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.001	0.0015	0.0013
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0605	0.0687
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0639	0.0638
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0052	0.0605	0.0701
Onchocerca volvulus		0.0621	0.8611	1
Schistosoma mansoni	coup transcription factor	0.0011	0.0021	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0022
Onchocerca volvulus		0.0055	0.0639	0.0727
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0639	0.0626
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0605	0.0687
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0021	0.0024
Schistosoma mansoni	amine GPCR	0.0055	0.0639	0.0626
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0055	0.0639	0.0638
Echinococcus multilocularis	neuropeptides capa receptor	0.0055	0.0639	0.0638
Onchocerca volvulus		0.0055	0.0639	0.0727
Schistosoma mansoni	biogenic amine receptor	0.0055	0.0639	0.0626
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1057	0.1075
Echinococcus multilocularis	geminin	0.0178	0.2379	0.2378
Echinococcus granulosus	cpg binding protein	0.0032	0.0317	0.0315
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0055	0.0649	0.4744
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0021	0.0006
Schistosoma mansoni	lamin	0.0029	0.028	0.0266
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.001	0.0015	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Onchocerca volvulus		0.0055	0.0639	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0021	0.0019
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.122	0.1218
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0058	0.0682	0.068
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0021	0.0006
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0639	0.0638
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0021	0.0019
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.001	0.0015	0.0015
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1057	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0206	0.2769	0.2768
Brugia malayi	Protein-tyrosine phosphatase	0.001	0.0015	0.0017
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Loa Loa (eye worm)	G-protein coupled receptor	0.0055	0.0639	0.0741
Echinococcus multilocularis	cyclin dependent kinase 1	0.0052	0.0605	0.0603
Echinococcus granulosus	RUN	0.0021	0.0161	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0218	0.2944	0.3408
Plasmodium vivax	importin-beta 2, putative	0.003	0.0294	0.0526
Onchocerca volvulus		0.0055	0.0639	0.0727
Plasmodium vivax	multidomain scavenger receptor, putative	0.0021	0.0161	0.0048
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0055	0.0639	0.0638
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0218	0.2944	1
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0218	0.2944	0.3418
Schistosoma mansoni	amine GPCR	0.0055	0.0639	0.0626
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0021	0.0019
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0055	0.0639	0.0742
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0605	0.0687
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.011	0.0126
Trypanosoma cruzi	aminopeptidase, putative	0.0621	0.8611	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.001	0.0015	0.0013
Echinococcus multilocularis	lamin	0.0029	0.028	0.0279
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0055	0.0639	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Echinococcus granulosus	protein tyrosine phosphatase n9	0.001	0.0015	0.0013
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.001	0.0015	0.0013
Onchocerca volvulus		0.003	0.0293	0.0324
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.001	0.0015	0.0017
Echinococcus granulosus	orexin receptor type 2	0.0055	0.0639	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0069	0.0067
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0021	0.0019
Trypanosoma cruzi	cdc2-related kinase 3	0.0052	0.0605	0.0687
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Schistosoma mansoni	ap endonuclease	0.002	0.0147	0.0133
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0055	0.0639	0.0626
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0147	0.0154
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Trypanosoma cruzi	cdc2-related kinase 1	0.0052	0.0605	0.0687
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0605	0.0702
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0055	0.0639	0.0638
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0055	0.0639	0.0742
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0021	0.0019
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0147	0.0154
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0621	0.8611	0.8611
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.001	0.0015	0.0017
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0084	0.1057	0.1056
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.001	0.0015	0.0015
Echinococcus multilocularis	serotonin receptor	0.0055	0.0639	0.0638
Brugia malayi	hypothetical protein	0.0218	0.2944	0.3419
Plasmodium vivax	protein kinase Crk2	0.0052	0.0605	0.1636
Schistosoma mansoni	biogenic amine receptor	0.0055	0.0639	0.0626
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0147	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0022
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0052	0.0605	0.0687
Schistosoma mansoni	histamine h1 receptor	0.0055	0.0639	0.0626
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0029	0.028	0.0474
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0147	0.0154
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0052	0.0605	0.0687
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.001	0.0015	0.0013
Schistosoma mansoni	hypothetical protein	0.0037	0.0388	0.0374
Echinococcus multilocularis	microtubule associated protein 2	0.0719	1	1
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0206	0.2769	0.2759
Echinococcus multilocularis	somatostatin receptor	0.0055	0.0639	0.0638
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0183	0.0181
Schistosoma mansoni	hypothetical protein	0.0321	0.4389	0.4381
Echinococcus granulosus	neuropeptides capa receptor	0.0055	0.0639	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0218	0.2944	0.3418
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0021	0.0024
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.001	0.0015	0.0013
Schistosoma mansoni	amine GPCR	0.0055	0.0639	0.0626
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0621	0.8611	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.001	0.0015	0.0013
Brugia malayi	neuropeptide F receptor	0.0055	0.0639	0.0742
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0218	0.2944	0.3408
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0055	0.0639	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0403	0.5538	0.6431
Echinococcus multilocularis	neuropeptide s receptor	0.0055	0.0639	0.0638
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0021	0.0006
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0639	0.0626
Entamoeba histolytica	hypothetical protein	0.0024	0.0214	0.0233
Echinococcus multilocularis	Polycystic kidney disease protein	0.0021	0.0161	0.0159
Brugia malayi	steroid hormone receptor	0.0011	0.0021	0.0024
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1057	0.3254
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0021	0.0024
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Brugia malayi	hypothetical protein	0.0055	0.0639	0.0742
Schistosoma mansoni	neuropeptide F-like receptor	0.0055	0.0639	0.0626
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0639	0.0626
Echinococcus granulosus	dnaJ subfamily B	0.0426	0.5875	0.5874
Brugia malayi	hypothetical protein	0.0055	0.0639	0.0742
Brugia malayi	hypothetical protein	0.0021	0.0161	0.0187
Brugia malayi	larval opioid receptor	0.0055	0.0639	0.0742
Toxoplasma gondii	aminopeptidase N, putative	0.0218	0.2944	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0147	0.0146
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0206	0.2769	0.3215
Brugia malayi	G protein-coupled receptor	0.0055	0.0639	0.0742
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0161	0.0159
Schistosoma mansoni	amine GPCR	0.0055	0.0639	0.0626
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Echinococcus granulosus	lamin	0.0029	0.028	0.0279
Schistosoma mansoni	neuropeptide F-like receptor	0.0055	0.0639	0.0626
Loa Loa (eye worm)	doublecortin family protein	0.0021	0.0161	0.0185
Schistosoma mansoni	peptidase Clp (S14 family)	0.0084	0.1057	0.1044
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Echinococcus granulosus	allatostatin A receptor	0.0055	0.0639	0.0638
Onchocerca volvulus		0.0029	0.028	0.0309
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0055	0.0639	0.0626
Echinococcus multilocularis	g protein coupled receptor	0.0055	0.0639	0.0638
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.011	0.0109
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0218	0.2944	0.2943
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0055	0.0639	0.0638
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0021	0.0022
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.001	0.0015	0.0013
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0055	0.0639	0.0638
Echinococcus granulosus	aminopeptidase N	0.0621	0.8611	0.8611
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.011	0.0109
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0621	0.8611	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0294	0.034
Brugia malayi	Serotonin receptor	0.0055	0.0639	0.0742
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.001	0.0015	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Schistosoma mansoni	cpg binding protein	0.003	0.0293	0.0279
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.0403	0.5538	0.5532
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0021	0.0022
Echinococcus multilocularis	cyclin dependent kinase 1	0.0052	0.0605	0.0603
Loa Loa (eye worm)	aminopeptidase N	0.0621	0.8611	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Echinococcus granulosus	7TM GPCR rhodopsin	0.0055	0.0639	0.0638
Brugia malayi	hypothetical protein	0.001	0.0015	0.0017
Brugia malayi	RNA, U transporter 1	0.0085	0.1075	0.1248
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0022
Giardia lamblia	Kinase, CMGC CDK	0.0052	0.0605	1
Onchocerca volvulus		0.0021	0.0161	0.017
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.001	0.0015	0.0013
Mycobacterium ulcerans	aminopeptidase N PepN	0.0218	0.2944	0.3304
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0055	0.0639	0.0638
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0021	0.0022
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0639	0.0638
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Echinococcus multilocularis	g protein coupled receptor	0.0055	0.0639	0.0638
Brugia malayi	hypothetical protein	0.0055	0.0639	0.0742
Schistosoma mansoni	biogenic amine receptor	0.0055	0.0639	0.0626
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Schistosoma mansoni	neuropeptide f receptor 76f	0.0055	0.0639	0.0626
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.001	0.0015	0.0015
Onchocerca volvulus		0.0055	0.0639	0.0727
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0206	0.2769	0.3216
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Trypanosoma cruzi	cdc2-related kinase 1	0.0052	0.0605	0.0687
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.001	0.0015	0.0015
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0055	0.0649	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0021	0.0024
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0147	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0022
Brugia malayi	hypothetical protein	0.0055	0.0639	0.0742
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0218	0.2944	0.3408
Brugia malayi	G-protein coupled receptor	0.0055	0.0639	0.0742
Schistosoma mansoni	hypothetical protein	0.0017	0.011	0.0096
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0639	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0161	0.0185
Schistosoma mansoni	neuropeptide receptor	0.0055	0.0639	0.0626
Toxoplasma gondii	aminopeptidase n, putative	0.0218	0.2944	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0022
Onchocerca volvulus		0.0021	0.0161	0.017
Entamoeba histolytica	cell division protein kinase 2, putative	0.0052	0.0605	0.0687
Echinococcus multilocularis	neuropeptide receptor	0.0055	0.0639	0.0638
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.001	0.0015	0.0013
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.122	0.1218
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0161	0.0159
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0055	0.0639	0.0626
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0218	0.2944	1
Echinococcus granulosus	sex peptide receptor	0.0055	0.0639	0.0638
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0055	0.0639	0.0638
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Brugia malayi	Peptidase family M1 containing protein	0.0218	0.2944	0.3419
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0639	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0403	0.5538	0.6431
Loa Loa (eye worm)	hypothetical protein	0.0218	0.2944	0.3418
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.122	0.1207
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0052	0.0605	0.1636
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0605	0.0591
Echinococcus multilocularis	neuropeptides capa receptor	0.0055	0.0639	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0022
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0206	0.2769	0.2768
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0055	0.0639	0.0742
Loa Loa (eye worm)	neuropeptide F receptor	0.0055	0.0639	0.0741
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0021	0.0019
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0021	0.0006
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0058	0.0682	0.068
Brugia malayi	hypothetical protein	0.0055	0.0639	0.0742
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0055	0.0639	0.0742
Brugia malayi	hypothetical protein	0.0055	0.0639	0.0742
Trypanosoma cruzi	cdc2-related kinase 3	0.0052	0.0605	0.0687
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0293	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0021	0.0024
Schistosoma mansoni	rab6-interacting	0.0021	0.0161	0.0146
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.001	0.0015	0.0015
Brugia malayi	Melatonin receptor type 1A	0.0055	0.0639	0.0742
Brugia malayi	hypothetical protein	0.001	0.0015	0.0017
Echinococcus multilocularis		0.001	0.0015	0.0013
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0621	0.8611	0.8611
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0021	0.0024
Echinococcus multilocularis	fmrfamide receptor	0.0055	0.0639	0.0638
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0055	0.0639	0.0638
Schistosoma mansoni	lamin	0.0029	0.028	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Echinococcus granulosus	snurportin 1	0.0321	0.4389	0.4388
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1057	0.5
Brugia malayi	GnHR receptor homolog	0.0055	0.0639	0.0742
Onchocerca volvulus		0.0011	0.0021	0.0007
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0218	0.2944	0.3408
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0021	0.0019
Onchocerca volvulus		0.0055	0.0639	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0627	0.0729
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0021	0.0006
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0218	0.2944	0.3408
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0147	0.0154
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0639	0.0638
Schistosoma mansoni	hypothetical protein	0.0017	0.011	0.0096
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0021	0.0024
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0021	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Entamoeba histolytica	aminopeptidase, putative	0.0621	0.8611	1
Schistosoma mansoni	cpg binding protein	0.0032	0.0317	0.0303
Echinococcus multilocularis	neuropeptide Y receptor	0.0055	0.0639	0.0638
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.001	0.0015	0.0013
Echinococcus granulosus	fmrfamide receptor	0.0055	0.0639	0.0638
Echinococcus multilocularis	neuropeptide receptor	0.0055	0.0639	0.0638
Echinococcus multilocularis	snurportin 1	0.0321	0.4389	0.4388
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Schistosoma mansoni	ran	0.0022	0.0183	0.0168
Brugia malayi	ORL1-like opioid receptor	0.0055	0.0639	0.0742
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0021	0.0024
Onchocerca volvulus		0.0055	0.0639	0.0727
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0029	0.028	0.0474
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0096	0.122	0.1416
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0621	0.8611	1
Echinococcus multilocularis	allatostatin A receptor	0.0055	0.0639	0.0638
Echinococcus granulosus	geminin	0.0178	0.2379	0.2378
Giardia lamblia	Kinase, CMGC CDK	0.0052	0.0605	1
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0294	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0621	0.8611	0.8611
Schistosoma mansoni	cpg binding protein	0.0032	0.0317	0.0303
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0214	0.0233
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1057	0.5
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0084	0.1057	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.001	0.0015	0.0013
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.001	0.0015	0.0013
Schistosoma mansoni	hypothetical protein	0.0055	0.0639	0.0626
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0639	0.0638
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.001	0.0015	0.0013
Brugia malayi	AKH receptor	0.0055	0.0639	0.0742
Brugia malayi	hypothetical protein	0.001	0.0015	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Brugia malayi	neuropeptide F receptor	0.0055	0.0639	0.0742
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.001	0.0015	0.0013
Onchocerca volvulus		0.0055	0.0639	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.001	0.0015	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Echinococcus multilocularis	cyclin dependent kinase	0.0052	0.0605	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0069	0.0078
Schistosoma mansoni	myosin xvIII	0.0055	0.0639	0.0626
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0639	0.0638
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0084	0.1057	0.1056
Echinococcus multilocularis	fmrfamide receptor	0.0055	0.0639	0.0638
Schistosoma mansoni	microtubule-associated protein tau	0.0719	1	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0055	0.0639	0.0626
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0639	0.0638
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0021	0.0019
Echinococcus multilocularis	G protein coupled receptor 139	0.0055	0.0639	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0183	0.0127
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0214	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0627	0.0727
Trypanosoma brucei	Aminopeptidase M1, putative	0.0621	0.8611	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0055	0.0639	0.0638
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1057	0.1226
Schistosoma mansoni	hypothetical protein	0.0017	0.011	0.0096
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.001	0.0015	0.0013
Echinococcus multilocularis	musashi	0.0029	0.028	0.0279
Trypanosoma brucei	Aminopeptidase M1, putative	0.0621	0.8611	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0055	0.0639	0.0638
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0021	0.0006
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0084	0.1057	0.3254
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0294	0.0326
Brugia malayi	Protein-tyrosine phosphatase 1	0.001	0.0015	0.0017
Echinococcus granulosus	neuropeptide Y receptor	0.0055	0.0639	0.0638
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0627	0.0729
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0218	0.2944	0.2943
Schistosoma mansoni	adenoreceptor	0.0055	0.0639	0.0626
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0055	0.0639	0.0638
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0605	0.0591
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.009	0.0103
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0021	0.0019
Trypanosoma brucei	aminopeptidase, putative	0.0218	0.2944	0.3408
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0218	0.2944	0.2934
Onchocerca volvulus		0.0218	0.2944	0.3408
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.001	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Echinococcus granulosus	cyclin dependent kinase 5	0.0052	0.0605	0.0603
Echinococcus granulosus	neuropeptides capa receptor	0.0055	0.0639	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0639	0.0741
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0147	0.2249
Schistosoma mansoni	hypothetical protein	0.0178	0.2379	0.2368
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0021	0.0022
Brugia malayi	cell division control protein 2 homolog	0.0052	0.0605	0.0702
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0183	0.0212
Brugia malayi	hypothetical protein	0.0055	0.0639	0.0742
Brugia malayi	Peptidase family M1 containing protein	0.0621	0.8611	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0639	0.0638
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0183	0.021
Leishmania major	GTP-binding protein, putative	0.0022	0.0183	0.0196
Echinococcus granulosus	neuropeptide receptor	0.0055	0.0639	0.0638
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0183	0.0127
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0621	0.8611	0.8611
Echinococcus granulosus	serotonin receptor	0.0055	0.0639	0.0638
Echinococcus multilocularis	RUN	0.0021	0.0161	0.0159
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Brugia malayi	Importin beta-1 subunit	0.003	0.0294	0.0342
Brugia malayi	Peptidase family M1 containing protein	0.0621	0.8611	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0055	0.0639	0.0638
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.001	0.0015	0.0013
Brugia malayi	TATA binding protein associated factor	0.0218	0.2944	0.3419
Onchocerca volvulus		0.0055	0.0639	0.0727
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.001	0.0015	0.0013
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0621	0.8611	0.8611
Brugia malayi	follicle stimulating hormone receptor	0.0302	0.4128	0.4794
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0621	0.8611	1
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0218	0.2944	0.3408
Onchocerca volvulus		0.0055	0.0639	0.0727
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.001	0.0015	0.0013
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.122	0.1218
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.001	0.0015	0.0015
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0388	0.0451
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.001	0.0015	0.0013
Onchocerca volvulus		0.0055	0.0639	0.0727
Brugia malayi	CXXC zinc finger family protein	0.003	0.0293	0.034
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.001	0.0015	0.0017

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.03 uM	Inhibitory concentration against Cyclin dependent kinase 1.	ChEMBL.	12941319
IC50 (binding)	= 0.03 uM	Inhibitory concentration against Cyclin dependent kinase 1.	ChEMBL.	12941319
IC50 (functional)	= 1.1 uM	Cytotoxic property against MCF-7 cell line was determined	ChEMBL.	12941319
IC50 (functional)	= 1.1 uM	Cytotoxic property against MCF-7 cell line was determined	ChEMBL.	12941319
IC50 (functional)	= 1.4 uM	Cytotoxic property against K562 cell line was determined	ChEMBL.	12941319
IC50 (functional)	= 1.4 uM	Cytotoxic property against K562 cell line was determined	ChEMBL.	12941319

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	12941319

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL102871

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 169991