Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hexokinase | 0.0506 | 0.6181 | 0.6128 |
Onchocerca volvulus | 0.0807 | 1 | 1 | |
Echinococcus multilocularis | hexokinase | 0.0807 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0807 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.055 | 0.6741 | 0.6696 |
Echinococcus granulosus | hexokinase | 0.0807 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0807 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0807 | 1 | 0.5 |
Brugia malayi | hexokinase type II | 0.0257 | 0.3009 | 0.3009 |
Echinococcus granulosus | hexokinase type 2 | 0.0807 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0807 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0807 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0807 | 1 | 1 |
Onchocerca volvulus | 0.0807 | 1 | 1 | |
Plasmodium vivax | hexokinase, putative | 0.0807 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0807 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0273 | 0.0138 |
Trypanosoma cruzi | hexokinase, putative | 0.0807 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.0137 | 0.0137 |
Plasmodium falciparum | hexokinase | 0.0807 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.0807 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0807 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0807 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.025 | 0.2922 | 0.2823 |
Onchocerca volvulus | 0.0807 | 1 | 1 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0515 | 0.0515 |
Echinococcus multilocularis | hexokinase type 2 | 0.0807 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0807 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.3009 | 0.2912 |
Trypanosoma cruzi | hexokinase, putative | 0.0807 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0515 | 0.0383 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0515 | 0.0383 |
Toxoplasma gondii | hexokinase | 0.0807 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0807 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0807 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0807 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0273 | 0.0273 |
Loa Loa (eye worm) | hexokinase | 0.0807 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.3009 | 0.2912 |
Echinococcus granulosus | hexokinase | 0.0807 | 1 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0807 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.025 | 0.2922 | 0.2922 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0515 | 0.0515 |
Brugia malayi | Hexokinase family protein | 0.0506 | 0.6181 | 0.6181 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.