Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0039 | 0.4531 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0031 | 0.3157 | 0.6252 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0042 | 0.505 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0072 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0039 | 0.4531 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0019 | 0.1334 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0019 | 0.1334 | 1 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0072 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0015 | 0.0519 | 0.1028 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1334 | 0.2945 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.1334 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0019 | 0.1334 | 0.2945 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0015 | 0.0519 | 0.1145 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0032 | 0.3416 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0019 | 0.1334 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.3157 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0039 | 0.4531 | 0.4531 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0527 | 0.1162 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0527 | 0.1162 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0019 | 0.1334 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0015 | 0.0519 | 0.0519 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0015 | 0.0519 | 0.0519 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3785 | 0.8354 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0015 | 0.0527 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.3157 | 0.6252 |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.3157 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0042 | 0.505 | 1 |
Brugia malayi | hypothetical protein | 0.0031 | 0.3157 | 0.6968 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0015 | 0.0519 | 0.0519 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0527 | 0.1162 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0015 | 0.0527 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0019 | 0.1334 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0015 | 0.0519 | 0.1028 |
Onchocerca volvulus | 0.0019 | 0.1334 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.3157 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0015 | 0.0527 | 0.139 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0519 | 0.1145 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0032 | 0.3416 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0019 | 0.1334 | 0.2945 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1334 | 0.2945 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0019 | 0.1334 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0015 | 0.0519 | 0.0519 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0031 | 0.3157 | 0.3157 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0527 | 0.1162 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1334 | 0.2945 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0019 | 0.1334 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0527 | 0.1162 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0019 | 0.1334 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0015 | 0.0527 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0019 | 0.1334 | 0.2945 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0039 | 0.4531 | 0.4531 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0019 | 0.1334 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0031 | 0.3157 | 0.3157 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0019 | 0.1334 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.3157 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0019 | 0.1334 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.