Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Platelet activating factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.3218 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0544 | 0.1603 | 0.1603 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0544 | 0.1603 | 0.5 |
Echinococcus multilocularis | activated cdc42 kinase 1 | 0.0543 | 0.1601 | 0.1104 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0048 | 0.0048 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0544 | 0.1603 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0048 | 0.0048 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0544 | 0.1603 | 0.1107 |
Echinococcus multilocularis | acetylcholinesterase | 0.3218 | 1 | 1 |
Onchocerca volvulus | 0.0544 | 0.1603 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0544 | 0.1603 | 0.1603 |
Loa Loa (eye worm) | hypothetical protein | 0.0544 | 0.1603 | 0.1603 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3218 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 0.1592 | 0.1592 |
Loa Loa (eye worm) | hypothetical protein | 0.3218 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0544 | 0.1603 | 0.1603 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0544 | 0.1603 | 0.1107 |
Loa Loa (eye worm) | carboxylesterase | 0.0544 | 0.1603 | 0.1603 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0544 | 0.1603 | 0.1107 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.0558 | 0.0558 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0544 | 0.1603 | 0.1603 |
Onchocerca volvulus | 0.0544 | 0.1603 | 0.5 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0544 | 0.1603 | 0.1107 |
Echinococcus granulosus | acetylcholinesterase | 0.3218 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0544 | 0.1603 | 0.5 |
Brugia malayi | hypothetical protein | 0.0544 | 0.1603 | 0.1603 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0544 | 0.1603 | 0.1603 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0544 | 0.1603 | 0.1107 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0544 | 0.1603 | 0.1107 |
Loa Loa (eye worm) | hypothetical protein | 0.0544 | 0.1603 | 0.1603 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0549 | 0.0549 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0544 | 0.1603 | 0.1603 |
Echinococcus multilocularis | transfer RNA-Thr | 0.0543 | 0.1601 | 0.1104 |
Brugia malayi | Carboxylesterase family protein | 0.0544 | 0.1603 | 0.1603 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0544 | 0.1603 | 0.1603 |
Echinococcus granulosus | acetylcholinesterase | 0.3218 | 1 | 1 |
Onchocerca volvulus | 0.0544 | 0.1603 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0549 | 0.0549 |
Brugia malayi | Carboxylesterase family protein | 0.0544 | 0.1603 | 0.1603 |
Brugia malayi | Carboxylesterase family protein | 0.0544 | 0.1603 | 0.1603 |
Loa Loa (eye worm) | hypothetical protein | 0.0543 | 0.1601 | 0.1601 |
Loa Loa (eye worm) | hypothetical protein | 0.0544 | 0.1603 | 0.1603 |
Echinococcus granulosus | carboxylesterase 5A | 0.3218 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.3218 | 1 | 1 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.0543 | 0.1601 | 0.1104 |
Loa Loa (eye worm) | hypothetical protein | 0.3218 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0544 | 0.1603 | 0.1603 |
Schistosoma mansoni | tyrosine kinase | 0.0211 | 0.0558 | 0.0558 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3218 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0544 | 0.1603 | 0.1603 |
Loa Loa (eye worm) | carboxylesterase | 0.3218 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0544 | 0.1603 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0544 | 0.1603 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0544 | 0.1603 | 0.1107 |
Onchocerca volvulus | 0.0544 | 0.1603 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.0544 | 0.1603 | 0.1107 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0544 | 0.1603 | 0.1603 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.0543 | 0.1601 | 0.1104 |
Brugia malayi | Protein kinase domain containing protein | 0.0543 | 0.1601 | 0.1601 |
Brugia malayi | Carboxylesterase family protein | 0.0544 | 0.1603 | 0.1603 |
Echinococcus multilocularis | acetylcholinesterase | 0.3218 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0544 | 0.1603 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0544 | 0.1603 | 0.1603 |
Schistosoma mansoni | acetylcholinesterase | 0.0544 | 0.1603 | 0.1603 |
Onchocerca volvulus | 0.0544 | 0.1603 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.031 uM | Inhibition of PAF-induced platelet aggregation | ChEMBL. | 8411016 |
IC50 (functional) | = 0.031 uM | Inhibition of PAF-induced platelet aggregation | ChEMBL. | 8411016 |
ID50 (functional) | = 0.035 mg kg-1 | Intravenous dose required to reduce the arterial blood pressure caused by PAF by 50% in rats | ChEMBL. | 8411016 |
ID50 (functional) | = 0.035 mg kg-1 | Intravenous dose required to reduce the arterial blood pressure caused by PAF by 50% in rats | ChEMBL. | 8411016 |
ID50 (functional) | = 0.09 mg kg-1 | Dose required to inhibit PAF-induced mortality by 50% in mice | ChEMBL. | 8411016 |
ID50 (functional) | = 0.09 mg kg-1 | Dose required to inhibit PAF-induced mortality by 50% in mice | ChEMBL. | 8411016 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.