Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0028 | 0.104 | 0.1684 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0089 | 0.5083 | 0.8206 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0892 | 0.0892 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0028 | 0.104 | 0.1559 |
Onchocerca volvulus | 0.0026 | 0.0892 | 0.5 | |
Echinococcus multilocularis | musashi | 0.0026 | 0.0892 | 0.0892 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.423 | 0.3665 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0892 | 0.1445 |
Echinococcus granulosus | GPCR family 2 | 0.0028 | 0.104 | 0.104 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.423 | 0.6851 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.423 | 0.3665 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0061 | 0.3211 | 0.5129 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.423 | 0.3665 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0092 | 0.0148 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0089 | 0.5083 | 0.8206 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.5083 | 0.8233 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0089 | 0.5083 | 0.8233 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0106 | 0.6174 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0106 | 0.6174 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0028 | 0.104 | 0.104 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0892 | 0.1445 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0892 | 0.0892 |
Echinococcus multilocularis | geminin | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0106 | 0.6174 | 1 |
Echinococcus granulosus | lamin | 0.0026 | 0.0892 | 0.0892 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.423 | 0.6804 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.086 | 0.1394 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.104 | 0.0162 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0892 | 0.1316 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.423 | 0.3665 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0892 | 0.0892 |
Onchocerca volvulus | 0.0026 | 0.0892 | 0.5 | |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.423 | 0.423 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3211 | 0.5202 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.104 | 0.0162 |
Echinococcus multilocularis | GPCR, family 2 | 0.0028 | 0.104 | 0.104 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0028 | 0.104 | 0.104 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.423 | 0.6851 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.104 | 0.0162 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0028 | 0.104 | 0.1559 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.104 | 0.1684 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0892 | 0.1316 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.423 | 0.423 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0028 | 0.104 | 0.104 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.104 | 0.0162 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.423 | 0.6851 |
Brugia malayi | RNA binding protein | 0.0076 | 0.423 | 0.6804 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.423 | 0.6804 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0892 | 0.1445 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0028 | 0.104 | 0.104 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.423 | 0.3665 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.3211 | 0.2547 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0892 | 0.0892 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.